Quality of life in angina therapy: focus on the beneficial effects of nitrates

2000 ◽  
pp. 89-98
Keyword(s):  
Quality Of Life ◽  
Beneficial Effects

scholarly journals Glatiramer Acetate Treatment in Multiple Sclerosis-Associated Fatigue—Beneficial Effects on Self-Assessment Scales But Not on Molecular Markers

Biomolecules ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 393
Author(s):  
Oliver Neuhaus ◽  
Wolfgang Köhler ◽  
Florian Then Bergh ◽  
Wolfgang Kristoferitsch ◽  
Jürgen Faiss ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Multiple Sclerosis ◽  
Glatiramer Acetate ◽  
Neurotrophic Factors ◽  
Common Symptom ◽  
Mrna Levels ◽  
Open Label ◽  
Immunological Parameters ◽  
Beneficial Effects

Although fatigue is a common symptom in multiple sclerosis (MS), its pathomechanisms are incompletely understood. Glatiramer acetate (GA), an immunomodulatory agent approved for treatment of relapsing-remitting MS (RRMS), possesses unique mechanisms of action and has been shown to exhibit beneficial effects on MS fatigue. The objective of this study was to correlate clinical, neuropsychological, and immunological parameters in RRMS patients with fatigue before and during treatment with GA. In a prospective, open-label, multicenter trial, 30 patients with RRMS and fatigue were treated with GA for 12 months. Inclusion criterion was the presence of fatigue as one of the most frequent and disabling symptoms. Before and during treatment, fatigue was assessed using the Fatigue Severity Scale (FSS), the MS-FSS, and the Modified Fatigue Impact Scale (MFIS). In addition, fatigue and quality of life were assessed using the Visual Analog Scales (VAS). Laboratory assessments included screening of 188 parameters using real-time PCR microarrays followed by further analysis of several cytokines, chemokines, and neurotrophic factors. Fatigue self-assessments were completed in 25 patients. After 12 months of treatment with GA, 13 of these patients improved in all three scales (with the most prominent effects on the MFIS), whereas 5 patients had deteriorated. The remaining 7 patients exhibited inconsistent effects within the three scales. Fatigue and overall quality of life had improved, as assessed via VAS. Laboratory assessments revealed heterogeneous mRNA levels of cytokines, chemokines, and neurotrophic factors. In conclusion, we were not able to correlate clinical and molecular effects of GA in patients with RRMS and fatigue.

scholarly journals Rehabilitation therapy in patients with psoriatic arthritis after SARS-CoV-2 infection

2021 ◽  
Vol 30 (3) ◽  
pp. 110-114
Author(s):  
Diana Maghiar ◽  
◽  
Nicoleta Anamaria Pascalau ◽  
Liviu Lazar ◽  
◽  
...  
Keyword(s):  
Quality Of Life ◽  
Psoriatic Arthritis ◽  
Pain Scale ◽  
Important Change ◽  
Emotional Impact ◽  
Rehabilitation Treatment ◽  
Rehabilitation Therapy ◽  
Social And Emotional ◽  
Beneficial Effects

Objectives. We want to present the evolution of a lot of patients, previously diagnosed with psoriatic arthritis, who last spring went through a difficult period due to infection with the new coronavirus. After healing from COVID-19, the patients had returned to the hospital after a period of 4-6 months, to follow a rehabilitation treatment, the majority of the accusations being those related to psoriatic arthritis, with close follow-up of these patients in connection with the treatment applied. Material and methods. The patients were evaluated at hospitalization (biological inflammatory markers like CRP and ESR), pain scale, DAPSA score, PASI and the quality of life score (DLQI and QOL scale), after which they followed different rehabilitation treatments for a period of 21 days. After 3 months of completing this treatment they were re-evaluated. Patients diagnosed with psoriatic arthritis who do not have documentation to suggest SARS-CoV-2 infection (antibodies/ previous RT-PCR positive tests) were not included in the study. Outcomes. There were some significant differences in terms of the initial score at hospitalization and that performed after rehabilitation treatment. Most of the indices performed had lower values at reassessment (pain scale score, DAPSA, PASI, DLQI and even lower values of CRP and ESR), thus resulting in an important step in terms of the beneficial effects of rehabilitation therapy, both for patients with psoriatic arthritis and for post-COVID-19 recovery. The most important change was observed in the score for quality of life. Conclusions. The inclusion of rehabilitation therapy in patients with psoriatic arthritis should be a step that each patient should take. Its effects are long-term, with periods of pain decreasing in frequency and intensity, thus changing the quality of life of these patients. The mental, social and emotional impact of COVID-19 on people who have gone through the disease can be changed in a good way, also following a rehabilitation therapy.

scholarly journals Effects of exercise rehabilitation training on patients with pulmonary hypertension

2020 ◽  
Vol 10 (3) ◽  
pp. 204589402093712
Author(s):  
Xiaojun Zhang ◽  
Danyan Xu
Keyword(s):  
Quality Of Life ◽  
Pulmonary Hypertension ◽  
Right Heart Failure ◽  
Professional Staff ◽  
Safety And Efficacy ◽  
Rehabilitation Training ◽  
Exercise Rehabilitation ◽  
Beneficial Effects ◽  
Intensity Of Exercise

