scholarly journals Impact of stimulating cognitive-motor training on neuropsychological status and quality of life in patients with Parkinson's disease

2018 ◽  
Vol 10 (4) ◽  
pp. 65-71
Author(s):  
Yu. N. Bykov ◽  
T. B. Bender ◽  
Yu. N. Vasiliev ◽  
A. N. Kalyagin ◽  
Т. М. Maksikova ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Combination Therapy ◽  
Mobile Devices ◽  
Physical Functioning ◽  
Motor Training ◽  
Neuropsychological Status ◽  
Sf 36

Motor and non-motor symptoms are identified in the clinical picture of Parkinson's disease (PD). Among its non-motor manifestations, cognitive impairment (CI) and emotional disorders play a special role in PD. It is important to search for new forms and methods of cognitive therapy in patients with PD.Objective:to analyze neuropsychological status and quality of life (QOL) in PD patients and to evaluate the efficiency of personalized combination therapy with a stimulating cognitive motor training on computer and mobile devices in these patients.Patients and methods. The investigation enrolled 112 patients with PD. A study group included 56 PD patients who received a cycle of combination therapy with cognitive-motor training on PC and mobile devices; a control group consisted of 56 PD patients who had only a drug therapy cycle. To evaluate neuropsychological status and QOL, the investigators used the Montreal Cognitive Assessment (MoCA), the McNair and Kahn memory self-evaluation scale, the Hospital Anxiety and Depression Scale (HADS), and the 36-Item Short Form Health Survey (SF-36) questionnaire.Results and discussion. According to MoCA scores, CI of varying severity was diagnosed in the majority of patients: in 75 and 80.4% in the study and control groups, respectively. Depressive syndrome was detected in 53.6 and 64.3% in these groups, respectively. According to the SF-36, the physical status of patients had the greatest effect in reducing their QOL. There were treatment-induced statistically significant positive changes for the following domains: physical functioning (p<0.01), role-physical functioning (p<0.001), pain intensity (p<0.01), general health (p<0.01), role emotional (p<0.0001), and mental health (p<0.01).Conclusion.The investigation has shown the efficiency of personalized therapy including stimulating cognitive-motor training on computer and mobile devices, which improves neuropsychological status and QOL in patients with PD.

scholarly journals Karakteristik dan Kualitas Hidup Pasien Penyakit Parkinson dengan Probabel Gangguan Perilaku Tidur Fase Gerak Mata Cepat di Manado

e-CliniC ◽  
2019 ◽  
Vol 8 (1) ◽  
Author(s):  
Grisheila M. Koleangan ◽  
Arthur H. P. Mawuntu ◽  
Mieke A. H. M. Kembuan
Keyword(s):  
Quality Of Life ◽  
High School ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Eye Movement ◽  
Junior High School ◽  
Rapid Eye Movement ◽  
Rapid Eye Movement Sleep ◽  
Sf 36

Abstract: Rapid eye movement sleep behavior disorder (RBD) often occurs in patients with Parkinson's disease (PD) and it could reduce their quality of life (QoL). This study was aimed to obtain the characteristics and QoL of PD patients with pRBD in Manado. This was a descriptive study with a cross-sectional design. Subjects were PD patients with pRBD at Prof. Dr. R. D. Kandou Hospital from October to November 2019. The QoL was measured by using the SF-36 QoL questionnaire. The results obtained 48 eligible subjects. Male patients were more common than females (52.1% vs 47.9%). Most of the subjects were 60-69 years (54.1%), had senior high school and junior high school education (each of 29.1%), and unemployed (41.7%). Moreover, 62.5% of patients had been diagnosed as PD since 1-5 years ago. The mean score of the physical and mental component of the subjects were 46.5 and 60.8 subsequently. In conclusion, the majority of patients with Parkinson's disease and pRBD were 60-69 years, senior or junior high school educated, unemployed, and had been diagnosed as PD since 1-5 years ago. Their quality of life in physical component was below norm-based score but in mental component was still good.Keywords: Parkinson's disease, probable RBD, quality of life, SF-36 Abstrak: Gangguan perilaku tidur fase gerak mata cepat (rapid eye movement sleep behaviour disorder/RBD) sering terjadi pada pasien penyakit Parkinson (PD) yang mungkin menurunkan kualitas hidup mereka. Penelitian ini bertujuan untuk mengetahui karakteristik dan kualitas hidup pasien PD dengan probabel RBD (pRBD) di Manado. Jenis penelitian ialah deskriptif dengan desain potong lintang terhadap pasien PD dengan pRBD yang datang ke RSUP Prof. Dr. R. D. Kandou Manado bulan Oktober-November 2019. Kualitas hidup diukur menggu-nakan kuesioner kualitas hidup SF-36. Hasil penelitian mendapatkan 48 pasien yang meme-nuhi kriteria penelitian. Pasien berjenis kelamin laki-laki lebih banyak daripada perempuan (52,1% vs 47,9%). Sebagian besar pasien berada pada kelompok usia 60-69 tahun (54,1%), tingkat pendidikan terakhir SMA/Sederajat dan SMP sama banyak (29,1%), dan tidak bekerja (41,7%). Sebanyak 62,5% subjek telah terdiagnosis PD sejak 1-5 tahun sebelumnya. Skor rerata komponen fisik dan komponen mental kualitas hidup SF-36 ialah 46,5 dan 60,8. Sim-pulan penelitian ini ialah mayoritas pasien penyakit Parkinson dengan pRBD berusia 60-69 tahun, pendidikan SMA/sederajat atau SMP, tidak bekerja, dan telah terdiagnosis PD sejak 1-5 tahun sebelumnya. Kualitas hidup pasien penyakit Parkinson dengan pRBD pada komponen fisik secara umum berada di bawah skor normatif tetapi komponen mental masih baik.Kata kunci: penyakit Parkinson, probabel RBD, kualitas hidup, SF-36

