scholarly journals Case Report. Extracorporeal Membrane Oxygenation in Nivolumab Associated Pneumonitis

2017 ◽  
Vol 3 (2) ◽  
pp. 84-88
Author(s):  
Thomas-Michael Schneider ◽  
Friederike Klenner ◽  
Franz Brettner
Keyword(s):  
Case Report ◽  
Extracorporeal Membrane Oxygenation ◽  
Therapeutic Option ◽  
High Dose ◽  
Great Success ◽  
Case Presentation ◽  
Computed Tomographic ◽  
Rehabilitation Hospital ◽  
Membrane Oxygenation ◽  
History Of

Abstract Background: Newly approved immunotherapeutic agents, like CTLA-4 inhibitors and antibodies against PD-1, are a promising therapeutic option in cancer therapy. Case presentation: A 74-year-old man, with a history of advanced stage melanoma and treatment with ipilimumab, pembrolizumab and nivolumab, was admitted to the hospital due to respiratory failure with hypoxemia and dyspnoea. He rapidly developed severe acute respiratory distress syndrome (ARDS), which required treatment in the intensive care unit which included mechanical ventilation and extracorporeal membrane oxygenation (ECMO). Computed tomographic imaging (CT) showed signs of a pneumonitis, with an ARDS pattern related to the use of PD-1 antibodies. Treating the patient with high-dose immunosuppressive steroids led to an overall improvement. He was transferred to a rehabilitation hospital and subsequently to his home. Discussion and conclusion: This is a unique case report of a patient suffering a grade 4 adverse event under nivolumab who survived having been treated with ECMO. It highlights the possibility of associated adverse reactions as well as the use of ECMO in palliative care patients. ECMO can be of great success even in patients with malignancies, but careful decision making should be done on a case by case basis.

scholarly journals Suspected Heparin-Induced Thrombocytopenia in a COVID-19 Patient on Extracorporeal Membrane Oxygenation Support: A Case Report.

2020 ◽  
Author(s):  
Xuan T. Phan ◽  
Tuan Huu Nguyen ◽  
Tung T. Tran ◽  
Thu-Hien T. Huynh ◽  
Thuy-Ha T. Hoang ◽  
...  
Keyword(s):  
Case Report ◽  
Adverse Events ◽  
Extracorporeal Membrane Oxygenation ◽  
Ecmo Support ◽  
Specific Situation ◽  
Heparin Induced Thrombocytopenia ◽  
Case Presentation ◽  
Membrane Oxygenation ◽  
Life Saving ◽  
Number Of Patients

Abstract Background: Extracorporeal membrane oxygenation (ECMO) support can be life-saving in critically ill COVID-19 patients. However, there are many complications associated with this procedure, including Heparin-induced thrombocytopenia (HIT.) Despite its rarity in ECMO cases, HIT can lead to devastating consequences and is difficult to manage. Case presentation: In this report, we present a case of a COVID-19 patient on ECMO support who was diagnosed with HIT and required intensive treatment. Initially, HIT was only suspected due to newly-developed thrombocytopenia and oxygenator dysfunction, with thrombi observed later. Regarding his treatment, since there was no recommended replacement to heparin available to us at the time of diagnosis, we decided to use rivaroxaban temporarily. No adverse events were recorded during that period. The patient was able to make a full recovery.Conclusion: HIT may jeopardize patient’s care during ECMO. As COVID-19 may bring about a surge in the number of patients requiring ECMO support, we need consented guidance to optimize treatment in this specific situation.

scholarly journals Extracorporeal Membrane Oxygenation for Secondary Organizing Pneumonia after Severe SARS-CoV-2 Infection: A Case Report

