Pregnancy outcome following bacteriuria in pregnancy and the significance of nitrites in urinalysis – a retrospective cohort study

2019 ◽  
Vol 47 (6) ◽  
pp. 611-618
Author(s):  
Eviatar Naamany ◽  
Irit Ayalon-Dangur ◽  
Eran Hadar ◽  
Iftach Sagy ◽  
Dafna Yahav ◽  
...  
Keyword(s):  
Cohort Study ◽  
Pregnant Women ◽  
Retrospective Cohort Study ◽  
Pregnancy Outcomes ◽  
Retrospective Cohort ◽  
Urine Culture ◽  
Premature Delivery ◽  
Positive Urine Culture ◽  
Positive Urine ◽  
Adverse Pregnancy

Abstract Background The association between bacteriuria and adverse pregnancy outcomes has been extensively described. The current practice of screening all pregnant women for bacteriuria is challenged by recent studies. We aimed to evaluate pregnancy outcomes among women with a positive urine culture, to assess the significance of positive urinary nitrites in this setting. Methods This was a retrospective cohort study at the emergency department (ED) of the Helen Schneider Hospital for Women, Israel, during 2014–2018. This included all gravida women >18 years old within the 20th week of pregnancy or above, admitted to the ED with diverse complains, who had urinalysis collected and subsequently had a positive urine culture. Clinical and obstetric characteristics were stratified by positive vs. negative nitrites in urinalysis. The primary outcome was premature delivery, and the secondary outcomes were a composite outcome of all recorded pregnancy complications and the significance of urinalysis in predicting urinary tract infection (UTI). Results Overall, 874 pregnant women with a positive urine culture were included. Of them, 721 (79%) patients had a negative nitrite in their urine exam (NNU-group) and 153 (21%) had a positive nitrite in their urine exam (PNU-group). Escherichia coli was the most common pathogen, with significantly higher rates of growth in the PNU-group vs. NNU-group [129 (84.3%) vs. 227 (38.4%), P < 0.001]. Premature delivery was recorded with no association of symptomaticity or nitrite status. Among symptomatic women with classic symptoms of UTI, PNU was significantly associated with decreased risk for major peripartum complications [odds ratio (OR) with 95% confidence interval (CI) of 0.22 (0.05–0.94)]. Conclusion Our findings support that PNU among symptomatic pregnant women with UTI-related symptoms was associated with lower risk of developing major adverse obstetrical outcomes.

scholarly journals Pregnancy outcomes with Primary Sjogren's syndrome among Chinese women: a retrospective cohort study

2019 ◽  
Author(s):  
Jinfeng Xu ◽  
Daijuan Chen ◽  
Yuan Tian ◽  
Bing Peng
Keyword(s):  
Logistic Regression ◽  
Cohort Study ◽  
Pregnant Women ◽  
Retrospective Cohort Study ◽  
Pregnancy Outcomes ◽  
Retrospective Cohort ◽  
Primary Sjögren’S Syndrome ◽  
Odds Ratios ◽  
Primary Sjogren’S Syndrome ◽  
Adverse Pregnancy

Abstract Background Data on pregnancy outcomes in Primary Sjogren's syndrome (pSS) women are scarce, and results have been conflicting. The aim of our study is to analyze the adverse pregnancy outcome in patients with pSS. Methods This was a retrospective cohort study conducted at a tertiary medical center located in Chengdu, Sichuan, China, from May 2013 to November 2018. The relevant medical records of all pregnant women were retrospectively reviewed. Logistic regression analyses were performed to compute crude odds ratios (crude OR) with 95% confidence intervals (CI) for maternal and fetal outcomes. Adjusted odds ratios (aOR) were estimated by logistic regression adjusted for confounders. Results Women with pSS had a significantly higher incidence of pre-eclampsia (aOR 11.49, 95% CI 1.65-79.98), PPROM (aOR 5.09, 95% CI 1.14-22.63). Compared to general population, pregnant women with pSS were at increased risks of fetal loss (aOR 15.06, 95%CI 1.19 to 191.11), and a higher risk of fetal growth restriction (aOR 15.69, 95%CI 1.61 to 153.33), preterm birth (aOR 5.52, 95%CI 1.83 to 16.65), a cesarean section (aOR 6.53, 95%CI 3.18 to 13.42) and a neonatal intensive care unit admission (aOR 12.86, 95%CI 1.88 to 87.82) after adjusting for confounding factors. The rate of congenital heart block in the pSS group was 4.7%. Conclusions Pregnant women with pSS were at increased risk of having adverse pregnancy outcomes. Women with pSS require prenatal counseling to explain the risks involved and well control of pSS condition before conception and a close antenatal monitoring should be performed by both rheumatologists and obstetricians.

