Characterization of antibacterial activity and mechanisms of two linear derivatives of bactenecin

LWT ◽  
2019 ◽  
Vol 107 ◽  
pp. 89-97 ◽  
Author(s):  
Fei Liu ◽  
Haimei Wang ◽  
Songsong Cao ◽  
Chenggang Jiang ◽  
Juncai Hou
Keyword(s):  
Antibacterial Activity ◽  
Derivatives Of

Microwave Synthesis and Characterization of Antibacterial Activity Evaluation of 2-(4, 5-dihydro-5-(4-chlorophenyl)-1H-pyrazol-3-yl) phenol

10.26524/sa1 ◽  
2018 ◽  
Vol 7 (3) ◽  
pp. 01-07
Author(s):  
L Ilavarasan ◽  
A Ravi ◽  
M Ganapathi ◽  
E Subitchayini ◽  
K Sivasakthi ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Inhibitory Concentration ◽  
Spectral Techniques ◽  
Peg 400 ◽  
Heterocyclic Derivatives ◽  
Ft Ir ◽  
Uv Visible ◽  
Benzaldehyde Derivatives ◽  
Derivatives Of

Chalcone derivatives were synthesized by reaction of some benzaldehyde derivatives with acetophenone, then the products obtained were allowed to react withurea, thiourea and hydroxylamine, to give the heterocyclic derivatives of oxazine, thiazine and isoxazole, respectively.In this study, a series of chalcones and substituted pyrazole compounds were synthesized according to green chemistry methods of conventional and microwave irradiation by using substituted acetophenone, substituted benzaldehyde, hydrazine hydrate and PEG-400. The synthesized compounds were characterized by UV-Visible, FT-IR and 1H NMR spectral techniques. The purity of the synthesized compounds were monitored by TLC and tested for their antibacterial activity by Minimum Inhibitory Concentration (MIC) method against two different microorganisms Staphylococcus auras (MTCC3381), and Escherichia coli (MTCC739).

scholarly journals SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF SUBSTITUTED 1,3,4-OXADIAZOLE DERIVATIVE: DERIVED FROM CIPROFLOXACIN

2019 ◽  
pp. 205-209
Author(s):  
ANUJ SINGHAI ◽  
M.K. GUPTA
Keyword(s):  
Antibacterial Activity ◽  
Biological Evaluation ◽  
Diffusion Method ◽  
Gram Positive ◽  
Standard Drug ◽  
Gram Negative ◽  
Oxadiazole Derivatives ◽  
Gram Negative Organisms ◽  
Derivatives Of

Objective: The purpose of this research is synthesized and evaluates different derivatives of oxadiazole. Methods: A novel series of substituted 1,3,4-oxadiazole derivative were synthesized by condensing different amine with 1-cyclopropyl-6-fluoro-7- (piperazin-1-yl)-3-(5-thioxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)quinolin-4(1H)-one (III) in the presence of formaldehyde. The structure of these novel synthesized compounds was characterized on the bases of physicochemical and spectral analysis. The title compounds (IVa-h) were screened for antibacterial activity by disc diffusion method. Results: Substituted 1,3,4-oxadiazole derivative was synthesized, characterized, and evaluated for antibacterial activity. Compounds IVa, IVd, IVe, IVf, and IV h showed enhance activities then ciprofloxacin against all Gram-positive and Gram-negative organisms. Compound IVe showed the highest activity against Staphylococcus aureus and compound IV showed the highest activity against Escherichia coli. Conclusion: The present study demonstrates the synthesis and characterization of 1,3,4-oxadiazole derivatives derived from ciprofloxacin. These compounds were evaluated for antibacterial activity against different Gram-positive and Gram-negative organism. In some cases, antibacterial activity is found to be enhanced as compared to standard drug ciprofloxacin.

scholarly journals Eco-Friendly Novel Synthesis, Characterization of 2,3-Disubstituted 4-Thiazolidinone Derivatives and their Antimicrobial Evaluations

2021 ◽  
Vol 33 (11) ◽  
pp. 2685-2692
Author(s):  
Ashutosh Pathak ◽  
P. Malairajan ◽  
Parmesh Kumar Dwivedi ◽  
Devdutt Chaturvedi
Keyword(s):  
Antibacterial Activity ◽  
Microwave Irradiation ◽  
Schiff Bases ◽  
Thioglycolic Acid ◽  
Aminobenzoic Acid ◽  
Microwave Irradiation Method ◽  
Novel Synthesis ◽  
Good Antibacterial Activity ◽  
Derivatives Of

A total of nine derivatives of 4-thiazolidinone were synthesized involving the reaction of benzene-1,2- diamine with 4-aminobenzoic acid followed by reaction with substituted benzaldehyde to get the Schiff bases. These synthesized Schiff bases were further reacted with thioglycolic acid to get the desired thiazolidinones (29-37). In addition to conventional synthesis, the microwave irradiation method has also been employedfor the synthesis of these compounds which provides not only pollution free and eco-friendly environment but also excellent yields. The results showed that 2-substituted thiazolidinone derivatives exhibit good antibacterial activity. It was also recorded that the compounds containing -Cl, -NO2 group with thiazolidinone nucleus are more active than other compounds of the synthesized series.

scholarly journals Synthesis, characterization of 2-substituted benzimidazole derivatives and evaluation of antimicrobial activity

