scholarly journals Stability Indicating Reverse Phase High Performance Liquid Chromatographic Method with Photodiode Array Detection for the Simultaneous Quantification of Quinapril and Hydrochlorthiazide in Bulk and Tablet Dosage Forms

2018 ◽  
Vol 30 (4) ◽  
pp. 873-878 ◽  
Author(s):  
K. Lakshmi Prameela ◽  
P. Rama Krishna Veni ◽  
P.V.V. Satyanarayana ◽  
B. Hari Babu
Keyword(s):  
High Performance ◽  
High Performance Liquid Chromatographic ◽  
Reverse Phase ◽  
Photodiode Array Detection ◽  
Simultaneous Quantification ◽  
Liquid Chromatographic Method ◽  
Photodiode Array ◽  
Array Detection ◽  
Tablet Dosage ◽  
Liquid Chromatographic

scholarly journals Simultaneous Determination of Simvastatin and Ezetimibe in Tablets by HPLC

2009 ◽  
Vol 6 (2) ◽  
pp. 541-544 ◽  
Author(s):  
D. Anantha Kumar ◽  
D. P. Sujan ◽  
V. Vijayasree ◽  
J. V. L. N. Seshagiri Rao
Keyword(s):  
Simultaneous Determination ◽  
High Performance ◽  
Ammonium Acetate ◽  
High Performance Liquid Chromatographic ◽  
Dosage Forms ◽  
Reverse Phase ◽  
Liquid Chromatographic Method ◽  
Tablet Dosage ◽  
Liquid Chromatographic

A reverse phase high performance liquid chromatographic method was developed for the simultaneous determination of simvastatin and ezetimibe in tablet dosage forms. The separation was effected on a C18 Supelcosil column (250 mm x 4.6 mm; 5µ) using a mobile phase consisting of 0.01 M ammonium acetate buffer and acetonitrile (35:65v/v) at a flow rate of 1 mL/min. The detection was made at 240 nm. The retention times for ezetimibe and simvastatin were 5.9 and 8.5 min respectively. Calibration curves were linear over the ranges of 0.5-40 µg/mL for simvastatin and 2.5-50 µg/mL for ezetimibe. The proposed method was validated as per the ICH and USP guidelines. The method is accurate and precise and found to be suitable for the quantitative analysis of both the drugs individually and in combination in tablet dosage forms.

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