3D and 4D studies from human reproduction to perinatal medicine

2017 ◽  
Vol 45 (6) ◽  
Author(s):  
Sonal Panchal ◽  
Asim Kurjak ◽  
Chaitanya Nagori
Keyword(s):  
Prenatal Diagnosis ◽  
Congenital Malformations ◽  
Three Dimensional ◽  
Endometrial Receptivity ◽  
Human Reproduction ◽  
Fallopian Tubes ◽  
Perinatal Medicine ◽  
Tubal Patency ◽  
Pretreatment Assessment

AbstractThree-dimensional ultrasound (3D US) is a modality of choice for prenatal diagnosis of congenital malformations. But 3D-four-dimensional US(4D US) is of utmost importance also to achieve pregnancy. 3D US plays an important role for diagnosis of PCO, to assess ovarian reserve and response and thus to decide optimum stimulation protocols. It adds to the information on follicular maturity and endometrial receptivity, thus improving the chances to achieve pregnancy for patients under treatment for fertility. 3D hystero-contrast-salpingography (HyCoSy) has also proved itself to be one of the best modalities for assessment of tubal patency. In this article, the role of 3D and 4D US is discussed for the following. I. Pretreatment assessment of the females desiring fertility which includes assessment of uterus and fallopian tubes. II. Monitoring of infertile females undergoing treatment. III. Assessment of very early pregnancy – especially in abnormal locations.

Prenatal diagnosis of Pfeiffer syndrome and role of three-dimensional ultrasound: case report and review of literature

2021 ◽  
pp. 1-4
Author(s):  
Antonella Vimercati ◽  
Claudiana Olivieri ◽  
Miriam Dellino ◽  
Mattia Gentile ◽  
Raffaele Tinelli ◽  
...  
Keyword(s):  
Case Report ◽  
Prenatal Diagnosis ◽  
Three Dimensional ◽  
Review Of Literature ◽  
Pfeiffer Syndrome

scholarly journals Role of Three Dimensional Doppler Ultrasonography And Leukemia Inhibitory Factor From Endometrial Secretion In Predicting Clinical Pregnancy In IVF Treatment

2021 ◽  
Author(s):  
Ivan Sini ◽  
Nining Handayani ◽  
Ph.D Hara Alida MD ◽  
Arief Boediono ◽  
Budi Wiweko ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Leukemia Inhibitory Factor ◽  
Protein Concentration ◽  
Power Doppler ◽  
Three Dimensional ◽  
Endometrial Receptivity ◽  
Clinical Pregnancy ◽  
Inhibitory Factor ◽  
Flow Index

Abstract PurposeThis study aimed to evaluate the potential synergistic role of three-dimensional power Doppler angiography ultrasound and the expression of Leukemia Inhibitory factor (LIF) protein in predicting the endometrial receptivity of fresh In Vitro Fertilization (IVF) cycles. Materials and methods This prospective study involved 29 good prognosis women who underwent fresh IVF cycles with fresh blastocysts transfer. Serial measurements of sub-endometrial parameters via power Doppler angiography including vascularity index (VI), flow index (FI), and vascularization flow index (VFI) were conducted consecutively on the day of oocyte maturation trigger, ovum pick-up, and blastocyst transfer. Aspiration of endometrial secretion was performed on the day of embryo transfer. ResultsAfter performing multiple logistic regression analyses, the mean index of VI on the trigger day and LIF protein concentration at the window of implantation was significantly higher in clinically pregnant women than that of the non-pregnant women (p <0.05). The area under the curve (AUC) of LIF concentration was shown to have a powerful predictive value to forecast clinical pregnancy (0.884, p <0.05), with a cut-off value of 713 pg/mL. Likewise, VI index on the trigger day was adequate to become a predictor for the pregnancy event (AUC 0.803, the cut-off value >5.381, p<0.05). A combination of both variables utilizing the cut-off value was adequate for the differentiation of pregnant and non-pregnant cases (p <0.05). ConclusionVI index assessed on trigger day and the expression of LIF protein concentration at the window of implantation provided sufficient information to predict endometrial receptivity.