Marijuana Use in Young Mothers and Adverse Pregnancy Outcomes: A Retrospective Cohort Study

2020 ◽  
Vol 40 (3) ◽  
pp. 148-148
Author(s):  
C.E. Rodriguez ◽  
J. Sheeder ◽  
A.A. Allshouse ◽  
S. Scott ◽  
E. Wymore ◽  
...  
Keyword(s):  
Cohort Study ◽  
Retrospective Cohort Study ◽  
Pregnancy Outcomes ◽  
Retrospective Cohort ◽  
Marijuana Use ◽  
Adverse Pregnancy Outcomes ◽  
Young Mothers ◽  
Adverse Pregnancy

scholarly journals Maternal age and the risk of adverse pregnancy outcomes: a retrospective cohort study

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Ambrogio P. Londero ◽  
Emma Rossetti ◽  
Carla Pittini ◽  
Angelo Cagnacci ◽  
Lorenza Driul
Keyword(s):  
Cohort Study ◽  
Retrospective Cohort Study ◽  
Pregnancy Outcomes ◽  
Retrospective Cohort ◽  
Maternal Age ◽  
Adverse Pregnancy Outcomes ◽  
Adverse Pregnancy

scholarly journals Risk Factors Associated with Coronavirus Disease 2019 (COVID-19) Symptoms and Potential Vertical Transmission During Pregnancy: A Retrospective Cohort Study

2021 ◽  
Author(s):  
Bibita Peter ◽  
Nicholas Ree ◽  
Karen Ferrer ◽  
Laila Younes ◽  
Barbara Lepe ◽  
...  
Keyword(s):  
Cohort Study ◽  
Pregnant Women ◽  
Disease Severity ◽  
Vertical Transmission ◽  
Retrospective Cohort Study ◽  
Pregnancy Outcomes ◽  
Retrospective Cohort ◽  
Public Hospitals ◽  
Growing Body ◽  
The Impact

Abstract Objective: The COVID-19 pandemic is of special concern for pregnant women. A growing body of evidence suggests the virus can have a deleterious impact upon outcomes related to birth and newborn health. There is a paucity of published research demonstrating the factors that influence disease severity among those who are pregnant, while a growing body of evidence demonstrates that vertical transmission occurs. Our study investigated the impact of maternal characteristics upon COVID-19 outcomes, as well as whether disease severity impacted pregnancy outcomes. Methods: We conducted a retrospective cohort study of pregnant women with COVID-19 who were admitted to two public hospitals in our state between April-August, 2020. Pregnancy outcomes and clinical, laboratory, and placental data were collected. Results: Thirty-four pregnant women tested positive for SARS-CoV-2. Among them, 55% (19/34) were symptomatic. Of those who were symptomatic, 68% (13/19) presented with fever and cough. Those with symptoms had a statistically significant higher pregestational mean BMI compared with asymptomatic women (35.7±7.9 vs 26.7±6.9, P=0.004). Screening of biochemical records demonstrated that symptomatic women had lower potassium levels compared with those who were asymptomatic (median: 3.70 mEq/L vs 4.30 mEq/L, P=0.009). High BMI (42.4 kg/m2) and low potassium levels (3.0 mEq/L) were observed in the only case of postpartum mortality among the symptomatic women. We did not observe any influence of maternal COVID-19 severity on placental histopathology/infant health or evidence of vertical transmission, regardless of preterm status or duration of fetal exposure. Conclusion: High pregestational BMI and lower potassium levels were associated with the presence of COVID-19 symptoms among pregnant women.

scholarly journals A retrospective cohort study of risk factors and pregnancy outcomes in 14,014 Chinese pregnant women

Medicine ◽  
2018 ◽  
Vol 97 (33) ◽  
pp. e11748 ◽  
Author(s):  
Yuan-Yuan Yang ◽  
Yi-Hua Fang ◽  
Xue Wang ◽  
Ying Zhang ◽  
Xiao-Jun Liu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cohort Study ◽  
Pregnant Women ◽  
Retrospective Cohort Study ◽  
Pregnancy Outcomes ◽  
Retrospective Cohort
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