Serum thyroglobulin reference values according to NACB criteria in healthy subjects with normal thyroid ultrasound

2012 ◽  
Vol 50 (5) ◽  
Author(s):  
Luca Giovanella ◽  
Mauro Imperiali ◽  
Anna Ferrari ◽  
Alessia Palumbo ◽  
Lino Furlani ◽  
...  
Keyword(s):  
Reference Values ◽  
Healthy Subjects ◽  
Reference Interval ◽  
Reference Population ◽  
Specific Reference ◽  
Logarithmic Scale ◽  
Reference Ranges ◽  
Thyroid Ultrasound ◽  
Serum Thyroglobulin ◽  
Automated Platform

AbstractThe present study was undertaken to establish serum thyroglobulin (Tg) normal reference values in a large group of healthy subjects.Four hundred and thirty-eight non-smoking healthy subjects were selected to assess the Tg reference values (209 males, 229 non-pregnant females, age 34.7±13.1 years). Inclusion criteria were: no personal or familial history of thyroid disease, thyrotropin levels from 0.5 to 2.00 mUI/L, negative thyroperoxidase and thyroglobulin antibodies. In addition, the patients had a normal size thyroid (females ≤18 mL, males ≤25 mL) without nodules on the thyroid ultrasound (TUS). According to National Academy of Clinical Biochemistry (NACB) criteria the Tg results were transformed to a logarithmic scale and reference ranges were calculated as mean±2 SD.Serum Tg was measured on the Beckman Coulter UniCel DxI 800 automated platform by the simultaneous 1-step immunoenzymatic Access Thyroglobulin assay (Beckmann-Coulter SA, Nyon, Switzerland). Serum Tg levels were higher in females than in males (p=0.0022). Accordingly, gender-specific reference values were calculated (i.e., males: 1.40–29.2 ng/mL; females: 1.50–38.5 ng/mL).To the best of the authors’ knowledge, the first reference interval study for Tg that integrates NACB criteria and TUS assessment for the selection of the reference population is provided here.

scholarly journals Study of thyroid volume by ultrasonography in clinically euthyroid patients

1970 ◽  
Vol 32 (2) ◽  
pp. 36-43 ◽  
Author(s):  
P Kayastha ◽  
S Paudel ◽  
DM Shrestha ◽  
RJ Ghimire ◽  
S Pradhan
Keyword(s):  
Surface Area ◽  
Body Surface Area ◽  
Reference Values ◽  
Body Surface ◽  
Pearson Correlation ◽  
Thyroid Volume ◽  
Specific Reference ◽  
Reference Ranges ◽  
Hilly Region ◽  
Significant Difference

Introduction: The purpose of this study was to establish reference ranges of total thyroid volume among clinically euthyroid Nepalese population using Ultrasonography and correlate this volume with age, sex, individual’s built and geographic location. Methods: This was a prospective cross sectional study involving 485 clinically euthyroid individuals. B - mode Ultrasonography was used to measure the total thyroid volume by combining the volume of both the lobes obtained by using formula for prolate ellipsoid. Age specific reference values for thyroid volume were obtained and Pearson correlation test was used to see the relationship with various factors. Results: Among 485 individuals between 1 to 83 years of age, 221(45.57%) were males and 264(54.43%) were females. Maximum [354 individuals (72.99%)] were from hilly region and minimum [16 individual (3.30%)] were from Himalayan region. Mean thyroid volume was 6.629 ± 2.5025 ml. In general, thyroid volume was found to be more in older individuals than in young age group. There was no significant difference of thyroid volume between males and females. Thyroid volume best correlated with body surface area (r=0.444, p<0.0001). The volume had a positive correlation with weight (r=0.443, p<0.0001), body mass index (r=0.371, p<0.0001) and height (r=0.320, p<0.0001) of the individual. Conclusions: This study estimated the reference range of total thyroid volume for Nepalese population. These ranges are significantly lower than the WHO/ICCIDD thyroid volume references and reference values obtained in various other countries. Total thyroid volume best correlated with Body surface area. Keywords: Body surface area; clinically euthyroid; total thyroid volume; ultrasonography DOI: http://dx.doi.org/10.3126/joim.v32i2.4944 Journal of Institute of Medicine, August, 2010; 32: 36-43

scholarly journals P737 Left ventricular hemodynamic forces: towards establishing reference values for healthy adults

2020 ◽  
Vol 21 (Supplement_1) ◽  
Author(s):  
F Capuano ◽  
R Cocchia ◽  
F Ferrara ◽  
S Lanero ◽  
V Russo ◽  
...  
Keyword(s):  
Reference Values ◽  
Healthy Subjects ◽  
Left Ventricular ◽  
Healthy Adults ◽  
Disease Assessment ◽  
Lv Function ◽  
Specific Reference ◽  
Endocardial Contour ◽  
Hemodynamic Forces ◽  
Lv Volume

