Pregnancy outcome and long-term follow-up of fetuses with isolated increased NT: a retrospective cohort study

To assess the prevalence of associated findings, diagnosed either prior to or after birth, among fetuses with increased nuchal translucency (NT) and normal karyotype and to investigate the prevalence of children under therapy at school age, among cases confirmed to be isolated both prior to and after birth.Retrospective cohort study of all singleton pregnancies were referred for the 1There were 19 106 women screened for Down syndrome. Among them, 846 (4.4%) had a NT >95Parents should be informed that fetuses with increased NT and normal karyotype need detailed ultrasound scans during pregnancy and detailed pediatric evaluation at birth; if these are normal, the risk from adverse outcome at school age is the same as for general population.