scholarly journals The protective effects of rapamycin on intestinal ischemia/reperfusion induced remote lung injury in mice

2014 ◽  
Vol 7 (1) ◽  
pp. 40a-40a
Author(s):  
Takaya Iida ◽  
Yuji Naito ◽  
Tomohisa Takagi ◽  
Kazuhiro Katada ◽  
Katsura Mizushima ◽  
...  
Keyword(s):  
Lung Injury ◽  
Intestinal Ischemia ◽  
Ischemia Reperfusion ◽  
Protective Effects ◽  
Intestinal Ischemia Reperfusion

scholarly journals Dexmedetomidine Ameliorates Lung Injury Induced by Intestinal Ischemia/Reperfusion by Upregulating Cannabinoid Receptor 2, Followed by the Activation of the Phosphatidylinositol 3-Kinase/Akt Pathway

2020 ◽  
Vol 2020 ◽  
pp. 1-14
Author(s):  
Meng Chen ◽  
Xue-Tao Yan ◽  
Li Ye ◽  
Jun-Jiao Tang ◽  
Zong-Ze Zhang ◽  
...  
Keyword(s):  
Lung Injury ◽  
Protective Effect ◽  
Receptor Antagonist ◽  
Intestinal Ischemia ◽  
Ischemia Reperfusion ◽  
Akt Pathway ◽  
High Morbidity ◽  
Protective Effects ◽  
Sod Activity ◽  
Intestinal Ischemia Reperfusion

Intestinal ischemia/reperfusion (I/R) is a clinical emergency, which often causes lung injury with high morbidity and mortality. Although dexmedetomidine has been identified to have a protective effect on lung injury caused by intestinal I/R, its specific mechanism is still elucidated. In recent years, the cannabinoid (CB2) receptor pathway has been found to be involved in I/R injury of some organs. In the current study, we investigated whether the CB2 receptor pathway contributes to the protective effect of dexmedetomidine on the intestinal I/R-induced lung injury in rats. Dexmedetomidine treatment upregulated the expression of CB2 receptor and suppressed the I/R-induced increases in lung injury scores, inflammatory cell infiltration, lung wet/dry ratio, MPO activity, MDA level, inflammatory cytokines, and caspase-3 expression while augmenting SOD activity and Bcl-2 expression, indicating attenuation of lung injury. Dexmedetomidine treatment also increased the expression of Akt. The protective effects of dexmedetomidine treatment were reversed by the CB2 receptor antagonist AM630 or the PI3K inhibitor wortmannin. And the CB2 receptor antagonist AM630 also downregulated the expression of Akt. Thus, our findings suggest that treatment with dexmedetomidine provides a protective role against lung injury caused by intestinal I/R in rats, possibly due to the upregulation of the CB2 receptor, followed by the activation of the PI3K/Akt pathway.

scholarly journals Ginsenoside Rb1 Treatment Attenuates Pulmonary Inflammatory Cytokine Release and Tissue Injury following Intestinal Ischemia Reperfusion Injury in Mice

2015 ◽  
Vol 2015 ◽  
pp. 1-12 ◽  
Author(s):  
Ying Jiang ◽  
Zhen Zhou ◽  
Qing-tao Meng ◽  
Qian Sun ◽  
Wating Su ◽  
...  
Keyword(s):  
Lung Injury ◽  
Signaling Pathway ◽  
Intestinal Ischemia ◽  
Ischemia Reperfusion ◽  
Critical Role ◽  
Weight Ratio ◽  
Heme Oxygenase 1 ◽  
Related Factor ◽  
Ginsenoside Rb1 ◽  
Intestinal Ischemia Reperfusion

Objective. Intestinal ischemia reperfusion (II/R) injury plays a critical role in remote organ dysfunction, such as lung injury, which is associated with nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) signaling pathway. In the present study, we tested whether ginsenoside Rb1 attenuated II/R induced lung injury by Nrf2/HO-1 pathway.Methods. II/R injury was induced in male C57BL/6J mice by 45 min of superior mesenteric artery (SMA) occlusion followed by 2 hours of reperfusion. Ginsenoside Rb1 was administrated prior to reperfusion with or without ATRA (all-transretinoic acid, the inhibitor of Nrf2/ARE signaling pathway) administration before II/R.Results. II/R induced lung histological injury, which is accompanied with increased levels of malondialdehyde (MDA), interleukin- (IL-) 6, and tumor necrosis factor- (TNF-)αbut decreased levels of superoxide dismutase (SOD) and IL-10 in the lung tissues. Ginsenoside Rb1 reduced lung histological injury and the levels of TNF-αand MDA, as well as wet/dry weight ratio. Interestingly, the increased Nrf2 and HO-1 expression induced by II/R in the lung tissues was promoted by ginsenoside Rb1 treatment. All these changes could be inhibited or prevented by ATRA.Conclusion. Ginsenoside Rb1 is capable of ameliorating II/R induced lung injuries by activating Nrf2/HO-1 pathway.

Role of integrins and intracellular adhesion molecule-1 in lung injury after intestinal ischemia-reperfusion

2002 ◽  
Vol 183 (1) ◽  
pp. 70-74 ◽  
Author(s):  
M.Ayhan Kuzu ◽  
Cüneyt Köksoy ◽  
Işınsu Kuzu ◽  
Ismet Gürhan ◽  
Hakan Ergün ◽  
...  
Keyword(s):  
Lung Injury ◽  
Adhesion Molecule ◽  
Intestinal Ischemia ◽  
Ischemia Reperfusion ◽  
Intracellular Adhesion Molecule ◽  
Intestinal Ischemia Reperfusion

scholarly journals Corrigendum to: Acute Lung Injury in A Rat Model Of Intestinal Ischemia-Reperfusion: The Potential Time Depended Role Of Phospholipases

2021 ◽  
Vol 263 ◽  
pp. 291
Author(s):  
Georgia Kostopanagiotou ◽  
Efthimios Avgerinos ◽  
Konstantinos Kostopanagiotou ◽  
Nikolaos Arkadopoulos ◽  
Ioanna Andreadou ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Rat Model ◽  
Intestinal Ischemia ◽  
Ischemia Reperfusion ◽  
Intestinal Ischemia Reperfusion

scholarly journals Protective effects of ascorbic acid pretreatment in a rat model of intestinal ischemia-reperfusion injury: a histomorphometric study

Clinics ◽  
2007 ◽  
Vol 62 (3) ◽  
pp. 315-320 ◽  
Author(s):  
Oscar Haruo Higa ◽  
Edwin Roger Parra ◽  
Alexandre Muxfeldt Ab'Saber ◽  
Cecilia Farhat ◽  
Rita Higa ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Reperfusion Injury ◽  
Rat Model ◽  
Intestinal Ischemia ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Protective Effects ◽  
Acid Pretreatment ◽  
Histomorphometric Study ◽  
Intestinal Ischemia Reperfusion

scholarly journals Ischemic post-conditioning attenuates acute lung injury induced by intestinal ischemia–reperfusion in mice: role of Nrf2

2016 ◽  
Vol 96 (10) ◽  
pp. 1087-1104 ◽  
Author(s):  
Qing-Tao Meng ◽  
Chen Cao ◽  
Yang Wu ◽  
Hui-Min Liu ◽  
Wei Li ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Intestinal Ischemia ◽  
Ischemia Reperfusion ◽  
Intestinal Ischemia Reperfusion
Sign in / Sign up

Export Citation Format

Share Document