Vitamin D status in infants during the first 9 months of age and its effect on growth and other biochemical markers: A Prospective Cohort Study

Background and aim. We planned this prospective cohort study in term newborn babies, with the objective to determine the incidence of vitamin D deficiency in infancy and to determine the level of vitamin D which triggers the physiological PTH axis of the body so as to differentiate truly deficient from sufficient vitamin D status.Methods. 96 participants at birth were enrolled and followed up till 9 months of age. Serum25OHD was estimated in cord blood at birth and at 14 ± 1 weeks of life. 77 participants were followed up at 9 months for estimation of serum 25OHD, PTH, Alkaline phosphatase (ALP), calcium and phosphorus. Vitamin D deficiency was defined as serum 25OHD <15 ng/mL as per USIOM guidelines.Results. Serum 25OHD levels at 9 months of age (15.78±8.97ng/mL) were significantly increased in comparison to the level of 3 months of age (14.04±7.10ng/mL) and at birth (8.94±2.24ng/mL).At birth all the participants (77) were deficient in 25OHD levels. It was found that 16/94 (17%)and 19/77 (24.7%) participants at 3 and 9 months of age respectively became vitamin D sufficient without any vitamin D supplementation. There was a significant inverse correlation between serum 25OHD and PTH concentration (r=-0.522, p<0.001), serum 25OHD and ALP(r=-.501, p<0.001). It was found that reduction in serum vitamin D level to below 10.25 ng/mL results in surge of serum PTH.Conclusion: Vitamin D deficiency is common from birth to 9 months of age but incidence decreases spontaneously even without supplementation. Also large number of babies may be falsely labelled as vitamin D deficient with currently followed cutoffs. So a new cutoff for vitamin D deficiency needs to be established for neonates and infants.

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Serum vitamin D levels and survival of patients with colorectal cancer: Post-hoc analysis of a prospective cohort study

BMC Cancer ◽

10.1186/1471-2407-10-347 ◽

2010 ◽

Vol 10 (1) ◽

Cited By ~ 58

Author(s):

Hidetoshi Mezawa ◽

Tsutomu Sugiura ◽

Michiaki Watanabe ◽

Chihiro Norizoe ◽

Daisuke Takahashi ◽

...

Keyword(s):

Colorectal Cancer ◽

Vitamin D ◽

Cohort Study ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Serum Vitamin ◽

Post Hoc Analysis ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Post Hoc

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Serum Vitamin D in Patients with Chronic Obstructive Lung Disease Does Not Correlate with Mortality – Results from a 10-Year Prospective Cohort Study

PLoS ONE ◽

10.1371/journal.pone.0053670 ◽

2013 ◽

Vol 8 (1) ◽

pp. e53670 ◽

Cited By ~ 23

Author(s):

Dennis Back Holmgaard ◽

Lone Hagens Mygind ◽

Ingrid Louise Titlestad ◽

Hanne Madsen ◽

Palle Bach Nielsen Fruekilde ◽

...

Keyword(s):

Vitamin D ◽

Cohort Study ◽

Lung Disease ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Obstructive Lung Disease ◽

Serum Vitamin ◽

Chronic Obstructive Lung Disease ◽

Chronic Obstructive ◽

Serum Vitamin D

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Associations of urine metals and metal mixtures during pregnancy with cord serum vitamin D Levels: A prospective cohort study with repeated measurements of maternal urinary metal concentrations

Environment International ◽

10.1016/j.envint.2021.106660 ◽

2021 ◽

Vol 155 ◽

pp. 106660

Author(s):

Xingjie Fang ◽

Jingyu Qu ◽

Shu Huan ◽

Xiaojie Sun ◽

Juxiao Li ◽

...

Keyword(s):

Vitamin D ◽

Cohort Study ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Serum Vitamin ◽

Repeated Measurements ◽

Metal Mixtures ◽

Cord Serum ◽

Serum Vitamin D ◽

Vitamin D Levels

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Vitamin D status and incidence of tuberculosis infection conversion in contacts of pulmonary tuberculosis patients: a prospective cohort study

Epidemiology and Infection ◽

10.1017/s0950268814002386 ◽

2014 ◽

Vol 143 (8) ◽

pp. 1731-1741 ◽

Cited By ~ 21

Author(s):

A. ARNEDO-PENA ◽

J. V. JUAN-CERDÁN ◽

M. A. ROMEU-GARCÍA ◽

D. GARCÍA-FERRER ◽

R. HOLGUÍN-GÓMEZ ◽

...

Keyword(s):

Vitamin D ◽

Cohort Study ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Protective Factor ◽

Serum Vitamin ◽

Interferon Gamma Release Assay ◽

High Exposure ◽

Serum Vitamin D ◽

Latent Tb Infection

SUMMARYThe objective of this study was to estimate the relationship between serum vitamin D (VitD) status and tuberculosis (TB) infection conversion (TBIC), measured by the tuberculin skin test (TST) and an interferon-gamma release assay, the QuantiFERON-TB Gold In-Tube (QFT-GIT) test, in the contacts of pulmonary TB patients in Castellon (Spain) in a prospective cohort study from 2010 to 2012. Initially, the participants were negative to latent TB infection after a screening that included TST and QFT-GIT tests, and other examinations. A baseline determination of 25-hydroxyvitamin D [25(OH)D] was obtained by chemiluminescence immunoassay. After 8–10 weeks, participants were screened for a second time to determine TB infection conversion (TBIC). Poisson regression models were used in the statistical analysis. Of the 247 participants in the cohort, 198 (80·2%) were screened twice and 18 (9·1%) were TBIC cases. The means of VitD concentration in the TBIC cases and the non-cases were 20·7±11·9 and 27·2±11·4 ng/ml (P = 0·028), respectively. Adjusted for high exposure and TB sputum acid-fast bacilli (AFB)-positive index case, higher serum VitD concentration was associated with low incidence of TBIC (Ptrend = 0·005), and an increase of 1 ng/ml VitD concentration decreased the incidence of TBIC by 6% (relative risk 0·94, 95% confidence interval 0·90–0·99, P = 0·015). The results suggest that sufficient VitD level could be a protective factor of TBIC.

