Burning mouth syndrome: a review of therapeutic approach

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Tahereh Nosratzehi
Keyword(s):  
Therapeutic Approach ◽  
Botulinum Toxin A ◽  
Burning Mouth Syndrome ◽  
Therapeutic Interventions ◽  
Cochrane Library ◽  
Pharmacological Treatments ◽  
Therapeutic Approaches ◽  
Wide Range ◽  
Detailed Assessment ◽  
Burning Mouth

Abstract Burning mouth syndrome (BMS) is described by an intense burning sensation of the tongue or other oral areas without a clear etiopathology. The diagnosis of BMS is challenging due to variations of manifestations. The management of BMS is complicated due to the complex etiology of the disease. Many medications and treatment methods have been recommended for BMS management, but no one confirmed as the standard method. In this study, the therapeutic approaches of BMS were evaluated. The data of the article was obtained from PubMed/MEDLINE, Cochrane Library, and Web of Science. The following terms including “burning mouth syndrome”, “therapy”, and “treatment” were used for search in the databases. A wide range of articles about the therapeutic approach of BMS was searched and reviewed. Pharmacological and non-pharmacological approaches have been used for BMS management. Pharmacological treatments are including Capsaicin, Clonazepam, Low-dose aripiprazole, Alpha-lipoic acid, Duloxetine, Amitriptyline, Gabapentin, and Pregabalin, and ultra-micronized palmitoylethanolamide. Non-pharmacological therapies for BMS are cognitive therapy, Electroconvulsive therapy, Laser therapy, Acupuncture and auriculotherapy, Transcranial Magnetic Stimulation (rTMS), Salivary Mechanical Stimulation, and Botulinum Toxin. A detailed assessment of the etiology and pathophysiology of BMS, and having information about novel therapeutic interventions are essential for the management of BMS.

scholarly journals Burning Mouth Syndrome: Case Reports

2020 ◽  
Vol 5 (4) ◽  
pp. 76-78
Author(s):  
Catarina da Costa Campos ◽  
Maria do Céu Ferreira ◽  
Joana Mesquita
Keyword(s):  
Psychological Factors ◽  
Case Reports ◽  
Burning Mouth Syndrome ◽  
Burning Sensation ◽  
Therapeutic Approaches ◽  
Physiological Factors ◽  
Common Chronic Disease ◽  
Clinically Normal ◽  
Nosological Entity ◽  
Burning Mouth

Burning mouth syndrome (BMS) is a relatively common chronic disease of unclear etiopathogenesis. It is defined as a distinctive nosological entity that includes all forms of burning sensation in the mouth, including stinging sensation or pain, in association with an oral mucosa that appears clinically normal, in the absence of local or systemic diseases. It was hypothesized that psychological factors could influence its appearance, but also physiological factors, with some authors suggesting a neuropathic etiology. Regarding the treatment of BMS, benefits were found in individual or group psychotherapy, as well as in psychopharmacological interventions, however its current therapeutic approach is not completely satisfactory. In this paper we describe two cases of BMS and discuss the possible etiopathogenesis and current therapeutic approaches.

scholarly journals Role of Photobiomodulation Therapy in Neurological Primary Burning Mouth Syndrome. A Systematic Review and Meta-Analysis of Human Randomised Controlled Clinical Trials

Pharmaceutics ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 1838
Author(s):  
Reem Hanna ◽  
Snehal Dalvi ◽  
Rene Jean Bensadoun ◽  
Judith E. Raber-Durlacher ◽  
Stefano Benedicenti
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Burning Mouth Syndrome ◽  
Photobiomodulation Therapy ◽  
Control Treatment ◽  
Time Interval ◽  
Treatment Protocols ◽  
Wide Range ◽  
Burning Mouth

