Sustaining Lake Superior asks, What can we learn from the conservation recoveries of Lake Superior over the past century as we face new challenges of persistent pollutants that are mobilizing with climate change? Communities around Lake Superior have long struggled to address pollution concerns, and local, regional, and international efforts met with significant successes in the twentieth century. Pollution—and concerns about that pollution—have a complex history in the Great Lakes. As soon as industrial development burgeoned in the region during the nineteenth century, people began trying to comprehend and control industrial wastes. Some of the earliest efforts to control pollution worked surprisingly well, for they rested on understandings of natural resiliency that made a great deal of sense at the time—and still have much to teach us. The nature of pollutants has changed since World War II, but, nevertheless, exploring the success—and failures—of pollution control in the past can help us devise resilient strategies for facing the challenges of pollution in a globalized, warming world.