Medicina ◽  
2021 ◽  
Vol 57 (10) ◽  
pp. 1013
Author(s):  
Tomoyuki Kimura ◽  
Chisato Onitsuka ◽  
Tomoko Kawahara ◽  
Yosuke Fukuda ◽  
Tetsuya Homma ◽  
...  
Keyword(s):  
Case Report ◽  
Extracorporeal Membrane Oxygenation ◽  
Large Scale ◽  
Late Phase ◽  
Treatment Strategies ◽  
Favorable Outcome ◽  
Organizing Pneumonia ◽  
Case Presentation ◽  
Membrane Oxygenation ◽  
Life Threatening

(Background) COVID-19 is caused by SARS-CoV-2 infection and may result in unfavorable outcomes. A recent large-scale study showed that treatment with dexamethasone leads to favorable outcomes in patients with severe COVID-19, and the use of extracorporeal membrane oxygenation (ECMO) has also been shown to improve outcomes. Recently, secondary organizing pneumonia (SOP) has been reported after SARS-CoV-2 infection, but the diagnostic and treatment strategies are still unclear. (Case presentation) Here, we report a patient with severe COVID-19 who developed SOP even after the use of dexamethasone, for whom the introduction of ECMO on the 19th day after hospitalization led to a favorable outcome. (Conclusions) Life-threatening SOP may evolve even after the use of dexamethasone, and the late-phase introduction of ECMO may save such patients with COVID-19.

scholarly journals Successfully Treatment of Application Awake Extracorporeal Membrane Oxygenation in Critical COVID-19 Patient: A Case Report

2020 ◽  
Author(s):  
Junyi Tang ◽  
Wencan Li ◽  
Fanli Jiang ◽  
Tao Wang
Keyword(s):  
Public Health ◽  
Case Report ◽  
Infectious Diseases ◽  
Extracorporeal Membrane Oxygenation ◽  
Female Patient ◽  
Cardiac Failure ◽  
Public Health Emergency ◽  
Case Presentation ◽  
Membrane Oxygenation

Abstract Background: A newly infectious diseases named coronavirus disease 2019 (COVID-19) emerged in China and now has spread in many countries, and constituted a public health emergency of international concern. Extracorporeal membrane oxygenation (ECMO) is used as salvage therapies in critical COVID-19 patients with respiratory/cardiac failure. Case presentation: A 49-year-old female patient was diagnosed with COVID-19 and progressed to critical cases, she was successfully treated with the application of awake extracorporeal membrane oxygenation. This case is the first reported successfully treatment of application awake ECMO in critical COVID-19 patient in China.Conclusions: Here we present the first reported successfully treatment of application awake ECMO in critical COVID-19 patient, however, whether awake ECMO can be widely used in the treatment of critical COVID-19 patients need more practice.

scholarly journals Suspected Heparin-Induced Thrombocytopenia in a COVID-19 Patient on Extracorporeal Membrane Oxygenation Support: A Case Report.

2020 ◽  
Author(s):  
Xuan T. Phan ◽  
Tuan Huu Nguyen ◽  
Tung T. Tran ◽  
Thu-Hien T. Huynh ◽  
Thuy-Ha T. Hoang ◽  
...  
Keyword(s):  
Case Report ◽  
Adverse Events ◽  
Extracorporeal Membrane Oxygenation ◽  
Ecmo Support ◽  
Specific Situation ◽  
Heparin Induced Thrombocytopenia ◽  
Case Presentation ◽  
Membrane Oxygenation ◽  
Life Saving ◽  
Number Of Patients

Abstract Background: Extracorporeal membrane oxygenation (ECMO) support can be life-saving in critically ill COVID-19 patients. However, there are many complications associated with this procedure, including Heparin-induced thrombocytopenia (HIT.) Despite its rarity in ECMO cases, HIT can lead to devastating consequences and is difficult to manage. Case presentation: In this report, we present a case of a COVID-19 patient on ECMO support who was diagnosed with HIT and required intensive treatment. Initially, HIT was only suspected due to newly-developed thrombocytopenia and oxygenator dysfunction, with thrombi observed later. Regarding his treatment, since there was no recommended replacement to heparin available to us at the time of diagnosis, we decided to use rivaroxaban temporarily. No adverse events were recorded during that period. The patient was able to make a full recovery. Conclusion: HIT may jeopardize patient’s care during ECMO. As COVID-19 may bring about a surge in the number of patients requiring ECMO support, we need consented guidance to optimize treatment in this specific situation.

