Urine oxalate and citrate excretion in patients with kidney stone disease: An ab initio clinical prediction

AbstractBackground and purposeVisceral and somatic afferents activate the same neuronal structures in the central nervous system. Assessing somatosensory function and trophic changes in the referred pain area may therefore indirectly increase information on mechanisms involved in painful visceral diseases. The aim of this study was to evaluate the sensory and trophic changes in the flank corresponding to the referred pain area in patients with kidney stone disease.MethodsA total of 24 patients with unilateral pain-causing kidney stone disease were studied before and after endoscopic percutaneous kidney stone surgery. Trophic changes and sensitivity on the affected and on the contra-lateral side in the pain free period were investigated. For this purpose we used standardized experimental sensory testing including pressure stimulation and electrical (single and repeated) skin stimulation. Five repeated stimuli were used to investigate temporal summation (increased responses to repeated stimuli). To investigate trophic changes ultrasound as well as CT-scan was used, since the latter is considered more precise for exact tissue layer measurements.ResultsThe pain tolerance thresholds to pressure and pain thresholds to electrical stimulation were not significantly different on the two sides (all P>0.1). After surgery no significant alterations in sensitivity were detected, but there was a tendency to higher pain thresholds to electrical stimuli on the affected side (single stimuli P=0.06; repeated stimuli P=0.09). No trophic changes were observed (all P>0.3), and there were no relations between the pain thresholds or trophic findings and the number of colics (all P >0.08).ConclusionIn patients with unilateral pain-causing kidney stone disease the pain to experimental pressure and electrical stimuli were comparable on the affected and contra-lateral side. For the first time a CT-scan was used to evaluate tissue thickness in the referred pain area. No trophic changes were seen in the muscle or subcutaneous tissue at the affected side, and there were no correlations between the pain thresholds or trophic findings and the patients history of number of colics. After the operation no significant alterations in sensitivity were detected.ImplicationsThis study could not confirm previous studies showing referred hyperalgesia in the skin and trophic changes in the referred pain area to painful visceral disease. Differences in the pain intensity/duration between different diseases and hence the corresponding central neuronal changes may explain the negative findings in the present study.

Nutrition and Kidney Stone Disease

Nutrients ◽

10.3390/nu13061917 ◽

2021 ◽

Vol 13 (6) ◽

pp. 1917

Author(s):

Roswitha Siener

Keyword(s):

Kidney Stone ◽

Fluid Intake ◽

Stone Formation ◽

Urinary Stone ◽

Stone Disease ◽

Urinary Stones ◽

Dietary Therapy ◽

Effective Prevention ◽

Kidney Stone Disease ◽

Nutrition And Diet

The prevalence of kidney stone disease is increasing worldwide. The recurrence rate of urinary stones is estimated to be up to 50%. Nephrolithiasis is associated with increased risk of chronic and end stage kidney disease. Diet composition is considered to play a crucial role in urinary stone formation. There is strong evidence that an inadequate fluid intake is the major dietary risk factor for urolithiasis. While the benefit of high fluid intake has been confirmed, the effect of different beverages, such as tap water, mineral water, fruit juices, soft drinks, tea and coffee, are debated. Other nutritional factors, including dietary protein, carbohydrates, oxalate, calcium and sodium chloride can also modulate the urinary risk profile and contribute to the risk of kidney stone formation. The assessment of nutritional risk factors is an essential component in the specific dietary therapy of kidney stone patients. An appropriate dietary intervention can contribute to the effective prevention of recurrent stones and reduce the burden of invasive surgical procedures for the treatment of urinary stone disease. This narrative review has intended to provide a comprehensive and updated overview on the role of nutrition and diet in kidney stone disease.

Central adiposity and diabetes are causally associated with kidney stone disease

Endocrine Abstracts ◽

10.1530/endoabs.77.p54 ◽

2021 ◽

Author(s):

Catherine Lovegrove ◽

Akira Wiberg ◽

Thomas Littlejohns ◽

Naomi Allen ◽

Benjamin Turney ◽

...

Keyword(s):

Kidney Stone ◽

Stone Disease ◽

Central Adiposity ◽

Kidney Stone Disease

Heat Shock Protein 90 in Kidney Stone Disease

Heat Shock Proteins - Heat Shock Protein 90 in Human Diseases and Disorders ◽

10.1007/978-3-030-23158-3_26 ◽

2019 ◽

pp. 575-589

Author(s):

Visith Thongboonkerd

Keyword(s):

Heat Shock ◽

Heat Shock Protein ◽

Kidney Stone ◽

Heat Shock Protein 90 ◽

Stone Disease ◽

Kidney Stone Disease

Gene expression of prothrombin in the human kidney and its potential relevance to kidney stone disease

BJU International ◽

10.1046/j.1464-410x.1998.00620.x ◽

1998 ◽

Vol 81 (5) ◽

pp. 666-672 ◽

Cited By ~ 17

Author(s):

Stapleton ◽

Timme ◽

Ryall

Keyword(s):

Gene Expression ◽

Kidney Stone ◽

Human Kidney ◽

Stone Disease ◽

Kidney Stone Disease

Macro- and microelement status of patients with kidney stone disease

Health of Man ◽

10.30841/2307-5090.1.2018.144077 ◽

2018 ◽

Vol 0 (1) ◽

pp. 106-108

Author(s):

Є. А. Литвинець ◽

Н. Т. Скоропад

Keyword(s):

Kidney Stone ◽

Stone Disease ◽

Kidney Stone Disease

Metabolic disorders in kidney stone disease in children

Journal of Education, Health and Sport ◽

10.12775/jehs.2020.10.03.017 ◽

2020 ◽

Vol 10 (3) ◽

pp. 158

Author(s):

Monika Kusz ◽

Adam Alzubedi ◽

Paweł Polski ◽

Paulina Pawluczuk ◽

Agnieszka Maślak

Keyword(s):

Kidney Stone ◽

Metabolic Disorders ◽

Stone Disease ◽

Kidney Stone Disease