Influence of maternal HIV infection on fetal thymus size

2019 ◽  
Vol 48 (1) ◽  
pp. 67-73
Author(s):  
Clara L. Gasthaus ◽  
Ralf Schmitz ◽  
Kerstin Hammer ◽  
Kathrin Oelmeier de Murcia ◽  
Maria K. Falkenberg ◽  
...  
Keyword(s):  
Hiv Infection ◽  
Fetal Outcome ◽  
Hiv Positive ◽  
Control Group ◽  
Fetal Thymus ◽  
Hiv Positive Mothers ◽  
Maternal Hiv ◽  
Maternal Hiv Infection ◽  
Hiv Exposed ◽  
Thymus Size

AbstractObjectiveTo reveal the effect of a maternal human immunodeficiency virus (HIV) infection on the fetal thymus size.MethodsThe sonographic fetal thymus size was measured retrospectively in 105 pregnancies with maternal HIV infection and in 615 uncomplicated singleton pregnancies. The anteroposterior thymic and the intrathoracic mediastinal diameter were determined in the three-vessel view and their quotient, the thymic-thoracic ratio (TT ratio), was calculated. The study group was subdivided into three groups by the maternal viral load on the date of ultrasound (<50 cop./mL, 50–1000 cop./mL, >1000 cop./mL). Furthermore, an association between prognostic factors of the HIV infection such as the lymphocyte count, CD4/CD8 ratio, HIV medication and the thymus size, was investigated using correlation analyses.ResultsFetal thymus size in pregnancies of HIV-positive mothers showed to be noticeably larger than in uncomplicated pregnancies. The mean TT ratio in the HIV-positive group was 0.389 and in the control group 0.345 (P < 0.001). There was no association between any maternal HIV parameter or medication and the size of the thymus gland.ConclusionMaternal HIV infection was associated with an increased fetal thymus size. Further consequences of intrauterine HIV exposure for fetal outcome and the development of the immune system of HIV-exposed uninfected (HEU) infants must be discussed.

scholarly journals OC31.07: Influence of maternal HIV‐infection on fetal thymus size

2019 ◽  
Vol 54 (S1) ◽  
pp. 83-83
Author(s):  
M. Falkenberg ◽  
C. Gasthaus ◽  
R. Schmitz ◽  
K. Hammer ◽  
K. Oelmeier de Murcia ◽  
...  
Keyword(s):  
Hiv Infection ◽  
Fetal Thymus ◽  
Maternal Hiv ◽  
Maternal Hiv Infection ◽  
Thymus Size

scholarly journals Neonatal Tetanus Immunity in Nigeria: The Effect of HIV Infection on Serum Levels and Transplacental Transfer of Antibodies

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Muhammad Faruk Bashir ◽  
Hassan Abdullahi Elechi ◽  
Mohammed Garba Ashir ◽  
Adamu Ibrahim Rabasa ◽  
David Nadeba Bukbuk ◽  
...  
Keyword(s):  
Hiv Infection ◽  
Serum Levels ◽  
Neonatal Tetanus ◽  
Hiv Positive ◽  
Serum Samples ◽  
Transplacental Transfer ◽  
Maternal Hiv ◽  
Maternal Hiv Infection ◽  
Hiv Exposed ◽  
Tetanus Antibodies

Background. Tetanus toxoid immunisation of pregnant mother has remained the most effective strategy in eliminating neonatal tetanus. Impaired production and/or transplacental transfer of antibodies may affect the effectiveness of this strategy. We studied the effect of maternal HIV infection on serum levels and transplacental transfer of anti-tetanus antibodies.Methods. A total of 162 mother-baby paired serum samples were taken and analysed for anti-tetanus antibody levels using ELISA. Maternal HIV status was also determined by double ELISA technique. Maternal TT vaccination status was also documented.Results. Thirty-eight (23.5%) mothers and 41 (25.3%) babies were seronegative, out of whom 8 mothers were HIV positive and 9 babies were HIV exposed. HIV infected mothers and HIV exposed infants were, respectively, 16.27 times (OR = 16.27, 95% CI = 3.28 to 80.61) and 33.75 times (OR = 33.75, 95% CI = 4.12 to 276.40) more likely to be seronegative for anti-tetanus antibody. Similarly, HIV positive mother-newborn pairs were 7.46 times more likely to have a poor transplacental transfer of tetanus antibodies (OR = 7.46, 95% CI = 1.96 to 28.41).Conclusions. Maternal HIV infection is associated with impaired maternofoetal transfer of anti-tetanus antibodies and seronegativity among mothers and their newborns. Hence, this may hinder efforts to eliminate neonatal tetanus.

