scholarly journals Synthesis and fungicidal activity of novel imidazo[4, 5-b]pyridine derivatives

2019 ◽  
Vol 25 (1) ◽  
pp. 8-14
Author(s):  
Daoxin Wu ◽  
Minhua Liu ◽  
Zhong Li ◽  
Mingming Dang ◽  
Xingping Liu ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Nmr Spectroscopy ◽  
Elemental Analysis ◽  
Fungicidal Activity ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Pyridine Derivatives ◽  
Structure Activity ◽  
Puccinia Polysora

AbstractA series of novel imidazo[4,5-b]pyridine derivatives were synthesized and their structures were characterized by NMR spectroscopy, mass spectrometry and elemental analysis. The results of bioassays showed that some compounds exhibit good fungicidal activity against Puccinia polysora In particular, compound 7b showed an EC50 value of 4.00 mg/L, which was comparable with that of tebuconazole. Besides, preliminary structure-activity relationship was discussed.

scholarly journals Structure-activity relationship study for fungicidal activity of 1-(4-phenoxymethyl-2-phenyl-[1,3]dioxolan-2-ylmethyl)-1H-1,2,4-triazole derivatives against rice blast

2015 ◽  
Vol 55 (4) ◽  
pp. 383-388 ◽  
Author(s):  
Tomoki Hoshi ◽  
Kazuhiro Yamada ◽  
Yuko Yoshizawa ◽  
Keimei Oh
Keyword(s):  
Antifungal Activity ◽  
Rice Blast ◽  
Fungicidal Activity ◽  
Antifungal Agents ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Triazole Derivatives ◽  
Structure Activity ◽  
Ring Structures

Abstract To explore new antifungal agents for rice blast control, the antifungal activity of a series of novel 1,2,4-triazole derivatives against Magnaporthe oryzae has been evaluated. The antifungal activity was determined by using in vitro mycelial growth inhibition tests. Among the 19 test compounds, we found that the compound 1-(4-phenoxymethyl-2-phenyl-[1,3]dioxolan-2-ylmethyl)-1H-1,2,4- triazole (Gj) displayed potent antifungal activity against M. oryzae. The IC50 value was found approximately 3.8±0.5 μM and the IC50 value of propiconazole was found to be approximately 3.7±0.2 μM, respectively. Structure-activity relationship studies on aromatic ring structures provided insight and information about the structural requirements for antifungal activity of this synthetic series against M. oryzae.

A facile one-pot multi-component synthesis of novel adamantine substituted imidazo[1,2-a]pyridine derivatives: identification and structure–activity relationship study of their anti-HIV-1 activity

RSC Advances ◽  
2016 ◽  
Vol 6 (97) ◽  
pp. 95177-95188 ◽  
Author(s):  
Tazeem Tazeem ◽  
Xin Han ◽  
Qingjun Zhou ◽  
Jingchen Wei ◽  
Po Tien ◽  
...  
Keyword(s):  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Pyridine Derivatives ◽  
One Pot ◽  
Structure Activity ◽  
Relationship Study ◽  
Anti Hiv ◽  
Hiv 1

A series of adamantine substituted imidazo[1,2-a]pyridine derivatives were developed through a one-pot multi-component Groebke–Blackburn–Bienaymé reaction, among them several compounds were identified to be the potent inhibitors against HIV-1 cells.

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