Plasma but not serum brain-derived neurotrophic factor concentration is decreased by oral glucose tolerance test-induced hyperglycemia in children

2017 ◽  
Vol 30 (5) ◽  
Author(s):  
Shunsuke Araki ◽  
Yukiyo Yamamoto ◽  
Reiko Saito ◽  
Aoi Kawakita ◽  
Mami Eguchi ◽  
...  
Keyword(s):  
Glucose Tolerance ◽  
Oral Glucose Tolerance Test ◽  
Neurotrophic Factor ◽  
Plasma Levels ◽  
Glucose Tolerance Test ◽  
Serum Levels ◽  
Brain Derived Neurotrophic Factor ◽  
Tolerance Test ◽  
Oral Glucose ◽  
Oral Glucose Tolerance

AbstractBackground:Little is known regarding the relationships among circulating brain-derived neurotrophic factor (BDNF) levels and glucose or insulin in children and adolescents. The objective of this study was to investigate whether circulating BDNF levels would change during the oral glucose tolerance test (OGTT).Methods:We performed the OGTT and measured the serial changes in BDNF levels in both plasma and serum.Results:There were 22 subjects in the normal type (N) group and 20 in the borderline/diabetic type (B/D) group, defined by the results of the OGTT. Serum levels of BDNF were almost five times higher and plasma levels gradually decreased during the OGTT, whereas serum levels showed no significant change. The reduction of plasma BDNF level changes from baseline to 120 min were significantly different between the N and B/D groups (36.3% vs. 20.8%, p=0.023).Conclusions:Our results showed that plasma levels of BDNF are more sensitive to acute changes in glucose or insulin levels than serum.

scholarly journals Brain-Derived Neurotrophic Factor during Oral Glucose Tolerance Test Predicts Cardiovascular Outcomes

2020 ◽  
Vol 21 (14) ◽  
pp. 5008
Author(s):  
I-Te Lee ◽  
Yu-Hsuan Li ◽  
Wayne Huey-Herng Sheu
Keyword(s):  
Glucose Tolerance ◽  
Oral Glucose Tolerance Test ◽  
Primary Endpoint ◽  
Neurotrophic Factor ◽  
Glucose Tolerance Test ◽  
Brain Derived Neurotrophic Factor ◽  
Tolerance Test ◽  
Oral Glucose ◽  
Oral Glucose Tolerance

We investigated if brain-derived neurotrophic factor (BDNF) accumulation after glucose intake could predict cardiovascular outcomes. We enrolled patients admitted for angiography due to angina. After their conditions stabilized, serum BDNF levels were detected at 0, 30, and 120 min during oral glucose tolerance test (OGTT). Area under the curve (AUC) of BDNF was calculated. The first occurrence of nonfatal myocardial infarction, nonfatal stroke, and all-cause mortality served as the primary composite endpoint. Of 480 enrolled patients, 428 completed the follow-up, and 36 primary endpoint events occurred during a median follow-up of 4.4 years. The area under the receiver operating characteristic curve significantly increased from 0.61 (95% confidence interval (CI): 0.52–0.73) for the Framingham risk score (FRS) alone model to 0.72 (95%CI: 0.63–0.81) for the AUC of BDNF plus FRS model (p = 0.016) for predicting the primary endpoint, but not to 0.65 (95%CI: 0.55–0.75) for the fasting BDNF plus FRS model (p = 0.160). Grouped by median AUC of BDNF of 38.0 (ng/mL) × h, the low BDNF group had a significantly higher risk of the endpoint than the high BDNF group (hazard ratio = 3.410, 95%CI: 1.520–7.653, p = 0.003). In conclusion, AUC of BDNF during OGTT could be superior to fasting BDNF for predicting a low cardiovascular risk.

scholarly journals Serum angiopoietin-like 3 levels are elevated in obese non diabetic men but are unaffected during an oral glucose tolerance test

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Maria Fernanda Garcés ◽  
Julieth Daniela Buell-Acosta ◽  
Haiver Antonio Rodríguez-Navarro ◽  
Estefania Pulido-Sánchez ◽  
Juan José Rincon-Ramírez ◽  
...  
Keyword(s):  
Glucose Tolerance ◽  
Oral Glucose Tolerance Test ◽  
Glucose Tolerance Test ◽  
Area Under The Curve ◽  
Serum Levels ◽  
Tolerance Test ◽  
Oral Glucose ◽  
Oral Glucose Tolerance ◽  
Matsuda Index ◽  
Obese Subjects

AbstractThis study aimed to determine ANGPTL3 serum levels in healthy young lean and obese non-diabetic men during an oral glucose tolerance test (OGTT) and correlate them with anthropometric, biochemical and hormonal parameters. A case–control study was carried out and 30 young obese non-diabetic (23.90 ± 3.84 years and BMI 37.92 ± 4.85 kg/m2) and 28 age-matched healthy lean (24.56 ± 3.50 years and BMI of 22.10 ± 1.72 kg/m2) men were included in this study. The primary outcome measures were serum basal ANGPTL3 and ANGPTL3–area under the curve (AUC) levels. The percentage of body fat was measured by dual-energy X-ray absorptiometry and biochemical, hormonal and insulin resistance indices were determined. Basal ANGPTL3 and ANGPTL3–AUC levels were significantly elevated (p < 0.05) in young obese subjects compared with lean subjects and were positively and significantly associated with different anthropometric measurements. Fasting ANGPTL3 serum levels were positively correlated with fasting insulin, leptin, Leptin/Adiponectin index and triglyceride—glucose index. Moreover, ANGPTL3–AUC was negatively correlated with Matsuda index. In this regard, chronically high ANGPTL3 levels in young obese subjects might favor triglyceride-rich lipoprotein clearance to replenish triglyceride stores by white adipose tissue rather than oxidative tissues.

The role of ranitidine infusion on glucose, insulin and C-peptide serum levels induced by oral glucose tolerance test in healthy subjects

1986 ◽  
Vol 23 (2) ◽  
pp. 165-170 ◽  
Author(s):  
Sandro Gentile ◽  
Riccardo Marmo ◽  
Andrea Costume ◽  
Cosimo Orlando ◽  
Rita D’Alessandro ◽  
...  
Keyword(s):  
Glucose Tolerance ◽  
Oral Glucose Tolerance Test ◽  
Healthy Subjects ◽  
Glucose Tolerance Test ◽  
Serum Levels ◽  
Tolerance Test ◽  
Oral Glucose ◽  
Oral Glucose Tolerance ◽  
C Peptide
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