scholarly journals Grinding-Assisted Synthesis of Some Heterocyclic Compounds

2020 ◽  
Vol 32 (7) ◽  
pp. 1713-1718
Author(s):  
Jasim Ali Abdullah ◽  
Muwafaq Ayesh Rabeaa
Keyword(s):  
Schiff Base ◽  
Melting Point ◽  
Maleic Anhydride ◽  
1H Nmr ◽  
Phthalic Anhydride ◽  
13C Nmr ◽  
Sodium Azide ◽  
Heterocyclic Compounds ◽  
Succinic Anhydride ◽  
Benzaldehyde Derivatives

This article involves synthesis of some heterocyclic compounds from an amine derivative using ecofriendly approach (grinding). The first step involves synthesis of Schiff base from benzaldehyde derivatives (3-hydroxybenzaldehyde and 4-nitrobenzaldehyde) with 4-aminoantipyrine. These compounds were used as precursor for the synthesis of heterocyclic compounds and then synthesized tetrazole, oxazepine oxazepane derivatives from Schiff base with sodium azide, phthalic anhydride, maleic anhydride and succinic anhydride, respectively. The heterocyclic compounds were characterized by TLC, melting point, FTIR, 1H NMR, 13C NMR, GC-mass and HRMS analyses.

scholarly journals Synthesis and Characterization of Some New Monemer and Polymers Containing Hetero Cyclic Rings With Study of Their Physical Properties.

2016 ◽  
Vol 13 (2) ◽  
pp. 172-180
Author(s):  
Baghdad Science Journal
Keyword(s):  
Acetic Acid ◽  
Schiff Base ◽  
Maleic Anhydride ◽  
Phthalic Anhydride ◽  
Sodium Azide ◽  
Heterocyclic Compounds ◽  
Synthesis And Characterization ◽  
X Ray ◽  
Ft Ir

Number of new polyester and polyamide are prepared as derivatives from 5,5`-(1,4-phenylene)-bis-(1,3,4-thiadiazole-2-amine) [C1], three series of heterocyclic compounds were synthesized.The first series includes the Schiff base [C2] prepared from the reaction between compound [C1] with p-hydroxy benzaldehyde in presence of acetic acid and absolute ethanol , then these derivatives have reaction with maleic anhydride , phthalic anhydride and sodium azide, respectively to obtain the compounds [C3-5] contaning (oxazepine and tetrazole) rings.The third series of compounds [C1-5] has transformed to their polymers [C6-15] by reaction with adipoyl chloride and glutroyl chloride , respectively. The reaction was followed by T.L.C and identified by FT-IR , 1H-NMR ,C.H.N analysis , softening point , viscosity, TGA , DSC and X-ray.

Synthesis and Characterization of Some New Esters Containing Heterocyclic and Derived From Azo Dyes

2019 ◽  
Vol 9 (02) ◽  
Author(s):  
Zena G. Alrecabi ◽  
Zainab Amer ◽  
Naeemah Al-Lami
Keyword(s):  
Schiff Base ◽  
13C Nmr ◽  
Azo Dyes ◽  
Spectral Methods ◽  
Anthranilic Acid ◽  
Heterocyclic Compounds ◽  
Synthesis And Characterization ◽  
Cooh Group ◽  
Molecular Weights

This study including prepared new colored esters containing heterocyclic with high molecular weights. In the first part of work we synthesized azo dyes [1,2] from the reaction p-toluidine with β-naphthol and o-nitro phenol, thin we synthesized Schiff bases [3,4] by the reaction anthranilic acid with benzaldehyde and dimethyl benzaldehyde. The reaction azo dyes (contain OH group) with Schiff base (contain COOH group) these led to produce the new colored esters [A1-A4]. The second part of work was modification the (C=N-) group in esters to heterocyclic compounds by reacting with phenyl iso cyanide to produce new β-lactam [B1-B4] and with anthranilic acid to get new hydroquinazoline [C1-C4]. All these compounds were characterized by physical properties and spectral methods FTIR, 1H-NMR and 13C-NMR.

scholarly journals Preparation and Characterization of Some Hyperbranched Polyesteramides/Montmorillonite Nanocomposites

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Amal Amin ◽  
Moshera Samy
Keyword(s):  
Maleic Anhydride ◽  
Phthalic Anhydride ◽  
Succinic Anhydride ◽  
Thermal Analyses ◽  
Hyperbranched Polymers ◽  
H Nmr ◽  
Tga And Dsc ◽  
Montmorillonite Nanocomposites

Different polyesteramides hyperbranched polymers (HPEA1-6)/montomorillonite clay (MMT) nanocomposites were prepared with three different loading contents of clay (4, 10, and 15 wt%). The obtained nanocomposites were characterized via XRD, thermal analyses, and TEM. Generally, intercalation behavior was observed. The hyperbranched polyesteramides (HPEA1-6) were originally prepared by the bulky reaction between maleic anhydride (MAn), succinic anhydride (ScAn), and phthalic anhydride (PhAn) with either diethanolamine (DEA) or diisopropanolamine (DiPA). The resulting hyperbranched polyesteramides (HPEA1-6) were characterized by GPC, IR,1H-NMR, TGA, and DSC.

scholarly journals Quinazolin-4(3H)-ones and 5,6-Dihydropyrimidin-4(3H)-ones from β-Aminoamides and Orthoesters