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Vitamin D Deficiency Manifested by Premature Ventricular Complexes from RVOT: A Report on Two Twins

International Journal of Biomedicine ◽

10.21103/article11(2)_cr4 ◽

2021 ◽

Vol 11 (2) ◽

pp. 220-223

Author(s):

Gabriel Cismaru ◽

Cecilia Lazea ◽

Daniela Iacob ◽

Simona Cainap

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Serum Vitamin ◽

Right Ventricular Outflow Tract ◽

Structural Heart Disease ◽

Vitamin D Supplementation ◽

Normal Serum ◽

The Body ◽

Premature Ventricular Contractions ◽

Serum Vitamin D

Vitamin D receptor is present in almost every cell of the body. Although some studies have suggested that values >30ng/ml would be sufficient, there is no consensus on the optimal values of serum vitamin D. Vitamin D deficiency can lead to “benign” manifestations, such as back pain, joint pain, fatigue, and heavy sweating. Premature ventricular contractions (PVCs) originating from the right ventricular outflow tract (RVOT) are considered “benign,” as they occur in patients without structural heart disease and their exact cause remains unknown. We describe the case of a 10-year-old boy with frequent PVCs and vitamin D deficiency that was corrected after vitamin D supplementation. On the contrary, his twin brother had normal serum vitamin D and no PVCs. The disappearance of PVCs occurred after treatment with vitamin D 2000 IU/day.

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Micronutrient levels and their effect on the prognosis of visceral leishmaniasis treatment; a prospective cohort study.

10.21203/rs.3.rs-33284/v2 ◽

2020 ◽

Author(s):

berhanu elfu feleke ◽

Teferi Elfu Feleke

Keyword(s):

Vitamin D ◽

Cohort Study ◽

Chronic Illness ◽

Visceral Leishmaniasis ◽

Family Size ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Serum Vitamin ◽

Serum Selenium ◽

Serum Vitamin D

Abstract Background: Micronutrients are minerals and vitamins required in small amounts, and they are essential for normal physiological activities. The objectives of the study were to describe the progress and determinants of micronutrients level and to assess the effect of micronutrients in the treatment outcomes. Methods: A prospective cohort study was implemented. The data were collected using interviews, measuring anthropometric indicators, collecting blood, urine, and stool samples from each patient. The blood samples were collected five times: before starting anti-leishmaniasis treatments, in the first week, in the second week, in the third week, and in the 4th week of anti-leishmaniasis treatments. Descriptive statistics were used to describe the profile of patients and to compare the treatment success rate of visceral leishmaniasis patients. The generalized estimating equation was used to identify the determinants of serum micronutrients.Results: The serum zinc level of visceral leishmaniasis patients was affected by alcohol, DDS, family size, HIV, and sex. The serum iron level of visceral leishmaniasis patients were affected by alcohol, family size, malaria, hookworm, chronic diseases, and HIV. The serum selenium level of visceral leishmaniasis patients was affected by HIV and family size. The iodine level of visceral leishmaniasis patients was affected by HIV, DDS, smoking, chronic illness, and regular physical exercise. The serum vitamin D level of visceral leishmaniasis patients was affected by HIV, alcohol, chronic illness, DDS, malaria, family size, age, residence, and MUAC. The serum vitamin D level of visceral leishmaniasis patients was affected by BMI, DDS, malaria, hookworm, family size, HIV, and age. Conclusion: The Micronutrient levels of visceral leishmaniasis patients were significantly low. Anti-leishmaniasis treatment did not increase the serum micronutrient levels of the patients.

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Evaluation of the hormonal and biochemical changes in obese and non-obese PCOS Iraqi women before and after vitamin D supplementation

International Journal of Drug Delivery Technology ◽

10.25258/ijddt.v9i3.2 ◽

2019 ◽

Vol 9 (o3) ◽

Author(s):

Suaad Muhssen Ghazi ◽

Fatin Shallal Farhan

Keyword(s):

Vitamin D ◽

Serum Vitamin ◽

Follicular Development ◽

High Body Mass Index ◽

Vitamin D Supplementation ◽

The Body ◽

Obese People ◽

Serum Vitamin D ◽

Before And After ◽

Granulose Cells

Vitamin D deficiency is common in women with polycystic ovarian syndrome. Vitamin D plays an important physiologic role in reproductive functions of ovarian follicular development and luteinization through altering anti-müllerian hormone signaling, follicular stimulating hormone activity and progesterone production in human granulose cells. Vitamin D is precipitated in adipose fat tissues, making it notable to be used for the body as a result; obese people with high body mass index are already highly expected to have low levels of serum vitamin D.

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