scholarly journals The role of mannose binding lectin in infectious complications of paediatric hemato-oncologic diseases

2021 ◽  
Author(s):  
Ferenc Fekete
Keyword(s):  
Infectious Complications ◽  
Mannose Binding Lectin ◽  
Mannose Binding ◽  
Oncologic Diseases ◽  
Binding Lectin

The role of mannose binding lectin in infectious complications of hemato-oncologic diseases

2013 ◽  
Vol 56 (3) ◽  
pp. 299
Author(s):  
M. Dobi ◽  
I. Szil gyi ◽  
D. Csuka ◽  
L. Varga ◽  
Z. Proh szka ◽  
...  
Keyword(s):  
Infectious Complications ◽  
Mannose Binding Lectin ◽  
Mannose Binding ◽  
Oncologic Diseases ◽  
Binding Lectin

The Role of Mannose-binding Lectin in Infectious Complications of Pediatric Hemato-Oncologic Diseases

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Marianna Dobi ◽  
Ágnes Szilágyi ◽  
Dorottya Csuka ◽  
Lilian Varga ◽  
Zoltán Prohászka ◽  
...  
Keyword(s):  
Infectious Complications ◽  
Mannose Binding Lectin ◽  
Mannose Binding ◽  
Oncologic Diseases ◽  
Binding Lectin

Influence of Mannose Binding Lectin (MBL) Gene Polymorphisms on Infectious Complications during Treatment for Childhood Malignancy.

Blood ◽  
2006 ◽  
Vol 108 (11) ◽  
pp. 1260-1260
Author(s):  
Rachel M. Dommett ◽  
Mona Bajaj-Elliott ◽  
Julia Chisholm ◽  
Nigel Klein
Keyword(s):  
High Risk ◽  
Infectious Complications ◽  
Mannose Binding Lectin ◽  
Diagnosis And Treatment ◽  
Study Cohort ◽  
Wide Range ◽  
Mannose Binding ◽  
Binding Lectin ◽  
Mbl Deficiency

Abstract Infection remains a major cause of morbidity and hospitalisation in children receiving chemotherapy. At present clinical parameters provide a guide to risk of severe infection but it has become increasingly apparent that, among patients with the same diagnosis and treatment regimen, not all suffer equally from infectious complications. Mannose binding lectin is a pattern recognition molecule of the innate immune system which, upon binding to a wide range of microorganisms, activates the lectin pathway of complement. Polymorphisms in the MBL2 gene result in low levels of MBL protein and are frequently associated with increased susceptibility to infection. Studies investigating the role of MBL in defence against infection following chemotherapy have reported conflicting findings to date. MBL replacement therapy is a potential treatment option in the future and we consider it imperative that we clarify the role of MBL in this clinical setting. Clinical data from episodes of febrile neutropenia (FN) in children aged 0−16 receiving chemotherapy for childhood cancer was recorded prospectively from April 2004−March 2005, including clinical and microbiological evidence of infection, antibiotic days and duration of admission. MBL genotyping was performed using a reverse hybridisation technique and results were analysed against FN outcome. 269 children were recruited into the study. A total of 513 episodes of FN were captured over the study period from 211 patients. 58 patients had no recorded episodes of FN. There was no association between age, sex, ethnicity or diagnosis and MBL genotype. 75% of subjects had a haematological malignancy and of these 84% had acute lymphoblastic leukaemia (ALL). Overall, patients with MBL2 polymorphisms experienced more episodes of FN than wildtype individuals (median 2 and 1, respectively, p=0.074). Analysis of episodes with documented clinical/microbiological infection revealed that the proportion of patients with ≥ 3 episodes was 14.6% in those with polymorphisms and 8% in wildtype, p=0.045. This trend was also true for the supgroup of patients with ALL. The duration of inpatient stay for FN, used as a surrogate measure of severity, was influenced by MBL genotype in some groups of patients. Longer inpatient stays and antibiotic days were most apparent in the MBL deficient patients with high risk diagnoses e.g. AML and B NHL who spent up to 4.5 days longer/per episode in hospital than high risk wildtype patients. These results suggest that MBL deficiency influences both susceptibility to FN and outcome of FN episodes in this study cohort. The effect of MBL deficiency differs between diagnostic groups and may be most important in those patients who are at higher risk of severe FN by virtue of their underlying diagnosis and treatment regime.