Abstract Introduction Left ventricular hemodynamic forces (LV-HDF) have been recently demonstrated to be promising markers of sub-clinical dysfunction and potential predictors of disease outcome. However, there is a lack of reference values in healthy subjects. Knowledge of physiologic ranges is mandatory towards the use of LV-HDF-based indices for disease assessment in future clinical applications. Purpose Aim of the current study is to define the normal reference values for LV-HDF parameters in a large cohort of healthy adults. Here we present preliminary results for the initial set of enrolled subjects. Methods We enrolled 82 healthy subjects [mean age 44 ± 13.2 years (range 18-88), 41 men]. All participants underwent standard transthoracic echocardiography (TTE) examination, as recommended by current guidelines, including apical two-, three- and four-chamber windows, acquired at a frame rate above 40 Hz. These were then analyzed by tri-plane tissue tracking, measuring LV volume and LV ejection fraction (EF) as reference parameters. The same tracking method was used to evaluate the global hemodynamic force by a novel mathematical calculation technique applied to the three-dimensional endocardial contour. Physical-based LV-HDF parameters were then extracted for clinical application; these included the amplitude (root mean square) of the longitudinal and transversal force components (FL and FT) and their alignment angle relative to the LV axis. Parameters were computed as average over the whole cardiac cycle as well as limited to the systolic phase. Forces were normalized with LV volume to reduce variability with LV dimension, and divided by specific weight to yield a dimensionless measure. Results Mean EF was 63 ± 9%. Whole cycle LV-HDF parameters were: FL = 16.0 ± 5.6%, FT = 2.3 ± 0.8%, with significant longitudinal alignment FT/FL = 0.15 ± 0.04, angle = 13.0°±3.1°. Systolic HDF parameters were: FL = 22.7 ± 8.2%, FT = 2.9 ± 1.1%, with longitudinal alignment FT/FL = 0.13 ± 0.04, angle = 11.2°±3.1°. Importantly, dimensionless physical-based LV-HDF parameters showed no significant variation with age, gender or BSA. Conclusions We report the physiologic range of LV-HDF parameters measured by TTE. Knowledge of age- and gender-specific reference values, for a combination of standard, mechanical and hemodynamic indices, can improve the global assessment of the LV function and may help to detect sub-clinical stages of LV dysfunction.

scholarly journals DETERMINING REFERENCE RANGES FOR TREC AND KREC ASSAYS IN IMMUNE DEFICIENCY SCREENING OF NEWBORNS IN RUSSIAN FEDERATION

2019 ◽  
Vol 21 (3) ◽  
pp. 527-538
Author(s):  
M. A. Gordukova ◽  
I. A. Korsunsky ◽  
Yu. V. Chursinova ◽  
M. M. Byakhova ◽  
I. P. Oscorbin ◽  
...  
Keyword(s):  
Reference Interval ◽  
Reference Population ◽  
Dried Blood Spots ◽  
Reference Intervals ◽  
Asymmetric Distribution ◽  
Reference Ranges ◽  
Individual Values ◽  
Experimental Values ◽  
Deficiency Screening ◽  
Guthrie Cards

In this work, we used a reference population of newborns and sampled dried blood spots on Guthrie cards of 2,739 individual samples to determine the reference intervals for TRECs and KRECs values, in order to diagnose primary immunodeficiency by means of neonatal screening. The median absolute values for TRECs and KRECs were 195 (CI95%: 185-206) and 185 (CI95%: 176-197) copies per μl, respectively; the normalized value for TRECs was 2780 (CI95%: 2690-2840), and for KRECs, 2790 (CI95%: 2700-2900) copies per 2 × 105 copies of the albumin gene or 105 cells. The reference interval was calculated for 99 and 99.9 percentiles of total TRECs and KRECs individual values. Due to asymmetric distribution of data, the outliers were filtered off, using the Tukey’s criterion applied after logarithmic transformation of the data. When analyzing absolute values for TREC/KREC (per μL of blood), no “drop-down” TRECs values were identified; for KRECs, 18 experimental values were excluded from further analysis (from 9.8 to 13.5). The outlying values were not identified among the normalized values of TRECs/KRECs. The obtained reference values for TRECs and KRECs (at the 0.1 percentile level) were, respectively, 458 and 32 per 105 cells, or 23 and 17 per μl of blood samples from neonates.

scholarly journals Reference values for fetal Doppler-based cardiocirculatory indices in monochorionic-diamniotic twin pregnancy

