scholarly journals Features of pain syndrome in genital endometriosis and migraine

2021 ◽  
Vol 13 (1) ◽  
pp. 31-37
Author(s):  
U. A. Bagirova ◽  
E. G. Chernukha ◽  
E. G. Filatova
Keyword(s):  
Chronic Migraine ◽  
Pelvic Pain ◽  
Comparison Group ◽  
Clinical Manifestations ◽  
Interdisciplinary Approach ◽  
Pain Syndrome ◽  
Episodic Migraine ◽  
Leading Role ◽  
Clinical Neurological Examination

Migraine is often concurrent with endometriosis; however, the mechanisms of comorbidity of these conditions are inadequately studied. Pain is considered as the most significant clinical symptom and maladaptive manifestation of both migraine and endometriosis. Studying the relationship between the clinical manifestations of pain syndrome in patients with endometriosis and migraine is important, since it will contribute to the understanding of the mechanisms of comorbidity of these diseases.Objective: to analyze the features of pain syndrome in patients with migraine and genital endometriosis to clarify the neurogenic mechanisms of their comorbid relationship.Patients and methods. A total of 125 patients who had gone to a gynecologist for endometriosis were examined for the presence of migraine. In accordance with the inclusion criteria, 79 patients (mean age, 34.68±7.11 years) with genital endometriosis confirmed by diagnostic laparoscopy participated in the further study. Two age-matched groups were formed: a study group consisted of 38 patients with endometriosis and concomitant migraine; a comparison group included 41 patients with endometriosis without migraine. All the patients underwent clinical neurological examination, questionnaire survey, pelvic ultrasound, assessment of the severity of pelvic pain according to the pelvic pain index, and determination of the level of central sensitization (CS) using the CS Inventory.Results and discussion. 42% out of the 125 patients who had visited their gynecologist for endometriosis suffered from concomitant migraine, which confirms the comorbidity of these diseases. Chronic pelvic pain (CPP), dysmenorrhea, dyspareunia, and dyschesia were more common in patients with endometriosis and migraine; there were more patients with asymptomatic endometriosis in the comparison group. The patients of the two groups did not differ in the presentation of different forms of endometriosis, which favors the leading role of central mechanisms in the pathogenesis of pain syndrome in comorbidity of these diseases.In addition, there was a statistically significant increase in the presentation of CPP and dysmenorrhea in patients with chronic migraine compared to those with episodic migraine and to those without migraine. Significantly higher levels of CS according to CSI and pelvic pain index were found in patients with chronic migraine and endometriosis, which suggests that CS plays a key role in the comorbidity of these diseases.Conclusion. The phenomenon of CS is one of the mechanisms of comorbidity of migraine and endometriosis, contributes to both the worsening of various painful manifestations of endometriosis and the increase in migraine attacks, thereby causing obvious maladaptation in patients. The role of CS in the comorbidity of migraine and endometriosis opens up possibilities for the elaboration of a comprehensive interdisciplinary approach to treating these diseases.

Optimization of diagnostic system of hand diseases in employees working under combined effects of vibration and physical overloads

2019 ◽  
pp. 950-955
Author(s):  
M. M. Poroshina ◽  
E. M. Vlasova ◽  
A. Ya. Perevalov
Keyword(s):  
Working Conditions ◽  
Comparison Group ◽  
Clinical Manifestations ◽  
Diagnostic System ◽  
Pain Syndrome ◽  
Observation Group ◽  
Combined Effects ◽  
X Rays ◽  
Industrial Enterprises ◽  
Special Assessment

