scholarly journals Micronutrient levels and their effect on the prognosis of visceral leishmaniasis treatment; a prospective cohort study.

2020 ◽  
Author(s):  
berhanu elfu feleke ◽  
Teferi Elfu Feleke
Keyword(s):  
Vitamin D ◽  
Cohort Study ◽  
Chronic Illness ◽  
Visceral Leishmaniasis ◽  
Family Size ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Serum Vitamin ◽  
Serum Selenium ◽  
Serum Vitamin D

Abstract Background: Micronutrients are minerals and vitamins required in small amounts, and they are essential for normal physiological activities. The objectives of the study were to describe the progress and determinants of micronutrients level and to assess the effect of micronutrients in the treatment outcomes. Methods: A prospective cohort study was implemented. The data were collected using interviews, measuring anthropometric indicators, collecting blood, urine, and stool samples from each patient. The blood samples were collected five times: before starting anti-leishmaniasis treatments, in the first week, in the second week, in the third week, and in the 4th week of anti-leishmaniasis treatments. Descriptive statistics were used to describe the profile of patients and to compare the treatment success rate of visceral leishmaniasis patients. The generalized estimating equation was used to identify the determinants of serum micronutrients.Results: The serum zinc level of visceral leishmaniasis patients was affected by alcohol, DDS, family size, HIV, and sex. The serum iron level of visceral leishmaniasis patients were affected by alcohol, family size, malaria, hookworm, chronic diseases, and HIV. The serum selenium level of visceral leishmaniasis patients was affected by HIV and family size. The iodine level of visceral leishmaniasis patients was affected by HIV, DDS, smoking, chronic illness, and regular physical exercise. The serum vitamin D level of visceral leishmaniasis patients was affected by HIV, alcohol, chronic illness, DDS, malaria, family size, age, residence, and MUAC. The serum vitamin D level of visceral leishmaniasis patients was affected by BMI, DDS, malaria, hookworm, family size, HIV, and age. Conclusion: The Micronutrient levels of visceral leishmaniasis patients were significantly low. Anti-leishmaniasis treatment did not increase the serum micronutrient levels of the patients.

scholarly journals Micronutrient levels and their effects on the prognosis of visceral leishmaniasis treatment, a prospective cohort study.

2020 ◽  
Author(s):  
berhanu elfu feleke ◽  
Teferi Elfu Feleke
Keyword(s):  
Cohort Study ◽  
Visceral Leishmaniasis ◽  
Family Size ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Treatment Success ◽  
Serum Vitamin ◽  
Iron Level ◽  
Serum Selenium ◽  
Visceral Leishmaniasis Patient

Abstract Background: Micronutrients are minerals and vitamins and they are essential for normal physiological activities. The objectives of the study were to describe the progress and determinants of micronutrient levels and to assess the effects of micronutrients in the treatment outcome of kalazar.Methods: A prospective cohort study design was used. The data were collected using patient interviews, measuring anthropometric indicators, and collecting laboratory samples. The blood samples were collected at five different periods during the leishmaniasis treatments: before starting anti-leishmaniasis treatments, in the first week, in the second week, in the third week, and in the 4th week of anti-leishmaniasis treatments. Descriptive statistics were used to describe the profile of patients and to compare the treatment success rate. The generalized estimating equation was used to identify the determinants of serum micronutrients.Results: The mean age of the patients were 32.88 years [SD (standard deviation) ±15.95]. Male constitute 62.3 % of the patients and problematic alcohol use was present in 11.5 % of the patients. The serum zinc level of visceral leishmaniasis patients was affected by alcohol (B -2.7 [95 % CI: -4.01 - -1.5]), DDS (B 9.75 [95 % CI: 7.71 – 11.79]), family size (B -1.63 [95 % CI: -2.68 - -0.58]), HIV (B -2.95 [95 % CI: -4.97 - -0.92]), and sex (B -1.28 [95 % CI: -2.5 - -0.07]). The serum iron level of visceral leishmaniasis patients was affected by alcohol (B 7.6 [95 % CI: 5.86 – 9.35]), family size (B -5.14 [95 % CI: -7.01 - -3.28]), malaria (B -12.69 [95 % CI: -14.53 - -10.87]), Hookworm (-4.48 [-6.82 - -2.14]), chronic diseases (B -7.44 [95 % CI: -9.75 - -5.13]), and HIV (B -5.51 [95% CI: -8.23 - -2.78]). The serum selenium level of visceral leishmaniasis patient was affected by HIV (B -18.1 [95 % CI: -20.63 - -15.58]) and family size (B -11.36 [95 % CI: -13.02 - -9.7]). The iodine level of visceral leishmaniasis patient was affected by HIV (B -38.02 [95 % CI: -41.98 - -34.06]), DDS (B 25 .84 [95 % CI: 22.57 – 29.1]), smoking (B -12.34 [95 % CI: -15.98 - -8.7]), chronic illness (B -5.14 [95 % CI: -7.82 - -2.46]), and regular physical exercise (B 5.82 [95 % CI: 0.39 - 11.26]). The serum vitamin D level of visceral leishmaniasis patient was affected by HIV (B -9.43 [95 % CI: -10.92 - -7.94]), DDS (B 16.24 [95% CI: 14.89 – 17.58]), malaria (B -0.61 [95 % CI: -3.37 - -3.37]), and family size (B -1.15 [95 % CI: -2.03 - -0.28]). The serum vitamin A level of visceral leishmaniasis patient was affected by residence (B 0.81 [95 % CI: 0.08 - 1.54]), BMI (B 1.52 [95 % CI: 0.42 – 2.6]), DDS (B 1.62 [95 % CI: 0.36 – 2.88]), family size (B -5.03 [95 % CI: -5.83 - -4.22]), HIV (B -2.89 [95% CI: -4.44 - -1.34]),MUAC (B 0.86 [95 % CI: 0.52 – 1.21]), and age (B 0.09 [95 % CI: 0.07 – 0.12]).Conclusion: The micronutrient levels of visceral leishmaniasis patients were significantly lower. The anti-leishmaniasis treatment did not increase the serum micronutrient level of the patients.