A STUDY ON THE ROLE OF SALINE SONOSALPINGOGRAPHY AS A TEST FOR TUBAL PATENCY IN THE ASSESSMENT OF INFERTILITY

2021 ◽  
pp. 80-82
Author(s):  
Bishnu Prasad Das ◽  
Manoj Kumar Majumdar ◽  
Chumi Deka
Keyword(s):  
Predictive Value ◽  
High Sensitivity ◽  
Fallopian Tubes ◽  
Perfect Agreement ◽  
Tubal Patency ◽  
Primary Health ◽  
Infertility Patients ◽  
Work Up ◽  
Tubal Pathology

Background: Tubal pathology is one of the major causes of infertility and evaluation of fallopian tubes forms an essential part of work up of infertility patients. The aim of the study was to evaluate tubal patency by Saline Sonosalpingography and compare the results with that of hysterosalpingography. Methods: A total of 22 patients with primary infertility and 13 patients with secondary infertility attending our Obstetrics and Gynecology department were recruited for the study from July 2019 to June 2020. All the study subjects underwent Saline Sonosalpingography on day 7 to day 9 and Hysterosalpingography on 7th to 11th day of the menstrual cycle. Data was collected and compared to assess the sensitivity and specicity of Sonosalpingography with Hysterosalpingography as reference standard. Results: Sonosalpingography (SSG) has 98.18% sensitivity and 66.67% specicity in comparison to hysterosalpingography (HSG). Analysis of the raw data gave positive predictive value of 91.52% and negative predictive value of 90.9%. Near perfect agreement (Cohen's Kappa coefcient =0.9) was seen between the results of the two methods (SSG and HSG). Conclusions: Sonosalpingogrpahy has a high sensitivity for tubal patency and is less invasive. It is found to be a reliable and relatively less expensive diagnostic procedure in the management of infertility in females. Easy availability and accessibility of ultrasound in all primary health care centres denitely can prove superior to conventional method of diagnosis of tubal patency in such patient.

Three-dimensional Hysterosalpingo Contrast Sonography with Lignosal as Contrast for Evaluation of Tubal Patency in the Infertile Women – An Observational Cohort Study

2019 ◽  
Vol 2 ◽  
pp. 4
Author(s):  
Chegondi V N Rao ◽  
Chegondi Sindhu ◽  
Murali Krishna Kota
Keyword(s):  
Three Dimensional ◽  
Second Phase ◽  
Imaging Method ◽  
Fallopian Tubes ◽  
Tubal Patency ◽  
Tubal Occlusion ◽  
Infertile Women ◽  
Institutional Review ◽  
Observational Cohort ◽  
Infertile Patients

Objectives The objectives of the study were to evaluate the two-dimensional (2D)/three-dimensional (3D) hysterosalpingo contrast sonography (HyCoSy) using lignosal (a mixture of lignocaine 2% jelly with normal saline) as a contrast agent for assessing fallopian tubal patency in infertile patients. Materials and Methods After obtaining the Institutional Review Board permission, a single center prospective study was conducted to evaluate the validity of 3D-HyCoSy with lignosal to assess the patency of fallopian tubes in infertile women. In total 540 infertile patients were recruited for this study. Bilateral fallopian tube patency was confirmed when fallopian tubes were seen as echogenic tubular structures with peritoneal spill under real-time 3D/2D-HyCoSy. Results In the first phase of the study, 2D-HyCoSy without 3D acquisition was made in 20 patients (40 tubes). 2D-HyCoSy with lignosal contrast shown tubal patency in 95% and radiographic hysterosalpingography (HSG) resulted in 97.5% tubal patency with 5% inconclusive results by HyCoSy. In the second phase, data from 520 patients showed bilateral tubal patency in 463 patients (89.03%), unilateral tubal occlusion in 49 patients (9.42%), and bilateral tubal occlusion in eight patients (1.53%). No untoward side effects were noticed and reported by the patients during and after the HyCoSy procedure with lignosal. Conclusions 3D-HyCoSy with lignosal allowed the entire length of the fallopian tubes to be seen as contrast moved through the fallopian tubes to the fimbrial end. A “shower” of contrast around the ovaries is visualized confirming the peritoneal spill. Use of lignosal provides an alternative imaging method for evaluating the tubal patency in infertile patients.

scholarly journals Combined Real-Time Three-Dimensional Hysterosalpingo-Contrast Sonography with B Mode Hysterosalpingo-Contrast Sonography in the Evaluation of Fallopian Tube Patency in Patients Undergoing Infertility Investigations

2019 ◽  
Vol 2019 ◽  
pp. 1-7 ◽  
Author(s):  
Sumin Chen ◽  
Xiya Du ◽  
Qingzi Chen ◽  
Shaoqi Chen
Keyword(s):  
Contrast Agent ◽  
Real Time ◽  
Three Dimensional ◽  
Kappa Coefficient ◽  
Fallopian Tubes ◽  
Agreement Rate ◽  
Tubal Patency ◽  
Medical College ◽  
Infertility Patients ◽  
Distal Occlusion

