An efficient and catalyst-free synthesis of N-arylidene-2-arylimidazo[1,2-a]pyridine-3-ylamine derivatives via Strecker reaction under controlled microwave heating

2017 ◽  
Vol 6 (4) ◽  
Author(s):  
Afaf Mohamed Abdel Hameed ◽  
Moustafa Sherief Moustafa ◽  
Saleh Mohammed Al-Mousawi ◽  
Reham R. Awed ◽  
Kamal Usef Sadek
Keyword(s):  
Microwave Heating ◽  
Multicomponent Reaction ◽  
Aromatic Aldehydes ◽  
Atom Economy ◽  
One Pot ◽  
Strecker Reaction ◽  
Catalyst Free ◽  
Benzoyl Cyanide

AbstractAn efficient one-pot multicomponent reaction of 2-aminopyridine with aromatic aldehydes and either benzoyl cyanide or cyanamide in pyridine under controlled microwave heating afforded N-aryldene-2-arylimidazo[1,2-a]-pyridine-3-ylamine derivatives. The reaction is catalyst free and is of high atom economy.

scholarly journals An efficient green synthesis of novel 1H-imidazo[1,2-a]imidazole-3-amine and imidazo[2,1-c][1,2,4]triazole-5-amine derivatives via Strecker reaction under controlled microwave heating

2019 ◽  
Vol 8 (1) ◽  
pp. 297-301 ◽  
Author(s):  
Kamal Usef Sadek ◽  
Afaf Mohamed Abdel-Hameed ◽  
Hisham A. Abdelnabi ◽  
Yasser Meleigy
Keyword(s):  
Reaction Time ◽  
Green Synthesis ◽  
Microwave Heating ◽  
Environmentally Friendly ◽  
Aromatic Aldehydes ◽  
One Pot ◽  
Short Reaction Time ◽  
Strecker Reaction ◽  
Benzoyl Cyanide ◽  
High Yields

Abstract A highly efficient multi-component one-pot synthesis of novel 1H-imidazo[1,2-a]imidazole-3-amine and imidazo[2,1-c][1,2,4]triazole-5-amine derivatives has been developed through the reaction of easily available aromatic aldehydes, benzoyl cyanide and either 2-aminoimidazole-4,5-dicarbonitrile or 3-amino-1,2,4-triazole in pyridine under controlled microwave heating. The process is environmentally friendly, is operationally simple, with short reaction time and with high yields.

Novel One-pot Synthesis of Pyranocarbazole Derivatives via an Isocyanide-based Three-component Reaction

2020 ◽  
Vol 17 ◽  
Author(s):  
Visarapu Malathi ◽  
Pedavenkatagari Narayana Reddy ◽  
Pannala Padmaja
Keyword(s):  
Efficient Method ◽  
Atom Economy ◽  
Reaction Conditions ◽  
One Pot ◽  
Catalyst Free ◽  
One Pot Synthesis ◽  
Three Component Reaction ◽  
High Yields

Abstract:: An efficient method has been developed for the synthesis of new pyrano[3,2-c] and pyrano[3,2-a]carbazole de-rivatives via a three component reaction of 4-hydroxycarbazole or 2-hydroxycarbazole, isocyanides, and dialkylacetylenedi-carboxylates. Noteworthy features of this protocol include mild reaction conditions, catalyst-free, high atom-economy and high yields.

One-pot multicomponent synthesis of β-acetamidoketones catalysed by pTSA1

2007 ◽  
Vol 85 (7-8) ◽  
pp. 479-482 ◽  
Author(s):  
Biswanath Das ◽  
Kongara Ravinder Reddy ◽  
Yallamalla Srinivas ◽  
Rathod Aravind Kumar
Keyword(s):  
Multicomponent Reaction ◽  
Acetyl Chloride ◽  
Reaction Times ◽  
Aromatic Aldehydes ◽  
Catalytic Amount ◽  
Multicomponent Synthesis ◽  
One Pot ◽  
High Yields ◽  
Three Component Coupling

A catalytic amount of pTSA has been found to be effective to carry out a one-pot three-component coupling of aromatic aldehydes, enolizable ketones or ketoesters, and acetonitrile in the presence of acetyl chloride to afford β-acetamidoketones in high yields. Short reaction times and inexpensive catalyst are main advantages of this protocol.Key words: β-acetamidoketone, pTSA, multicomponent reaction, diastereoselectivity.

scholarly journals A one-pot catalyst-free synthesis of functionalized pyrrolo[1,2-a]quinoxaline derivatives from benzene-1,2-diamine, acetylenedicarboxylates and ethyl bromopyruvate

2013 ◽  
Vol 9 ◽  
pp. 510-515 ◽  
Author(s):  
Mohammad Piltan ◽  
Loghman Moradi ◽  
Golaleh Abasi ◽  
Seyed Amir Zarei
Keyword(s):  
Multicomponent Reaction ◽  
One Pot ◽  
Dialkyl Acetylenedicarboxylates ◽  
Catalyst Free ◽  
Quinoxaline Derivatives ◽  
Ethyl Bromopyruvate

The catalyst-free multicomponent reaction of 1,2-diaminobenzene, dialkyl acetylenedicarboxylates, and ethyl bromopyruvate forms pyrrolo[1,2-a]quinoxaline derivatives in good yields. Ethylenediamine also reacts under similar conditions to produce new pyrrolo[1,2-a]pyrazine derivatives.

scholarly journals One-pot multicomponent synthesis of highly substituted pyridines using hydrotalcite as a solid base and reusable catalyst

2021 ◽  
pp. 169-174
Author(s):  
Sandip R. Kale ◽  
Santosh Kumar Surve
Keyword(s):  
Catalytic Activity ◽  
Multicomponent Reaction ◽  
Aromatic Aldehydes ◽  
Significant Loss ◽  
Solid Base ◽  
Reusable Catalyst ◽  
Multicomponent Synthesis ◽  
One Pot ◽  
One Pot Synthesis ◽  
Substituted Pyridines

One-pot synthesis of highly substituted pyridines has been demonstrated via multicomponent reaction of aldehydes, malononitrile and thiophenol using Mg-Al hydrotalcite as a solid base and reusable catalyst. The catalytic activity is intimately connected to the basicity of the catalyst. The best activities were observed with the Mg/Al: 5 catalyst. The catalyst could be reused for further run without a significant loss in activity. The protocol was also applicable for various aromatic aldehydes which affords desired product in good to excellent yield.