scholarly journals The impact of poor medication knowledge on health-related quality of life in people with Parkinson’s disease: a mediation analysis

2021 ◽  
Author(s):  
Hannah M. Zipprich ◽  
Sarah Mendorf ◽  
Aline Schönenberg ◽  
Tino Prell
Keyword(s):  
Quality Of Life ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Assessment ◽  
Medication Knowledge ◽  
Sf 36 ◽  
Related Quality ◽  
Health Related ◽  
The Relationship

Abstract Purpose This study aimed to determine how limited medication knowledge as one aspect of health literacy contributes to poorer health-related quality of life (HRQoL) in people with Parkinson’s disease (PD). Methods Demographical data, PD-specific data (MDS-Unified Parkinson’s Disease-Rating Scale, Nonmotor symptom scale), and data about depressive symptoms (Beck’s depression inventory), cognition (Montreal cognitive assessment), HRQoL (Short-Form Health Questionnaire-36, SF-36), and medication knowledge (names, time of taking, indication, dosage) were assessed in 193 patients with PD. Multivariate analysis of variance (MANOVA), multivariate analysis of covariance, and mediation analyses were used to study the relationship between medication knowledge and HRQoL in combination with different mediators and covariates. Results Overall, 43.5% patients showed deficits in at least one of the 4 knowledge items, which was associated with higher age, number of medications per day and depression level, and poorer cognitive function, motor function, and lower education level. Using one-way MANOVA, we identified that medication knowledge significantly impacts physical functioning, social functioning, role limitations due to physical problems, and role limitations due to emotional problems. Mediation models using age, education level, and gender as covariates showed that the relationship between knowledge and SF-36 domains was fully mediated by Beck’s Depression Inventory but not by Montreal Cognitive Assessment. Conclusions Patients who expressed unawareness of their medication did not necessarily have cognitive deficits; however, depressive symptoms may instead be present. This concomitant depressive symptomatology is crucial in explaining the contribution of nonadherence and decreased medication knowledge to poor quality of life.

scholarly journals Health-Related Quality of Life Subdomains in Patients with Parkinson’s Disease: The Role of Gender

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Anja Ophey ◽  
Carsten Eggers ◽  
Richard Dano ◽  
Lars Timmermann ◽  
Elke Kalbe
Keyword(s):  
Quality Of Life ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Physical Functioning ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
Negative Predictor