scholarly journals Impact of maternal HIV infection on pregnancy outcomes in southwestern China – a hospital registry based study

2019 ◽  
Vol 147 ◽  
Author(s):  
M. Yang ◽  
Y. Wang ◽  
Y. Chen ◽  
Y. Zhou ◽  
Q. Jiang
Keyword(s):  
Immune Deficiency ◽  
Hiv Infection ◽  
Pregnancy Outcomes ◽  
Adverse Pregnancy Outcomes ◽  
Southwestern China ◽  
Hiv Positive ◽  
Rural Residence ◽  
Maternal Hiv ◽  
Maternal Hiv Infection ◽  
Adverse Pregnancy

AbstractGlobally, human immune deficiency virus (HIV)/acquired immune deficiency syndrome (AIDS) continues to be a major public health issue. With improved survival, the number of people living with HIV/AIDS is increasing, with over 2 million among pregnant women. Investigating adverse pregnant outcomes of HIV-infected population and associated factors are of great importance to maternal and infant health. A cross-sectional data collected from hospital delivery records of 4397 mother–infant pairs in southwestern China were analysed. Adverse pregnant outcomes (including low birthweight/preterm delivery/low Apgar score) and maternal HIV status and other characteristics were measured. Two hundred thirteen (4.9%) mothers were HIV positive; maternal HIV infection, rural residence and pregnancy history were associated with all three indicators of adverse pregnancy outcomes. This research suggested that maternal population have high prevalence in HIV infection in this region. HIV-infected women had higher risks of experiencing adverse pregnancy outcomes. Rural residence predisposes adverse pregnancy outcomes. Findings of this study suggest social and medical support for maternal-infant care needed in this region, selectively towards rural areas and HIV-positive mothers.

scholarly journals Maternal HIV infection and other factors associated with growth outcomes of HIV-uninfected infants in Entebbe, Uganda

2013 ◽  
Vol 16 (9) ◽  
pp. 1548-1557 ◽  
Author(s):  
Lawrence Muhangi ◽  
Swaib A Lule ◽  
Harriet Mpairwe ◽  
Juliet Ndibazza ◽  
Moses Kizza ◽  
...  
Keyword(s):  
Hiv Infection ◽  
Maternal Education ◽  
Hiv Transmission ◽  
Growth Data ◽  
Poor Growth ◽  
Growth Outcomes ◽  
Maternal Hiv ◽  
Maternal Hiv Infection ◽  
Hiv Exposed ◽  
Living Children

AbstractObjectiveTo assess the associations between maternal HIV infection and growth outcomes of HIV-exposed but uninfected infants and to identify other predictors for poor growth among this population.DesignWithin a trial of de-worming during pregnancy, the cohort of offspring was followed from birth. HIV status of the mothers and their children was investigated and growth data for children were obtained at age 1 year. Length-for-age, weight-for-age and weight-for-length Z-scores were calculated for each child; Z-scores <−2 were defined as stunting, underweight and wasting, respectively.SettingThe study was conducted in Entebbe municipality and Katabi sub-county, Uganda.SubjectsThe sample consisted of 1502 children aged 1 year: HIV-unexposed (n 1380) and HIV-exposed not infected (n 122).ResultsPrevalence of stunting, underweight and wasting was 14·2 %, 8·0 % and 3·9 %, respectively. There was evidence for an association between maternal HIV infection and odds of being underweight (adjusted OR = 2·32; 95 % CI 1·32, 4·09; P = 0·006) but no evidence for an association with stunting or with wasting. Young maternal age, low maternal education, low birth weight, early weaning and experiencing a higher number of episodes of malaria during infancy were independent predictors for stunting and underweight. A higher number of living children in the family was associated with wasting.ConclusionsMaternal HIV infection was associated with being underweight in HIV-exposed uninfected infants. The success of programmes for prevention of mother-to-child HIV transmission means that an increasing number of infants will be born to HIV-infected women without acquiring HIV. Therefore, viable nutritional interventions need to be identified for this population.

scholarly journals Placental Transfer of Respiratory Syncytial Virus Antibody Among HIV-Exposed, Uninfected Infants

2019 ◽  
Vol 9 (3) ◽  
pp. 349-356
Author(s):  
Sweta M Patel ◽  
Sabelle Jallow ◽  
Sefelani Boiditswe ◽  
Shabir A Madhi ◽  
Kristen A Feemster ◽  
...  
Keyword(s):  
Hiv Infection ◽  
Neutralizing Antibodies ◽  
Placental Transfer ◽  
Immunodeficiency Virus ◽  
Maternal Hiv ◽  
Maternal Hiv Infection ◽  
Syncytial Virus ◽  
Hiv Exposed ◽  
Antibody Levels ◽  
Exposed Uninfected

