Ultrasound-Promoted Organic Synthesis – A Recent Update

2021 ◽  
Vol 25 ◽  
Author(s):  
Goutam Brahmachari ◽  
Nayana Nayek ◽  
Mullicka Mandal ◽  
Anindita Bhowmick ◽  
Indrajit Karmakar
Keyword(s):  
Organic Chemistry ◽  
Green Chemistry ◽  
Organic Synthesis ◽  
Ultrasound Irradiation ◽  
Present Review ◽  
Organic Transformations ◽  
Reaction Conditions ◽  
Catalytic Systems ◽  
Bond Forming ◽  
Reducing Energy

: Ultrasonication, nowadays, is well-regarded as an effective green tool in implementing a plethora of organic transformations. The last decade has seen quite useful applications of ultrasound irradiation in synthetic organic chemistry. Ultrasound has already come out as a unique technique in green chemistry practice, for its inherent properties of minimizing wastes and reducing energy and time, thereby increasing the product yields with higher purities under milder reaction conditions. The present review summarizes ultrasound-promoted useful organic transformations involving both carbon-carbon and carbon-heteroatom (N, O, S) bond-forming reactions in the absence or presence of varying catalytic systems, reported during the period 2016-2020.

Modern Organic Synthesis in the Laboratory

2008 ◽  
Author(s):  
Jie Jack Li ◽  
Chris Limberakis ◽  
Derek A. Pflum
Keyword(s):  
Organic Chemistry ◽  
Graduate Students ◽  
Organic Synthesis ◽  
Functional Group ◽  
Bond Formation ◽  
Reaction Conditions ◽  
Carbon Bond ◽  
Oxidation Reduction ◽  
Carbon Carbon Bond ◽  
Daunting Task

Searching for reaction in organic synthesis has been made much easier in the current age of computer databases. However, the dilemma now is which procedure one selects among the ocean of choices. Especially for novices in the laboratory, it becomes a daunting task to decide what reaction conditions to experiment with first in order to have the best chance of success. This collection intends to serve as an "older and wiser lab-mate" one could have by compiling many of the most commonly used experimental procedures in organic synthesis. With chapters that cover such topics as functional group manipulations, oxidation, reduction, and carbon-carbon bond formation, Modern Organic Synthesis in the Laboratory will be useful for both graduate students and professors in organic chemistry and medicinal chemists in the pharmaceutical and agrochemical industries.

Chiral imidazolidinones: A class of priviliged organocatalysts in stereoselective organic synthesis

2020 ◽  
Vol 5 (5) ◽  
Author(s):  
Laura Raimondi ◽  
Chiara Faverio ◽  
Monica Fiorenza Boselli
Keyword(s):  
Pharmaceutical Industry ◽  
Green Chemistry ◽  
Organic Synthesis ◽  
Catalytic Synthesis ◽  
Biological Chemistry ◽  
Chiral Molecules ◽  
Catalytic Systems ◽  
Drug Synthesis ◽  
Industry Needs

AbstractChiral molecules hold a mail position in Organic and Biological Chemistry, so pharmaceutical industry needs suitable strategies for drug synthesis. Moreover, Green Chemistry procedures are increasingly required in order to avoid environment deterioration. Catalytic synthesis, in particular organocatalysis, in thus a continuously expanding field. A survey of more recent researches involving chiral imidazolidinones is here presented, with a particular focus on immobilized catalytic systems.

scholarly journals Asymmetric Synthesis of Quinine: A Landmark in Organic Synthesis

2006 ◽  
Vol 1 (10) ◽  
pp. 1934578X0600101 ◽  
Author(s):  
Vijay Nair ◽  
Rajeev S. Menon ◽  
Sreekumar Vellalath
Keyword(s):  
Organic Chemistry ◽  
Total Synthesis ◽  
Asymmetric Synthesis ◽  
Organic Synthesis ◽  
Chemical Industry ◽  
Crucial Role ◽  
Historical Perspective ◽  
Modern Medicine ◽  
Present Review ◽  
Catalytic Asymmetric Synthesis

