scholarly journals Analysis of ticagrelor’s cardio-protective effects on patients with ST-segment elevation acute coronary syndrome accompanied with diabetes

Open Medicine ◽  
2019 ◽  
Vol 14 (1) ◽  
pp. 234-240 ◽  
Author(s):  
Dong-Tao Li ◽  
Shun-Bao Li ◽  
Jian-Yong Zheng ◽  
Hai-hong Tang ◽  
Yi-Gang Qiu ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Adverse Reactions ◽  
Left Ventricular ◽  
Control Group ◽  
Observation Group ◽  
Protective Effects ◽  
St Segment Elevation ◽  
Coronary Syndrome ◽  
St Segment ◽  
Elevation Acute Coronary Syndrome

AbstractBackgroundTo analyze the cardio-protective effects of ticagrelor in patients with acute coronary syndrome with S-T segment elevation.MethodsThe sample was 200 patients who had been diagnosed with acute coronary syndrome accompanied by diabetes Mellitus type II. Only patients having ST segment elevation before the treatment were included. Then, the subjects were further randomly divided into an observation group and a control group. The control group of 100 patients received clopidogrel; the observation group of 100 patients of ticagrelor. The serous creatine kinase CK-MB, functional cardiac indexes of left ventricular end diastolic diameter (LVDD), cardiac troponin I, ventricular ejection fraction, and relevant major adverse cardiovascular events (MACE) were compared between the two groups.ResultsOne month after a percutaneous coronary intervention (PCI) the observation group showed better results against angina, stent thrombosis, and all-cause mortality compared with those of the control subjects. Six months after treatment, both groups suffered adverse reactions. The number of patients who suffered adverse reactions in respiratory tract in the observation group was higher than in the control group. The inhibition of platelet aggregation IPA of ticagrelor was found to be significantly higher than clopidogrel, having a significant p value.ConclusionTicagrelor can effectively protect myocardial function for patients with ST-segment elevation acute coronary syndrome accompanied by diabetes and can reduce the incidence of adverse reactions..

Effect of recombinant human brain natriuretic peptide on patients with non-ST segment elevation acute coronary syndrome

2021 ◽  
Vol 7 (5) ◽  
pp. 3226-3231
Author(s):  
Wubin Wu ◽  
LiZhi Liu ◽  
Jiacai Chen
Keyword(s):  
Acute Coronary Syndrome ◽  
Human Brain ◽  
Brain Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Control Group ◽  
Study Group ◽  
St Segment Elevation ◽  
Coronary Syndrome ◽  
St Segment ◽  
Elevation Acute Coronary Syndrome

Objective: To investigate the effect of recombinant human brain natriuretic peptide on patients with non-ST segment elevation acute coronary syndrome. Methods: 80 patients with non-ST segment elevation acute coronary syndrome diagnosed and treated in our hospital from January 2017 to December 2019 were randomly divided into study group (n = 41) and control group (n = 39). All patients were treated with basal therapy, the control group was treated with isosorbide dinitrate, and the study group was treated with recombinant human brain natriuretic peptide on the basis of the control group. The changes of cardiac function indexes, renal function indexes and hemodynamic parameters before and after treatment were observed and compared between the two groups. Results: The total effective rate of the study group was 87.80%, which was significantly higher than that of the control group (69.23%) (P<0.05). There was no significant difference in left ventricular end-diastolic dimension (LVEDD), left ventricular end-systolic dimension (LVESD) and left ventricular ejection fraction (LVEF), hemodynamic parameters’ cardiac index (CI), central venous pressure (CVP), mean arterial pressure (MAP), systemic vascular resistance index (SVRI) and glomerular filtration rate (eGFR) between the two groups before treatment (P>0.05). After treatment, LVEDD, LVESD and SVRI were all decreased than that before treatment in the two groups, LVEF, CI, CVP, MAP and eGFR were higher than those before treatment (P<0.05), and LVEDD, LVESD and SVRI in the study group were lower than those in the control group, and LVEF, CI, CVP, MAP and eGFR were higher than those in the control group (P<0.05). Conclusion: Recombinant human brain natriuretic peptide is effective in the treatment of non-ST segment elevation acute coronary syndrome, which is beneficial not only for the recovery of cardiac function, but also for the improvement of hemodynamic staus and renal function.

