scholarly journals Association between thyroid stimulating hormone receptor gene intron polymorphisms and autoimmune thyroid disease in a Chinese Han population

2012 ◽  
Vol 59 (8) ◽  
pp. 717-723 ◽  
Author(s):  
Lin Liu ◽  
Hu-qun Wu ◽  
Qiong Wang ◽  
Yuan-feng Zhu ◽  
Wen Zhang ◽  
...  
Keyword(s):  
Thyroid Disease ◽  
Hormone Receptor ◽  
Autoimmune Thyroid Disease ◽  
Receptor Gene ◽  
Thyroid Stimulating Hormone ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
Autoimmune Thyroid ◽  
Hormone Receptor Gene

scholarly journals Lack of association between polymorphisms in the UBASH3A gene and autoimmune thyroid disease: a case control study

2014 ◽  
Vol 58 (6) ◽  
pp. 640-645 ◽  
Author(s):  
TianTian Cai ◽  
Xuan Wang ◽  
Fatuma-Said Muhali ◽  
RongHua Song ◽  
XiaoHong Shi ◽  
...  
Keyword(s):  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Chinese Han Population ◽  
Control Group ◽  
Nucleotide Polymorphisms ◽  
Chinese Han ◽  
Han Population ◽  
Autoimmune Thyroid ◽  
Allelic Frequencies ◽  
Significant Difference

Objective: The aim of this study was to investigate UBASH3A gene variation association with autoimmune thyroid disease and clinical features in a Chinese Han population. Subjects and methods: A total of 667 AITD patients (417 GD and 250 HT) and 301 healthy controls were genotyped for two single nucleotide polymorphisms (SNPs) rs11203203, rs3788013 of UBASH3A gene, utilizing the Matrix Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometer (MALDI-TOF-MS) Platform. Results: Between the control group and AITD, GD and HT group, no statistically significant difference was observed in the genotypic and allelic frequencies of the two SNPs. There was no significant difference in allelic frequencies of the two SNPs between GD with and without ophthalmopathy. There was no significant difference in haplotype distributions between the control group and AITD, GD or HT group. Conclusion: Rs11203203 and rs3788013 in UBASH3A gene may not be associated with AITD patients in Chinese Han population.

Psoriasis Susceptibility 1 Candidate 1 (PSORS1C1) Polymorphism is Associated with Autoimmune Thyroid Disease in a Chinese Han Population

2021 ◽  
pp. 1-10
Author(s):  
Yanfei Jiang ◽  
Xudong Mao ◽  
Ronghua Song ◽  
Kaida Mu ◽  
Yanping Yang ◽  
...  
Keyword(s):  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
Autoimmune Thyroid

The Antibody Response in Human Autoimmune Thyroid Disease

1997 ◽  
Vol 92 (6) ◽  
pp. 529-541 ◽  
Author(s):  
Richard S. McIntosh ◽  
M. Suhail Asghar ◽  
Anthony P. Weetman
Keyword(s):  
Antibody Response ◽  
Thyroid Disease ◽  
Hormone Receptor ◽  
Autoimmune Thyroid Disease ◽  
Thyroid Stimulating Hormone ◽  
Thyroid Peroxidase ◽  
Autoimmune Thyroid ◽  
Thyroid Autoantigens ◽  
Reactive Antibody ◽  
Stimulating Hormone

