Synthesis and antiproliferative activity of flavonoid triazolyl glycosides
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AbstractSixteen flavonoid triazolyl glycosides4–19were synthesized in good yieldsviaCu(I)-catalyzed azide-alkyne cycloadditions of terminal alkynes of flavonoids1–3with acetylated sugar azides followed by deacetylation with sodium methoxide in anhydrous methanol. The antiproliferative activity of the synthesized compounds against three human cancer cell lines (Hela, HCC1954 and SK-OV-3)in vitrowas evaluated. Flavonoids1,2and flavonoid triazolyl glycosides7,12,17exhibit potent antiproliferative activity against these cancer cell lines.
2013 ◽
Vol 21
(7)
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pp. 2001-2006
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2012 ◽
Vol 35
(1)
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pp. 51-57
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2011 ◽
Vol 11
(1)
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2009 ◽
Vol 44
(3)
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pp. 1223-1229
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2008 ◽
Vol 26
(5)
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pp. 437-444
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2020 ◽
Vol 20
(10)
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pp. 1241-1249
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