Clinical and prognostic comparison between left ventricular transient dyskinesia and a first non-ST-segment elevation acute coronary syndrome

2008 ◽  
Vol 19 (7) ◽  
pp. 449-453 ◽  
Author(s):  
Iván Javier Núñez-Gil ◽  
Antonio Fernández-Ortiz ◽  
Leopoldo Pérez-Isla ◽  
María Luaces ◽  
Juan Carlos García-Rubira ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Left Ventricular ◽  
St Segment Elevation ◽  
Coronary Syndrome ◽  
St Segment ◽  
Elevation Acute Coronary Syndrome

scholarly journals Gender features of clinical course and outcomes of acute coronary syndrome with segment rise

2020 ◽  
pp. 90-96
Author(s):  
N.V. Lareva ◽  
◽  
A.S. Kurupanova ◽  
Keyword(s):  
Risk Factors ◽  
Acute Coronary Syndrome ◽  
Cardiogenic Shock ◽  
Left Ventricular ◽  
Left Ventricular Cavity ◽  
St Segment Elevation ◽  
Coronary Syndrome ◽  
St Segment ◽  
Males And Females ◽  
Elevation Acute Coronary Syndrome

The aim of the research is to study clinical, hemodynamic, affective disorders in ST-segment elevation acute coronary syndrome (STEACS); to identify gender risk factors affecting the outcomes. Material and methods. The study included 90 males and 90 females with ST-segment elevation acute coronary syndrome. All patients underwent echocardiography, coronary angiography (CAG), and a set of laboratory examinations. Spielberger test, CES-D scales, Morisky-Green test, and Montreal Cognitive Function Scale were uses to study psycho-emotional status of 75 males and females. The treatment was carried out in accordance with current clinical protocols, clinical guidelines and standards. The prognosis was assessed in a year. The results were processed using nonparametric statistics methods. Results. It was revealed that the females, included in the study, were older than males; they more often suffered from coronary artery disease, hypertension, type 2 diabetes, constitutive obesity (before the index event); they more regularly underwent antihypertensive therapy; they more often reached target BP values. There were no differences in features of coronary anatomy, frequency of invasive treatment, but females were significantly more likely to undergo thrombolytic therapy. Males smoked more often; asked for medical help earlier from the onset of anginal syndrome; they were more susceptible to dilatation of the left ventricular cavity. Females more often than males had high and medium level of personal anxiety, as well as high level of situational anxiety. Predictors of worsening prognosis in females are 4-vascular lesion of coronary bed, cardiogenic shock upon admission, decreased hemoglobin, dilatation of the left atrium, decreased cognitive functions, smoking. In males the predictors are: 3-vascular damage, cardiogenic shock, renal failure. Conclusion. It was found that in STEACS there are differences between males and females in several clinical, anatomical and functional characteristics. Risk factors for an unfavorable prognosis are gender specific. The revealed facts can be useful in individualized treatment, rehabilitation and secondary prevention programs.

Baseline CHA 2 DS 2 ‐VASc score and prognosis in octogenarians with non‐ST segment elevation acute coronary syndrome

2021 ◽  
Author(s):  
Pablo Díez‐Villanueva ◽  
Alberto Vera ◽  
Albert Ariza‐Solé ◽  
Francesc Formiga ◽  
Manuel Martínez‐Sellés ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
St Segment Elevation ◽  
Coronary Syndrome ◽  
St Segment ◽  
Elevation Acute Coronary Syndrome

scholarly journals Analysis of risk factors for different subtypes of acute coronary syndrome

2021 ◽  
Vol 49 (5) ◽  
pp. 030006052110083
Author(s):  
Lei Zhang ◽  
Juledezi Hailati ◽  
Xiaoyun Ma ◽  
Jiangping Liu ◽  
Zhiqiang Liu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Acute Coronary Syndrome ◽  
Brain Natriuretic Peptide ◽  
Left Ventricular ◽  
St Segment Elevation ◽  
Amino Terminal ◽  
Coronary Syndrome ◽  
Segment Elevation Myocardial Infarction ◽  
St Segment

Aims To investigate the different risk factors among different subtypes of patients with acute coronary syndrome (ACS). Methods A total of 296 patients who had ACS were retrospectively enrolled. Blood and echocardiographic indices were assessed within 24 hours after admission. Differences in risk factors and Gensini scores of coronary lesions among three groups were analyzed. Results Univariate analysis of risk factors for ACS subtypes showed that age, and levels of fasting plasma glucose, amino-terminal pro-brain natriuretic peptide, and creatine kinase isoenzyme were significantly higher in patients with non-ST-segment elevation myocardial infarction (NSTEMI) than in those with unstable angina pectoris (UAP). Logistic multivariate regression analysis showed that amino-terminal pro-brain natriuretic peptide and the left ventricular ejection fraction (LVEF) were related to ACS subtypes. The left ventricular end-diastolic diameter was an independent risk factor for UAP and ST-segment elevation myocardial infarction (STEMI) subtypes. The severity of coronary stenosis was significantly higher in NSTEMI and STEMI than in UAP. Gensini scores in the STEMI group were positively correlated with D-dimer levels (r = 0.429) and negatively correlated with the LVEF (r = −0.602). Conclusion Different subtypes of ACS have different risk factors. Our findings may have important guiding significance for ACS subtype risk assessment and clinical treatment.

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