Ag-doped phosphate bioactive glasses: thermal, structural and in-vitro dissolution properties

Microparticles open up new vistas of research in the development of novel drug delivery systems. Microparticles are defined as particulate dispersions or solid particles with size range of 1-1000 µm. Hydrochlorothiazide (HCT), diuretic drug, is practically insoluble in water and has a solubility of 250µg/mL in 0.1 N HCl (25 °C). Presently, the improvement of drug solubility is one of the most challenging fields in pharmaceutical development, therefore, we choose hydrochlorothiazide for the micro-particulate drug delivery. Microparticles of hydrochlorothiazide were prepared by solvent evaporation technique. The prepared microparticles were evaluated for various properties. Particle size determination of microparticles by optical microscopy showed uniform size distribution. The in vitro dissolution studies of hydrochlorothiazide microparticles showed better release effect (99.45%) over a period of 60 min as compared to pure drug. Thus a successful attempt was made to formulate microparticles of this BCS class II drug which resulted in increase in dissolution properties of hydrochlorothiazide microparticles.

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In Vitro Dissolution Behavior of Gel-Derived Bioactive Glasses in the SiO2-CaO-P2O5-MgO System

Advanced Biomaterials VI - Key Engineering Materials ◽

10.4028/0-87849-967-9.541 ◽

2005 ◽

pp. 541-544

Author(s):

Yurong Cai ◽

L. Zhou ◽

Jianhua Wei ◽

Zhentao Yu ◽

Jin Long Niu

Keyword(s):

In Vitro Dissolution ◽

Dissolution Behavior ◽

Bioactive Glasses

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Preparation of K2O-CaO-P2O5 Eco-Glass Fertilizers and Effect in Crops

Materials Science Forum ◽

10.4028/www.scientific.net/msf.486-487.407 ◽

2005 ◽

Vol 486-487 ◽

pp. 407-410 ◽

Cited By ~ 2

Author(s):

Hoi Kwan Lee ◽

Sheng Jian Hwang ◽

Won Ho Kang

Keyword(s):

Glass Composition ◽

Phosphate Glasses ◽

Melt Quenching ◽

Ph Values ◽

Dissolution Properties ◽

Quenching Process ◽

Environmentally Safe ◽

Icp Analysis ◽

Glass Compositions ◽

Main Factor

For the application of environment conscious glass-fertilizer, K2O-CaO-P2O5 glasses were fabricated by melt-quenching process, and the dissolution properties of these glasses were investigated using pH meter and ICP analyzer. Additionally, the fertilizer effects on rice culture were evaluated. The pH values depended on the glass compositions, and the ICP analysis confirmed that the dissolution amount was inversely proportional to the change of the K2O/P2O5 ratio, which was a main factor in controlling chemical durability, and which could be controlled by mother glass composition. The results of their application to rice plants indicated that the growth and quantity were similar to those used in chemical fertilizer. Therefore, the phosphate glasses are expected to provide the slow-releasing nutrient fertilizers that are easy to produce, environmentally safe, and widely applicable.

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Use of a Round-Bottom Resin Kettle for in vitro Dissolution Testing

Journal of AOAC INTERNATIONAL ◽

10.1093/jaoac/59.2.367 ◽

1976 ◽

Vol 59 (2) ◽

pp. 367-367

Author(s):

Ross D Kirchhoefer

Keyword(s):

In Vitro Dissolution ◽

Dissolution Testing ◽

Drug Bioavailability ◽

Dissolution Properties ◽

Dissolution Tests

Abstract Dissolution tests are used to assist in the evaluation of drug bioavailability. A piece of glassware has been designed which allows one to take advantage of the dissolution properties of a 3-neck round-bottom flask and is compatible with and easier to use than existing stirring and bath equipment.

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