Ever since its isolation in 1820, Quinine has played a crucial role in the development of organic chemistry, the chemical industry and modern medicine. A total synthesis of quinine, widely regarded as an event of epochal importance, was claimed by Woodward and Doering in 1945. This work, however, heavily relied on unsubstantiated literature reports and it appears that Woodward's work fell short of a total synthesis of quinine. The first total synthesis of quinine was reported by Uskokovic in the 1970s. The first stereoselective total synthesis of quinine was accomplished only in 2001, by Stork, who incidentally is the originator of the concept of stereoselectivity in total synthesis. Apart from the stereoselectivity, Stork's synthesis of quinine is remarkable for its conceptual uniqueness and retrosynthetic novelty. Naturally, this work has been attested as a landmark in organic synthesis by leaders in the field. Subsequently, Jacobson and Kobayashi reported the catalytic asymmetric synthesis of quinine in 2003 and 2004, respectively. Both these synthesis have followed a similar approach. The present review has attempted to provide a concise account of the synthesis of quinine from a historical perspective.

Task-specific Ionic Liquids as a Green Catalysts and Solvents for Organic Synthesis

2020 ◽  
Vol 7 (1) ◽  
pp. 105-119 ◽  
Author(s):  
Swapnil A. Padvi ◽  
Dipak S. Dalal
Keyword(s):  
Ionic Liquids ◽  
Physical Properties ◽  
Organic Synthesis ◽  
Review Article ◽  
Present Review ◽  
Organic Transformations ◽  
The Past ◽  
Properties Characterization

Task-specific ionic liquids (TSILs) have received increased attention over the past few years as a Green Catalysts and Solvents for a large number of organic transformations. The present review article aims to provide an introduction, types of task-specific ionic liquids, preparation/synthesis, physical properties, characterization, use of TSILs as solvent and catalyst in organic synthesis.

scholarly journals Flavin-Dependent Halogenases Catalyze Enantioselective Olefin Halocyclization

2020 ◽  
Author(s):  
Dibyendu Mondal ◽  
Brian F. Fisher ◽  
Yuhua Jiang ◽  
Jared C. Lewis
Keyword(s):  
Organic Chemistry ◽  
Catalytic Activity ◽  
High Selectivity ◽  
Organic Transformations ◽  
Docking Simulations ◽  
Bond Forming ◽  
Reaction Optimization ◽  
Wide Range ◽  
Site Selective ◽  
Insight Into

<div><div><div><p>Catalytic enantioselective halocyclization of alkenes is a powerful bond forming tool in synthetic organic chemistry and a key step in the biosynthesis of several natural products. To date, however, no examples of enantioselective halocyclization of simple achiral olefins catalyzed by enzymes have been reported. Herein, we report that flavin-dependent halogenases (FDHs) previously engineered to catalyze site-selective aromatic halogenation can also catalyze bromolactonization of olefins with high enantioselectivity and near-native catalytic proficiency. Analysis of the selectivity of FDH variants along the lineage for the most selective enzymes reveals mutations responsible for the emergence of halocyclase activity, and docking simulations provide insight into the origins of improvements imparted by these mutations. High selectivity was achieved by characterizing and mitigating the release of HOBr from FDH variants using a combination of protein engineering and reaction optimization. Given the range of different halocyclization reactions and other organic transformations that proceed via oxidative halogenation, this expansion of FDH catalytic activity bodes well for the development of a wide range of biocatalytic halogenation reactions.</p></div></div></div>

Lemon Juice: A versatile reusable biocatalyst for the synthesis of bioactive organic compounds as well as numerous nanoparticles based catalytic system

2021 ◽  
Vol 25 ◽  
Author(s):  
Yogesh Brijwashi Sharma ◽  
Bhakti Umesh Hirlekar ◽  
Yogesh P. Bharitkar ◽  
Abhijit Hazra
Keyword(s):  
Green Chemistry ◽  
Small Molecules ◽  
Organic Synthesis ◽  
Potential Role ◽  
Fruit Juice ◽  
Lemon Juice ◽  
Review Article ◽  
Organic Transformations ◽  
Environment Friendly ◽  
Principal Role

Green chemistry is an essential part of the chemistry for the organic synthesis and also plays a principal role to save the environment from the harmful and toxic catalysts. Fruit juice catalyzed chemistry is a vital part of green chemistry in which lemon juice play a potential role in a various organic transformations. This review article has been summarized (from 2011-2020) with the application and importance of lemon juice in synthetic organic transformation as well as synthesis of various type of nanoparticles and catalysts. This review article can help the researcher to develop the route for the synthesis of various scaffolds, small molecules, nanoparticles and catalysts under economical and environment friendly condition.

