Growth hormone and insulin-like growth factor-1 in prognosis coronary artery disease in patients with obesity

Introduction. In patients with obesity coronary atherosclerosis and chronic heart failure (CHF) progress rapidly and have a worse long-term prognosis than those with normal weight.Objective: To investigate the prognostic significance of GH and IGF-1 in the evaluation of cardiovascular risk in patients with obesity.Materials and Methods. The study included 75 men (mean age 55.31±6.32 years), which are overweight or have mild obesity (body mass index (BMI) 28.69±3.6 kg/m2). Group 1 included 45 patients (age 56.4±6.29 years, BMI 28.69±3.69 kg/m2, blood pressure 124±10.18/80±4.59 mm Hg) who underwent coronary angiography. Group 2 included 30 patients (mean age 53.6 ± 6.1 years, BMI 28.68±3.52 kg/m2, blood pressure 128±9/83±6.81 mm Hg), CAD who are excluded by treadmill test. The coronary artery calcium score was assessed in group 2. All participants were evaluated impaired glucose tolerance (IGT), triglycerides (TG), IGF-1 and GH, LPHD, LPLD, geometry of the heart chambers was assessed by echocardiography.Results. Patients in both groups did not differ in age, BMI, blood pressure. IGF-1 levels were not significantly different among the study groups. High circulating IGF-1 levels were frequently observed in group 1 (р=0.018). A statistically significant association of high IGF-1 observed with obesity (p=0.033), smoking (p=0.049), hypertension (p=0.002), end-diastolic dimension (p=0.045). GH was lower in group 1 compared with group 2 (p=0.046). Serum levels of GH are positively associated with EF (p=0.023) and E/A (p=0.043) and negatively associated with left atrial wall thickness (p=0.025) and coronary artery calcium score (p=0.005).Conclusion: 1. IGF-1 may be a useful indicator to assess the prognosis of CAD and CHF in patients with obesity. 2. Relative GH deficiency was more often associated with severe CAD in patients with obesity.

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Prognostic significance of subtle coronary calcification in patients with zero coronary artery calcium score: From the CONFIRM registry

Atherosclerosis ◽

10.1016/j.atherosclerosis.2020.07.011 ◽

2020 ◽

Vol 309 ◽

pp. 33-38

Author(s):

Donghee Han ◽

Eyal Klein ◽

John Friedman ◽

Heidi Gransar ◽

Stephan Achenbach ◽

...

Keyword(s):

Coronary Artery ◽

Coronary Artery Calcium ◽

Coronary Artery Calcium Score ◽

Prognostic Significance ◽

Calcium Score ◽

Coronary Calcification

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Juice Powder Concentrate and Systemic Blood Pressure, Progression of Coronary Artery Calcium and Antioxidant Status in Hypertensive Subjects: A Pilot Study

Evidence-based Complementary and Alternative Medicine ◽

10.1093/ecam/nel108 ◽

2007 ◽

Vol 4 (4) ◽

pp. 455-462 ◽

Cited By ~ 17

Author(s):

M. C. Houston ◽

B. Cooil ◽

B. J. Olafsson ◽

P. Raggi

Keyword(s):

Blood Pressure ◽

Coronary Artery ◽

Coronary Artery Calcium ◽

Coronary Artery Calcium Score ◽

Calcium Score ◽

Hdl Cholesterol ◽

Cardiovascular Effects ◽

Electron Beam Tomography ◽

Large Artery ◽

Vascular Health

Because micronutrients from plants may have beneficial cardiovascular effects, the hypothesis that an encapsulated juice powder concentrate might affect several measures of vascular health was tested in free living adults at low cardiovascular risk. Blood pressure, vascular compliance, lipid and antioxidant markers, and serial electron beam tomography (to calculate a coronary artery calcium score as a measure of atherosclerosis burden), were monitored in 51 pre-hypertensive and hypertensive subjects over 2 years. By the end of follow-up, systolic and diastolic blood pressure decreased significantly (−2.4 ± 1.0 mmHg,P< 0.05 and −2.2 ± 0.6 mmHg,P< 0.001), and large artery compliance improved significantly (1.9 ± 0.6 ml mmHg−1× 100,P< 0.01). The progression of coronary artery calcium score was smaller than expected compared with a historical database (P< 0.001). Laboratory testing showed a significant decrease in homocysteine (P= 0.05), HDL cholesterol (P= 0.025) and Apo A (P= 0.004), as well as a significant increase in β-carotene, folate, Co-Q10 and α-tocopherol (allP< 0.001). The phytonutrient concentrate we utilized induced several favorable modifications of markers of vascular health in the subjects. This study supports the notion that plant nutrients are important components of a heart healthy diet.

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Usefulness of the Intrarenal Resistivity Index As A Cardiovascular Risk Marker in Afro-Descendants: An Observational, Cross-Sectional Study

10.21203/rs.3.rs-126201/v1 ◽

2020 ◽

Author(s):

Francival Souza ◽

Joyce Lages ◽

Eliane Magalhaes ◽

Dyego Brito ◽

Vinicius Mendes ◽

...

Keyword(s):

Cardiovascular Risk ◽

Coronary Artery ◽

Diastolic Dysfunction ◽

Coronary Artery Calcium ◽

Carotid Plaque ◽

Coronary Artery Calcium Score ◽

Calcium Score ◽

Imaging Biomarkers ◽

Resistivity Index ◽

Group 2

Abstract Background: Cardiovascular diseases are a major cause of morbidity and mortality in Brazil and worldwide. Stratification of the risk of these diseases in asymptomatic patients using biomarkers can lead to early detection of patients at high risk of cardiovascular disease and promote the prevention of relevant events. The intrarenal resistivity index (IRI) is an imaging test that assesses renal perfusion, systemic hemodynamics, and atherosclerosis. It has been reported that changes in IRI are associated with morbidity and mortality in a population of patients with hypertension, diabetes, and chronic kidney disease. The present study tested a hypothesis that IRI is associated with imaging biomarkers of cardiovascular risk in a population of Afro-descendants. Methods: A total of 313 Afro-descendants with high cardiovascular risk were assessed using kidney ultrasound, Doppler echocardiography, carotid Doppler, and computed tomography to assess the calcium score. The individuals were divided into Group 1 with normal IRI and Group 2 with high IRI. Results: The mean intrarenal resistivity index was 0.61 in group 1 and 0.71 in group 2, and the mean age was 56.9 years, with 53% being female. Group 2 had significantly greater left ventricular mass, larger left atrium, and a higher prevalence of diastolic dysfunction (34.5% vs. 66.7%, p<0.0001). Group 2 also had a significantly higher frequency of carotid plaque (31% vs. 64%, p<0.001) as well as total coronary artery calcium score and higher frequency of high coronary artery calcium score (56.37 vs. 212.03, p<0.0001 and 24% vs. 50%, p<0.001, respectively). The presence of diastolic dysfunction with high left atrial pressure, coronary artery calcium score >0, and carotid plaque was independently associated with the intrarenal resistivity index. Conclusions: The intrarenal resistivity index is associated with imaging biomarkers of cardiovascular risk, mainly with the coronary artery calcium score, diastolic dysfunction, and atherosclerotic carotid plaque in people of African descent, with high cardiovascular risk.

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