scholarly journals One step before the market – the innovative Business Ph.D. program of the Faculty of Business and Economics of the University of Pécs

2020 ◽  
Vol 14 (4) ◽  
pp. 150-157
Author(s):  
Zsuzsanna Kispál-Vitai
Keyword(s):  
One Step ◽  
The University

The influence of mRNA secondary structures on ribosome conformational dynamics

2016 ◽  
Author(s):  
◽  
Bassem Shebl
Keyword(s):  
Protein Synthesis ◽  
Conformational Dynamics ◽  
Bacterial Cells ◽  
University Of Missouri ◽  
Novel Drugs ◽  
Wide Range ◽  
Complicated Process ◽  
One Step ◽  
The University ◽  
Control Protein

[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Synthesizing proteins in the cell is a critical aspect of life. Protein synthesis is a complicated process and involve highly functional machines at a molecular level. The ribosome is the molecular machine that translate coded sequences of nucleic acids into functional proteins. Understanding how ribosomes function is key to understanding protein synthesis / translation. We focus our work on ribosomes from bacterial cells. This allows us to study much simpler systems and extrapolate our knowledge to higher levels. One key challenge in the field is to be able to isolate a high quantity of good and active ribosomes out of the cell to study it in a controlled environment. Classically known methods involve extensive resources, high technical expertise, and a week of preparation. We developed a one-step protocol to purify ribosomes that are more active than the ones purified from classical methods. This developed technique saves time and money and results in much higher amounts of product. This approach also makes the technique approachable to a wider community of scientists and researchers. The same methodology could be applied towards purifying other molecular machines in the cells. Using these ribosomes, we wanted to investigate how the ribosomes function in cells when faced with specific signals. These signals are utilized by the cells to control protein synthesis. However, in dome diseased cells and for some viruses, normal protein synthesis is overridden by the invaders to produce faulty proteins that could result in a wide range of diseases such as Alzheimer and others. In this study, we investigated how the ribosome functions in the presence of such signals and how close do they need to be to the ribosome to affect protein synthesis. This allows us to design drugs to mimic or inhibit such changes thus fixing faulty protein production or sometimes induce it to inhibit protein synthesis in bacterial cells and as such designing and producing novel drugs.

Role of Universities on the Level of Regional Growth in Portugal

2020 ◽  
pp. 183-202
Author(s):  
Vitor Miguel Ribeiro ◽  
Celeste Varum ◽  
Ana Dias Daniel
Keyword(s):  
Economic Growth ◽  
Regional Development ◽  
Structural Breaks ◽  
Positive Impact ◽  
Regional Growth ◽  
Long Run ◽  
Key Players ◽  
One Step ◽  
The University

Universities nowadays are considered key players in the development of entrepreneurial ecosystems and, thus, may impact regional development. This chapter analyzes the role of the university as a determinant of regional economic growth in Portuguese NUTS III regions, from 2004-2017. One-step and two-step system GMM estimation results show a statistically significant and positive impact of universities upon regional growth. Moreover, the magnitude of effects is transversely stronger in the long run, which requires the need to avoid structural breaks in public actions previously initiated in the past.

Organic Functional Group Protection

2013 ◽  
Author(s):  
Douglass F. Taber
Keyword(s):  
Secondary Alcohol ◽  
Sigmatropic Rearrangement ◽  
Allylic Alcohols ◽  
State University ◽  
Triflic Acid ◽  
University Of Georgia ◽  
One Step ◽  
The One ◽  
The University ◽  
Ether Synthesis

