Microwave-assisted one-pot synthesis and antimicrobial evaluation of 2-(1-phenyl-3-(2-thienyl)-1H-pyrazol-4-yl)chroman-4-one derivatives

2016 ◽  
Vol 22 (5) ◽  
Author(s):  
Ashok Dongamanti ◽  
Hayder Hasan Naji ◽  
Vijaya Lakshmi Bommidi ◽  
Sarasija Madderla
Keyword(s):  
Antimicrobial Activity ◽  
Microwave Irradiation ◽  
Conventional Heating ◽  
One Pot ◽  
Microwave Assisted ◽  
Hybrid Compounds ◽  
One Pot Synthesis ◽  
Synthetic Strategy ◽  
Antimicrobial Evaluation

AbstractNew hybrid compounds containing flavanone and pyrazoline motifs were synthesized by microwave irradiation and conventional heating methods using one-pot synthetic strategy. The products were evaluated for their antimicrobial activity.

scholarly journals Microwave-assisted synthesis and antimicrobial evaluation of 6-[3-aryl-1-phenyl-4’,5’-dihydro[4,5’-bi-1H-pyrazol]-3’-yl]-2H-chromen-5-ols

2019 ◽  
Vol 84 (3) ◽  
pp. 237-244
Author(s):  
Dongamanti Ashok ◽  
Rangu Kavitha ◽  
Srinivas Gundu ◽  
Madderla Sarasija
Keyword(s):  
Antimicrobial Activity ◽  
Microwave Irradiation ◽  
Sodium Acetate ◽  
Analytical Data ◽  
Conventional Heating ◽  
Microwave Assisted Synthesis ◽  
Microwave Assisted ◽  
Structural Assignment ◽  
Antimicrobial Evaluation ◽  
Antimicrobial Potency

A new series of 6-[3-aryl-1-phenyl-4?,5?-dihydro[4,5?-bi-1H-pyrazol]-3?-yl]-2H-chromen-5-ol derivatives was synthesized by Michael addition of chalcones 5a?j with hydrazine hydrate in presence of sodium acetate under conventional heating and microwave irradiation. Structural assignment of the products was confirmed based on IR, 1H-NMR, 13C-NMR, MS and analytical data. All the synthesized compounds 6a?j were screened for their antimicrobial activity against various bacterial and fungal strains. Most of the compounds exhibited variable range of antimicrobial activity and compounds 6c?f and 6i showed promising antimicrobial potency.

Improved Protocols for Microwave-Assisted Cu(I)-Catalyzed Huisgen 1,3-Dipolar Cycloadditions

2007 ◽  
Vol 72 (8) ◽  
pp. 1014-1024 ◽  
Author(s):  
Pedro Cintas ◽  
Katia Martina ◽  
Bruna Robaldo ◽  
Davide Garella ◽  
Luisa Boffa ◽  
...  
Keyword(s):  
Heterogeneous Catalysis ◽  
Microwave Irradiation ◽  
Ultrasound Irradiation ◽  
Conventional Heating ◽  
Dipolar Cycloaddition ◽  
One Pot ◽  
Click Reactions ◽  
Dipolar Cycloadditions ◽  
Microwave Assisted ◽  
New Applications

The Huisgen 1,3-dipolar cycloaddition of azides and acetylenes catalyzed by Cu(I) salts, leading to 1,2,3-triazoles, is one of the most versatile "click reactions". We have developed a series of optimized protocols and new applications of this reaction starting from several substrates, comparing heterogeneous vs homogeneous catalysis, conventional heating vs microwave irradiation or simultaneous microwave/ultrasound irradiation. Both non-conventional techniques strongly promoted the cycloaddition (bromide → azide → triazole), that could be conveniently performed in a one-pot procedure. This was feasible even with such bulky molecules as functionalized β-cyclodextrins (β-CD), starting from 61-O-tosyl-β-CD or from heptakis[6-O-(tert-butyldimethylsilyl)]-21-O-propargyl-β-CD. "Greener" heterogeneous catalysis with charcoal-supported Cu(II) or Cu(I) (prepared under ultrasound) was advantageously employed.

scholarly journals Microwave assisted, one-pot synthesis of 5-nitro- 2-aryl substituted-1H-benzimidazole libraries: Screeningin vitrofor antimicrobial activity

2009 ◽  
Vol 24 (5) ◽  
pp. 1095-1100 ◽  
Author(s):  
Kallappa Mahadevappa Hosamani ◽  
Harisha Reddy Seetharamareddy ◽  
Rangappa Sangappa Keri ◽  
Manohar Shirugumbi Hanamanthagouda ◽  
Mark G. Moloney
Keyword(s):  
Antimicrobial Activity ◽  
One Pot ◽  
Microwave Assisted ◽  
One Pot Synthesis

ChemInform Abstract: Sulfamic Acid Catalyzed One-Pot Synthesis of 2,5-Diaryl-1,3,4-oxadiazoles under Microwave Irradiation and Conventional Heating.