scholarly journals Micronutrient levels and their effects on the prognosis of visceral leishmaniasis treatment, a prospective cohort study

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Berhanu Elfu Feleke ◽  
Teferi Elfu Feleke
Keyword(s):  
Cohort Study ◽  
Visceral Leishmaniasis ◽  
Family Size ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Treatment Success ◽  
Serum Vitamin ◽  
Iron Level ◽  
Serum Selenium ◽  
Visceral Leishmaniasis Patient

Abstract Background Micronutrients are minerals and vitamins and they are essential for normal physiological activities. The objectives of the study were to describe the progress and determinants of micronutrient levels and to assess the effects of micronutrients in the treatment outcome of kalazar. Methods A prospective cohort study design was used. The data were collected using patient interviews, measuring anthropometric indicators, and collecting laboratory samples. The blood samples were collected at five different periods during the leishmaniasis treatments: before starting anti-leishmaniasis treatments, in the first week, in the second week, in the third week, and in the 4th week of anti-leishmaniasis treatments. Descriptive statistics were used to describe the profile of patients and to compare the treatment success rate. The generalized estimating equation was used to identify the determinants of serum micronutrients. Results The mean age of the patients were 32.88 years [SD (standard deviation) ±15.95]. Male constitute 62.3% of the patients and problematic alcohol use was present in 11.5% of the patients. The serum zinc level of visceral leishmaniasis patients was affected by alcohol (B − 2.7 [95% CI: − 4.01 - -1.5]), DDS (B 9.75 [95% CI: 7.71–11.79]), family size (B -1.63 [95% CI: − 2.68 - -0.58]), HIV (B -2.95 [95% CI: − 4.97 - -0.92]), and sex (B − 1.28 [95% CI: − 2.5 - -0.07]). The serum iron level of visceral leishmaniasis patients was affected by alcohol (B 7.6 [95% CI: 5.86–9.35]), family size (B -5.14 [95% CI: − 7.01 - -3.28]), malaria (B -12.69 [95% CI: − 14.53 - -10.87]), Hookworm (− 4.48 [− 6.82 - -2.14]), chronic diseases (B -7.44 [95% CI: − 9.75 - -5.13]), and HIV (B -5.51 [95% CI: − 8.23 - -2.78]). The serum selenium level of visceral leishmaniasis patient was affected by HIV (B -18.1 [95% CI: − 20.63 - -15.58]) and family size (B -11.36 [95% CI: − 13.02 - -9.7]). The iodine level of visceral leishmaniasis patient was affected by HIV (B -38.02 [95% CI: − 41.98 - -34.06]), DDS (B 25 .84 [95% CI: 22.57–29.1]), smoking (B -12.34 [95% CI: − 15.98 - -8.7]), chronic illness (B -5.14 [95% CI: − 7.82 - -2.46]), and regular physical exercise (B 5.82 [95% CI: 0.39–11.26]). The serum vitamin D level of visceral leishmaniasis patient was affected by HIV (B -9.43 [95% CI: − 10.92 - -7.94]), DDS (B 16.24 [95% CI: 14.89–17.58]), malaria (B -0.61 [95% CI: − 3.37 - -3.37]), and family size (B -1.15 [95% CI: − 2.03 - -0.28]). The serum vitamin A level of visceral leishmaniasis patient was affected by residence (B 0.81 [95% CI: 0.08–1.54]), BMI (B 1.52 [95% CI: 0.42–2.6]), DDS (B 1.62 [95% CI: 0.36–2.88]), family size (B -5.03 [95% CI: − 5.83 - -4.22]), HIV (B -2.89 [95% CI: − 4.44 - -1.34]),MUAC (B 0.86 [95% CI: 0.52–1.21]), and age (B 0.09 [95% CI: 0.07–0.12]). Conclusion The micronutrient levels of visceral leishmaniasis patients were significantly lower. The anti-leishmaniasis treatment did not increase the serum micronutrient level of the patients.