We found (Tetrahedron Lett. 2010, 51, 3545) that the superiority of KH over NaH in the Williamson ether synthesis was particularly marked with congested partners such as 1. Geert-Jan Boons of the University of Georgia described (Org. Lett. 2010, 12, 4636) the selective removal of each of the several orthogonal protecting groups decorating the disaccharide 3. Yutaka Nishiyama of Kansai University reported (Synlett 2010, 3089) a Re catalyst for the selective acylation of an ether 5, to give the ester 6, from the less substituted side. Duen-Ren Hou of National Central University showed (Tetrahedron Lett. 2010, 51, 6143) that triphenylphosphine hydrobromide was a convenient reagent for debenzylation, converting 7 into 8. Junghyun Chae of Sungshin Women’s University established (Synlett 2010, 1651) that simply microwaving an aromatic methyl ether 9 in an ionic liquid led to smooth demethylation. Allylic selenides such as 11 can serve as masked allylic alcohols. Wei-Ming Xu of Hangzhou Normal University demonstrated (Org. Lett. 2010, 12, 4431) that the polystyrene-supported Se resin facilitated the purification of 11. Oxidation followed by sigmatropic rearrangement then installed the axial secondary alcohol. Clemens Richert of the Universität Stuttgart devised (Synlett 2010, 2267) a reagent 13 for the one-step protection of an amine 14 as its azidomethyl carbamate 15. Xueshun Jia of the Shanghai Institute of Organic Chemistry showed (Tetrahedron Lett. 2010, 51, 6049) that a substoichiometric quantity of Sm metal was sufficient to mediate the acylation of the congested amine 16. Frederik Rombouts of Johnson & Johnson, Beerse, and Andrés A. Trabanco of Johnson & Johnson, Toledo, found (Tetrahedron Lett. 2010, 51, 4815) that the triflic acid debenzylation of 18 was also promoted by microwave irradiation. Mark D. Spicer and John A. Murphy of the University of Strathclyde designed (J. Am. Chem. Soc. 2010, 132, 15462) a stoichiometric Ni reagent that deprotected even the unreactive sulfonamide 20. Steven M. Weinreb of Pennsylvania State University showed (Tetrahedron Lett. 2010, 51, 3555) that an oxime can be deprotected by Fe-mediated reduction of the pivalate 22. David A. Colby of Purdue University protected (Org. Lett. 2010, 12, 5588) the ketone of 24 by forming the adduct with methoxymethylamine, allowing selective addition to the ester, to give 25.

Teaching World Music

2021 ◽  
pp. 154-176
Author(s):  
Patricia Shehan Campbell
Keyword(s):  
Music Education ◽  
Instrumental Music ◽  
Classroom Practice ◽  
World Music ◽  
World Music Pedagogy ◽  
One Step ◽  
Course Features ◽  
Intensive Course ◽  
The University ◽  
Audio Video

For teaching musicians and music educators who work in elementary, secondary, and tertiary teacher education programs, questions of cultural diversity and social justice have triggered the development of teaching models, methods, and movements. One such program is the week-long intensive course in World Music Pedagogy by the University of Washington in partnership with Smithsonian Folkways Recordings, a Smithsonian Institution nonprofit record label that documents music from across the world. The course features an examination of audio, video, print, electronic, and human resources, with the aim of learning as well as developing an understanding of ways to teach music of the world’s cultures. Attention is given to learning cultural heritage through songs, movement and dance experiences, instrumental music, and contextualized cultural components. Musical experiences are tailored for use at various levels, including in classes for children, youth, and adults in university and community settings. Going on ten years of development, the course has succeeded in offering pathways to teaching world music at all levels. It has also been a labor of love for those in education and ethnomusicology who have fashioned it, and who have lived the challenges of connecting ethnomusicological principles to classroom practice. This essay tells the story of a “two steps forward and one step back” in shaping music education practices that center on diversity, equity, and inclusion in the design, delivery, and full facilitation of lessons in music of the world’s cultures.

scholarly journals Validation of a One-Step Reverse Transcription-Droplet Digital PCR (RT-ddPCR) Approach to Detect and Quantify SARS-CoV-2 RNA in Nasopharyngeal Swabs

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Catia Mio ◽  
Adriana Cifù ◽  
Stefania Marzinotto ◽  
Barbara Marcon ◽  
Corrado Pipan ◽  
...  
Keyword(s):  
Reverse Transcription ◽  
Digital Pcr ◽  
Droplet Digital Pcr ◽  
University Hospital ◽  
Reverse Transcription Pcr ◽  
Containment Measures ◽  
One Step ◽  
Molecular Biology Method ◽  
Sensitivity Specificity ◽  
The University

Background. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has rapidly spread worldwide from the beginning of 2020. Quantitative reverse transcription-PCR (RT-qPCR) is, to this day, the preferred methodology for viral RNA detection, even if not without problems. To overcome some of the limitations still existing for the detection and quantification of nucleic acids in various applications, the use of one-step reverse transcription-droplet digital PCR (RT-ddPCR) has been established. The purpose of this study was, then, to evaluate the efficacy of ddPCR for the detection of SARS-CoV-2 RNA in nasopharyngeal swabs, optimizing the detection of low-viral load-burdened samples. Methods. The RT-ddPCR workflow was validated for sensitivity, specificity, linearity, reproducibility, and precision using samples from 90 COVID-19-infected patients referred to the Department of Laboratory Medicine of the University Hospital of Udine (Italy). Results. The present study shows that RT-ddPCR allows the detection of as low as 10.3 copies of a SARS-COV-2 E-gene per sample with a higher level of accuracy and precision, especially at low concentration. Conclusion. During the postpeak phase of the SARS-CoV-2 pandemic, it is essential to rely on a highly robust molecular biology method to identify infected subjects, whether they have symptoms or not, in order to prepare appropriate containment measures.