The most frequently used instrument to assess health-related quality of life (HrQoL) in Parkinson’s disease (PD) is the Parkinson’s Disease Questionnaire 39 (PDQ-39). However, both the dimensionality of the eight PDQ-39 subscales and their summary score recently faced criticism. Furthermore, data on disease-related and neuropsychological determinants and the role of gender on HrQoL in PD are inconclusive yet. Therefore, our aim was to reevaluate the PDQ-39 structure and to further explore determinants of HrQoL in PD. 245 PD patients (age: M = 69.64, SD = 8.43; 62.9% male; H&Y: Md = 3.00; cognitive assessment with PANDA: M = 24.82, SD = 3.57) from the baseline database of the Cologne Parkinson Network were used to reevaluate the dimensionality of the PDQ-39 with a principal component analysis (PCA). Multiple regression analyses were conducted to clarify general and domain-specific relationships between clinical, (neuro)psychological, and sociodemographic variables, gender in particular, and HrQoL. The PCA identified three HrQoL domains: physical-functioning, cognition, and socioemotional HrQoL. Depressive symptoms were identified as the most important determinant of HrQoL across all models. Disease-related HrQoL determinants (UPDRS-III, H&Y stage, and LEDD) were less strong and consistent HrQoL determinants than nonmotor symptoms. Analyses did not reveal a global gender effect; however, female gender was a negative predictor for physical-functioning and socioemotional HrQoL, whereas male gender was a negative predictor for cognition HrQoL. Our analyses suggest the consideration of a reevaluation of the PDQ-39. Only the full understanding of HrQoL, its determinants, and their interrelationships will allow the development of PD intervention strategies focusing on what matters the most for patients’ HrQoL. Gender is one relevant variable that should be considered in this context.

Deep Brain Stimulation in Patients with Parkinson's Disease: Effect on Psychiatric Symptoms and Quality of Life

2017 ◽  
Vol 79 (02) ◽  
pp. 130-138
Author(s):  
Elisa Seijo Zazo ◽  
Fernando Fernandez ◽  
Elena Liebana ◽  
Antonio Ayala ◽  
Beatriz Aragoneses ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Psychiatric Symptoms ◽  
Medication Use ◽  
Sf 36 ◽  
Deep Brain

Background and Study Aims To determine the effect on psychiatric symptoms and quality of life in 30 patients with Parkinson's disease (PD) treated with deep brain stimulation (DBS) of both subthalamic nuclei (STN) after 1 year of follow-up. Material and Method We conducted a prospective 1-year follow-up study with a baseline assessment before and 6 and 12 months after surgery. The following were used as assessment instruments: the Bech-Rafaelsen Melancholia Scale (MES), the Bech-Rafaelsen Mania Scale (MAS), the Beck Scale for Suicidal Ideation (SSI), the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS), the Oviedo Sleep Questionnaire (OSQ), the 36-Item Short Form Health Survey (SF-36), the Unified Parkinson's Disease Rating Scale (UPDRS), the dose of levodopa, and the active contact stereotactic coordinates. Results We recorded a clinical improvement between baseline with medication use (ON medication) and the results obtained at 6 and 12 months with medication use and stimulation (ON stimulation, ON medication) in MES and OSQ (p < 0.0001) and in SF-36 (p < 0.005). No changes were observed in MAS and SSI. There was a clinical improvement between baseline with ON medication and the results obtained at 12 months with ON stimulation, ON medication in Y-BOCS (p < 0.04). Also, there was a 53.3% reduction in levodopa at 6 months and a 54.7% reduction at 12 months after surgery (p < 0.0001). There was an improvement between baseline with OFF medication and the results obtained at 6 and 12 months OFF medication, ON stimulation (p < 0.0001) in UPDRS-III. There were no statistically significant differences between the initial and final active contact coordinates, or between stimulation parameters. Conclusions DBS of the STN in patients with PD is associated with an improvement in psychiatric (affective and sleep-wake cycle) symptoms, clinical motor symptoms, and quality of life at 1 year after surgery.

scholarly journals Karakteristik dan Kualitas Hidup Pasien Penyakit Parkinson dengan Probabel Gangguan Perilaku Tidur Fase Gerak Mata Cepat di Manado

e-CliniC ◽  
2019 ◽  
Vol 8 (1) ◽  
Author(s):  
Grisheila M. Koleangan ◽  
Arthur H. P. Mawuntu ◽  
Mieke A. H. M. Kembuan
Keyword(s):  
Quality Of Life ◽  
High School ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Eye Movement ◽  
Junior High School ◽  
Rapid Eye Movement ◽  
Rapid Eye Movement Sleep ◽  
Sf 36