scholarly journals Micronutrient levels and their effect on the prognosis of visceral leishmaniasis treatment; a prospective cohort study.

2020 ◽  
Author(s):  
berhanu elfu feleke ◽  
Teferi Elfu Feleke
Keyword(s):  
Cohort Study ◽  
Visceral Leishmaniasis ◽  
Family Size ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Treatment Success ◽  
Serum Vitamin ◽  
Iron Level ◽  
Serum Selenium ◽  
Visceral Leishmaniasis Patient

Abstract Background: Micronutrients are minerals and vitamins and they are essential for normal physiological activities. The objectives of the study were to describe the progress and determinants of micronutrient levels and to assess the effects of micronutrients in the treatment outcome of kalazar. Methods: A prospective cohort study design was used. The data were collected using patient interviews, measuring anthropometric indicators, and collecting laboratory samples. The blood samples were collected at five different periods during the leishmaniasis treatments: before starting anti-leishmaniasis treatments, in the first week, in the second week, in the third week, and in the 4th week of anti-leishmaniasis treatments. Descriptive statistics were used to describe the profile of patients and to compare the treatment success rate. The generalized estimating equation was used to identify the determinants of serum micronutrients.Results: The mean age of the patients were 32.88 years [SD (standard deviation) ±15.95]. Male constitute 62.3 % of the patients and problematic alcohol use was present in 11.5 % of the patients. The serum zinc level of visceral leishmaniasis patients was affected by alcohol (B -2.7 [95 % CI: -4.01 - -1.5]), DDS (B 9.75 [95 % CI: 7.71 – 11.79]), family size (B -1.63 [95 % CI: -2.68 - -0.58]), HIV (B -2.95 [95 % CI: -4.97 - -0.92]), and sex (B -1.28 [95 % CI: -2.5 - -0.07]). The serum iron level of visceral leishmaniasis patients was affected by alcohol (B 7.6 [95 % CI: 5.86 – 9.35]), family size (B -5.14 [95 % CI: -7.01 - -3.28]), malaria (B -12.69 [95 % CI: -14.53 - -10.87]), Hookworm (-4.48 [-6.82 - -2.14]), chronic diseases (B -7.44 [95 % CI: -9.75 - -5.13]), and HIV (B -5.51 [95% CI: -8.23 - -2.78]). The serum selenium level of visceral leishmaniasis patient was affected by HIV (B -18.1 [95 % CI: -20.63 - -15.58]) and family size (B -11.36 [95 % CI: -13.02 - -9.7]). The iodine level of visceral leishmaniasis patient was affected by HIV (B -38.02 [95 % CI: -41.98 - -34.06]), DDS (B 25 .84 [95 % CI: 22.57 – 29.1]), smoking (B -12.34 [95 % CI: -15.98 - -8.7]), chronic illness (B -5.14 [95 % CI: -7.82 - -2.46]), and regular physical exercise (B 5.82 [95 % CI: 0.39 - 11.26]). The serum vitamin D level of visceral leishmaniasis patient was affected by HIV (B -9.43 [95 % CI: -10.92 - -7.94]), DDS (B 16.24 [95% CI: 14.89 – 17.58]), malaria (B -0.61 [95 % CI: -3.37 - -3.37]), and family size (B -1.15 [95 % CI: -2.03 - -0.28]). The serum vitamin A level of visceral leishmaniasis patient was affected by residence (B 0.81 [95 % CI: 0.08 - 1.54]), BMI (B 1.52 [95 % CI: 0.42 – 2.6]), DDS (B 1.62 [95 % CI: 0.36 – 2.88]), family size (B -5.03 [95 % CI: -5.83 - -4.22]), HIV (B -2.89 [95% CI: -4.44 - -1.34]),MUAC (B 0.86 [95 % CI: 0.52 – 1.21]), and age (B 0.09 [95 % CI: 0.07 – 0.12]). Conclusion: The micronutrient levels of visceral leishmaniasis patients were significantly lower. The anti-leishmaniasis treatment did not increase the serum micronutrient level of the patients.