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Thananan Chongsomboonsuk ◽  
Nisarat Phithakwatchara ◽  
Katika Nawapun ◽  
Sommai Viboonchart ◽  
Suparat Jaingam ◽  
...  
Keyword(s):  
Reference Values ◽  
Twin Pregnancy ◽  
Peak Systolic Velocity ◽  
Ductus Venosus ◽  
Diastolic Filling ◽  
Specific Reference ◽  
Reference Ranges ◽  
Cross Sectional ◽  
Filling Time ◽  
Doppler Indices

Abstract Background Placental anastomoses in monochorionic diamniotic (MCDA) twin pregnancy have a major impact on fetal circulation. This study was designed to define reference ranges of cardiac and vascular Doppler indices in MCDA twin pregnancies. Methods This cross-sectional study included 442 uncomplicated MCDA twin fetuses undergoing Doppler ultrasonography at 18–35 weeks of gestation. Left and right myocardial performance index (LV-MPI, RV-MPI), E/A ratio of atrioventricular valves, pulsatility indices of umbilical artery, middle cerebral artery (MCA), and ductus venosus (DV), cerebroplacental ratio, peak systolic velocity of MCA, S/a ratio of DV, and early diastolic filling time of ductus venosus (DV-E) were evaluated under standardized settings. The equation models between Doppler indices and gestational age (GA) were fitted. After adjustment for GA, the correlations between MPI and fetal heart rate (FHR), and between MPI and DV indices were analyzed. Results Estimated centiles of Doppler indices were derived as a function of GA, being distinct in values from those of singletons. There was no correlation between GA-adjusted MPI and FHR. DV-E was inversely related to LV-MPI. Conclusions MCDA twins showed significant changes in some Doppler indices throughout gestation with quantitative differences from singletons, emphasizing the importance of MC twin-specific reference values for clinical application. Further adjustment of MPI for FHR was unnecessary. DV-E is a vascular index indirectly representing fetal diastolic function.

Factor VII Antigen Levels in a Healthy Blood Donor Population

1994 ◽  
Vol 72 (01) ◽  
pp. 021-027 ◽  
Author(s):  
P R Howard ◽  
E G Bovill ◽  
J Pike ◽  
W R Chruch ◽  
R P Tracy
Keyword(s):  
Total Population ◽  
Solid Phase ◽  
Reference Interval ◽  
Factor Vii ◽  
Specific Reference ◽  
Reference Ranges ◽  
Age Related ◽  
Gender And Age ◽  
Donor Population ◽  
The Mean

SummaryWe determined factor VII antigen (FVIIag) levels in 705 healthy blood donors ranging in age from 17 to 79 years using a two-site solid-phase enzyme immunoassay developed in our laboratory. The mean (± SD) FVIIag level for the total population was 102 ± 31%. FVIIag levels for men (n = 375) and women (n = 330) were 101 ± 28% and 103 ± 33%, respectively. A significant increase in FVIIag was observed with age in both men (r = 0.25, p <0.0001) and women (r = 0.35, p <0.0001). FVIIag levels were significantly higher in women > 60 years when compared to men (median women: 125%; median men: 111%; p <0.05). On a subset of the study group (n = 45), FVIIag levels were correlated to total cholesterol (r = 0.27, p = 0.08) and triglyceride (r = 0.41, p <0.01). Assuming the commonly used reference interval of 60-140% for FVII, the frequencies of FVIIag values for <60% and >140% using our assay were 2.1% and 9.2%, respectively. Gender and age-related differences in FVIIag levels must be considered in a reference interval. We further suggest that assay-specific reference ranges be established, which may include values outside the commonly used values of 60-140%.

Population-specific reference values for thyroid hormones on the Abbott ARCHITECT i2000 analyzer

2004 ◽  
Vol 42 (5) ◽  
Author(s):  
Manuel González-Sagrado ◽  
Francisco Javier Martín-Gil
Keyword(s):  
Thyroid Hormones ◽  
Reference Values ◽  
Patient Population ◽  
Laboratory Data ◽  
Thyroid Stimulating Hormone ◽  
Specific Reference ◽  
Reference Ranges ◽  
Free Triiodothyronine ◽  
Total Triiodothyronine ◽  
Abbott Architect

AbstractReliable reference ranges are important in the interpretation of laboratory data, and it is incumbent on each laboratory to verify that the ranges they use are appropriate for the patient population they serve. The objective of this study was to determine population-specific reference ranges for thyroid stimulating hormone (TSH), free thyroxine (fT4), free triiodothyronine (fT3) and total triiodothyronine (TT3) on the Abbott ARCHITECT

scholarly journals First- and Second-Trimester Reference Intervals for Thyroid Hormones during Pregnancy in “Rhea” Mother-Child Cohort, Crete, Greece