Abstract: Rapid eye movement sleep behavior disorder (RBD) often occurs in patients with Parkinson's disease (PD) and it could reduce their quality of life (QoL). This study was aimed to obtain the characteristics and QoL of PD patients with pRBD in Manado. This was a descriptive study with a cross-sectional design. Subjects were PD patients with pRBD at Prof. Dr. R. D. Kandou Hospital from October to November 2019. The QoL was measured by using the SF-36 QoL questionnaire. The results obtained 48 eligible subjects. Male patients were more common than females (52.1% vs 47.9%). Most of the subjects were 60-69 years (54.1%), had senior high school and junior high school education (each of 29.1%), and unemployed (41.7%). Moreover, 62.5% of patients had been diagnosed as PD since 1-5 years ago. The mean score of the physical and mental component of the subjects were 46.5 and 60.8 subsequently. In conclusion, the majority of patients with Parkinson's disease and pRBD were 60-69 years, senior or junior high school educated, unemployed, and had been diagnosed as PD since 1-5 years ago. Their quality of life in physical component was below norm-based score but in mental component was still good.Keywords: Parkinson's disease, probable RBD, quality of life, SF-36 Abstrak: Gangguan perilaku tidur fase gerak mata cepat (rapid eye movement sleep behaviour disorder/RBD) sering terjadi pada pasien penyakit Parkinson (PD) yang mungkin menurunkan kualitas hidup mereka. Penelitian ini bertujuan untuk mengetahui karakteristik dan kualitas hidup pasien PD dengan probabel RBD (pRBD) di Manado. Jenis penelitian ialah deskriptif dengan desain potong lintang terhadap pasien PD dengan pRBD yang datang ke RSUP Prof. Dr. R. D. Kandou Manado bulan Oktober-November 2019. Kualitas hidup diukur menggu-nakan kuesioner kualitas hidup SF-36. Hasil penelitian mendapatkan 48 pasien yang meme-nuhi kriteria penelitian. Pasien berjenis kelamin laki-laki lebih banyak daripada perempuan (52,1% vs 47,9%). Sebagian besar pasien berada pada kelompok usia 60-69 tahun (54,1%), tingkat pendidikan terakhir SMA/Sederajat dan SMP sama banyak (29,1%), dan tidak bekerja (41,7%). Sebanyak 62,5% subjek telah terdiagnosis PD sejak 1-5 tahun sebelumnya. Skor rerata komponen fisik dan komponen mental kualitas hidup SF-36 ialah 46,5 dan 60,8. Sim-pulan penelitian ini ialah mayoritas pasien penyakit Parkinson dengan pRBD berusia 60-69 tahun, pendidikan SMA/sederajat atau SMP, tidak bekerja, dan telah terdiagnosis PD sejak 1-5 tahun sebelumnya. Kualitas hidup pasien penyakit Parkinson dengan pRBD pada komponen fisik secara umum berada di bawah skor normatif tetapi komponen mental masih baik.Kata kunci: penyakit Parkinson, probabel RBD, kualitas hidup, SF-36

scholarly journals Cognitive disorders and life quality of parkinsonism patients

2008 ◽  
Vol 7 (5-1) ◽  
pp. 145-149
Author(s):  
I. A. Zhoukova ◽  
N. G. Zhoukova ◽  
V. M. Alifirova ◽  
F. F. Gashilova
Keyword(s):  
Quality Of Life ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Impairment ◽  
Life Quality ◽  
Cognitive Disorders ◽  
Treatment Quality ◽  
Sf 36 ◽  
Wide Dissemination

Quality of life is a new characteristic of health of patient, and efficacy of treatment. Quality of life had wide dissemination during last time. The aim of study was to exanimate and to compare quality of life patients with Parkinson’s disease which depended on gender, age, form of disease and cognitive impairment. We examined quality of life of 90 patients with Parkinson’s disease by questioner SF-36 and PDQ-39. Quality of life increased in patients with Parkinson’s disease, and depends from form and cognitive impairment.

Critical issues of the biopsychosocial treatment of Parkinson’s disease

2015 ◽  
Vol 156 (12) ◽  
pp. 472-478 ◽  
Author(s):  
Péter Kincses ◽  
Norbert Kovács ◽  
Kázmér Karádi ◽  
János Kállai
Keyword(s):  
Quality Of Life ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Psychological Health ◽  
Interdisciplinary Approach ◽  
Cognitive Status ◽  
Psychological Burden ◽  
Her Family ◽  
Critical Issues

This paper is a summary report on the basic questions of the biopsychosocial approach to Parkinson’s disease. It deals with cognitive, affective and psychological health issues which significantly influence the outcome of the physical rehabilitation. In spite of the unchanged cognitive status, the psychological burden of the changes in the quality of life, the obstruction, the change in the affective tone, and the shrinking ability to fulfil social roles decrease the patient’s quality of life. An interdisciplinary approach is best suited for mitigating these effects. Not only the patient but also his/her family and environment is seriously affected by the disease and its consequences. Treatment and rehabilitation options for increasing or maintaining the quality of life of the affected patients are diverse, and significantly depend on the features of the health care system. The authors believe that the following review emphasizing health psychological principles may contribute to the work of professionals working in clinical and rehabilitational fields and through them may increase the quality of life of patients and their family. Orv. Hetil., 2015, 156(12), 472–478.

