scholarly journals Efficacy and safety of sitagliptin as add-on therapy on glycemic control and blood glucose fluctuation in Japanese type 2 diabetes subjects ongoing with multiple daily insulin injections therapy

2013 ◽  
Vol 60 (10) ◽  
pp. 1207-1214 ◽  
Author(s):  
Seiya Shimoda ◽  
Shinsuke Iwashita ◽  
Shinji Ichimori ◽  
Yasuto Matsuo ◽  
Rieko Goto ◽  
...  
Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1664-P
Author(s):  
MINORI SHINODA ◽  
TADASHI YAMAKAWA ◽  
RIKA SAKAMOTO ◽  
JUN SUZUKI ◽  
KENICHIRO TAKAHASHI ◽  
...  

2021 ◽  
Vol 12 ◽  
pp. 204201882110100
Author(s):  
Shunsuke Kobayashi ◽  
Mototsugu Nagao ◽  
Izumi Fukuda ◽  
Shinichi Oikawa ◽  
Hitoshi Sugihara

Background: A prolonged QT interval plays a causal role in fatal arrhythmia and is known to be a risk factor for sudden cardiac death. Although diabetic patients with microvascular complications tend to have a longer QT interval, the therapeutic effect of diabetes on the QT interval remains unclear. Here, we assessed the changes in QT interval in patients with type 2 diabetes (T2D) who received multiple daily insulin injections. Materials and methods: Patients with T2D ( n = 34) who were admitted to our hospital and initiated multiple daily insulin injections for glycemic control were enrolled in this study. Clinical measurements, including electrocardiogram, were taken on admission and discharge. The QT interval was measured manually in lead II on the electrocardiogram, and corrected QT interval (QTc) was calculated using Bazett’s formula. The change in QTc (ΔQTc) during hospitalization (median, 15 days) and clinical parameters affecting ΔQTc were investigated. Results: QTc was shortened from 439 ± 24 to 427 ± 26 ms during hospitalization ( p < 0.0001). ΔQTc was positively correlated with the changes in fasting plasma glucose (ΔFPG, r = 0.55, p = 0.0008) and glycated albumin ( r = 0.38, p = 0.026) following insulin therapy, but not with the final dose of insulin ( r = −0.20, p = 0.26). The multiple regression analyses revealed that ΔFPG was independently associated with ΔQTc. Conclusions: Multiple daily insulin injections can ameliorate QT interval by lowering the blood glucose levels in T2D, suggesting that glycemic control is important for preventing patients with T2D from sudden cardiac death.


Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 941-P
Author(s):  
LEI ZHANG ◽  
YAN GU ◽  
YUXIU YANG ◽  
NA WANG ◽  
WEIGUO GAO ◽  
...  

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