scholarly journals Serum vitamin D levels and survival of patients with colorectal cancer: Post-hoc analysis of a prospective cohort study

BMC Cancer ◽  
2010 ◽  
Vol 10 (1) ◽  
Author(s):  
Hidetoshi Mezawa ◽  
Tsutomu Sugiura ◽  
Michiaki Watanabe ◽  
Chihiro Norizoe ◽  
Daisuke Takahashi ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Vitamin D ◽  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Serum Vitamin ◽  
Post Hoc Analysis ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Post Hoc

scholarly journals Serum Vitamin D in Patients with Chronic Obstructive Lung Disease Does Not Correlate with Mortality – Results from a 10-Year Prospective Cohort Study

PLoS ONE ◽  
2013 ◽  
Vol 8 (1) ◽  
pp. e53670 ◽  
Author(s):  
Dennis Back Holmgaard ◽  
Lone Hagens Mygind ◽  
Ingrid Louise Titlestad ◽  
Hanne Madsen ◽  
Palle Bach Nielsen Fruekilde ◽  
...  
Keyword(s):  
Vitamin D ◽  
Cohort Study ◽  
Lung Disease ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Obstructive Lung Disease ◽  
Serum Vitamin ◽  
Chronic Obstructive Lung Disease ◽  
Chronic Obstructive ◽  
Serum Vitamin D

Vitamin D status and incidence of tuberculosis infection conversion in contacts of pulmonary tuberculosis patients: a prospective cohort study

2014 ◽  
Vol 143 (8) ◽  
pp. 1731-1741 ◽  
Author(s):  
A. ARNEDO-PENA ◽  
J. V. JUAN-CERDÁN ◽  
M. A. ROMEU-GARCÍA ◽  
D. GARCÍA-FERRER ◽  
R. HOLGUÍN-GÓMEZ ◽  
...  
Keyword(s):  
Vitamin D ◽  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Protective Factor ◽  
Serum Vitamin ◽  
Interferon Gamma Release Assay ◽  
High Exposure ◽  
Serum Vitamin D ◽  
Latent Tb Infection

SUMMARYThe objective of this study was to estimate the relationship between serum vitamin D (VitD) status and tuberculosis (TB) infection conversion (TBIC), measured by the tuberculin skin test (TST) and an interferon-gamma release assay, the QuantiFERON-TB Gold In-Tube (QFT-GIT) test, in the contacts of pulmonary TB patients in Castellon (Spain) in a prospective cohort study from 2010 to 2012. Initially, the participants were negative to latent TB infection after a screening that included TST and QFT-GIT tests, and other examinations. A baseline determination of 25-hydroxyvitamin D [25(OH)D] was obtained by chemiluminescence immunoassay. After 8–10 weeks, participants were screened for a second time to determine TB infection conversion (TBIC). Poisson regression models were used in the statistical analysis. Of the 247 participants in the cohort, 198 (80·2%) were screened twice and 18 (9·1%) were TBIC cases. The means of VitD concentration in the TBIC cases and the non-cases were 20·7±11·9 and 27·2±11·4 ng/ml (P = 0·028), respectively. Adjusted for high exposure and TB sputum acid-fast bacilli (AFB)-positive index case, higher serum VitD concentration was associated with low incidence of TBIC (Ptrend = 0·005), and an increase of 1 ng/ml VitD concentration decreased the incidence of TBIC by 6% (relative risk 0·94, 95% confidence interval 0·90–0·99, P = 0·015). The results suggest that sufficient VitD level could be a protective factor of TBIC.