scholarly journals The Parkinson’s Real-World Impact Assessment (PRISM) Study: A European Survey of the Burden of Parkinson’s Disease in Patients and their Carers

2021 ◽  
pp. 1-15
Author(s):  
Eduardo Tolosa ◽  
Georg Ebersbach ◽  
Joaquim J. Ferreira ◽  
Olivier Rascol ◽  
Angelo Antonini ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Impact Assessment ◽  
Real World ◽  
European Countries ◽  
Life Questionnaire ◽  
Motor Symptoms ◽  
Non Motor Symptoms

Background: A greater understanding of the everyday experiences of people with Parkinson’s disease (PD) and their carers may help improve clinical practice. Objective: The Parkinson’s Real-world Impact assesSMent (PRISM) study evaluated medication use, health-related quality of life (HRQoL) and the use of healthcare resources by people with PD and their carers. Methods: PRISM is an observational cross-sectional study, in which people with PD and their carers completed an online survey using structured questionnaires, including the Parkinson’s Disease Quality of Life Questionnaire (PDQ-39), Non-Motor Symptoms Questionnaire (NMSQuest) and Zarit Burden Interview (ZBI). Results: Data were collected from 861 people with PD (mean age, 65.0 years; mean disease duration, 7.7 years) and 256 carers from six European countries. People with PD reported a large number of different co-morbidities, non-motor symptoms (mean NMSQuest score, 12.8), and impaired HRQoL (median PDQ-39 summary score, 29.1). Forty-five percent of people with PD reported at least one impulse control behaviour. Treatment patterns varied considerably between different European countries. Levodopa was taken in the last 12 months by 85.9% of participants, and as monotherapy by 21.8% . Carers, who were mostly female (64.8%) and the partner/spouse of the person with PD (82.1%), reported mild to moderate burden (mean ZBI total score, 26.6). Conclusions: The PRISM study sheds light on the lives of people with PD and those who care for them, re-emphasising the many challenges they face in everyday life. The study also provides insights into the current treatment of PD in Europe.

Effects of music-based movement therapy on motor function, balance, gait, mental health, and quality of life for patients with Parkinson’s disease: A systematic review and meta-analysis

2021 ◽  
pp. 026921552199052
Author(s):  
Zonglei Zhou ◽  
Ruzhen Zhou ◽  
Wen Wei ◽  
Rongsheng Luan ◽  
Kunpeng Li
Keyword(s):  
Quality Of Life ◽  
Mental Health ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Motor Function ◽  
Meta Analysis ◽  
Freezing Of Gait ◽  
Movement Therapy ◽  
Walking Velocity

Objective: To conduct a systematic review evaluating the effects of music-based movement therapy on motor function, balance, gait, mental health, and quality of life among individuals with Parkinson’s disease. Data sources: A systematic search of PubMed, Embase, Cochrane Library, Web of Science, PsycINFO, CINAHL, and Physiotherapy Evidence Database was carried out to identify eligible papers published up to December 10, 2020. Review methods: Literature selection, data extraction, and methodological quality assessment were independently performed by two investigators. Publication bias was determined by funnel plot and Egger’s regression test. “Trim and fill” analysis was performed to adjust any potential publication bias. Results: Seventeen studies involving 598 participants were included in this meta-analysis. Music-based movement therapy significantly improved motor function (Unified Parkinson’s Disease Rating Scale motor subscale, MD = −5.44, P = 0.002; Timed Up and Go Test, MD = −1.02, P = 0.001), balance (Berg Balance Scale, MD = 2.02, P < 0.001; Mini-Balance Evaluation Systems Test, MD = 2.95, P = 0.001), freezing of gait (MD = −2.35, P = 0.039), walking velocity (MD = 0.18, P < 0.001), and mental health (SMD = −0.38, P = 0.003). However, no significant effects were observed on gait cadence, stride length, and quality of life. Conclusion: The findings of this study show that music-based movement therapy is an effective treatment approach for improving motor function, balance, freezing of gait, walking velocity, and mental health for patients with Parkinson’s disease.

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