Antibacterial profile against drug-resistant Staphylococcus epidermidis clinical strain and structure–activity relationship studies of 1H-pyrazolo[3,4-b]pyridine and thieno[2,3-b]pyridine derivatives

2008 ◽  
Vol 16 (17) ◽  
pp. 8196-8204 ◽  
Author(s):  
Bruno Leal ◽  
Ilídio F. Afonso ◽  
Carlos R. Rodrigues ◽  
Paula A. Abreu ◽  
Rafael Garrett ◽  
...  
Keyword(s):  
Staphylococcus Epidermidis ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Clinical Strain ◽  
Drug Resistant ◽  
Pyridine Derivatives ◽  
Structure Activity

A facile one-pot multi-component synthesis of novel adamantine substituted imidazo[1,2-a]pyridine derivatives: identification and structure–activity relationship study of their anti-HIV-1 activity

RSC Advances ◽  
2016 ◽  
Vol 6 (97) ◽  
pp. 95177-95188 ◽  
Author(s):  
Tazeem Tazeem ◽  
Xin Han ◽  
Qingjun Zhou ◽  
Jingchen Wei ◽  
Po Tien ◽  
...  
Keyword(s):  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Pyridine Derivatives ◽  
One Pot ◽  
Structure Activity ◽  
Relationship Study ◽  
Anti Hiv ◽  
Hiv 1

A series of adamantine substituted imidazo[1,2-a]pyridine derivatives were developed through a one-pot multi-component Groebke–Blackburn–Bienaymé reaction, among them several compounds were identified to be the potent inhibitors against HIV-1 cells.

scholarly journals Synthesis and fungicidal activity of novel imidazo[4, 5-b]pyridine derivatives

2019 ◽  
Vol 25 (1) ◽  
pp. 8-14
Author(s):  
Daoxin Wu ◽  
Minhua Liu ◽  
Zhong Li ◽  
Mingming Dang ◽  
Xingping Liu ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Nmr Spectroscopy ◽  
Elemental Analysis ◽  
Fungicidal Activity ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Pyridine Derivatives ◽  
Structure Activity ◽  
Puccinia Polysora

AbstractA series of novel imidazo[4,5-b]pyridine derivatives were synthesized and their structures were characterized by NMR spectroscopy, mass spectrometry and elemental analysis. The results of bioassays showed that some compounds exhibit good fungicidal activity against Puccinia polysora In particular, compound 7b showed an EC50 value of 4.00 mg/L, which was comparable with that of tebuconazole. Besides, preliminary structure-activity relationship was discussed.

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