Experience with sulphamethoxazole (SMZ)/trimethoprim (TMP) combination in purulent meningitis not responding to conventional microbial therapy

1981 ◽  
Vol 21 (1-2) ◽  
pp. 11
Author(s):  
Sumarmo Sumarmo ◽  
Mugiyo K. ◽  
Mandoyono Mandoyono ◽  
Lauritha S. P. ◽  
Adji Suntoro
Keyword(s):  
Renal Function ◽  
Side Effects ◽  
Bacterial Meningitis ◽  
Propylene Glycol ◽  
The Other ◽  
Renal Function Test ◽  
Purulent Meningitis ◽  
Daily Dose ◽  
Function Test ◽  
Gastrointestinal Side Effects

Tell infants ranging in age from two days to nine months with purulent meningitis who were considered therapeutic failures after conventional microbial therapy (i.e. ampicillin, chloramphenicol, gentamicin, amikin, cloxacillin in any combination) were included in this study. A solution consisting of SMZ 80 mg/mL and TMP 16 mg/mL in propylene glycol (Bactrilll, Hoffman-La Roche A.G. Basle/Switzerland) was given intravenously to the patients. The daily dose was 10 mg/kg BW TMP/24 hours for the first three days followed by 6 mg/kg BW TMP/24 hours divided in two doses given intravenously every 12 hours.Nine patients recovered, 7 of them rapidly within 10 - 21 days after SMZ/TMP administration and the other 2 patients within 27 and 33 days respectively. One infant improved but died afterwards of complicatIons not related to the treatment.No hematological nor cutaneous and gastrointestinal side effects were observed. The liver and renal function test performed on 3 out of 10 cases on the first few days of the commencement of treatment and 3 weeks later, were all within normal limits.Our experience with the use of parenteral SMZ/TMP in infants with bacterial meningitis not responding to conventional microbial therapy gave encouraging results.

P0430EFFECT OF CORTICOSTEROIDS THERAPY FOR PATIENTS OF IGA NEPHROPATHY WITH CRESCENTS

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Mengjun Liang ◽  
Aihua Li ◽  
Zongpei Jiang
Keyword(s):  
Renal Function ◽  
Side Effects ◽  
Iga Nephropathy ◽  
Steroid Therapy ◽  
Oral Prednisone ◽  
Pulse Therapy ◽  
The Other ◽  
Intravenous Methylprednisolone ◽  
Steroid Pulse ◽  
Renal Function Deterioration

Abstract Background and Aims Patients with IgA nephropathy (IgAN) presented proteinuria≥1g/d and eGFR≥50ml/min/1.73m2 after supportive treatment had been advised 6-month course of corticosteroids therapy. Update of Oxford classification of IgAN had recommended crescents be added to the MEST score for they were predictive of outcome. Whether we should take some more positive therapy for crescents? Method We conducted a single-center, retrospective cohort study enrolling 46 patients from 2017.01 to 2018.06, diagnosed with IgAN by renal biopsy. Eligible patients had proteinuria of 0.5∼3.5g/d, eGFR≥30ml/min/1.73m2 and crescent proportion <50%. Patients were divided into two groups, one for classical steroid treatment (intravenous methylprednisolone 0.25g/d for 3 days at the beginning of months 1, 3 and 5, plus oral prednisone 0.5 mg/kg/d for 6 months, called 1-3-5 Group) and the other assigned an optimized steroid therapy (intravenous methylprednisolone 0.25g/d for 3 days at the beginning of months 1, 2 and 3, plus oral prednisone 0.5 mg/kg/d for 6 months, called 1-2-3 Group). The primary endpoint was remission of proteinuria, secondary endpoint was deterioration in renal function. Results There were 23 patients in each group and no significant differences in age, gentle, baseline proteinuria and eGFR between the two groups, except for the proportion of crescents (for Oxford C1 and C2: 52.5% and 13% in 1-3-5 Group vs. 95.7% and 4.3% in 1-2-3 Group respectively, p=0.001). After 6 months therapy, proteinuria in 1-3-5 Group was 0.5(0.2,0.8)g/d (vs. 1.2(0.8,2.6)g/d at baseline, p <0.001) and that in 1-2-3 Group was 0.3(0.2,0.6)g/d (vs. 1.5(0.7,2.6)g/d at baseline, p <0.001). 78.3% of patients in 1-3-5 Group had got remission of proteinuria, while 95.7% in 1-2-3 Group (p=0.187). The 6th month eGFR in 1-3-5 Group was 80.7(59.8,116.2)ml/min/1.73m2 (vs. 77.5(54.8,104.6)ml/min/1.73m2 at baseline, p=0.212), while that in 1-2-3 Group was 97.8(68.6,130.9)ml/min/1.73m2 (vs. 79.5(52.9,108.7)ml/min/1.73m2 at baseline, p=0.002). The slope of eGFR in 1-3-5 Group was 0.7(-1.7,3.3)ml/min/1.73m2/month, while that in 1-2-3 Group was 3(1.2,5.4)ml/min/1.73m2/month, p=0.027. For side effects, two patients in 1-2-3 Group had met bronchitis during the 2nd and 3rh therapy-month respectively; in 1-3-5 Group, one patient had got glaucoma during the 2nd therapy-month and the other had happened steroid-induced diabetes mellitus during the 3rd therapy-month. Conclusion Our preliminary results had indicated that optimized steroid therapy had equal effect on reducing proteinuria but more significant advantage to protect against renal function deterioration in IgAN with crescents. 1-2-3 month-steroid pulse therapy had not increase the morbidity of irreversible or severe side effects.

