scholarly journals Eco-Friendly Novel Synthesis, Characterization of 2,3-Disubstituted 4-Thiazolidinone Derivatives and their Antimicrobial Evaluations

2021 ◽  
Vol 33 (11) ◽  
pp. 2685-2692
Author(s):  
Ashutosh Pathak ◽  
P. Malairajan ◽  
Parmesh Kumar Dwivedi ◽  
Devdutt Chaturvedi
Keyword(s):  
Antibacterial Activity ◽  
Microwave Irradiation ◽  
Schiff Bases ◽  
Thioglycolic Acid ◽  
Aminobenzoic Acid ◽  
Microwave Irradiation Method ◽  
Novel Synthesis ◽  
Good Antibacterial Activity ◽  
Derivatives Of

A total of nine derivatives of 4-thiazolidinone were synthesized involving the reaction of benzene-1,2- diamine with 4-aminobenzoic acid followed by reaction with substituted benzaldehyde to get the Schiff bases. These synthesized Schiff bases were further reacted with thioglycolic acid to get the desired thiazolidinones (29-37). In addition to conventional synthesis, the microwave irradiation method has also been employedfor the synthesis of these compounds which provides not only pollution free and eco-friendly environment but also excellent yields. The results showed that 2-substituted thiazolidinone derivatives exhibit good antibacterial activity. It was also recorded that the compounds containing -Cl, -NO2 group with thiazolidinone nucleus are more active than other compounds of the synthesized series.

Preparation, Characterisation, Crystal Structure and Antibacterial Activity of two Bis-Schiff Bases Containing a Piperazine Ring

2018 ◽  
Vol 42 (10) ◽  
pp. 512-514
Author(s):  
Rui-bo Xu ◽  
Xiao-tian Yang ◽  
Hai-nan Li ◽  
Peng-cheng Zhao ◽  
Jiao-jiao Li ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Antibacterial Activity ◽  
Bacillus Subtilis ◽  
Schiff Bases ◽  
Piperazine Ring ◽  
X Ray ◽  
X Ray Crystallography ◽  
Good Antibacterial Activity

Two new bis-Schiff bases containing a piperazine ring, N,N‘-bis(4-chlorobenzylidene)- and N,N‘-bis(4-cyanobenzylidene)-1,4-bis(3-aminopropyl)piperazine, were prepared by the reaction of N,N‘-bis(3-aminopropyl)piperazine with 4-chloro- and 4-cyanobenzaldehyde, respectively. The dichloro compound was fully identified by X-ray crystallography and it exhibited good antibacterial activity against Escherichia coli, Staphylococcus aureus and Bacillus subtilis.

scholarly journals Synthesis characterization and antibacterial studies of 4-aminoantipyrine schiff’s bases

2017 ◽  
Vol 2 (01) ◽  
pp. 8-14 ◽  
Author(s):  
K Sunand ◽  
K Vinay Kumar ◽  
K Ashwini ◽  
P Suresh Kumar ◽  
S Vishnu ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Schiff Bases ◽  
Vital Role ◽  
Spectroscopic Techniques ◽  
Schiff’S Bases ◽  
Pharmacological Activities ◽  
Schiff's Bases ◽  
Ir Spectroscopic

Aim: To synthesize and evaluate 4-aminoantipyrine related schiff’s bases as antibacterial agents. Objective: To synthesize, purify, characterize and evaluate 4-aminoantipyrine. Method: Schiff bases derived from 4-aminoantipyrine play a vital role in biological and pharmacological activities. Knowing the importance of 4-aminoatipyrine schiff bases and their analogues wide varieties of bioactivities like analgesic, antiviral, antipyretic, anti-rheumatic, antimicrobial and anti-inflammatory activities have been widely studied. 4-aminoantipyrine compounds C1 (anisaldehyde), C2 (p-hydroxybenzaldehyde) and C3(vanillin) were prepared by condensation between 4-amino antipyrine and substituted aromatic benzaldehydes. The products were purified by recrystallization by using ethanol, characterized by IR spectroscopy. The N-H stretching in 4-aminoantipyrine is shown at 3430 cm-1 and -3325 cm-1. The -HC=N- stretching is observed in the range of 1508-1504 cm-1 The –OCH3 stretching is found at 1888 cm-1. 4-amino antipyrine related schiff’s bases evaluated their activity as antimicrobials in-vitro by spread plate method against E.coli. Schiff bases have potent antibacterial activity with gram negative bacteria E.coli. Results: Synthesis and characterization of a schiff bases derived from substituted benzaldehydes and 4-aminoantipyrine was evaluated and characterized with the IR spectroscopic techniques and schiff bases have shown potent antibacterial activity against E.Coli.

Characterization of antibacterial activity and mechanisms of two linear derivatives of bactenecin

LWT ◽  
2019 ◽  
Vol 107 ◽  
pp. 89-97 ◽  
Author(s):  
Fei Liu ◽  
Haimei Wang ◽  
Songsong Cao ◽  
Chenggang Jiang ◽  
Juncai Hou
Keyword(s):  
Antibacterial Activity ◽  
Derivatives Of

scholarly journals Synthesis and Antibacterial Activity Studies of Some 2-(Substitutedphenyl)-3-bis2, 4-(4′-methylphenylamino)-s-triazine-6-ylaminobenzoylamino-5-H-4-thiazolidinone

2012 ◽  
Vol 9 (2) ◽  
pp. 988-992
Author(s):  
Mukesh Kumar Ahirwar ◽  
S. P. Shrivastava
Keyword(s):  
Antibacterial Activity ◽  
Schiff Bases ◽  
Thioglycolic Acid ◽  
Spectral Studies

Some 4-thiazolidinone derivatives6(a-l)have been prepared bearing s-triazine moiety by the condensation of Schiff bases from bis-2,4 (4′-methyl-phenylamino)-s-triazine-6-ylaminobenzoyl substituted benzylhydrazone5(a-l)with thioglycolic acid. The structures of synthesized compound have been characterized by IR, 1HNMR spectral studies. The synthesized compounds6(a-l)has been screened for antibacterial activity.

Characterization of CoMCM-41 mesoporous molecular sieves obtained by the microwave irradiation method

2008 ◽  
Vol 181 (9) ◽  
pp. 2298-2305 ◽  
Author(s):  
Tingshun Jiang ◽  
Wei Shen ◽  
Qian Zhao ◽  
Mei Li ◽  
Jinyu Chu ◽  
...  
Keyword(s):  
Microwave Irradiation ◽  
Molecular Sieves ◽  
Mesoporous Molecular Sieves ◽  
Microwave Irradiation Method

Preparation and characterization of guluronic acid oligosaccharides degraded by a rapid microwave irradiation method

2013 ◽  
Vol 373 ◽  
pp. 53-58 ◽  
Author(s):  
Ting Hu ◽  
Chunxia Li ◽  
Xia Zhao ◽  
Guangsheng Li ◽  
Guangli Yu ◽  
...  
Keyword(s):  
Microwave Irradiation ◽  
Microwave Irradiation Method ◽  
Guluronic Acid
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