scholarly journals Key Considerations for Traditional Residential Universities Intending to Offer Bachelor of Laws (LLB) through the Distance Mode of Tuition: A Case Study

2021 ◽  
Vol 24 ◽  
pp. 1-36
Author(s):  
Hermanus Moolman ◽  
Adri Du Plessis
Keyword(s):  
Policy Framework ◽  
Funding Model ◽  
Tuition Policy ◽  
Limited Success ◽  
Assessment Policies ◽  
Residential University ◽  
Potential Benefits ◽  
One Step ◽  
The University

This case study aims to provide key considerations that traditional residential universities should consider when deciding to offer a distance tuition programme alongside an existing contact tuition programme. The University of the Free State is the only residential university to offer the Bachelor of Laws through both contact and distance modes of tuition. Therefore, an evaluation of this programme serves as an ideal case study to extract specific and essential considerations that other institutions, faculties or departments may use when deciding to offer a distance tuition programme in addition to its contact programme. The case study suggests that it is not feasible to merely duplicate an existing contact tuition programme and present it as a distance programme. A distinct pedagogical approach must be followed. It entails training, redesign of material, and rethinking assessment policies. Faculties should weigh the potential benefits of presenting a distance LLB against the labour-intensive nature of distance tuition and its probable limited success in realising broader access and student success. The funding model for distance tuition remains problematic and is financially unfeasible and unsustainable for many higher education institutions. Rethinking the funding model will be one step closer to achieving the objectives set out in the distance tuition policy framework.

scholarly journals Regulation of universities as charities: one step forward, two steps back

Legal Studies ◽  
2021 ◽  
pp. 1-20
Author(s):  
Mary Synge
Keyword(s):  
Playing Field ◽  
Charity Commission ◽  
One Step ◽  
The University ◽  
Regulatory Practice ◽  
Law Regulation

Abstract Most universities (bar profit-making institutions) are charities as a matter of law but, historically, have been exempt from charity law regulation. This paper considers the statutory reforms of 2006, which sought to level the regulatory playing field by appointing ‘Principal Regulators’ of such ‘exempt charities’ to promote compliance with charity law. Focusing on the university sector – where some universities are now registered charities (and regulated by the Charity Commission) whilst others remain exempt – it will note how the reforms have resulted in the application of significantly different degrees of scrutiny and accountability, both between individual universities and between universities and other charities. In part, this is due to the statutory framework itself but, significantly, is also attributable to the radically different approach taken by the Office for Students, which replaced HEFCE as Principal Regulator in 2018. Possible improvements in regulatory practice and statutory reform are offered.

Proceedings of The Modern Language Association of America

PMLA ◽  
1935 ◽  
Vol 50 (4) ◽  
pp. 1343-1343
Keyword(s):  
Modern Language Association ◽  
Modern Language ◽  
Local Committee ◽  
Tuesday Morning ◽  
University Of Cincinnati ◽  
The University ◽  
Plaza Hotel

The fifty-second meeting of the Modern Language Associationof America was held, on the invitation of the University of Cincinnati, at Cincinnati, Ohio, Monday, Tuesday, and Wednesday, December 30 and 31, 1935, and January 1, 1936. The Association headquarters were in the Netherland Plaza Hotel, where all meetings were held except those of Tuesday morning and afternoon. These took place at the University of Cincinnati. Registration cards at headquarters were signed by about 900, though a considerably larger number of members were in attendance. The Local Committee estimated the attendance at not less than 1400. This Committee consisted of Professor Frank W. Chandler, Chairman; Professor Edwin H. Zeydel; Professor Phillip Ogden; Mr. John J. Rowe (for the Directors); and Mr. Joseph S. Graydon (for the Alumni).

Spectrophotometric reductions with an IBM 1620

1966 ◽  
Vol 24 ◽  
pp. 116-117
Author(s):  
P.-I. Eriksson
Keyword(s):  
Astronomical Data ◽  
Spectrophotometric Data ◽  
Electronic Computers ◽  
The University ◽  
Near Future

Nowadays more and more of the reductions of astronomical data are made with electronic computers. As we in Uppsala have an IBM 1620 at the University, we have taken it to our help with reductions of spectrophotometric data. Here I will briefly explain how we use it now and how we want to use it in the near future.

Sign in / Sign up

Export Citation Format

Share Document