Chiral imidazolidinones: A class of priviliged organocatalysts in stereoselective organic synthesis

2020 ◽  
Vol 5 (5) ◽  
Author(s):  
Laura Raimondi ◽  
Chiara Faverio ◽  
Monica Fiorenza Boselli
Keyword(s):  
Pharmaceutical Industry ◽  
Green Chemistry ◽  
Organic Synthesis ◽  
Catalytic Synthesis ◽  
Biological Chemistry ◽  
Chiral Molecules ◽  
Catalytic Systems ◽  
Drug Synthesis ◽  
Industry Needs

AbstractChiral molecules hold a mail position in Organic and Biological Chemistry, so pharmaceutical industry needs suitable strategies for drug synthesis. Moreover, Green Chemistry procedures are increasingly required in order to avoid environment deterioration. Catalytic synthesis, in particular organocatalysis, in thus a continuously expanding field. A survey of more recent researches involving chiral imidazolidinones is here presented, with a particular focus on immobilized catalytic systems.

scholarly journals Diversifying Arena of Drug Synthesis: In the Realm of Lipase Mediated Waves of Biocatalysis

Catalysts ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 1328
Author(s):  
Sahil Verma ◽  
Rahul Narayanlal Choudhary ◽  
Akash Prakash Kanadje ◽  
Uttam Chand Banerjee
Keyword(s):  
Pharmaceutical Industry ◽  
Genetic Engineering ◽  
Organic Synthesis ◽  
Process Development ◽  
Industrial Process ◽  
Cascade Reactions ◽  
Third Wave ◽  
Catalytic Systems ◽  
Industrial Utilization ◽  
Drug Synthesis

Hydrolases, being most prominent enzymes used in industrial processes have left no stone unturned in fascinating the pharmaceutical industry. Lipases, being a part of acyl hydrolases are the ones that function similarly to esterases (except an interfacial action) wherein they generally catalyze the hydrolysis of ester bonds. Be it in terms of stereoselectivity or regioselectivity, lipases have manifested their promiscuous proficiency in rendering biocatalytic drug synthesis and intermediates thereof. Industrial utilization of lipases is prevalent since decades ago, but their distinctive catalytic competencies have rendered them suitable for maneuverability in various tides of biocatalytic industrial process development. Numbers of exquisite catalysts have been fabricated out of lipases using nanobiotechnology whereby enzyme reusability and robustness have been conferred to many of the organic synthesis procedures. This marks a considerable achievement of lipases in the second wave of biocatalysis. Furthermore, in the third wave an advent of genetic engineering has fostered an era of customized lipases for suitable needs. Be it stability or an enhanced efficacy, genetic engineering techniques have ushered an avenue for biocatalytic development of drugs and drug intermediates through greener processes using lipases. Even in the forthcoming concept of co-modular catalytic systems, lipases may be the frontiers because of their astonishing capability to act along with other enzymes. The concept may render feasibility in the development of cascade reactions in organic synthesis. An upcoming wave demands fulfilling the vision of tailored lipase whilst a far-flung exploration needs to be unveiled for various research impediments in rendering lipase as a custom fit biocatalyst in pharmaceutical industry.

Ultrasound-Promoted Organic Synthesis – A Recent Update

2021 ◽  
Vol 25 ◽  
Author(s):  
Goutam Brahmachari ◽  
Nayana Nayek ◽  
Mullicka Mandal ◽  
Anindita Bhowmick ◽  
Indrajit Karmakar
Keyword(s):  
Organic Chemistry ◽  
Green Chemistry ◽  
Organic Synthesis ◽  
Ultrasound Irradiation ◽  
Present Review ◽  
Organic Transformations ◽  
Reaction Conditions ◽  
Catalytic Systems ◽  
Bond Forming ◽  
Reducing Energy

: Ultrasonication, nowadays, is well-regarded as an effective green tool in implementing a plethora of organic transformations. The last decade has seen quite useful applications of ultrasound irradiation in synthetic organic chemistry. Ultrasound has already come out as a unique technique in green chemistry practice, for its inherent properties of minimizing wastes and reducing energy and time, thereby increasing the product yields with higher purities under milder reaction conditions. The present review summarizes ultrasound-promoted useful organic transformations involving both carbon-carbon and carbon-heteroatom (N, O, S) bond-forming reactions in the absence or presence of varying catalytic systems, reported during the period 2016-2020.