The results of research carried out by theFederalScientificCenterfor Medical and Preventive Technologies of Public Health Risk Management Technologies for the period 2013–2018 showed that diseases associated with the combined effects of vibration and physical overload, employees of hazardous industries develop with experience of 15 years or more. The risk group is women older than 35 years and men older than 40 years. Pathology at the stage of detailed clinical manifestations is characterized by persistent pain syndrome, and, as a consequence, a decrease in the ability to work of workers.The aim of the study was to optimize the system of diagnosis of hand diseases in workers of industrial enterprises engaged in labor activities under the combined effects of vibration and physical overload, for the development of primary prevention programs.The observation group consisted of 32 employees aged 39.3±4.3 years, with an experience of 17.4±4.3 years; the comparison group consisted of 30 employees whose working conditions are not related to the studied factors; the average age was 40.6±3.4 years, experience was 19.1±3.1 years. The examination included analysis of the results of a special assessment of working conditions; assessment of neurological status; functional tests; laboratory studies (assessment of inflammation), hand dynamometry, stimulation electroneuromyography; x-rays of the hands and wrist joints, ultrasound examination of the hands.More than half of the surveyed persons of the observation group and 3/4 of the workers of the comparison group did not make complaints. Indicators of dynamometry of workers in both groups corresponded to physiological norm (p>0.05). Analysis of the results of dynamometer with data from previous years of PMO showed a decrease in strength of muscles of the hand leading hands on 2je,0–16. 7% and from 83.3% of the employees of the monitoring group and in 44.4% of the comparison group (p<0.05), in 50 % of the cases there was a decrease in the percentage of changes in the hand force variation (HFV) in the observation group, and in 38.9% of the cases the indicators remained unchanged. According to ultrasound of the hands, signs of tendinopathy were established in 85% of the employees of the observation group in the absence of persons with similar changes in the comparison group.In order to optimize the diagnosis of diseases of the hand in industrial workers who carry out their work under the combined effects of vibration and physical overload, in the case of a decrease in the rate of carpal dynamometry by 5% or more during the year, it is recommended to conduct ultrasound of the tendon-ligamentous apparatus of the hand, which will allow timely identification of early signs of tendinopathy.

scholarly journals Role of gram‐positive bacteria in chronic pelvic pain syndrome (CPPS)

The Prostate ◽  
2018 ◽  
Vol 79 (2) ◽  
pp. 160-167 ◽  
Author(s):  
Stephen F. Murphy ◽  
Jonathan F. Anker ◽  
Daniel J. Mazur ◽  
Christel Hall ◽  
Anthony J. Schaeffer ◽  
...  
Keyword(s):  
Pelvic Pain ◽  
Chronic Pelvic Pain ◽  
Chronic Pelvic Pain Syndrome ◽  
Pain Syndrome ◽  
Pelvic Pain Syndrome ◽  
Gram Positive ◽  
Gram Positive Bacteria

The Displays of Connective Tissue Dysplasia (Hypermobility) in Patients with Vertebral Syndrome of Lumbosacral Spine

2016 ◽  
pp. 149-154
Author(s):  
Oleksandr Piantkovskiy
Keyword(s):  
Connective Tissue ◽  
Varicose Veins ◽  
Pain Syndrome ◽  
Lumbosacral Spine ◽  
Duration Of Treatment ◽  
Medical Practitioners ◽  
Clinical Neurological Examination ◽  
Connective Tissue Dysplasia ◽  
Neurological Features

In recent years medical practitioners more often pay their attention on role of pathology of different organs and systems of human’s body which are associated with connective tissue dysplasia. The importance of this problem is caused by the great prevalence of connective tissue dysplasia, systemacity of damage, high probability of different diseases’ formation. Connective tissue dysplasia is the violation of the connective tissue structure during embryonic and postnatal periods because of genetically modified fibrillogenesis of extracellular matrix, leading to homeostasis disorder on tissue and organ levels with the progressive course. There was held the clinical neurological examination with 120 patients, who had neurological features of vertebral syndrome of lumbosacral spine. Analysis of the clinical examination results demonstrated that patients with vertebral syndrome of lumbosacral spine (p<0,05) more common can occur pathology of joints and varicose veins of the lower extremities. Significantly (p<0,05) (scoliosis, kyphosis, kyphoscoliosis, tendency to dislocation, stretching the ligaments) increase the duration of treatment and the expression of a pain syndrome. The results of examination and monitoring of patients in the dynamics of the treatment showed that patients with vertebral syndrome of lumbosacral spine (p<0,05) more often have anatomical changes in the lumbosacral spine than patients without evidence of DST.

