scholarly journals Atherogenic potential of the blood serum in patients with type 1 diabetes mellitus

1993 ◽  
Vol 39 (6) ◽  
pp. 11-14
Author(s):  
M. M. Shagaeva ◽  
I. A. Sobenin ◽  
L. S. Slavina ◽  
A. N. Orekhov
Keyword(s):  
Diabetes Mellitus ◽  
Blood Serum ◽  
Cultured Cells ◽  
Type I Diabetes ◽  
Insulin Dose ◽  
Cholesterol Content ◽  
Type I ◽  
Exogenous Insulin ◽  
Insulin Effect ◽  
Intracellular Cholesterol

The task of this research was to study exogenous insulin effect on blood serum atherogenic potential in patients with type I diabetes mellitus. Under study were relationship between blood serum atherogenic potential in diabetics and daily insulin dose and duration of therapy, as well as exogenous insulin effect on the major atherosclerotic manifestations in tissue cultures, such as intracellular cholesterol content in cultured cells and labeled thymidine incorporation in cellular nuclei DNA. Blood serum atherogenicity did not correlate with insulin dose and duration of insulin therapy both in adult patients and children. Insulin prescription to newly detected patients with type I condition did not influence blood serum atherogenic potential. Exogenic insulin did not influence the major atherosclerotic manifestations at the cellular level, namely, on intracellular cholesterol content in cultured cells and these cells proliferative activity; it had no influence on blood serum atherogenic potential of the patients with type I condition.

Urinary C-Peptide: A Useful Tool for Evaluating the Endogenous Insulin Reserve in Cohort and Longitudinal Studies of Diabetes in Childhood

1988 ◽  
Vol 25 (5) ◽  
pp. 552-559 ◽  
Author(s):  
C E de Beaufort ◽  
N C den Boer ◽  
G J Bruining ◽  
G A M Eilers ◽  
R van Strik ◽  
...  
Keyword(s):  
Linear Correlation ◽  
Type I Diabetes ◽  
Insulin Dose ◽  
Type I ◽  
Exogenous Insulin ◽  
Insulin Production ◽  
C Peptide ◽  
Endogenous Insulin ◽  
Diabetic Children ◽  
Endogenous Insulin Production

Increasing research into the remission phase of type I diabetes mellitus stresses the importance of a non-traumatic and reliable method for the evaluation of endogenous insulin production. We compared 24-h urinary C-peptide excretion (UCE) with plasma C-peptide values before and after stimulation with 1 mg glucagon in 24 type I diabetic children. Fasting plasma C-peptide values and stimulated plasma C-peptide values showed a linear correlation with 24 h UCE. Mean plasma C-peptide levels correlated inversely with the exogenous insulin dose. A slightly better correlation was found between the exogenous insulin dose and 24 h UCE. Control data of 24 h UCE were obtained from healthy siblings. A linear correlation with age was found up to 10 years of age above which UCE values seem to reach a plateau. This effect of age, as well as the frequency of sampling was taken into account in the derivation of 95% reference intervals for UCE. The measurement of 24 h UCE appears to be a useful parameter to assess endogenous insulin production in diabetic children, provided that age is taken into account.

Effects of long-term optimization and short-term deterioration of glycemic control on glucose counterregulation in type I diabetes mellitus

Diabetes ◽  
1984 ◽  
Vol 33 (4) ◽  
pp. 394-400 ◽  
Author(s):  
G. Bolli ◽  
P. De Feo ◽  
S. De Cosmo ◽  
G. Perriello ◽  
G. Angeletti ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Glycemic Control ◽  
Type I Diabetes ◽  
Type I Diabetes Mellitus ◽  
Type I ◽  
Short Term

Competitive insulin autoantibody assay. Prospective evaluation of subjects at high risk for development of type I diabetes mellitus

Diabetes ◽  
1987 ◽  
Vol 36 (11) ◽  
pp. 1286-1291 ◽  
Author(s):  
P. Vardi ◽  
S. A. Dib ◽  
M. Tuttleman ◽  
J. E. Connelly ◽  
M. Grinbergs ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
High Risk ◽  
Type I Diabetes ◽  
Type I Diabetes Mellitus ◽  
Type I ◽  
Prospective Evaluation ◽  
Insulin Autoantibody

Pilot study on omega-3 fatty acids in type I diabetes mellitus

Diabetes ◽  
1990 ◽  
Vol 39 (3) ◽  
pp. 369-375 ◽  
Author(s):  
M. M. Landgraf-Leurs ◽  
C. Drummer ◽  
H. Froschl ◽  
R. Steinhuber ◽  
C. Von Schacky ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Fatty Acids ◽  
Pilot Study ◽  
Type I Diabetes ◽  
Type I Diabetes Mellitus ◽  
Type I ◽  
Omega 3 Fatty Acids ◽  
Omega 3

Differential sensitivity to beta-cell secretagogues in "early," type I diabetes mellitus

Diabetes ◽  
1984 ◽  
Vol 33 (6) ◽  
pp. 516-521 ◽  
Author(s):  
O. P. Ganda ◽  
S. Srikanta ◽  
S. J. Brink ◽  
M. A. Morris ◽  
R. E. Gleason ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Beta Cell ◽  
Type I Diabetes ◽  
Type I Diabetes Mellitus ◽  
Differential Sensitivity ◽  
Type I ◽  
Early Type

scholarly journals Poorly Controlled Type I Diabetes Mellitus in Young Men Selectively Suppresses Luteinizing Hormone Secretory Burst Mass

2002 ◽  
Vol 87 (12) ◽  
pp. 5507-5515 ◽  
Author(s):  
Juan Carlos López-Alvarenga ◽  
Teresa Zariñán ◽  
Aleida Olivares ◽  
Jorge González-Barranco ◽  
Johannes D. Veldhuis ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Luteinizing Hormone ◽  
Type I Diabetes ◽  
Young Men ◽  
Type I Diabetes Mellitus ◽  
Type I
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