Evaluation of anti-inflammatory and analgesic activities and the phytochemical study of Astragalus arbusculinus gum in animal models

2015 ◽  
Vol 26 (4) ◽  
Author(s):  
Asie Shojaii ◽  
Manijeh Motevalian ◽  
Nazanin Rahnama
Keyword(s):  
Aqueous Extract ◽  
Wistar Rats ◽  
Inflammatory Diseases ◽  
Phytochemical Study ◽  
Analgesic Effects ◽  
Male Wistar Rats ◽  
Anti Inflammatory ◽  
Analgesic Activities ◽  
First Time ◽  
Different Doses

AbstractThe importance of inflammatory diseases and side effects of conventional drugs necessitate the finding of new anti-inflammatory agents from natural sources. In this study, for the first time, the anti-inflammatory and analgesic effects of the aqueous extract ofThirty-five male Wistar rats were divided into five groups and pretreated with different doses ofThe extract ofThe aqueous extract of

scholarly journals Investigation of the Anti-Inflammatory and Analgesic Activities of Ethanol Extract of Stem Bark of SonapathaOroxylum indicum In Vivo

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
K. Lalrinzuali ◽  
M. Vabeiryureilai ◽  
Ganesh Chandra Jagetia
Keyword(s):  
Inflammatory Diseases ◽  
Ethanol Extract ◽  
Stem Bark ◽  
The Body ◽  
Protective Measure ◽  
Analgesic Effects ◽  
Oroxylum Indicum ◽  
Anti Inflammatory ◽  
Analgesic Activities

Inflammation is all a pervasive phenomenon, which is elicited by the body in response to obnoxious stimuli as a protective measure. However, sustained inflammation leads to several diseases including cancer. Therefore it is necessary to neutralize inflammation. Sonapatha (Oroxylum indicum), a medicinal plant, is traditionally used as a medicine in Ayurveda and other folk systems of medicine. It is commonly used to treat inflammatory diseases including rheumatoid arthritis and asthma. Despite this fact its anti-inflammatory and analgesic effects are not evaluated scientifically. Therefore, the anti-inflammatory and analgesic activities of Sonapatha (Oroxylum indicum) were studied in Swiss albino mice by different methods. The hot plate, acetic acid, and tail immersion tests were used to evaluate the analgesic activity whereas xylene-induced ear edema and formalin induced paw edema tests were used to study the anti-inflammatory activity of Sonapatha. The administration of mice with 250 and 300 mg/kg b.wt. ofO. indicumreduced pain and inflammation indicating that Sonapatha possesses analgesic and anti-inflammatory activities. The maximum analgesic and anti-inflammatory activities were observed in mice receiving 300 mg/kg b.wt. ofO. indicumethanol extract.Our study indicates thatO. indicumpossesses both anti-inflammatory and analgesic activities and it may be useful as an anti-inflammatory agent in the inflammation related disorders.

Analgesic and Anti-Inflammatory Effects of Aqueous Extract of Zea mays Husk in Male Wistar Rats

2010 ◽  
Vol 13 (2) ◽  
pp. 343-347 ◽  
Author(s):  
Bamidele V. Owoyele ◽  
Muhammed N. Negedu ◽  
Samuel O. Olaniran ◽  
Samuel A. Onasanwo ◽  
Stephen O. Oguntoye ◽  
...  
Keyword(s):  
Zea Mays ◽  
Aqueous Extract ◽  
Wistar Rats ◽  
Male Wistar Rats ◽  
Anti Inflammatory

Anti-inflammatory and antipyretic properties of Corchorus olitorius aqueous root extract in Wistar rats

2015 ◽  
Vol 26 (4) ◽  
Author(s):  
Bamidele V. Owoyele ◽  
Aboyeji L. Oyewole ◽  
Modupe L. Alimi ◽  
Shukurat A. Sanni ◽  
Sabitiu A. Oyeleke
Keyword(s):  
Aqueous Extract ◽  
Normal Saline ◽  
Wistar Rats ◽  
Root Extract ◽  
Corchorus Olitorius ◽  
Reference Groups ◽  
Male Wistar Rats ◽  
Anti Inflammatory ◽  
Aqueous Root Extract

AbstractThis study was designed to provide information about the antipyretic and anti-inflammatory effects ofThirty male Wistar rats were divided into six groups of five animals each; the control and reference groups were administered normal saline (10 mL/kg) and indomethacin (5 mg/kg), respectively, whereas the remaining four groups were administered aqueous extract ofThe results showed that

Ameliorating and anti-inflammatory role of Balanites aegyptiaca aqueous extract on Doxorubicin-induced hepatotoxicity in male Wistar rats