Mannose-binding lectin genetics: from A to Z

2008 ◽  
Vol 36 (6) ◽  
pp. 1461-1466 ◽  
Author(s):  
Peter Garred
Keyword(s):  
Epidemiological Studies ◽  
Mannose Binding Lectin ◽  
Host Cells ◽  
Lectin Pathway ◽  
Mannose Binding ◽  
The Stability ◽  
Genetically Determined ◽  
Micro Organisms ◽  
Binding Lectin

MBL (mannose-binding lectin) is primarily a liver-derived collagen-like serum protein. It binds sugar structures on micro-organisms and on dying host cells and is one of the four known mediators that initiate activation of the complement system via the lectin pathway. Common variant alleles situated both in promoter and structural regions of the human MBL gene (MBL2) influence the stability and the serum concentration of the protein. Epidemiological studies have suggested that genetically determined variations in MBL serum concentrations influence the susceptibility to and the course of different types of infectious, autoimmune, neoplastic, metabolic and cardiovascular diseases, but this is still a subject under discussion. The fact that these genetic variations are very frequent, indicates a dual role of MBL. This overview summarizes the current molecular understanding of human MBL2 genetics.

scholarly journals ON VASCULAR STENOSIS, RESTENOSIS AND MANNOSE BINDING LECTIN

2016 ◽  
Vol 29 (1) ◽  
pp. 57-59 ◽  
Author(s):  
Barbara Stadler KAHLOW ◽  
Rodrigo Araldi NERY ◽  
Thelma L SKARE ◽  
Carmen Australia Paredes Marcondes RIBAS ◽  
Gabriela Piovezani Ramos ◽  
...  
Keyword(s):  
Innate Immunity ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Mannose Binding Lectin ◽  
Mannose Binding ◽  
Vascular Stenosis ◽  
Micro Organisms ◽  
The Complement System ◽  
Binding Lectin

Mannose binding lectin is a lectin instrumental in the innate immunity. It recognizes carbohydrate patterns found on the surface of a large number of pathogenic micro-organisms, activating the complement system. However, this protein seems to increase the tissue damage after ischemia. In this paper is reviewed some aspects of harmful role of the mannose binding lectin in ischemia/reperfusion injury.

Role of mannose-binding lectin-2 polymorphism in the development of acute cellular rejection after transplantation for hepatitis C virus-induced liver disease

2012 ◽  
Vol 14 (5) ◽  
pp. 488-495 ◽  
Author(s):  
D. Eurich ◽  
S. Boas-Knoop ◽  
A. Yahyazadeh ◽  
R. Neuhaus ◽  
R. Somasundaram ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Liver Disease ◽  
Hepatitis C ◽  
Acute Cellular Rejection ◽  
Mannose Binding Lectin ◽  
Mannose Binding ◽  
Binding Lectin ◽  
Cellular Rejection

533 ROLE OF MANNOSE-BINDING-LECTIN-GENE-POLYMORPHISM IN THE DEVELOPMENT OF ACUTE CELLULAR REJECTION AFTER TRANSPLANTATION FOR HCV-INDUCED LIVER DISEASE

2011 ◽  
Vol 54 ◽  
pp. S218
Author(s):  
P. Eurich ◽  
S. Boas-Knoop ◽  
R. Neuhaus ◽  
R. Somasundaram ◽  
U.P. Neumann ◽  
...  
Keyword(s):  
Liver Disease ◽  
Gene Polymorphism ◽  
Acute Cellular Rejection ◽  
Mannose Binding Lectin ◽  
Lectin Gene ◽  
Mannose Binding ◽  
Binding Lectin ◽  
Cellular Rejection

scholarly journals Potential Role of Mannose-Binding Lectin in Intrauterine Transmission of Hepatitis B Virus

2013 ◽  
Vol 66 (5) ◽  
pp. 391-393 ◽  
Author(s):  
Yuzhong Wu ◽  
Qunyan Zhou ◽  
Huihua Wang ◽  
Ting Tian ◽  
Qiuyuan Zhu ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Potential Role ◽  
Mannose Binding Lectin ◽  
Intrauterine Transmission ◽  
B Virus ◽  
Mannose Binding ◽  
Binding Lectin

Role of mannose binding lectin in susceptibility to tuberculosis

2013 ◽  
Vol 56 (3) ◽  
pp. 299-300
Author(s):  
M. Krusch ◽  
K. Walter ◽  
T. Thye ◽  
S. Niemann ◽  
S. Homolka ◽  
...  
Keyword(s):  
Mannose Binding Lectin ◽  
Mannose Binding ◽  
Binding Lectin
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