Mitochondrial homeostasis is crucial for energy production and neuronal survival in neurological primary burning mouth syndrome (npBMS). Photobiomodulation therapy (PBMT) has been utilised in npBMS management, however, its role of intervention remains controversial. The aim of this systematic review and meta-analysis of CRD 42020198921 PROSPERO registration reference was to oversee and determine the efficacy of PBMT in patients with npBMS, identifying the gaps and bridge them by proposing recommendations for future studies purposes. PRISMA guidelines and Cochrane Collaboration recommendations followed. Various search engines employed to analyse a total of 351 studies of which 12 were included. A wide range of utilised PBM wavelengths was between 635–980 nm and the power output ranged between 30 mW and 4000 mW. A high risk of bias (RoB) was noted in 7 out of 12 included studies (58.3%), as results of qualitative analysis. Meta-analysis findings of 4 out of 12 studies showed statistically significant intergroup differences (SSID) for visual analogue scale (VAS) values (MD = −1.47; 95% CI = −2.40 to −0.53; Z = 3.07 (p = 0.002) whereas meta-analysis on 5 out of 12 studies revealed SSID for anxiety/depression and quality of life (MD = −1.47; 95% CI = −2.40 to −0.53; Z = 3.07 (p = 0.002), favouring PBMT group to the control treatment strategies. Despite the inconsistency and diversity in PBM parameters (wavelength, power, light source, spot size, emission mode, energy per point, total energy) and treatment protocols (exposure time, number of sessions, time interval between sessions, treatment duration)—majority of the included studies showed positive PBM results. The high RoB and meta-analytical heterogeneity in the eligible studies warrant the necessity to perform well-designed and robust RCTs after acknowledging the drawbacks of the available scientific literature and addressing our suggested recommendations highlighted in our review.

scholarly journals Burning mouth syndrome: A review on its diagnostic and therapeutic approach

2014 ◽  
Vol 6 (5) ◽  
pp. 21 ◽  
Author(s):  
R Aravindhan ◽  
Santhanam Vidyalakshmi ◽  
MuniapillaiSiva Kumar ◽  
C Satheesh ◽  
AMurali Balasubramanium ◽  
...  
Keyword(s):  
Therapeutic Approach ◽  
Burning Mouth Syndrome ◽  
Burning Mouth

scholarly journals Role of Receptors in Relation to Plaques and Tangles in Alzheimer’s Disease Pathology

2021 ◽  
Vol 22 (23) ◽  
pp. 12987
Author(s):  
Kavita Sharma ◽  
Samjhana Pradhan ◽  
Lawrence K. Duffy ◽  
Sabina Yeasmin ◽  
Nirajan Bhattarai ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Therapeutic Strategy ◽  
Neuronal Degeneration ◽  
Therapeutic Interventions ◽  
Therapeutic Approaches ◽  
Wide Range ◽  
Agonist And Antagonist ◽  
Viral Mimicry

Despite the identification of Aβ plaques and NFTs as biomarkers for Alzheimer’s disease (AD) pathology, therapeutic interventions remain elusive, with neither an absolute prophylactic nor a curative medication available to impede the progression of AD presently available. Current approaches focus on symptomatic treatments to maintain AD patients’ mental stability and behavioral symptoms by decreasing neuronal degeneration; however, the complexity of AD pathology requires a wide range of therapeutic approaches for both preventive and curative treatments. In this regard, this review summarizes the role of receptors as a potential target for treating AD and focuses on the path of major receptors which are responsible for AD progression. This review gives an overall idea centering on major receptors, their agonist and antagonist and future prospects of viral mimicry in AD pathology. This article aims to provide researchers and developers a comprehensive idea about the different receptors involved in AD pathogenesis that may lead to finding a new therapeutic strategy to treat AD.

Risk Factors in Burning Mouth Syndrome among Older Adults

2021 ◽  
Vol 15 (8) ◽  
pp. 2060-2063
Author(s):  
Muhammad Shoaib Yousaf ◽  
Muhammad Anwaar Alam ◽  
Mustafa Qadeer ◽  
Fareed Ahmad ◽  
Rabia Huma Riaz ◽  
...  
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Elderly People ◽  
Data Extraction ◽  
Burning Mouth Syndrome ◽  
Cochrane Library ◽  
Psychiatric Disease ◽  
Female Population ◽  
Aged People ◽  
Burning Mouth