Vitamin D status in infants during the first 9 months of age and its effect on growth and other biochemical markers: A Prospective Cohort Study

2016 ◽  
Vol 62 (5) ◽  
pp. 19
Author(s):  
Manish Gutch ◽  
Sukriti Kumar ◽  
Uday Kumar Mandal
Keyword(s):  
Vitamin D ◽  
Cohort Study ◽  
Vitamin D Deficiency ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Serum Vitamin ◽  
Vitamin D Supplementation ◽  
The Body ◽  
Serum 25Ohd ◽  
Serum Vitamin D

Background and aim. We planned this prospective cohort study in term newborn babies, with the objective to determine the incidence of vitamin D deficiency in infancy and to determine the level of vitamin D which triggers the physiological PTH axis of the body so as to differentiate truly deficient from sufficient vitamin D status.Methods. 96 participants at birth were enrolled and followed up till 9 months of age. Serum25OHD was estimated in cord blood at birth and at 14 ± 1 weeks of life. 77 participants were followed up at 9 months for estimation of serum 25OHD, PTH, Alkaline phosphatase (ALP), calcium and phosphorus. Vitamin D deficiency was defined as serum 25OHD <15 ng/mL as per USIOM guidelines.Results. Serum 25OHD levels at 9 months of age (15.78±8.97ng/mL) were significantly increased in comparison to the level of 3 months of age (14.04±7.10ng/mL) and at birth (8.94±2.24ng/mL).At birth all the participants (77) were deficient in 25OHD levels. It was found that 16/94 (17%)and 19/77 (24.7%) participants at 3 and 9 months of age respectively became vitamin D sufficient without any vitamin D supplementation. There was a significant inverse correlation between serum 25OHD and PTH concentration (r=-0.522, p<0.001), serum 25OHD and ALP(r=-.501, p<0.001). It was found that reduction in serum vitamin D level to below 10.25 ng/mL results in surge of serum PTH.Conclusion: Vitamin D deficiency is common from birth to 9 months of age but incidence decreases spontaneously even without supplementation. Also large number of babies may be falsely labelled as vitamin D deficient with currently followed cutoffs. So a new cutoff for vitamin D deficiency needs to be established for neonates and infants.

scholarly journals Micronutrient levels of visceral leishmaniasis patients, a longitudinal study.

2020 ◽  
Author(s):  
berhanu elfu feleke ◽  
Teferi Elfu Feleke
Keyword(s):  
Vitamin D ◽  
Chronic Illness ◽  
Family Size ◽  
Treatment Success ◽  
Serum Vitamin ◽  
Serum Zinc ◽  
Iron Level ◽  
Serum Selenium ◽  
Serum Iron Level ◽  
Serum Vitamin D

Abstract Background: Micronutrients are minerals and vitamins required in small amounts, and they are essential for the normal physiological activities. The objectives of the study were to describe the progress and determinants of micronutrients level and to assess the effect of micronutrients in the treatment outcomes. Methods: A prospective cohort study was implemented. The data were collected using interviews, measuring anthropometric indicators, collecting blood, urine and stool samples from each patient. The blood samples were collected five times: before starting anti-leishmaniasis treatments, in the first week, in the second week, in the third week and in the 4th week of anti-leishmaniasis treatments. Descriptive statistics were used to describe the profile of patients and to compare the treatment success rate of Kalazar patients. The generalized estimating equation was used to identify the determinants of serum micronutrients.Results: The serum zinc level of Kalazar patients was affected by alcohol, DDS, family size, HIV, and sex. The serum iron level of kalazar patients was affected by alcohol, family size, malaria, hookworm, chronic disease, and HIV. The serum selenium level of kalazar patients was affected by HIV and family size. The iodine level of kalazar patients was affected by HIV, DDS, smoking, chronic illness, and regular physical exercise. The serum vitamin D level of kalazar patients was affected by HIV, alcohol, chronic illness, DDS, malaria, family size, age, residence, and MUAC. The serum vitamin D level of kalazar patients was affected by BMI, DDS, malaria, hookworm, family size, HIV, and age. Conclusion: The Micronutrient levels of Kalazar patients were significantly low. Anti-leishmaniasis treatment did not increase the serum micronutrient levels of the patients.

Sign in / Sign up

Export Citation Format

Share Document