2018 ◽  
Vol 8 (5) ◽  
pp. 460-464 ◽  
Author(s):  
M Shahnaz ◽  
Parminder Kaur ◽  
J Parkash ◽  
DN Parsad
Keyword(s):  
Antibacterial Activity ◽  
Carbon Disulphide ◽  
Research Work ◽  
Benzimidazole Derivatives ◽  
Chromatography Method ◽  
Wide Range ◽  
Derivatives Of ◽  
In Vitro Antifungal Activity

Benzimidazole has attracted a great deal of importance due to their interesting chemistry and wide utility. Benzimidazole has wide range of uses and applications and is produced in great quantities throughout the world. The current research work was aim to evaluate the in vitro antifungal activity of series of benzimidazole derivatives. A series of benzimidazole derivatives were synthesized by reacting the various amine derivatives of o phenylene diame with carbon disulphide in presence of Potassium hydroxide. All the bis derivatives were characterized by IR, 1H NMR and chromatography method (TLC). The antibacterial activity was evaluated by their MIC and zone of inhibition of synthesized compounds by taking ciprofloxacin as reference standard. The microbiological assay revealed that the compounds show promising antibacterial activity. Keywords: Ciprofloxacin, Benzimidazole, antibacterial activity.

Preparation of esterified derivatives of α-lactalbumin and investigation of their antibacterial activity

2014 ◽  
Vol 1 (1) ◽  
Author(s):  
Negar Ghorbani ◽  
Abdol-Khalegh Bordbar ◽  
Asghar Taheri-Kafrani ◽  
Akbar Vaseghi
Keyword(s):  
Antibacterial Activity ◽  
Derivatives Of

Extraction and characterization of sea anemones compound and its Anti bacterial and hemolytic studies

2020 ◽  
Vol 10 (4) ◽  
pp. 93-97
Author(s):  
Anil Kumar A ◽  
Raja Sheker K ◽  
Naveen B ◽  
Abhilash G ◽  
Akila CR
Keyword(s):  
Antibacterial Activity ◽  
Focal Point ◽  
Haemolytic Activity ◽  
Klebsiella Pneumonia ◽  
Bacterial Strains ◽  
Sea Anemones ◽  
Marine Plants ◽  
Heteractis Magnifica ◽  
Trididemnum Solidum

Seas assets that give us a variety of characteristic items to control bacterial, contagious and viral ailment and mostly utilized for malignancy chemotherapy practically from spineless creatures, for example, bryozoans, wipes, delicate corals, coelenterates, ocean fans, ocean bunnies, molluscs and echinoderms. In the previous 30 - 40 years, marine plants and creatures have been the focal point of overall endeavours to characterize the regular results of the marine condition. Numerous marine characteristic items have been effectively exceptional to the last phases of clinical preliminaries, including dolastatin-10, a group of peptides disengaged from Indian ocean rabbit, Dollabella auricularia. Ecteinascidin-743 from mangrove tunicate Ecteinascidia turbinata, Didemnins was isolated from Caribbean tunicate Trididemnum solidum and Conopeptides from cone snails (Conus sp.), and a developing number of up-and-comers have been chosen as promising leads for expanded pre-clinical appraisals. Sea anemones possess numerous tentacles containing stinging cells or cnidocytes. The stinging cells are equipped with small organelles known as nematocysts. The two species of sea anemones namely, Heteractis magnificaandStichodactyla haddoni, were collected from Mandapam coastal waters of Ramanathapuram district, Tamilnadu, India. The Nematocyst was collected and centrifuged, and the supernatant was lyophilized and stored for further analysis. The amount of protein from Heteractis Magnifica and Stichodactyla haddoni was estimated. The crude extract has shown haemolytic activity on chicken blood and goat blood. In the antibacterial activity of the sea anemone against six bacterial strains Staphylococcus aureus, Salmonella typhii, Salmonella paratyphii, Klebsiella pneumonia, Vibrio cholerae, Pseudomonas aeruginosa. Antibacterial activity of H. Magnifica and S.haddoni was measured as the radius of the zone of inhibition.

Synthesis and Spectral Characterization of Derivatives of Benzotriazole and Piperidine

2018 ◽  
Vol 8 (2) ◽  
pp. 278-287
Author(s):  
Selvarathy Grace P ◽  
Ravindran Durainayagam B ◽  
Pon Matheswari P.
Keyword(s):  
Spectral Characterization ◽  
Derivatives Of

Synthesis and Evaluation of Aromatic Surfactants as Potential Antibacterial and Cytotoxic Agents

2019 ◽  
Vol 16 (6) ◽  
pp. 478-484
Author(s):  
Kenia Barrantes ◽  
Mary Fuentes ◽  
Luz Chacón ◽  
Rosario Achí ◽  
Jorge Granados-Zuñiga ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Hela Cells ◽  
Cytotoxic Agents ◽  
Cytotoxic Activities ◽  
Hydroxybenzoic Acid ◽  
Derivatives Of

Two ether and one ester derivatives of the 4-nitro-3-hydroxybenzoic acid were synthesized and characterized. The in vitro antimicrobial and cytotoxic activities of the three novel compounds were also evaluated. The aromatic derivatives showed antibacterial activity against one of the four microorganisms tested and two compounds (C8 and NOBA) had a lower IC50 in HeLa cells.

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