scholarly journals Diagnostic and Therapeutic Challenges of Rare Urogenital Cancers: Urothelial Carcinoma of the Renal Pelvis, Ureters and Urethra

2021 ◽  
Vol 12 (1) ◽  
pp. 20-27
Author(s):  
Ayun Cassell ◽  
Burgess Manobah ◽  
Soeghen Willie
Keyword(s):  
Urothelial Carcinoma ◽  
Renal Pelvis ◽  
Urogenital Cancers

Microcystic Transitional Cell Carcinoma

2002 ◽  
Vol 126 (7) ◽  
pp. 859-861 ◽  
Author(s):  
Xavier Leroy ◽  
Emmanuelle Leteurtre ◽  
Alexandre De La Taille ◽  
David Augusto ◽  
Jacques Biserte ◽  
...  
Keyword(s):  
Transitional Cell Carcinoma ◽  
Urothelial Carcinoma ◽  
Cell Carcinoma ◽  
Renal Pelvis ◽  
Transitional Cell ◽  
Macroscopic Hematuria ◽  
Computed Tomographic ◽  
First Case ◽  
History Of ◽  
Invasive Transitional Cell Carcinoma

Abstract Microcystic transitional cell carcinoma is a rare variant of urothelial carcinoma; to date, it has been described only in the urinary bladder. We report 2 cases of microcystic transitional cell carcinoma arising in the renal pelvis. The first case occurred in a 73-year-old man with a history of superficially invasive transitional cell carcinoma who presented with macroscopic hematuria and anemia. The second case occurred in a 62-year-old woman who had no relevant medical history and presented with hematuria. Computed tomographic scan revealed a tumor of the renal pelvis. In both cases, microscopic examination showed invasive transitional cell carcinoma with prominent cystic features. The cysts were irregular in size and were deeply infiltrative. The cysts were lined by single or multiple layers of cuboidal or flattened cells with minimal cytological atypia. The first patient died of his disease 18 months after presentation. The second patient remained well at her 6-month follow-up examination. Microcystic transitional cell carcinoma is an unusual, deceptively bland variant of urothelial carcinoma, which can mimic benign lesions.

scholarly journals Synchronous ipsilateral renal cell carcinoma and urothelial carcinoma of the renal pelvis

2013 ◽  
Vol 3 (1) ◽  
pp. 64 ◽  
Author(s):  
Mike Leveridge ◽  
Phillip A. Isotalo ◽  
Alexander H. Boag ◽  
Jun Kawakami
Keyword(s):  
Renal Cell Carcinoma ◽  
Urothelial Carcinoma ◽  
Cell Carcinoma ◽  
Renal Pelvis ◽  
Renal Cell ◽  
Preoperative Imaging ◽  
Time Of Surgery ◽  
Urological Malignancies ◽  
Carcinome Urothélial ◽  
Fresh Specimen

Renal cell carcinoma (RCC) and urothelial carcinoma of the upperurinary tract are not uncommon urological malignancies. Theirsimultaneous occurrence in a patient is, however, extraordinarilyrare. We report the case of a patient who underwent laparoscopicnephrectomy for suspected RCC. Preoperative imaging wassuspicious for renal pelvic involvement, which was confirmedupon bivalving the fresh specimen at the time of surgery, with thediscovery of a separate urothelium-based lesion. We discuss thisrare occurrence and our management approach.Individuellement, l’hypernéphrome et le carcinome urothélial desvoies urinaires supérieures ne sont pas des tumeurs urologiquesrares. Leur survenue simultanée chez un même patient est cependantextrêmement rare. La reconnaissance préopératoire ou intraopératoireest cruciale afin que soit effectuée la résection urétéralerequise. Nous décrivons un cas d’hypernéphrome et de carcinomeurothélial simultanés et homolatéraux.

scholarly journals FOXA1 Expression in Urothelial Carcinoma of the Renal pelvis

2012 ◽  
Vol 138 (suppl 2) ◽  
pp. A296.2-A296
Author(s):  
Riley Alexander ◽  
Sunil Badve ◽  
Muhammad T. Idrees
Keyword(s):  
Urothelial Carcinoma ◽  
Renal Pelvis ◽  
Foxa1 Expression

scholarly journals Plasmacytoid urothelial carcinoma of renal pelvis with positive zinc finger E–box–binding homeobox 1: a case report

