The Final Response

2020 ◽  
pp. 120-123
Keyword(s):  
2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Carlotta Peruzzi ◽  
Silvia Battistoni ◽  
Daniela Montesarchio ◽  
Matteo Cocuzza ◽  
Simone Luigi Marasso ◽  
...  

AbstractIn several biomedical applications, the detection of biomarkers demands high sensitivity, selectivity and easy-to-use devices. Organic electrochemical transistors (OECTs) represent a promising class of devices combining a minimal invasiveness and good signal transduction. However, OECTs lack of intrinsic selectivity that should be implemented by specific approaches to make them well suitable for biomedical applications. Here, we report on a biosensor in which selectivity and a high sensitivity are achieved by interfacing, in an OECT architecture, a novel gate electrode based on aptamers, Au nanoparticles and graphene hierarchically organized to optimize the final response. The fabricated biosensor performs state of the art limit of detection monitoring biomolecules, such as thrombin-with a limit of detection in the picomolar range (≤ 5 pM) and a very good selectivity even in presence of supraphysiological concentrations of Bovine Serum Albumin (BSA-1mM). These accomplishments are the final result of the gate hierarchic structure that reduces sterich indrance that could contrast the recognition events and minimizes false positive, because of the low affinity of graphene towards the physiological environment. Since our approach can be easily applied to a large variety of different biomarkers, we envisage a relevant potential for a large series of different biomedical applications.


1929 ◽  
Vol 50 (4) ◽  
pp. 489-512 ◽  
Author(s):  
Peyton Rous ◽  
H. P. Gilding

A study of the blanchings (Bier's spots) which develop in human skin deprived of circulation has proved them referable to the same general causes that lead to ischemic patching of the skin of animals, and that they are conditioned by the same factors. Both are expressions of a secondary contraction of vessels that have become hyperirritable owing to an inadequate circulation. The contraction is favored by emptying the vessels, but it occurs pronouncedly even when there is a trickle through them of arterial blood. In the case of man the contractile impulse is sometimes so great as to overcome the maximum pressure that the vessels will support. The significance of the observations is discussed.


PEDIATRICS ◽  
1992 ◽  
Vol 90 (4) ◽  
pp. 573-581 ◽  
Author(s):  
Brian W. McCrindle ◽  
Barbara Starfield ◽  
Catherine DeAngelis

This study was undertaken to describe subspecialty characteristics and practices of the population of pediatricians given the ongoing controversy regarding a projected manpower oversupply of general pediatricians. A questionnaire was mailed to a national random sample of 1620 United States physicians listed in the American Medical Association's Pysician Masterfile as being in office-based pediatric practice. The final response rate was 63%. Seventy percent of respondents designated their practices as "general pediatrics" versus 17% as "general pediatrics with a specific subspecialty interest" and 13% as "subspecialty practice." The general pediatricians with a specific subspecialty interest were intermediate in the proportion that had some training in a pediatric fellowship program (general pediatricians with a specific subspecialty interest, 63% versus general pediatricians, 14%, P < .0001, and pediatricians with a subspecialty practice, 92%, P < .0001) and that were certified in a pediatric subspecialty by the American Board of Pediatrics (general pediatricians with a specific subspecialty interest 16% versus general pediatricians, 2%, P < .0001, and pediatricians with subspecialty practice, 62%, P < .0001). They were also intermediate in the proportion involved in various academic pursuits. Their practices, however, more closely resembled general pediatricians than pediatricians with a subspeciality practice in their location, setting, associates, and commitment to primary care. They were more likely than general pediatricians to utilize or provide specialized tests or procedures. A large percentage of pediatricians incorporate subspecilaty elements into their general pediatric practices. Models of current and projected pediatric manpower supply need to be reassessed in light of this form of practice.


1964 ◽  
Vol 19 (3) ◽  
pp. 550-553 ◽  
Author(s):  
Irving Fatt

Redesign of the Severinghaus pCO2 and the Clark pO2 electrodes yields electrodes which are easier to make and assemble. When used with a new membrane material, paraffin-treated Millipore filter paper, the redesigned Severinghaus pCO2 electrode gives 99% response in 15 sec for a 40 mm Hg change in pCO2 in the region of 15–60 mm Hg pCO2 in either gas or water phase. The redesigned Clark pO2 electrode when used with treated Millipore paper gives 99% of final response in 1.24 sec for a 155 mm Hg change of pO2 in the gas phase in the range 0–160 mm Hg pO2. In aqueous solutions this electrode gives 99% response in 30 sec. Severinghaus electrode; polarographic oxygen electrode; pCO2 measurement; pO2 measurement Submitted on March 19, 1963


2017 ◽  
Author(s):  
Robert Stillwell
Keyword(s):  

2020 ◽  
Author(s):  
Ophelia George
Keyword(s):  

2020 ◽  
Author(s):  
Jasper Foets
Keyword(s):  

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