Pulmonary hypertension (PH) comprises a group of pathophysiological syndromes characterized by elevated pulmonary artery pressure and pulmonary vascular resistance, which lead to right ventricular overload, and even right heart failure. PH has a poor prognosis and severely leads to a decline in quality of life. Historically, patients with PH were advised to limit their physical activity. However, an increasing number of studies have reported the safety and efficacy of exercise rehabilitation training in PH. This review briefly examined and summarized the effects of exercise rehabilitation training on PH patients reported in the recent literature. The findings of the reviewed studies indicate that exercise rehabilitation training in PH patients has beneficial effects in terms of exercise capacity and quality of life, vascular and right ventricle remodelling, inflammatory response, muscular function and oxidative stress. However, the underlying mechanisms and appropriate exercise strategies (e.g. the duration and intensity of exercise) still need to be explored. In conclusion, exercise rehabilitation training of the appropriate intensity and frequency can improve the prognosis and quality of life of PH patients. The training should be monitored by professional staff and be provided as an adjunct to pharmacological treatment. Larger clinical trials are required to confirm the safety and efficacy of exercise rehabilitation training in PH.

Arborização Urbana e Microclima e a Percepção dos Acadêmicos de Educação Física Quanto a Essa Vegetação

UNICIÊNCIAS ◽  
2017 ◽  
Vol 21 (2) ◽  
pp. 99
Author(s):  
Ana Paula Barreto ◽  
Joaquim Mauro Mathias Filho ◽  
Richard Mistura Felisbino ◽  
Marcelo Studart Hunger ◽  
Lucas Rissete Delbim ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Physical Activities ◽  
Tree Planting ◽  
Air Humidity ◽  
Urban Centers ◽  
Resident Population ◽  
Beneficial Effects ◽  
Temperature And Humidity

A crescente urbanização das cidades, muitas vezes, sem planejamento tem provocado sérios danos às condições ambientais e de qualidade de vida das pessoas. Os efeitos benéficos das áreas arborizadas no que diz respeito ao microclima – temperatura e umidade do ar - sempre foram inerentes no que diz respeito à melhoria da qualidade de vida da população. Neste sentido, o objetivo desta pesquisa foi realizar um estudo quantitativo quanto a influência da arborização urbana no microclima dos centros urbanos, analisando as diferenças de temperatura e umidade do ar em dois locais da região central do município de Mogi Guaçu-SP, com características semelhantes de área, destacando-se pela quantidade de unidades arbóreas, assim como verificar a percepção de sessenta acadêmicos do primeiro ao quarto período do curso de Educação Física da Faculdade FMG, Mogi Guaçu–SP quanto aos benefícios dessa vegetação para a população residente. Está bem estabelecida a função exercida pela arborização na redução do calor e insolação no ambiente urbano, conforto térmico e evapotranspiração com aumento da umidade do ar, desempenhando assim, uma importante função na melhoria das condições ambientais das cidades, favorecimento da prática de atividades físicas e qualidade de vida de seus habitantes.Palavras-chave: Microclima. Arborização Urbana. Atividade Física.AbstractThe increasing urbanization of cities, often unplanned, has caused serious damage to the environment and people’s quality of life. The beneficial effects of wooded areas in terms of microclimate - air temperature and humidity have always been inherent in improving the population’s quality of life. In this sense, the objective of this research was to carry out a quantitative study on the influence of urban afforestation on the microclimate of urban centers, analyzing the differences in temperature and humidity of the air in two locations in the central region of the municipality of Mogi Guaçu-SP with similar characteristics of area, highlighing the number of tree units, as well as to verify the perception of 60 scholars from the first to the fourth period of the Physical Education course of the FMG College, Mogi Guaçu-SP, regarding the benefits of this vegetation to the resident population. The role of tree planting in reducing heat and sunshine in the urban environment, thermal comfort and evapotranspiration with increased air humidity is well established, thus playing an important role in improving the environmental conditions of cities, favoring the practice of physical activities and Quality of life of its inhabitants.Keywords: Microclimate. Urban Arborization. Physical Activity.

Evaluation of add on effect of carvedilol on standard protocol of digoxin, frusemide and benazepril in the management of dilated cardiomyopathy in dogs

2018 ◽  
Author(s):  
Akhilesh Kumar ◽  
Sahadeb Dey ◽  
Abhishek Chandra Saxena ◽  
Sumit Mahajan
Keyword(s):  
Quality Of Life ◽  
Cardiac Function ◽  
Dilated Cardiomyopathy ◽  
Standard Therapy ◽  
Ace Inhibitor ◽  
Systolic Function ◽  
Serum Levels ◽  
Post Treatment ◽  
Beneficial Effects

This is a prospective, controlled, randomized clinical trial in canine patients with overt Dilated Cardiomyopathy (DCM). We hypothesized that the addition of the third generation beta-blocker carvedilol to the standard treatment of diuretic (furosemide), inotropic support (digoxin) and ACE-inhibitor (benazepril) would have beneficial effects over cardiac function and quality of life (QoL) that would be measurable 90 days post-treatment. 16 dogs diagnosed with overt DCM were recruited. They underwent clinical examination, electrocardiography, echocardiography and neurohormonal profiling (NT-proBNP and NO). Dogs were divided in two groups, receiving standard therapy or standard therapy plus carvedilol and subjected to re-evaluation on 90 days post-treatment. Our results indicated that the addition of carvedilol to the standard therapy improved echocardiographic indices of systolic function (FS and EF), reduced NT-proBNP and NO serum levels and quality of life within the group but did not showed the significant improvement over standard therapy. This suggested that the addition of carvedilol to the standard therapy in canine patients with overt DCM might have beneficial effects in cardiac function and quality of life in the treatment was continued for longer period.

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