Catalyst free Synthesis of Highly Functionalized Indolizines from In Situ Generated Pyridinium Ylides via One‐Pot Multicomponent Reaction

2019 ◽  
Vol 4 (13) ◽  
pp. 3717-3721 ◽  
Author(s):  
Vediyappan Ramesh ◽  
Natarajan Savitha Devi ◽  
Marappan Velusamy ◽  
Sivakumar Shanmugam
Keyword(s):  
Multicomponent Reaction ◽  
One Pot ◽  
Catalyst Free ◽  
Pyridinium Ylides

Ultrasound Assisted One-Pot Synthesis of Tetrahydropyrimidne Deriva-tives through Biginelli Condensation: A Catalyst Free Green Chemistry Approach

2020 ◽  
Vol 17 ◽  
Author(s):  
Ashish Patel ◽  
Jinagna Shah ◽  
Kesha Patel ◽  
Krishna Patel ◽  
Harit Patel ◽  
...  
Keyword(s):  
Aromatic Aldehydes ◽  
Green Technology ◽  
Sustainable Chemistry ◽  
Structural Variants ◽  
One Pot ◽  
The Past ◽  
Catalyst Free ◽  
Classical Methodology ◽  
Ultrasound Assisted ◽  
Biginelli Condensation

: The chemical applications of ultrasound, "sonochemistry", has become an exciting new field of research during the past decade as it can increase reactivities by nearly a million fold. Owing to the increasing use of Green technology approach, due to its various merits over Classical methodology and as a need for sustainable Chemistry, this reaction has received renewed interest for preparing tetrahydropyrimidine (THPM) through Biginelii condensation in an environmentally thoughtful manner with improved yields. The classical reaction has been modified in the recent past with/without various catalysts and several structural variants in different solvents to synthesize a large number of Biginelli type compounds due to its diverse pharmacological properties. We reported ultrasound assisted one-pot catalyst free procedure for the synthesis of 6-Aryl substituted-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-Carbonitrile from various aromatic aldehydes, ethyl cyano-acetate and urea under a basic condition with affording isolated yield up to 99% within a reaction time of 5-20 min under mild condition. The synthesized products were characterized by MP, IR, NMR and Mass spectroscopies.

One-Pot Solvent-and Catalyst-Free Synthesis of Some New Heteroarylaminonaphthoquinones from Lawsone

2021 ◽  
Vol 18 ◽  
Author(s):  
Abolfazl Olyaei ◽  
Nilufar Rahmani ◽  
Mahdieh Sadeghpour ◽  
Amir Mohamadi
Keyword(s):  
Reaction Times ◽  
Aromatic Aldehydes ◽  
Heterocyclic Amines ◽  
Environmentally Benign ◽  
One Pot ◽  
Simple Operation ◽  
Catalyst Free ◽  
Three Component Reaction ◽  
Methyl Naphthalene ◽  
Work Up

: A clean and efficient one-pot protocol for the synthesis of a series of new 2-hydroxy-3-((3-aryl)(heteroarylamino)methyl)naphthalene-1,4-dione derivatives has been developed by the three-component reaction of 2-hydroxynaphthalene-1,4-dione, aromatic aldehydes and heterocyclic amines at 90 oC under solvent and catalyst-free conditions. The procedure avoids the use of toxic solvents, tedious work-up, catalyst and purification of the products by chromatographic methods. Simple operation, short reaction times, generating the desired compounds in high to excellent yields and an environmentally benign method are advantages of this protocol.

Three Component, One‐Pot Synthesis of Multifunctional Quinolinopyranpyrazoles via Catalyst‐Free Multicomponent Reaction

2019 ◽  
Vol 4 (27) ◽  
pp. 7996-7999 ◽  
Author(s):  
Manickam Bakthadoss ◽  
Varathan Vinayagam ◽  
Vishal Agarwal ◽  
Duddu S. Sharada
Keyword(s):  
Multicomponent Reaction ◽  
One Pot ◽  
Catalyst Free ◽  
One Pot Synthesis

An efficient catalyst-free chemoselective multicomponent reaction for the synthesis of pyrimidine functionalized pyrrolo-annelated derivatives

RSC Advances ◽  
2015 ◽  
Vol 5 (31) ◽  
pp. 24327-24335 ◽  
Author(s):  
Yuvaraj Dommaraju ◽  
Somadrita Borthakur ◽  
Nimmakuri Rajesh ◽  
Dipak Prajapati
Keyword(s):  
Multicomponent Reaction ◽  
Reaction Conditions ◽  
One Pot ◽  
Efficient Catalyst ◽  
Catalyst Free ◽  
High Yields

An efficient catalyst-free, one-pot multicomponent reaction has been developed for the synthesis of pyrimidine functionalized pyrrolo-annelated derivatives. The method offers easy and column free separation, mild reaction conditions and high yields.

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