Development of a Fetal Renal Function Test Using Endogenous Creatinine Clearance

1986 ◽  
Vol 135 (5) ◽  
pp. 1111-1112
Author(s):  
N.S. Adzick ◽  
M.R. Harrison ◽  
A.W. Flake ◽  
J.-M. Laberge
Keyword(s):  
Renal Function ◽  
Creatinine Clearance ◽  
Renal Function Test ◽  
Endogenous Creatinine Clearance ◽  
Function Test

scholarly journals KEUNTUNGAN DAN KERUGIAN PENJAMINAN MUTU BERDASARKAN UJI MEMASTIKAN KECERMATAN (POCT)

2018 ◽  
Vol 13 (1) ◽  
pp. 38
Author(s):  
Hartono Kahar
Keyword(s):  
Renal Function ◽  
Critical Care ◽  
Point Of Care ◽  
Occult Blood ◽  
Self Management ◽  
Renal Function Test ◽  
Advantages And Disadvantages ◽  
Function Test ◽  
Bedside Testing ◽  
Definition Of

Laboratory examination especially for critical care such as emergency care, intensive care has been developed near the site of patientcare which is referred to point-of-care testing (POCT). As to the definition of POCT, there are many synonyms such as ancillary testing,satellite testing, and bedside testing, near patient testing, home testing, self-management, patient self-management, remote testing andphysician’s office laboratories. Based on evidence-based POCT, the National Academy of Clinical Biochemistry (NACB) has recommendedsome POCT such as coagulation tests, transcutan bilirubin testing, marker for acute coronary syndromes, diabetes mellitus, drugsand ethanol, Infectious disease testing, occult blood test, pH testing, renal function test, intraoperative PTH, renal function test andreproduction test. Some researchers conclude that performing POCT for critical care is efficient, while others found it not efficient,therefore, careful assessment of the advantages and disadvantages is important when implementing POCT. Nurses are the personnelin the acute care unit who often perform POCT; however they desire that laboratory personnel take the responsibility, therefore it isimportant to discuss which personnel are appropriate to conduct quality control of POCT.

Amphotericin B Emulsion in Rhino-orbital Mucormycosis: Is It Most Effective?

2016 ◽  
Vol 9 (1) ◽  
pp. 40-42
Author(s):  
Sourabha K Patro ◽  
Anil K Dash ◽  
Subhranshu Patro ◽  
Rudra Narayan Biswal
Keyword(s):  
Renal Function ◽  
Case Report ◽  
Amphotericin B ◽  
Surgical Debridement ◽  
Healthy Individuals ◽  
Review Of The Literature ◽  
Lipid Complex ◽  
Renal Function Test ◽  
Function Test

ABSTRACT Mucormycosis is a fatal infection of the immunocompromised individuals. It is unusual to affect healthy individuals. The main aim of this case report is to highlight the role of amphotericin B emulsion in this disease. The case was managed in our setup with surgical debridement and followed by amphotericin B emulsion for 4 weeks. We did not notice hypokalemia and renal function test abnormality in the entire course of the treatment. We present the case and the review of the literature of newer lipid complex amphotericin. How to cite this article Dash AK, Patro S, Patro SK, Gupta AK, Biswal RN. Amphotericin B Emulsion in Rhino-orbital Mucormycosis: Is It Most Effective? Clin Rhinol An Int J 2016;9(1): 40-42.

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