scholarly journals Different Effects of Ethanol and Activation of TRPM8 ION Channel on Metabolic Response to Cold

2016 ◽  
Vol 1 (2) ◽  
pp. 1-11 ◽  
Author(s):  
Tamara V. Kozyreva ◽  
Elena Ya. Tkachenko ◽  
Valery P. Kozaruk ◽  
Galina M. Khramova
Author(s):  
Christopher J. O’Conor ◽  
Halei C. Benefield ◽  
Wolfgang Liedtke ◽  
Farshid Guilak

Dynamic mechanical loading can enhance the formation of engineered cartilage, potentially through secondary biophysical effects such as changes in interstitial osmolarity. This study examined the effects of daily osmotic loading, as well as direct activation of the osmosensitive ion channel TRPV4, on the biochemical and functional properties of chondrocyte-laden cartilage constructs. Osmotic loading, as well as exposure to the TRPV4-specific agonist GSK1016790A, enhanced extracellular matrix (ECM) accumulation, and TRPV4 activation enhanced the functional properties of the constructs. This study implicates the Ca ++-permeable TRPV4 ion channel in the metabolic response of articular chondrocytes to osmotic and mechanical loading. Furthermore, these results suggest that targeting TRPV4, either directly with channel agonists, or indirectly via osmotic loading, may provide a novel strategy for enhancing tissue engineered cartilage construct maturation.


Planta Medica ◽  
2015 ◽  
Vol 81 (16) ◽  
Author(s):  
A Vasas ◽  
P Orvos ◽  
L Tálosi ◽  
P Forgo ◽  
G Pinke ◽  
...  

2016 ◽  
Vol 11 (S 01) ◽  
Author(s):  
T Laeger ◽  
DC Albarado ◽  
L Trosclair ◽  
J Hedgepeth ◽  
CD Morrison

2005 ◽  
Vol 36 (02) ◽  
Author(s):  
CM Becker ◽  
J Brill ◽  
K Becker
Keyword(s):  

2011 ◽  
Vol 7 (2) ◽  
pp. 97 ◽  
Author(s):  
Niels Voigt ◽  
Dobromir Dobrev ◽  
◽  

Atrial fibrillation (AF) is the most common arrhythmia and is associated with substantial cardiovascular morbidity and mortality, with stroke being the most critical complication. Present drugs used for the therapy of AF (antiarrhythmics and anticoagulants) have major limitations, including incomplete efficacy, risks of life-threatening proarrhythmic events and bleeding complications. Non-pharmacological ablation procedures are efficient and apparently safe, but the very large size of the patient population allows ablation treatment of only a small number of patients. These limitations largely result from limited knowledge about the underlying mechanisms of AF and there is a hope that a better understanding of the molecular basis of AF may lead to the discovery of safer and more effective therapeutic targets. This article reviews the current knowledge about AF-related ion-channel remodelling and discusses how these alterations might affect the efficacy of antiarrhythmic drugs.


Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1950-P
Author(s):  
HEATHER ROGERS ◽  
CONSTANCE T. NOGUCHI
Keyword(s):  
Fat Mass ◽  

Diabetes ◽  
1976 ◽  
Vol 25 (9) ◽  
pp. 776-784 ◽  
Author(s):  
R. S. Sherwin ◽  
R. G. Hendler ◽  
P. Felig

2016 ◽  
Vol 94 (suppl_5) ◽  
pp. 526-526 ◽  
Author(s):  
A. B. Word ◽  
P. R. Broadway ◽  
N. C. Burdick Sanchez ◽  
K. P. Sharon ◽  
S. L. Roberts ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document