Sulfonated β-cyclodextrins: efficient supramolecular organocatalysts for diverse organic transformations

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Bubun Banerjee ◽  
Anu Priya ◽  
Aditi Sharma ◽  
Gurpreet Kaur ◽  
Manmeet Kaur
Keyword(s):  
Sulfonic Acid ◽  
Present Review ◽  
Reusable Catalyst ◽  
Organic Transformations ◽  
Reaction Conditions

Abstract The present review summarizes various organic transformations carried out by using sulfonated β-cyclodextrins such as β-cyclodextrin sulfonic acid, β-cyclodextrin propyl sulfonic acid, and β-cyclodextrin butyl sulfonic acid as an efficient, supramolecular reusable catalyst under diverse reaction conditions.

Application of Trimethylsilanolate Alkali Salts in Organic Synthesis

Synthesis ◽  
2018 ◽  
Vol 50 (06) ◽  
pp. 1199-1208 ◽  
Author(s):  
Jan Hlaváč ◽  
Kristýna Bürglová
Keyword(s):  
Alkali Metal ◽  
Organic Synthesis ◽  
Organic Solvents ◽  
Solid Phase ◽  
Chemical Transformations ◽  
Organic Transformations ◽  
Reaction Conditions ◽  
Phase Chemistry ◽  
Alkali Salts ◽  
Solid Phase Chemistry

Trimethylsilanolate alkali salts are widely used in organic synthesis, mainly due to their solubility in common organic solvents. They are frequently used as nucleophiles in ester hydrolysis, both in solution and solid-phase chemistry. However, they have also been used as mild bases or as specific reagents in some chemical transformations. Reactions employing trimethylsilanolate alkali salts as the key component are typically performed under mild reaction conditions. This review summarizes the utilization of trimethylsilanolate alkali salts in various organic transformations.1 Introduction2 Properties of Alkali Metal Trimethylsilanolates (TMSO[M])3 Trimethylsilanolate Alkali Salts in Organic Synthesis4 Conclusion

Catalytic Applications of Saccharin and its Derivatives in Organic Synthesis

2020 ◽  
Vol 23 (28) ◽  
pp. 3191-3205 ◽  
Author(s):  
Bubun Banerjee ◽  
Vaishali Bhardwaj ◽  
Amninder Kaur ◽  
Gurpreet Kaur ◽  
Arvind Singh
Keyword(s):  
Organic Synthesis ◽  
Water Soluble ◽  
Environmentally Benign ◽  
Organic Transformations ◽  
Reaction Conditions ◽  
Available Water ◽  
Catalytic Applications

: Saccharin (1,2-benzisothiazol-3(2H)-one-1,1-dioxide) is a very mild, cheap, commercially available, water soluble, environmentally benign and edible Brønsted acidic substance. Recently, with other utilities, saccharin and its derivatives were employed as catalysts for various organic transformations. In this review, catalytic applicability of saccharin and its derivatives under various reaction conditions is summarized.

Enzyme catalysis in organic synthesis

2017 ◽  
Vol 19 (2) ◽  
pp. 331-332 ◽  
Author(s):  
Toshiyuki Itoh ◽  
Ulf Hanefeld
Keyword(s):  
Organic Chemistry ◽  
Green Chemistry ◽  
Organic Synthesis ◽  
Enzyme Catalysis

Editorial to accompany the Green Chemistry themed issue “Enzyme Catalysis in Organic Chemistry”.

Sign in / Sign up

Export Citation Format

Share Document