2011 ◽  
Vol 2011 ◽  
pp. 1-12 ◽  
Author(s):  
Polyxeni Karakosta ◽  
Leda Chatzi ◽  
Emmanouil Bagkeris ◽  
Vasiliki Daraki ◽  
Dimitris Alegakis ◽  
...  
Keyword(s):  
Thyroid Hormones ◽  
Reference Interval ◽  
Reference Intervals ◽  
Thyroid Stimulating Hormone ◽  
Specific Reference ◽  
Reference Ranges ◽  
Thyroid Function Tests ◽  
Second Trimester ◽  
Free Triiodothyronine ◽  
Reference Limit

Estimation and interpretation of thyroid function tests in pregnant women is of utmost importance for maternal, fetal and neonatal health. Our objective was to calculate laboratory- and geography-specific reference intervals for thyroid hormones during pregnancy in an iodine-sufficient area of the Mediterranean, Crete, Greece. This project was performed in the context of “Rhea” mother-child cohort. Fulfillment of extensive questionnaires and estimation of free triiodothyronine (fT3), free thyroxine (fT4), thyroid-stimulating hormone (TSH), and antithyroid antibodies were performed. The reference population was defined using inclusion criteria regarding thyroidal, obstetric, and general medical status of women. Reference interval for TSH was 0.05–2.53 μIU/mL for the first and 0.18–2.73 μIU/mL for the second trimester. 6,8% and 5,9% of women in the first and second trimester, respectively, had TSH higher than the upper reference limit. These trimester-specific population-based reference ranges are essential in everyday clinical practice for the correct interpretation of thyroid hormone values and accurate classification of thyroid disorders.

Thyroid volume influences serum calcitonin levels in a thyroid-healthy population: results of a 3-assay, 519 subjects study

2012 ◽  
Vol 50 (5) ◽  
Author(s):  
Luca Giovanella ◽  
Mauro Imperiali ◽  
Anna Ferrari ◽  
Alessia Palumbo ◽  
Lorella Lippa ◽  
...  
Keyword(s):  
Thyroid Volume ◽  
Reference Population ◽  
Specific Reference ◽  
Healthy Population ◽  
Reference Ranges ◽  
Cross Sectional ◽  
Serum Calcitonin ◽  
Males And Females ◽  
The Difference ◽  
Gender Specific

AbstractWe aimed to assess determinants for serum calcitonin (CT) levels and to define reference ranges for different CT immunoassays integrating thyroid ultrasonography (TUS) and conventional clinical and biochemical criteria to select the reference population.Five hundred and nineteen thyroid-healthy subjects were included in this prospective cross-sectional population study. Thyroid volume was measured by TUS, while serum CT levels were measured by three different immunoassays.Significant interassay differences were found and the agreement between assays was poor. CT levels were higher in males than in females in all immunoassays. Using the first two assays, both gender and thyroid volume were independent determinants for CT levels. While using the third assay, one thyroid volume was the only determinant for CT levels.Thyroid volume is a relevant determinant for CT levels. In the clinical practice, the difference of the thyroid sizes in males and females warrants gender-specific reference ranges.

Long-term variability in serum thyroglobulin and thyroid related hormones in healthy subjects

1980 ◽  
Vol 95 (3) ◽  
pp. 328-334 ◽  
Author(s):  
U. Feldt-Rasmussen ◽  
P. Hyltoft Petersen ◽  
O. Blaabjerg ◽  
M. Hørder
Keyword(s):  
Healthy Subjects ◽  
Reference Ranges ◽  
Serum Thyroglobulin ◽  
Young Males ◽  
Young Females ◽  
Coefficients Of Variation ◽  
Individual Variations ◽  
Uptake Test ◽  
Healthy Persons

Abstract. From 5 young males and 5 young females blood was drawn under highly standardized conditions at 6 to 10 occasions during 4 months. The serum constituents thyroglobulin, thyroxine, triiodothyronine, T3-uptake test, TBG and TSH were determined, and four indices were calculated. The biological intra-individual coefficients of variation were below 0.14 for thyroglobulin, and the inter-individual coefficients of variation ranged from zero for T3-uptake test to 0.35 for thyroglobulin. All results were within the generally accepted reference ranges for normals. Within these ranges the calculations of indices for free thyroxine and triidothyronine according to T3-uptake test and TBG, did not significantly reduce the coefficients of variation for these serum constituents. Thyroglobulin concentrations did not correlate to any of the measured or calculated constituents. The knowledge of these intra- and inter-individual variations of serum thyroglobulin in healthy persons is of importance for the interpretation of variations found in patients.

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