2021 ◽  
Vol 0 (0) ◽  
pp. 0
Author(s):  
KhaledG Abdel-Wahhab ◽  
HanaaF.A Elkareem ◽  
Abd El-NabyI Essawy ◽  
Mahmoud Ashry ◽  
ManalA Badawi
Keyword(s):  
Aqueous Extract ◽  
Wistar Rats ◽  
Balanites Aegyptiaca ◽  
Male Wistar Rats ◽  
Anti Inflammatory

scholarly journals Evaluation of Anti-inflammatory And Analgesic Activities of Methanolic Extract of Mitragyna Inermis

2018 ◽  
Vol 1 (2) ◽  
pp. 85-94
Author(s):  
M.M. Onakpa
Keyword(s):  
Acute Inflammation ◽  
Methanolic Extract ◽  
Inflammatory Diseases ◽  
The Body ◽  
Protective Measure ◽  
Analgesic Effects ◽  
Tail Immersion ◽  
Anti Inflammatory ◽  
Analgesic Activities ◽  
Mitragyna Inermis

Inflammation is a pervasive phenomenon elicited by the body in response to obnoxious stimuli as a protective measure. However, a sustained inflammation lead to several diseases including cancer therefore the necessity to neutralize inflammation is paramount. Mitragyna inermis is a medicinal plant traditionally used as a medicine in Ayurveda and other folk systems of medicine. It is commonly used to treat inflammatory diseases including rheumatoid arthritis and asthma. Despite this fact its anti-inflammatory and analgesic effects have not been evaluated scientifically. Therefore, the anti-inflammatory and analgesic activities of M. inermis were studied in Wistar rats by different methods. The hot plate, acetic acid, and tail immersion tests were used to evaluate the analgesic activity whereas paw edema model for acute inflammation using egg albumin were used to study the anti-inflammatory activity. The administration of 250 and 300 mg/kg to rats reduced pain and inflammation indicating that M. inermis possesses analgesic and anti-inflammatory activities. The maximum analgesic and anti-inflammatory activities were observed in rats receiving 300 mg/kg of M. inermis extract. This study indicates that methanolic extract of M. inermis possess both anti-inflammatory and analgesic activiti

Antitumoral and Anticholinesterasic Activities of the Seven Species from Rubiaceae

2019 ◽  
Vol 20 (4) ◽  
pp. 302-308 ◽  
Author(s):  
Carla R.F. Volobuff ◽  
Pedro C.O. Junior ◽  
Sidney M. dos Santos ◽  
Zefa V. Pereira ◽  
Diego C. Ferreira ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Biological Activities ◽  
Brain Structures ◽  
Acetylcholinesterase Inhibition ◽  
Mato Grosso ◽  
Male Wistar Rats ◽  
First Time ◽  
Mato Grosso Do Sul ◽  
Antiproliferative Activities ◽  
Mcf 7

Background: The genus Psychotria and Palicourea are reported as a source of alkaloids and iridoids, which exhibit biological activities. This study aimed to evaluate antiproliferative and anticholinesterase activities and quantification of the alkaloids of seven species among the genus found in Mato Grosso do Sul region in Brazil. Methods: Concentrations of alkaloids were measured spectrophotometrically. The extracts were submitted to antiproliferative activity against ten cell lines. The anticholinesterase activity of the extracts was developed using brain structures of male Wistar rats: cerebral cortex, hippocampus, hypothalamus and striatum by the Ellman method. Results: Alkaloids from Psychotria and Palicourea species were quantified which showed values of 47.6 to 21.9 µg/g. Regarding the antiproliferative potential, Palicourea crocea demonstrated selectivity against the 786-0 cell line (GI50: 22.87 µg/mL). Psychotria leiocarpa inhibited cell growth against OVCAR-3 (GI50: 3.28 µg/mL), K-562 (GI50: 5.26 µg/mL), HaCaT (GI50: 27.20 µg/mL), PC-3 (GI50: 34.92 µg/mL), MCF-7 (GI50: 35.80 µg/mL) and P. capillacea showed activity against OVCAR-3 (GI50: 2.33 µg/ml) and U251 (GI50: 16.66 µg/ml). The effect of acetylcholinesterase inhibition was more effective in the hippocampus, demonstrating inhibition for Paliourea crocea, Psychotria deflexa, P. brachybotrya and P. leiocarpa of 70%, 57%, 50% and 40%, respectively, followed by P. poeppigiana and P. capillacea, inhibiting 21%, compared to the control. Conclusion: Herein, the present work showed for the first time, anticholinesterasic and antiproliferative activities of extracts of Palicourea and Psychotria seem to be mainly associated with the levels of alkaloids in the leaves of these species.

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