The thyroid hormone receptors as tumor suppressors

2011 ◽  
Vol 5 (2) ◽  
Author(s):  
Lidia Ruiz-Llorente ◽  
Olaia Martínez-Iglesias ◽  
Susana García-Silva ◽  
Stephan Tenbaum ◽  
Javier Regadera ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Thyroid Hormone ◽  
Malignant Transformation ◽  
Tumor Suppressors ◽  
Hormone Receptors ◽  
Thyroid Hormone Receptors ◽  
Growth Development ◽  
Transcriptional Induction

AbstractIn addition to the well-known role of the thyroid hormone receptors (TRs) in growth, development and metabolism, there is increasing evidence that they have profound effects on cell proliferation and malignant transformation. TRs repress transcriptional induction of

Thyroid Hormone Receptors and their Role in Cell Proliferation and Cancer

2021 ◽  
pp. 229-246
Author(s):  
Olaia Martínez-Iglesias ◽  
Lidia Ruiz-Llorente ◽  
Constanza Contreras Jurado ◽  
Ana Aranda
Keyword(s):  
Cell Proliferation ◽  
Thyroid Hormone ◽  
Hormone Receptors ◽  
Thyroid Hormone Receptors

scholarly journals The Thyroid Hormone Receptors as Modulators of Skin Proliferation and Inflammation

2011 ◽  
Vol 286 (27) ◽  
pp. 24079-24088 ◽  
Author(s):  
Constanza Contreras-Jurado ◽  
Laura García-Serrano ◽  
Mariana Gómez-Ferrería ◽  
Clotilde Costa ◽  
Jesús M. Paramio ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Hormone Receptors ◽  
Kinase Inhibitors ◽  
Skin Inflammation ◽  
Thyroid Hormone Receptors ◽  
Keratinocyte Proliferation ◽  
Functional Roles ◽  
Stat3 Phosphorylation ◽  
Interfollicular Epidermis

We have analyzed the role of the thyroid hormone receptors (TRs) in epidermal homeostasis. Reduced keratinocyte proliferation is found in interfollicular epidermis of mice lacking the thyroid hormone binding isoforms TRα1 and TRβ (KO mice). Similar results were obtained in hypothyroid animals, showing the important role of the liganded TRs in epidermal proliferation. In addition, KO and hypothyroid animals display decreased hyperplasia in response to 12-O-tetradecanolyphorbol-13-acetate. Both receptor isoforms play overlapping functional roles in the skin because mice lacking individually TRα1 or TRβ also present a proliferative defect but not as marked as that found in double KO mice. Defective proliferation in KO mice is associated with reduction of cyclin D1 expression and up-regulation of the cyclin-dependent kinase inhibitors p19 and p27. Paradoxically, ERK and AKT activity and expression of downstream targets, such as AP-1 components, are increased in KO mice. Increased p65/NF-κB and STAT3 phosphorylation and, as a consequence, augmented expression of chemokines and proinflammatory cytokines is also found in these animals. These results show that thyroid hormones and their receptors are important mediators of skin proliferation and demonstrate that TRs act as endogenous inhibitors of skin inflammation, most likely due to interference with AP-1, NF-κB, and STAT3 activation.

scholarly journals The Book of Opposites: The Role of the Nuclear Receptor Co-regulators in the Suppression of Epidermal Genes by Retinoic Acid and Thyroid Hormone Receptors

2005 ◽  
Vol 124 (5) ◽  
pp. 1034-1043 ◽  
Author(s):  
Sang H. Jho ◽  
Constantinos Vouthounis ◽  
Brian Lee ◽  
Olivera Stojadinovic ◽  
Mark J. Im ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Thyroid Hormone ◽  
Nuclear Receptor ◽  
Hormone Receptors ◽  
Thyroid Hormone Receptors

scholarly journals Role of Thyroid Hormone Receptors in Timing Oligodendrocyte Differentiation

2001 ◽  
Vol 235 (1) ◽  
pp. 110-120 ◽  
Author(s):  
Nathalie Billon ◽  
Yasuhito Tokumoto ◽  
Douglas Forrest ◽  
Martin Raff
Keyword(s):  
Thyroid Hormone ◽  
Hormone Receptors ◽  
Thyroid Hormone Receptors ◽  
Oligodendrocyte Differentiation