2020 ◽  
Author(s):  
Atsuko Takada-Owada ◽  
Yumi Nozawa ◽  
Masato Onozaki ◽  
Shuhei Noda ◽  
Tsengelumaa Jamiyan ◽  
...  
Keyword(s):  
Urothelial Carcinoma ◽  
Zinc Finger ◽  
Renal Pelvis ◽  
Plasma Cells ◽  
Epithelial Mesenchymal Transition ◽  
Resected Specimen ◽  
Mesenchymal Transition ◽  
E Box ◽  
Tumor Transformation ◽  
E Cadherin

Abstract BackgroundThe tumor transformation mechanism of a plasmacytoid urothelial carcinoma remains unexplained. We describe the case of a plasmacytoid urothelial carcinoma of the renal pelvis in which the expression of zinc finger E–box–binding homeobox 1 (ZEB1), a key nuclear transcription factor in an epithelial–mesenchymal transition, is involved in tumor transformation.Case presentationThe patient had a left nephrectomy with the clinical diagnosis of left pelvic renal cancer. The resected specimen showed that the tumor surface comprised a noninvasive papillary urothelial carcinoma with the carcinoma in situ, and the invasive area comprised a plasmacytoid urothelial carcinoma characterized by the presence of single dyscohesive malignant cells that resembled plasma cells in a loose myxoid stroma. The noninvasive urothelial carcinoma was positive for cytokeratin and E–cadherin, and negative for vimentin and ZEB1. In contrast, the invasive plasmacytoid urothelial carcinoma was positive for cytokeratin and also vimentin and ZEB1, and negative for E–cadherin. Additionally, this component was immunoreactive for CD138 and CD38 that are immunohistochemical markers for plasma cells.ConclusionWe suggest that ZEB1 is involved in the plasmacytoid transformation by repressing the E–cadherin in a plasmacytoid urothelial carcinoma.

Case 17.19

2014 ◽  
pp. 825-826
Author(s):  
Christine U. Lee ◽  
James F. Glockner
Keyword(s):  
Urothelial Carcinoma ◽  
Renal Pelvis ◽  
Incomplete Filling ◽  
Phase Images ◽  
History Of

60-year-old man with history of urothelial carcinoma Coronal oblique early excretory phase images from gadolinium-enhanced 3D SPGR MR urogram (Figure 17.19.1) demonstrate multiple small filling defects within the left renal pelvis, with incomplete filling of the renal pelvis. Delayed images (Figure ...

Urothelial Carcinoma of the Renal Pelvis and Ureter: Does Location Make a Difference?

2020 ◽  
Vol 18 (1) ◽  
pp. 45-49.e1 ◽  
Author(s):  
Aye A. Lwin ◽  
Chiu-Hsieh Hsu ◽  
Juan Chipollini
Keyword(s):  
Urothelial Carcinoma ◽  
Renal Pelvis

scholarly journals Non-invasive papillary urothelial carcinoma, low-grade of the renal pelvis mimicking a xanthogranulomatous pyelonephritis in a male patient: A case report and review of literature

2020 ◽  
Vol 34 ◽  
pp. 205873842092572
Author(s):  
Xi Xie ◽  
Ning Wang ◽  
Yuyong Wang ◽  
Huadong He ◽  
Fanlei Kong ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Back Pain ◽  
Urothelial Carcinoma ◽  
Male Patient ◽  
Renal Pelvis ◽  
Xanthogranulomatous Pyelonephritis ◽  
Low Grade ◽  
Histopathologic Examination ◽  
Non Invasive ◽  
Papillary Urothelial Carcinoma

We report on a 31-year-old male patient with non-invasive papillary urothelial carcinoma, low grade of the renal pelvis disguised as xanthogranulomatous pyelonephritis. The only symptom of the patient was lower back pain. The initial renal-enhanced computed tomography, magnetic resonance imaging and contrast-enhanced ultrasonography showed that the right kidney had a benign lesion and this inflammatory lesion might be xanthogranulomatous pyelonephritis. A percutaneous renal biopsy was performed and histopathologic examination revealed a xanthogranulomatous pyelonephritis. Initially, we diagnosed it as xanthogranulomatous pyelonephritis and treated it with antibiotics. One and a half years later, the patient suffered from back pain again. The lesion increased significantly and a right renal pelvic lesion with retroperitoneal lymphadenopathy was considered a malignant lesion on computed tomography scan. Therefore, radical resection of right renal pelvis carcinoma was performed under retroperitoneal laparoscopy. Intraoperative frozen section was reported as right renal urothelial carcinoma with no metastasis in renal hilar lymph node. Postoperative histopathologic examination revealed non-invasive papillary urothelial carcinoma, low grade of renal pelvis.

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