Objective. This prospective study aimed to investigate the use of real-time three-dimensional hysterosalpingo-contrast sonography (4D-HyCoSy), using contrast agent SonoVue, with B mode hysterosalpingo-contrast sonography (B mode-HyCoSy), to evaluate tubal patency and the wall of the Fallopian tubes in infertility patients. Method. In total, we recruited 739 women with fertility requirements from the First Affiliated Hospital of Shantou Medical College between January 2017 and July 2018. All cases received 4D-HyCoSy using contrast agent SonoVue, immediately followed by the B mode-HyCoSy. Of these patients, 145 showed pathological findings in the Fallopian tubes during HyCoSy; 34 of these (62 Fallopian tubes) were verified by laparoscopy and the dye test against routine reference standards. Sonographic findings, along with laparoscopic findings and dye test results, were used to compare the two techniques using the Cohen kappa coefficient. We also investigated the duration of examination and pain score. Results. Compared with laparoscopy and the dye test, the tubal occlusion diagnostic accordance rates for 4D-HyCoSy were 88.7% (32+23)/62, with a kappa coefficient of 0.769 and a 76.9% agreement rate. Distal occlusion diagnostic accordance rates for 4D-HyCoSy were 100% (8/8) with a k coefficient of 1.000 and a 100% agreement rate. Conclusions. The use of 4D-HyCoSy, with B mode-HyCoSy, for the diagnosis of tubal patency is safe, feasible, noninvasive, and highly accurate. B mode-HyCoSy allowed us to observe tubal walls in an intuitive manner.

Prenatal diagnosis of vertebral deformities associated with pentalogy of Cantrell: The role of three-dimensional sonography?

2010 ◽  
Vol 38 (8) ◽  
pp. 446-449 ◽  
Author(s):  
İsmet Gün ◽  
Mertihan Kurdoğlu ◽  
Ercüment Müngen ◽  
Murat Muhcu ◽  
Ali Babacan ◽  
...  
Keyword(s):  
Prenatal Diagnosis ◽  
Three Dimensional ◽  
Pentalogy Of Cantrell ◽  
Vertebral Deformities

The role of vitamin D in metabolic and reproductive disturbances of polycystic ovary syndrome: A narrative mini-review

2020 ◽  
pp. 1-8
Author(s):  
Daniela Menichini ◽  
Gianpiero Forte ◽  
Beatrice Orrù ◽  
Giuseppe Gullo ◽  
Vittorio Unfer ◽  
...  
Keyword(s):  
Vitamin D ◽  
Polycystic Ovary Syndrome ◽  
Embryo Quality ◽  
Polycystic Ovary ◽  
Vitamin D Supplementation ◽  
Endometrial Receptivity ◽  
Metabolic Disturbances ◽  
Ovary Syndrome ◽  
Beneficial Role

Abstract. Vitamin D is a secosteroid hormone that plays a pivotal role in several metabolic and reproductive pathways in humans. Increasing evidence supports the role of vitamin D deficiency in metabolic disturbances and infertility in women with polycystic ovary syndrome (PCOS). Indeed, supplementation with vitamin D seems to have a beneficial role on insulin resistance and endometrial receptivity. On the other hand, exceedingly high levels of vitamin D appear to play a detrimental role on oocytes development and embryo quality. In the current review, we summarize the available evidence about the topic, aiming to suggest the best supplementation strategy in women with PCOS or, more generally, in those with metabolic disturbances and infertility. Based on the retrieved data, vitamin D seems to have a beneficial role on IR, insulin sensitivity and endometrial receptivity, but high levels and incorrect timing of administration seem to have a detrimental role on oocytes development and embryo quality. Therefore, we encourage a low dose supplementation (400–800 IU/day) particularly in vitamin D deficient women that present metabolic disturbances like PCOS. As far as the reproductive health, we advise vitamin D supplementation in selected populations, only during specific moments of the ovarian cycle, to support the luteal phase. However, ambiguities about dosage and timing of the supplementation still emerge from the clinical studies published to date and further studies are required.

The Role of Three-Dimensional Imaging in Evaluation of the Sinonasal Mass

1996 ◽  
Vol 34 (1) ◽  
pp. 27
Author(s):  
Sue Yon Shim ◽  
Ki Joon Sung ◽  
Young Ju Kim ◽  
In Soo Hong ◽  
Myung Soon Kim ◽  
...  
Keyword(s):  
Three Dimensional ◽  
Three Dimensional Imaging ◽  
Sinonasal Mass
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