Background: The prevalence of hypertensive disorder in pregnancy has
been well-documented worldwide. In Chinese newborns, the risk of
hypospadias in women with hypertension during pregnancy remains
ambiguous. This study aimed to evaluate the relationship between
hypertension in pregnancy and neonatal hypospadias based on a large
sample of Chinese people. Methods: A retrospective cohort study was
conducted at our hospital from 2015 to 2019. Mothers who delivered male
infants with hypospadias or those without any malformations were
enrolled. Factors such as hypertension, placenta previa, thyroid
diseases, hepatitis B, obesity, multiple birth, amniotic fluid,
gestational age, birth weight, and in vitro fertilization were collected
to establish a regression analysis to assess risk factors for
hypospadias. Results: In total, 41,490 mothers and 42,244 male infants
were enrolled. The overall incidence of hypospadias was 0.23%. The
occurrence rate of hypospadias in pregnancy-induced hypertension (PIH)
group was higher than control group (0.944% vs. 0.186%, RR 5.08),
whereas the occurrence rate in chronic hypertension group was 0%.
Potential exposure factors were screened for hypospadias, and PIH,
multiple birth, hyperthyroidism, preterm delivery, low birth weight, and
small for gestational age (SGA) were found to have higher proportion of
hypospadias in offspring. After adjustment for potential confounders in
the multivariate regression analysis, PIH (OR: 2.437, 95% CI:
1.478–4.016, P<0.01), birth weight (OR: 0.852, 95% CI:
0.795–0.912, P<0.01), and SGA (OR: 3.282, 95% CI:
1.644–6.549, P<0.01) showed a significant relationship with
hypospadias. Conclusion: Women with PIH had higher risks of hypospadias
in offspring. Lower birth weight, SGA and hyperthyroidism were also
statistically associated with hypospadias.