Molecules ◽  
2018 ◽  
Vol 23 (11) ◽  
pp. 2925 ◽  
Author(s):  
Joshua Gavin ◽  
Joel Annor-Gyamfi ◽  
Richard Bunce
Keyword(s):  
Acetic Acid ◽  
Melting Point ◽  
1H Nmr ◽  
13C Nmr ◽  
Pressure Tube ◽  
Absolute Ethanol ◽  
Basic Nitrogen ◽  
One Step ◽  
Ft Ir

Quinazolin-4(3H)-ones have been prepared in one step from 2-aminobenzamides and orthoesters in the presence of acetic acid. Simple 2-aminobenzamides were easily converted to the heterocycles by refluxing in absolute ethanol with 1.5 equivalents of the orthoester and 2 equivalents of acetic acid for 12–24 h. Ring-substituted and hindered 2-aminobenzamides as well as cases incorporating an additional basic nitrogen required pressure tube conditions with 3 equivalents each of the orthoester and acetic acid in ethanol at 110 °C for 12–72 h. The reaction was tolerant towards functionality on the benzamide and a range of structures was accessible. Workup involved removal of the solvent under vacuum and either recrystallization from ethanol or trituration with ether-pentane. Several 5,6-dihydropyrimidin-4(3H)-ones were also prepared from 3-amino-2,2-dimethylpropionamide. All products were characterized by melting point, FT-IR, 1H-NMR, 13C-NMR, and HRMS.

scholarly journals synthesis Synthesis and Characterization ( Oxazepine , Thiazine and Quinazoline ) Derivatives and Study the Biological Activity as Antibacteria

2021 ◽  
Vol 26 (4) ◽  
Author(s):  
Shaimaa Adnan ◽  
Adel jasim
Keyword(s):  
Schiff Base ◽  
Biological Effect ◽  
Heterocyclic Compounds ◽  
Succinic Anhydride ◽  
Synthesis And Characterization ◽  
Second Step ◽  
Base Derivative ◽  
Ft Ir ◽  
Quinazoline Derivatives ◽  
Amino Benzoic Acid

This research. Included the preparation. and characterization some novel. Six and seven membered Heterocyclic. Compounds ( oxazepine , thiazine , quinazoline ) The first step in clode react 2-amino-6- methoxybenzothiazole with 4- amino acetophenone to get Schiff base derivative (1). The second step react (1) with 4 -hydroxy acetophenone to get schiff base derivative (2) the last step involve react (2) with ( Phthalic , Maleic , Succinic) anhydride to .get oxazepine derivatives (3,4and 5) also react (2) with(2-amino benzoic acid) and (2-mercaptobenzoic acid ) to get quinazoline (6)and thiazine (7) derivatives respectively .the physical; properties of the prepared; These Compounds. Were Identification (FT-IR) ,(1H-NMR) and (13C-NMR) by spectroscopy thene study their biological effect on two types of bacteria Staphylococcus aureuses (Gram positive) and Escherichia coli (Gram Negative)

New Heterocyclic Compounds from 1,2,4-triazoles Class with Potential Cytotoxic Activity

2017 ◽  
Vol 68 (11) ◽  
pp. 2503-2508 ◽  
Author(s):  
Laura Ileana Socea ◽  
Stefania Felicia Barbuceanu ◽  
Bogdan Socea ◽  
Constantin Draghici ◽  
Theodora Venera Apostol ◽  
...  
Keyword(s):  
Nmr Spectroscopy ◽  
Cytotoxic Activity ◽  
Spectral Data ◽  
1H Nmr ◽  
Elemental Analysis ◽  
13C Nmr ◽  
Heterocyclic Compounds ◽  
Cytotoxic Effect ◽  
13C Nmr Spectroscopy ◽  
New Compounds

Acylhydrazinecarbothioamides (2a,b) were synthesized by addition of 2-(5H-dibenzo[a,d][7]annulen-5-yl)acetohydrazide to different isothiocyanates. The new 1,2,4-triazol-3-thioles (3a,b) were synthesized by cyclization of new 2- acylhydrazinecarbothioamides (3a,b) in basic media. Alkylation of 1,2,4-triazole-3-thiols (3a-c) with ethyl bromide gave only S-substituted derivatives (4a-c). The structures of the synthesized compounds have been established on spectral data (IR, 1H-NMR and 13C-NMR spectroscopy) and elemental analysis. The cytotoxic effect of new compounds was evaluated using two alternative models on plant and invertebrate organisms.

scholarly journals Phytochemical constituents of the flowers of Sarcococca coriacea of Nepalese origin

1970 ◽  
Vol 21 ◽  
pp. 1-7 ◽  
Author(s):  
N. P. Rai ◽  
B. B. Adhikari ◽  
Arjun Paudel ◽  
K. Masuda ◽  
R. D. Mckelvey ◽  
...  
Keyword(s):  
Melting Point ◽  
Spectral Data ◽  
Oleanolic Acid ◽  
1H Nmr ◽  
13C Nmr ◽  
Chemical Society ◽  
Chromatographic Technique ◽  
Sugar Alcohol ◽  
Steroidal Glycosides ◽  
Phytochemical Constituents

From the flowers of Sarcococca coriacea, a triterpenoic acid, oleanolic acid, a pentahydric sugar alcohol, xylitol along with the mixture of steroidal glycosides, stigmasterol-3-O-β-D-glucopyranoside and β-sitosterol-3-O-β-D-glucopyranoside have been isolated by chromatographic technique. Their structures were established on the basis of IR, 1H-NMR, 13C-NMR, spectral data as well as melting point and Co-TLC comparison with the authentic samples. DOI: 10.3126/jncs.v21i0.214Journal of Nepal Chemical Society Vol.21 2006 p.1-7

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