Abstract Background Maternal human immunodeficiency virus (HIV) infection is associated with lower placental transfer of antibodies specific to several childhood pathogens. Our objective for this study was to evaluate the effect of maternal HIV infection on the placental transfer of respiratory syncytial virus (RSV)-neutralizing antibodies. Methods We conducted a cross-sectional study of mothers and their newborn infants at a tertiary hospital in Gaborone, Botswana, between March 2015 and December 2015. We measured serum RSV antibody levels by using a microneutralization assay. We used multivariable linear regression to evaluate the effect of maternal HIV infection on maternal RSV antibody levels, placental transfer of RSV antibodies, and newborn RSV antibody levels. Results Of 316 mothers, 154 (49%) were infected with HIV. The placental transfer ratios for RSV antibodies to HIV-exposed, uninfected (HEU) and HIV-unexposed, uninfected infants were 1.02 and 1.15, respectively. The geometric mean titer (95% confidence interval) of RSV-neutralizing antibodies was 2657 (2251–3136) among HEU newborns and 2911 (2543–3331) among HIV-unexposed, uninfected newborns. In multivariable analyses, maternal HIV infection was associated with lower placental transfer of RSV antibodies (P = .02) and a lower level of RSV antibodies among newborns (P = .002). Among HEU newborns, higher birth weight (P = .004) and an undetectable maternal antenatal viral load (P = .01) were associated with more effective placental transfer of RSV antibodies. Conclusions Maternal human immunodeficiency virus (HIV) infection is associated with lower mother-to-fetus transfer of serum RSV-neutralizing antibodies. HEU infants should be prioritized for preventive interventions for RSV. Maternal viral suppression through combination antiretroviral therapy has the potential to improve immunity to RSV among HIV-exposed infants.

Mother-to-child HIV-transmission prevention programs in a sub-Saharan African setting: The Gabonese experience

2017 ◽  
Vol 29 (3) ◽  
pp. 221-226 ◽  
Author(s):  
Armel Mintsa-Ndong ◽  
Corneille Ndong-Ella ◽  
Roselyne K Boussougou ◽  
Léatitia M Busugu ◽  
Alexandre Mba ◽  
...  
Keyword(s):  
Hiv Infection ◽  
Antenatal Care ◽  
Hiv Transmission ◽  
Care Delivery ◽  
Hiv Positive ◽  
Hiv Exposed Infants ◽  
Hiv Positive Mothers ◽  
Sub Saharan ◽  
Hiv Exposed ◽  
Mother To Child

In many developing countries, mothers’ awareness remains a challenge despite the scaling up of antenatal care and programs preventing mother-to-child (MTC) HIV transmission. The present study was done in Libreville, Gabon where all antenatal care (delivery included) is free of charge. Here we assessed the timing of antenatal antiretroviral (ARV) prophylaxis initiation, HIV-exposed infants’ age at their first postnatal HIV check visit and investigated the association between mothers’ awareness or knowledge on their ARV therapy and infants’ HIV infection. We interviewed HIV-positive mothers on their first and subsequent laboratory visits to investigate infants’ HIV status and tested infants for HIV RNA and antibody between 2012 and 2014. We established that (1) of 718 HIV-positive mothers, only 6% were fully aware and knew what ARV treatment they were on during pregnancy; (2) half of the women (54%) start their antenatal ARV prophylaxis initiation during the second trimester of pregnancy; (3) 64% of HIV-exposed infants had their first HIV infection screening between birth and three months of age; (4) the overall prevalence of HIV infection in infants born from infected mothers was 8.9%; and (5) infants born from mothers uncertain about taking prophylactic ARV therapy were 13.3 times more likely to be infected by HIV than infants born from mothers certain about taking prophylactic ARV therapy. In conclusion, the study showed that despite free antenatal care, early access and adherence to components of MTC, HIV transmission preventive care remains unsatisfactory.

The impact of maternal HIV infection on parenting in inner-city African American families.

1997 ◽  
Vol 11 (4) ◽  
pp. 447-461 ◽  
Author(s):  
Beth A. Kotchick ◽  
Rex Forehand ◽  
Gene Brody ◽  
Lisa Armistead ◽  
Patricia Simon ◽  
...  
Keyword(s):  
African American ◽  
Hiv Infection ◽  
Inner City ◽  
African American Families ◽  
Maternal Hiv ◽  
Maternal Hiv Infection ◽  
The Impact ◽  
American Families
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