Estrous cycle variation of TRPV1-mediated cross-organ sensitization between uterus and NMDA-dependent pelvic-urethra reflex activity

2008 ◽  
Vol 295 (3) ◽  
pp. E559-E568 ◽  
Author(s):  
Hsien-Yu Peng ◽  
Pei-Chen Huang ◽  
Jiuan-Miaw Liao ◽  
Kwong-Chung Tung ◽  
Shin-Da Lee ◽  
...  
Keyword(s):  
Estrous Cycle ◽  
Pelvic Pain ◽  
Intrathecal Injection ◽  
Pain Syndrome ◽  
Reflex Activity ◽  
Pelvic Pain Syndrome ◽  
Dependent Manner ◽  
The Cross ◽  
Cycle Dependent

Cross-organ sensitization between the uterus and the lower urinary tract (LUT) underlies the high concurrence of pelvic pain syndrome and LUT dysfunctions, and yet the role of gonadal steroids is still unknown. We tested the hypothesis that cross-organ sensitization on pelvic-urethra reflex activity caused by uterine capsaicin instillation is estrous cycle dependent. When compared with the baseline reflex activity (1.00 ± 0.00 spikes/stimulation), uterine capsaicin instillation significantly increased reflex activity (45.42 ± 9.13 spikes/stimulation, P < 0.01, n = 7) that was corroborated by an increase in phosphorylated NMDA NR2B ( P < 0.05, n = 4) but not NR2A subunit ( P > 0.05, n = 4) expression. Both intrauterine pretreatment with capsazepine (5.02 ± 2.11 spikes/stimulation, P < 0.01, n = 7) and an intrathecal injection of AP5 (3.21 ± 0.83 spikes/stimulation, P < 0.01, n = 7) abolished the capsaicin-induced cross-organ sensitization and the increment in the phosphorylated NR2B level ( P < 0.05, n = 4). The degrees of the cross-organ sensitization increased in a dose-dependent manner with the concentration of instilled capsaicin from 100 to 300 μM in both the proestrus and metestrus stages, whereas they weakened when the concentrations were higher than 1,000 μM. Moreover, the cross-organ sensitization caused by the uterine capsaicin instillation increased significantly in the rats during the proestrus stage when compared with the metestrus stage ( P < 0.01, n = 7). These results suggest that estrogen levels might modulate the cross-organ sensitization between the uterus and the urethra and underlie the high concurrence of pelvic pain syndrome and LUT dysfunctions.

scholarly journals Rehabilitation complex in treatment of chronic pelvic pain syndrome and erectile dysfunction in men

2019 ◽  
Vol 20 (3) ◽  
pp. 66-71
Author(s):  
V. V. Evdokimov ◽  
Sh. R. Satybaldyev ◽  
E. Sh. Satybaldyeva
Keyword(s):  
Erectile Dysfunction ◽  
Treatment Group ◽  
Pelvic Pain ◽  
Chronic Pelvic Pain ◽  
Comparison Group ◽  
Chronic Pelvic Pain Syndrome ◽  
Pain Syndrome ◽  
Pelvic Pain Syndrome ◽  
Study Objective ◽  
Prostatic Fluid