scholarly journals Suspected heparin-induced thrombocytopenia in a COVID-19 patient on extracorporeal membrane oxygenation support: a case report

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Xuan T. Phan ◽  
Tuan H. Nguyen ◽  
Tung T. Tran ◽  
Thu-Hien T. Huynh ◽  
Thuy-Ha T. Hoang ◽  
...  
Keyword(s):  
Case Report ◽  
Adverse Events ◽  
Extracorporeal Membrane Oxygenation ◽  
Ecmo Support ◽  
Specific Situation ◽  
Heparin Induced Thrombocytopenia ◽  
Case Presentation ◽  
Membrane Oxygenation ◽  
Life Saving ◽  
Number Of Patients

Abstract Background Extracorporeal membrane oxygenation (ECMO) support can be life-saving in critically ill COVID-19 patients. However, there are many complications associated with this procedure, including Heparin-induced thrombocytopenia (HIT.) Despite its rarity in ECMO cases, HIT can lead to devastating consequences and is difficult to manage. Case presentation In this report, we present a case of a COVID-19 patient on ECMO support who was diagnosed with HIT and required intensive treatment. Initially, HIT was only suspected due to newly-developed thrombocytopenia and oxygenator dysfunction, with thrombi observed later. Regarding his treatment, since there was no recommended replacement to heparin available to us at the time of diagnosis, we decided to use rivaroxaban temporarily. No adverse events were recorded during that period. The patient was able to make a full recovery. Conclusion HIT may jeopardize patient’s care during ECMO. As COVID-19 may bring about a surge in the number of patients requiring ECMO support, we need consented guidance to optimize treatment in this specific situation.

scholarly journals Suspected Heparin-Induced Thrombocytopenia in a COVID-19 Patient on Extracorporeal Membrane Oxygenation Support: A Case Report.

2020 ◽  
Author(s):  
Xuan T. Phan ◽  
Tuan Huu Nguyen ◽  
Tung T. Tran ◽  
Thu-Hien T. Huynh ◽  
Thuy-Ha T. Hoang ◽  
...  
Keyword(s):  
Case Report ◽  
Adverse Events ◽  
Extracorporeal Membrane Oxygenation ◽  
Ecmo Support ◽  
Specific Situation ◽  
Heparin Induced Thrombocytopenia ◽  
Case Presentation ◽  
Membrane Oxygenation ◽  
Life Saving ◽  
Number Of Patients

Abstract Background: Extracorporeal membrane oxygenation (ECMO) support can be life-saving in critically ill COVID-19 patients. However, there are many complications associated with this procedure, including Heparin-induced thrombocytopenia (HIT.) Despite its rarity in ECMO cases, HIT can lead to devastating consequences and is difficult to manage. Case presentation: In this report, we present a case of a COVID-19 patient on ECMO support who was diagnosed with HIT and required intensive treatment. Initially, HIT was only suspected due to newly-developed thrombocytopenia and oxygenator dysfunction, with thrombi observed later. Regarding his treatment, since there was no recommended replacement to heparin available to us at the time of diagnosis, we decided to use rivaroxaban temporarily. No adverse events were recorded during that period. The patient was able to make a full recovery.Conclusion: HIT may jeopardize patient’s care during ECMO. As COVID-19 may bring about a surge in the number of patients requiring ECMO support, we need consented guidance to optimize treatment in this specific situation.

scholarly journals Suspected Heparin-Induced Thrombocytopenia in a COVID-19 Patient on Extracorporeal Membrane Oxygenation Support: A Case Report.