Significance of Green Synthetic Chemistry from a Pharmaceutical Perspective

2020 ◽  
Vol 26 (45) ◽  
pp. 5767-5782
Author(s):  
Haseeb Ahsan ◽  
Salman Ul Islam ◽  
Muhammad Bilal Ahmed ◽  
Young Sup Lee ◽  
Jong Kyung Sonn
Keyword(s):  
Pharmaceutical Industry ◽  
Green Chemistry ◽  
Tertiary Education ◽  
Cost Effective ◽  
Drug Approval ◽  
Sustainable Environment ◽  
Conventional Drug ◽  
Drug Synthesis ◽  
Manufacturing Techniques ◽  
Green Synthetic Chemistry

Background: Conventional practices of synthesis, manufacturing, and processing have led to severe adverse consequences for living beings and the environment. Objectives: Although medications cannot be replaced, the methods of synthesizing, manufacturing, and processing them can be changed and/or replaced. This paper explains the significance of green chemistry practices in the pharmaceutical industry. It emphasizes that we must replace conventional drug synthesis, processing, and manufacturing techniques with greener ones that are cost-effective, sustainable, environment-friendly, and profitable. Discussion: This paper comprises five sections. Section 1 is an introduction to green chemistry and its correlation with the pharmaceutical industry. Section 2 discusses the metrics necessary to measure the greenness of a process. Section 3 is about solvents used in the pharmaceutical industry, hazards, safety status, and environmental effects, including the ozone depletion potential. Section 4 explains catalytic amidation reactions because amides are one of the most commonly occurring functional groups with pharmacological activity. Section 5 discusses successful cases of converting conventional synthesis of active pharmaceutical ingredients and/or their intermediates to greener, sustainable alternatives. Conclusion: A balance is necessary between profits, processes, consumers, and the environment to ensure the survival of all stakeholders and decrease the environmental burden of pharmaceuticals. Incentives such as green chemistry awards should be endorsed and encouraged, in addition to making green chemistry part of tertiary education. In addition, changes to rules and regulations for drug approval in the context of green chemistry principles are necessary in order to preserve our planet for future generations.

Green Chemistry Articles of Interest to the Pharmaceutical Industry

2014 ◽  
Vol 18 (12) ◽  
pp. 1602-1613 ◽  
Author(s):  
Rakeshwar Bandichhor ◽  
Apurba Bhattacharya ◽  
Louis Diorazio ◽  
Peter Dunn ◽  
Kenneth Fraunhoffer ◽  
...  
Keyword(s):  
Pharmaceutical Industry ◽  
Green Chemistry

Green Chemistry Articles of Interest to the Pharmaceutical Industry

2021 ◽  
Author(s):  
Marian C. Bryan ◽  
Charlotte Dalton ◽  
Louis J. Diorazio ◽  
Jaika Doerfler ◽  
Lisa M. Doyle ◽  
...  
Keyword(s):  
Pharmaceutical Industry ◽  
Green Chemistry

scholarly journals Learning from B12 enzymes: biomimetic and bioinspired catalysts for eco-friendly organic synthesis

2018 ◽  
Vol 14 ◽  
pp. 2553-2567 ◽  
Author(s):  
Keishiro Tahara ◽  
Ling Pan ◽  
Toshikazu Ono ◽  
Yoshio Hisaeda
Keyword(s):  
Organic Synthesis ◽  
Reaction Mechanisms ◽  
Catalytic Reactions ◽  
Vitamin B ◽  
Catalytic Systems ◽  
New Approach ◽  
Enzyme Functions

Cobalamins (B12) play various important roles in vivo. Most B12-dependent enzymes are divided into three main subfamilies: adenosylcobalamin-dependent isomerases, methylcobalamin-dependent methyltransferases, and dehalogenases. Mimicking these B12 enzyme functions under non-enzymatic conditions offers good understanding of their elaborate reaction mechanisms. Furthermore, bio-inspiration offers a new approach to catalytic design for green and eco-friendly molecular transformations. As part of a study based on vitamin B12 derivatives including heptamethyl cobyrinate perchlorate, we describe biomimetic and bioinspired catalytic reactions with B12 enzyme functions. The reactions are classified according to the corresponding three B12 enzyme subfamilies, with a focus on our recent development on electrochemical and photochemical catalytic systems. Other important reactions are also described, with a focus on radical-involved reactions in terms of organic synthesis.

Green Chemistry Articles of Interest to the Pharmaceutical Industry

2009 ◽  
Vol 13 (3) ◽  
pp. 397-408 ◽  
Author(s):  
Ian Andrews ◽  
Jian Cui ◽  
Jimmy DaSilva ◽  
Leo Dudin ◽  
Peter Dunn ◽  
...  
Keyword(s):  
Pharmaceutical Industry ◽  
Green Chemistry
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