The study objective is to evaluate the effectiveness of rehabilitation complex in treatment of chronic pelvic pain syndrome in men.Materials and methods. At the Kyrgyz Scientific Research Institute of Balneology and Rehabilitation, Ministry of Health of the Kyrgyz Republic, 86 patients aged between 18 and 55 years with chronic prostatitis, chronic pelvic pain syndrome in remission and erectile dysfunction (ED) were examined. In the treatment group (n = 56), rehabilitation complex (balneotherapy, physiotherapy, ultraviolet irradiation of autologous blood, psychotherapy) was used; in the comparison group (n = 30), only standard therapy was used. Blood and urine were tested; total testosterone, luteinizing, follicle-stimulating hormones were measured; ultrasound and rheography of the prostate and penis, color Doppler ultrasonography of the penile vessels, prostatic fluid cultures, spermogram analysis were performed.Results. In the treatment group, pain syndrome was diagnosed in 52 % of patients, severe ED – in 55 %; in the comparison group, pain syndrome was diagnosed in 33 % of patients, ED – in 23 %. Ultrasound of the prostate in both groups showed diffuse changes of moderate severity. After the rehabilitation complex, all patients of the treatment group showed improvement in general condition and microscopic content of the prostatic fluid, decreased pain syndrome, dysuria, sperm viscosity, increased sperm count, number of sperm with normal morphology and motility. Rheography showed increased volume of pulse blood filling of the lower pelvic organs, venous outflow to the prostate. Frequency of severe ED decreased in the treatment group from 55 to 26 %, in the comparison group – from 23 to 16 %.Conclusion. The results show the positive effect of rehabilitation complex on chronic nonbacterial prostatitis, especially in case of improvement of erectile function.

scholarly journals NEUROPHYSIOLOGICAL FEATURES OF THE NOCICEPTIVE TRIGEMINAL PATHWAY DURING DIFFERENT PHASES OF EPISODIC MIGRAINE

2019 ◽  
Vol 19 (1) ◽  
pp. 31-38
Author(s):  
O. Nikiforova ◽  
M. Delva
Keyword(s):  
High Current Density ◽  
Clinical Manifestations ◽  
Blink Reflex ◽  
Episodic Migraine ◽  
Physiological Data ◽  
Primary Headaches ◽  
High Current ◽  
Prodromal Phase ◽  
Stimulation Of

Migraine is one of the most common primary headaches, caused by functional abnormalities of information processing, which can be investigated by neurophysiological means during the various phases of the migraine cycle. The aim of the work was to study neurophysiological changes by means of nociception-specific blink reflex characteristics of trigeminocervical complex and to compare neuro-physiological data with clinical manifestations during various phases of episodic migraine. Methods. A 24-year old female patient with episodic migraine without aura underwent daily nociceptive stimulation of the trigeminal nerve for 30 days. Clinical data were collected directly from the patient using structured questionnaires. Neurophysiological changes were assessed using electromyography study of trigeminocervical blink reflex that was caused by stimulation of the supraorbital nerve with high current density electrode. Results. Within one month, the patient had two migraine attacks, preceded by the prodromal phase, and at the end of both migraine attacks, postdrome symptoms were present. We observed cyclical changes in the characteristics of component R2 of the nociception-specific blink reflex that coincided with clinical manifestations in different phases of the migraine cycle. Conclusions. 1. Electrophysiological excitability of trigeminocervical complex nociceptors differs significantly during different phases of the migraine cycle. 2. The habituation of component R2 is observed in the period between attacks can be considered as a specific phenomenon that probably is the background for migraine attack occurrence. 3. The highest excitability and facilitation of the trigeminocervical complex (increased amplitude and decreased latency of component R2) were observed during ictal phase that is additional evidence of the key role of the brainstem in migraine pathophysiology.

Interdisciplinary approach in management of women’s chronic pelvic pain

2018 ◽  
pp. 87-91
Author(s):  
S.I. Zhuk ◽  
◽  
O.A. Gordiychuk ◽  
Keyword(s):  
Medical Care ◽  
Key Words ◽  
Pelvic Pain ◽  
Chronic Pelvic Pain ◽  
Chronic Pelvic Pain Syndrome ◽  
Interdisciplinary Approach ◽  
Pain Syndrome ◽  
Pelvic Pain Syndrome ◽  
Medical Supervision

This review represents a look at the problem of chronic pelvic pain syndrome of obstetrician-gynecologist and neurologist. The necessity of an interdisciplinary approach at different stages of medical care for these women is shown in the review (from prevention and diagnosis to treatment and the establishment of a long-term medical supervision of these patients). The existing contradictions in this issue are shown and the necessity of creating a single classification and elaborating individual approaches to treatment is underlined. Key words: chronic pelvic pain, chronic pelvic pain syndrome, interdisciplinary approach.

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