Regulation of SERCA 2 expression by thyroid hormone in cultured chick embryo cardiomyocytes

1996 ◽  
Vol 270 (2) ◽  
pp. H638-H644 ◽  
Author(s):  
D. J. Fisher ◽  
S. Phillips ◽  
T. McQuinn
Keyword(s):  
Thyroid Hormone ◽  
Uptake Rate ◽  
Hormone Receptors ◽  
Thyroid Hormone Receptor ◽  
Thyroid Hormone Receptors ◽  
Transcriptional Level ◽  
Cardiac Sarcoplasmic Reticulum ◽  
Mrna Content ◽  
Level Effect

We investigated the role of thyroid hormone in the physiological perinatal increase in cardiac sarcoplasmic reticulum (SR) Ca(2+)-adenosinetriphosphatase (ATPase) expression. We isolated and cultured the cardiomyocytes in 10(-8) M triiodothyronine (T3) for 48 h and then measured SR Ca(2+)-ATPase mRNA and immunodetectable protein contents as well as SR-dependent 45Ca2+ uptake rate. We also examined the effect of T3 on expression of the same gene in monkey kidney CV-1 cells, which do not express thyroid hormone receptors. T3 increased cardiomyocyte SR Ca2+ pump mRNA content by 289 +/- 35%, and immunodetectable SR Ca2+ pump protein content by 255 +/- 44%, and SR-specific 45Ca2+ uptake rate by 189 +/- 22% (P < 0.01 for each). In contrast, T3 had no significant effect on the total cellular RNA or protein contents in the cardiomyocyte, and there was no effect of T3 on Ca(2+)-ATPase mRNA content in the thyroid hormone receptor-negative CV-1 cells. These data demonstrate that T3 increases expression of the cardiac SR Ca2+ pump, that the effect can be localized to the cardiomyocyte, and that the effect is dependent on thyroid hormone receptors. These data are consistent with pretranslational and possibly transcriptional level effect of thyroid hormone on the cardiac SR Ca2+ pump gene (SERCA 2). The gestation-associated increase in thyroid hormone may be at least partially responsible for the previously demonstrated perinatal increase in cardiac SR Ca2+ pump expression.

scholarly journals New Approaches to Thyroid Hormones and Purinergic Signaling

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Gabriel Fernandes Silveira ◽  
Andréia Buffon ◽  
Alessandra Nejar Bruno
Keyword(s):  
Cell Proliferation ◽  
Thyroid Hormone ◽  
Thyroid Hormones ◽  
Neurotransmitter Release ◽  
Hormone Receptors ◽  
Target Genes ◽  
Purinergic Signaling ◽  
Thyroid Hormone Receptors ◽  
New Information ◽  
The Relationship

It is known that thyroid hormones influence a wide variety of events at the molecular, cellular, and functional levels. Thyroid hormones (TH) play pivotal roles in growth, cell proliferation, differentiation, apoptosis, development, and metabolic homeostasis via thyroid hormone receptors (TRs) by controlling the expression of TR target genes. Most of these effects result in pathological and physiological events and are already well described in the literature. Even so, many recent studies have been devoted to bringing new information on problems in controlling the synthesis and release of these hormones and to elucidating mechanisms of the action of these hormones unconventionally. The purinergic system was recently linked to thyroid diseases, including enzymes, receptors, and enzyme products related to neurotransmitter release, nociception, behavior, and other vascular systems. Thus, throughout this text we intend to relate the relationship between the TH in physiological and pathological situations with the purinergic signaling.

Thyroid Hormone Receptors and their Role in Cell Proliferation and Cancer

2014 ◽  
pp. 1-17
Author(s):  
Olaia Martínez-Iglesias ◽  
Lidia Ruiz-Llorente ◽  
Constanza Contreras Jurado ◽  
Ana Aranda
Keyword(s):  
Cell Proliferation ◽  
Thyroid Hormone ◽  
Hormone Receptors ◽  
Thyroid Hormone Receptors
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