Background of the study: A chronic and untraceable condition of pain is burning mouth syndrome (BMS) and is commonly observed in middle-aged and elderly people of both the genders. Many psychiatric disease that include anxiety levels, personality disorders and depressions are caused by oral problems i.e dysgeusia, burning mouth, oral malodour and dry mouth. Objective: This study aimed investigation of factors of risk associated with BMS in elderly people of both the genders. Design: It was a systematic review. Material and Methods: Inclusion and exclusion criteria were used and studies published from 2008 till date of review were included in the systematic review. For gathering relevant studies, some key words were used to find already published material i.e “elder, older, burning mouth syndrome / BMS, oral health problems, and elderly people”. Moreover, for enhancing relevancy and appropriateness, Boolean operators like AND, OR, double quotations, asterisk etc. were used. Popular and good reputed databases with peer-reviewed articles and journals were used that included PubMed health, Google scholar, EBSCO host, CINAHL, Embase and Cochrane Library. A table comprising of columns like study title, name of author, sample size, research objective, limitations and key findings was prepared for data extraction. Results: Based on moderate or strong quality, thirteen studies relevant to the objective were shortlisted. These studies had highlighted BMS as risk factor. It was held that female population is more affected by BMS in comparison with males and its prevalence is high in elderly aged people i.e. above 55-years age. Conclusion: From findings of the review, it is established that in older population numerous risk factors of BMS are dental procedures, increased age, lacking therapeutic treatments, lack of knowledge besides poor knowledge and practices of medical staff and poor care being given to older age people especially in post-menopausal stage in women. Keywords: Burning mouth syndrome, WHO, global population, post-menopause.

Comparison of Pharmacological Treatments for Burning Mouth Syndrome

2012 ◽  
Vol 55 (11) ◽  
pp. 707 ◽  
Author(s):  
Hyo Geun Choi ◽  
Eun-Jung Jung ◽  
Won Yong Lee ◽  
Heejin Kim ◽  
Wonjae Cha ◽  
...  
Keyword(s):  
Burning Mouth Syndrome ◽  
Pharmacological Treatments ◽  
Burning Mouth

Burning Mouth Syndrome: A Therapeutic Approach Involving Mechanical Salivary Stimulation

2011 ◽  
Vol 52 (6) ◽  
pp. 1026-1034 ◽  
Author(s):  
Fabrício T. A. de Souza ◽  
Tânia M. P. Amaral ◽  
Tálita P. M. dos Santos ◽  
Evandro N. Abdo ◽  
Maria C. F. Aguiar ◽  
...  
Keyword(s):  
Therapeutic Approach ◽  
Burning Mouth Syndrome ◽  
Burning Mouth

Management of isolated cricopharyngeal dysfunction: systematic review

2016 ◽  
Vol 130 (7) ◽  
pp. 611-615 ◽  
Author(s):  
A Ashman ◽  
O T Dale ◽  
D L Baldwin
Keyword(s):  
Systematic Review ◽  
Qualitative Analysis ◽  
Botulinum Toxin A ◽  
Case Series ◽  
Good Evidence ◽  
Therapeutic Interventions ◽  
Treatment Modalities ◽  
Cochrane Library ◽  
Safety And Efficacy ◽  
Cricopharyngeal Dysfunction

AbstractObjective:A systematic review was performed to evaluate the safety and efficacy of different therapeutic interventions available for the management of isolated cricopharyngeal dysfunction.Methods:Studies were identified using the following databases: Ovid (Medline, Embase), the Cochrane Library, PubMed and Google Scholar. An initial search identified 339 articles. All titles and abstracts were reviewed. Fifty-six relevant articles were inspected in more detail; of these, 47 were included in the qualitative analysis.Results:No relevant randomised trials were found. A range of case series were used to perform a qualitative analysis. Botulinum toxin A injection and cricopharyngeal dilatation were associated with a higher risk of recurrence, but appear to be more suitable in elderly and co-morbid patients. In those patients requiring formal myotomy, endoscopic approaches appear to be as effective but less morbid when compared with classical open surgery.Conclusion:There is good evidence for the safety and efficacy of the different therapeutic options for isolated cricopharyngeal dysfunction. However, further studies are required to compare the efficacy of the various treatment modalities.

Burning Mouth Syndrome

2013 ◽  
Vol 56 (9) ◽  
pp. 550
Author(s):  
Jae Won Chang ◽  
Chul-Ho Kim
Keyword(s):  
Burning Mouth Syndrome ◽  
Burning Mouth
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