1. The analysis of the antibody response in autoimmune thyroid disease has followed several historical trends. It was the investigation of thyroid-reactive antibody that allowed the initial characterization of the three principle thyroid autoantigens, thyroglobulin, thyroid peroxidase and the thyroid stimulating hormone receptor. 2. Analysis can be grouped under two broad areas: analysis of the physiological and pathological effects of the antibody, and analysis of the structure of the antibodies themselves. This review will focus on the latter. 3. Within recent years there has been a great increase in knowledge of thyroid-reactive antibody structure, principally through the adoption of phage display combinatorial library methodologies. While this latter technique has established some general principles for antibodies to thyroglobin and especially thyroid peroxidase, there is still a substantial gap in our knowledge of the antibody response to the thyroid stimulating hormone receptor. 4. Thyroid peroxidase antibodies have a relatively restricted V-region usage, and there is a correlation between the V-regions used and the epitope on thyroid peroxidase bound. In particular the Vκ light chain, Vκl(O12), is associated with reactivity to one epitope. 5. The purpose of this review is to bring together the latest results concerning the molecular analysis of the antibody response in autoimmune thyroid disease, to highlight areas of ignorance and conflict, and to discuss the methods adopted to circumvent the problems associated with analysis of the antibody response.

scholarly journals Prevalence and clinical relevance of thyroid stimulating hormone receptor-blocking antibodies in autoimmune thyroid disease

2017 ◽  
Vol 189 (3) ◽  
pp. 304-309 ◽  
Author(s):  
T. Diana ◽  
J. Krause ◽  
P. D. Olivo ◽  
J. König ◽  
M. Kanitz ◽  
...  
Keyword(s):  
Thyroid Disease ◽  
Hormone Receptor ◽  
Clinical Relevance ◽  
Autoimmune Thyroid Disease ◽  
Thyroid Stimulating Hormone ◽  
Receptor Blocking ◽  
Autoimmune Thyroid ◽  
Blocking Antibodies ◽  
Stimulating Hormone

Thyroid-stimulating hormone receptor gene mutations and polymorphisms in thyroid disease

1996 ◽  
Vol 3 (5) ◽  
pp. 428-432 ◽  
Author(s):  
Diego Russo ◽  
Franco Arturi ◽  
Sebastiano Filetti
Keyword(s):  
Thyroid Disease ◽  
Hormone Receptor ◽  
Receptor Gene ◽  
Gene Mutations ◽  
Thyroid Stimulating Hormone ◽  
Hormone Receptor Gene ◽  
Stimulating Hormone

Human leukocyte antigen-C and killer cell immunoglobulin-like receptor gene polymorphisms among patients with syphilis in a Chinese Han population

Apmis ◽  
2012 ◽  
Vol 120 (10) ◽  
pp. 828-835 ◽  
Author(s):  
Yun-Long Zhuang ◽  
Gui-Jie Ren ◽  
Ke-Li Tian ◽  
Xin-Ye Li ◽  
Yong-Bao Zhu ◽  
...  
Keyword(s):  
Human Leukocyte Antigen ◽  
Gene Polymorphisms ◽  
Receptor Gene ◽  
Killer Cell ◽  
Human Leukocyte ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
Leukocyte Antigen ◽  
Receptor Gene Polymorphisms

Interleukin-23 receptor gene polymorphisms is associated with dilated cardiomyopathy in Chinese Han population

2009 ◽  
Vol 73 (4) ◽  
pp. 330-334 ◽  
Author(s):  
Y. Chen ◽  
B. Zhou ◽  
Y. Peng ◽  
Y. Wang ◽  
C. Li ◽  
...  
Keyword(s):  
Dilated Cardiomyopathy ◽  
Gene Polymorphisms ◽  
Receptor Gene ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
Receptor Gene Polymorphisms ◽  
Interleukin 23

Vitamin D Receptor Gene (VDR) Polymorphisms Are Not Associated with Autoimmune Thyroid Disease Risk in Turner Syndrome Patients

2011 ◽  
pp. P3-594-P3-594
Author(s):  
Bianca Bianco ◽  
Ieda Therezinha do Nascimento Verreschi ◽  
Kelly Cristina Oliveira ◽  
Alexis Dourado Guedes ◽  
Caio Parente Barbosa ◽  
...  
Keyword(s):  
Vitamin D ◽  
Turner Syndrome ◽  
Vitamin D Receptor ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Disease Risk ◽  
Receptor Gene ◽  
Vitamin D Receptor Gene ◽  
Autoimmune Thyroid ◽  
Vdr Polymorphisms
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