ChemInform ◽  
2009 ◽  
Vol 40 (37) ◽  
Author(s):  
J. Venu Madhav ◽  
Y. Thirupathi Reddy ◽  
P. Narsimha Reddy ◽  
Peter A. Crooks ◽  
V. Naveen Kumar ◽  
...  
Keyword(s):  
Microwave Irradiation ◽  
Sulfamic Acid ◽  
Conventional Heating ◽  
One Pot ◽  
One Pot Synthesis ◽  
Acid Catalyzed

scholarly journals Microwave Assisted One Pot Synthesis of Tetrazole Based 3-hydroxy-4H-chromen-4-ones by modified Algar-Flynn-Oyamada reaction and their Antimicrobial activity

2019 ◽  
Vol 63 (4) ◽  
Author(s):  
ASHOK DONGAMANTI ◽  
Nagaraju Nalaparaju ◽  
Sarasija Madderla ◽  
Vijaya Lakshmi Bommidi
Keyword(s):  
Escherichia Coli ◽  
Antimicrobial Activity ◽  
Klebsiella Pneumonia ◽  
Good Activity ◽  
One Pot ◽  
Microwave Assisted ◽  
One Pot Synthesis ◽  
Antimicrobial Studies ◽  
The One

In the present work, we report the one pot synthesis of tetrazole based 3-hydroxy-4H-chromen-4-ones 3(a-g) from  4-(1H-tetrazol-5-yl)benzaldehyde and 2-hydroxy acetophenone using KOH and H2O2 by modified Algar-Flynn-Oyamada reaction under conventional and microwave irradiation conditions. In this technique, flavonols are synthesized without isolating chalcones, in good yields. All the synthesized compounds were characterized by IR, NMR, MS and elemental. All newly synthesized compounds were screened for their in-vitro antimicrobial activity against strains such as Staphylococcus aurous, Bacillus subtilis, Klebsiella pneumonia, Escherichia coli, Aspergillus Niger, Aspergillus flavus, and Fusarium oxysporum. The results of antimicrobial studies revealed that most of the compounds exhibit good activity.

Microwave-assisted One-pot Synthesis of Amide Bond using WEB

2020 ◽  
Vol 7 (1) ◽  
pp. 50-59
Author(s):  
Kantharaju Kamanna ◽  
S.Y. Khatavi ◽  
P.B. Hiremath
Keyword(s):  
Carboxylic Acid ◽  
Microwave Irradiation ◽  
Primary Amine ◽  
Bond Formation ◽  
Amide Bond ◽  
Conventional Heating ◽  
Primary Amines ◽  
One Pot ◽  
Amide Bond Formation ◽  
One Pot Synthesis

Background: Amide bond plays a key role in medicinal chemistry, and the analysis of bioactive molecular database revealed that the carboxamide group appears in more than 25% of the existing database drugs. Typically amide bonds are formed from the union of carboxylic acid and amine; however, the product formation does not occur spontaneously. Several synthetic methods have been reported for amide bond formation in literature. Present work demonstrated simple and eco-friendly amide bond formation using carboxylic acid and primary amines through in situ generation of O-acylurea. The reaction was found to be more efficient, faster reaction rate; simple work-up gave pure compound isolation in moderate to excellent yield using microwave irradiation as compared to conventional heating. Methods: Developed one-pot synthesis of amide compounds using agro-waste derived greener catalyst under microwave irradiation. Results: Twenty amide bond containing organic compounds are synthesized from carboxylic acid with primary amine catalyzed by agro-waste derived medium under microwave irradiation. First, the reaction involved carboxylic acid activation using EDC.HCl, which is the required base for the neutralization and coupling. The method employed natural agro-waste derived from banana peel ash (WEB) for the coupling gave target amide product without the use of an external organic or inorganic base. Conclusion: In the present work, we demonstrated that agro-waste extract is an alternative greener catalytic medium for the condensation of organic carboxylic acid and primary amine under microwave irradiation. The method found several advantages compared to reported methods like solventfree, non-toxic, cheaper catalyst, and simple reaction condition. The final isolated product achieved chromatographically pure by simple recrystallization and did not require further purification.

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