2020 ◽  
Author(s):  
Xuan T. Phan ◽  
Tuan Huu Nguyen ◽  
Tung T. Tran ◽  
Thu-Hien T. Huynh ◽  
Thuy-Ha T. Hoang ◽  
...  
Keyword(s):  
Case Report ◽  
Adverse Events ◽  
Extracorporeal Membrane Oxygenation ◽  
Ecmo Support ◽  
Specific Situation ◽  
Heparin Induced Thrombocytopenia ◽  
Case Presentation ◽  
Membrane Oxygenation ◽  
Life Saving ◽  
Number Of Patients

Abstract Background: Extracorporeal membrane oxygenation (ECMO) support can be life-saving in critically ill COVID-19 patients. However, there are many complications associated with this procedure, including Heparin-induced thrombocytopenia (HIT.) Despite its rarity in ECMO cases, HIT can lead to devastating consequences and is difficult to manage.Case presentation: In this report, we present a case of a COVID-19 patient on ECMO support who was diagnosed with HIT and required intensive treatment. Initially, the patient showed no remarkable sign of thrombosis and HIT was only suspected due to newly-developed thrombocytopenia and oxygenator dysfunction. Regarding his treatment, since there was no recommended replacement to heparin available to us at the time of diagnosis, we decided to use Rivaroxaban temporarily. No adverse events were recorded during that period. The patient was able to make a full recovery.Conclusion: HIT may jeopardize patient’s care during ECMO. As COVID-19 may bring about a surge in the number of patients requiring ECMO support, we need consented guidance to optimize treatment in this specific situation.

scholarly journals Successfully treatment of application awake extracorporeal membrane oxygenation in critical COVID-19 patient: a case report

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
Junyi Tang ◽  
Wencan Li ◽  
Fanli Jiang ◽  
Tao Wang
Keyword(s):  
Public Health ◽  
Case Report ◽  
Infectious Diseases ◽  
Extracorporeal Membrane Oxygenation ◽  
Female Patient ◽  
Cardiac Failure ◽  
Public Health Emergency ◽  
Case Presentation ◽  
Membrane Oxygenation

Abstract Background A newly infectious diseases named coronavirus disease 2019 (COVID-19) emerged in China and now has spread in many countries, and constituted a public health emergency of international concern. Extracorporeal membrane oxygenation (ECMO) is used as salvage therapies in critical COVID-19 patients with respiratory/cardiac failure. Case presentation A 49-year-old female patient was diagnosed with COVID-19 and progressed to critical cases, she was successfully treated with the application of awake extracorporeal membrane oxygenation. This case is the first reported successfully treatment of application awake ECMO in critical COVID-19 patient in China. Conclusions Here we present the first reported successfully treatment of application awake ECMO in critical COVID-19 patient, however, whether awake ECMO can be widely used in the treatment of critical COVID-19 patients need more practice.

Application of extracorporeal membrane oxygenation in severe ARDS secondary to pneumonia: a case report

Open Medicine ◽  
2013 ◽  
Vol 8 (5) ◽  
pp. 658-661
Author(s):  
Xi-Hong Zhang ◽  
Rui-Xia Xiu ◽  
Tie-Jun Wu ◽  
Xiu-Li Zou ◽  
Long-Le Ma ◽  
...  
Keyword(s):  
Mechanical Ventilation ◽  
Acute Respiratory Distress Syndrome ◽  
Case Report ◽  
Extracorporeal Membrane Oxygenation ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Distress Syndrome ◽  
Therapeutic Option ◽  
Conventional Mechanical Ventilation ◽  
Membrane Oxygenation

AbstractThis report describes a 24-year-old patient with marked and continuous hypoxemia resulting from severe acute respiratory distress syndrome (ARDS) secondary to pneumonia, which in turn was refractory to mechanical ventilation and other conventional adjunctive therapies. Veno-venous extracorporeal membrane oxygenation (ECMO) was applied for 14 days and resulted in significant improvement in the hypoxemia. We conclude that ECMO presents a therapeutic option for ARDS patients who fail to respond to conventional mechanical ventilation.

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