scholarly journals High-sensitivity C-reactive protein is associated with 24-hour ambulatory blood pressure variability in type 2 diabetes and control subjects

2016 ◽  
Vol 24 (1) ◽  
pp. 65-74 ◽  
Author(s):  
Dana Mihaela Ciobanu ◽  
Cornelia Gabriela Bala ◽  
Ioan Andrei Veresiu ◽  
Petru Adrian Mircea ◽  
Gabriela Roman
Keyword(s):  
Blood Pressure ◽  
Type 2 Diabetes ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Control Subjects ◽  
Ambulatory Bp Monitoring ◽  
And Control

Abstract Background and Aim: Type 2 diabetes (T2DM) has been associated with hypertension (HTN) and elevated high-sensitivity C-reactive protein (hsCRP), but the possible implication of blood pressure (BP) variability in increasing hsCRP in T2DM are incompletely understood. We aimed to assess the association between hsCRP and BP variability during 24-hour ambulatory BP monitoring in T2DM and healthy control subjects. Material and Method: The cross-sectional study included data from T2DM patients with normal BP (n=9), controlled HTN (n=46), uncontrolled HTN (n=20), and healthy controls (n=11). HsCRP was assessed using ELISA technique. All subjects underwent 24-hour ambulatory BP monitoring; BP variability was calculated using standard deviation. Results: We found that hsCRP was associated with daytime and 24-hours systolic and diastolic BP variability. Higher hsCRP were observed in T2DM patients with uncontrolled HTN and high BP variability compared to the other three groups. In multiple regression analysis, hsCRP was predicted by daytime and 24-hour diastolic BP variability. Conclusions: Our findings suggest that high hsCRP was associated with increased ambulatory BP variability in T2DM and control subjects. The contribution of both hsCRP and BP variability to cardiovascular risk stratification in T2DM needs to be evaluated in prospective studies.

scholarly journals High-sensitivity C-reactive protein in subjects with type 2 diabetes mellitus and/or high blood pressure

2007 ◽  
Vol 51 (6) ◽  
pp. 956-960 ◽  
Author(s):  
Luciana M. Lima ◽  
Maria das Graças Carvalho ◽  
Anna L. Soares ◽  
Adriano de P. Sabino ◽  
Ana P. Fernandes ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
High Sensitivity ◽  
Normal Subjects ◽  
C Reactive Protein ◽  
Hypertensive Patients ◽  
Reactive Protein ◽  
Hs Crp

Type 2 diabetes mellitus (DM2) and high blood pressure (HBP) may contribute to the development of cardiovascular disease, and inflammation may be an important factor in these diseases. In the present study, plasma levels of high-sensitivity C-reactive protein (hs-CRP) were measured in subjects with DM2 and/or HBP and compared to those of normal subjects. Eighty-nine subjects were analyzed for hs-CRP, including 13 normotensive patients with DM2, 17 patients with HBP, 34 hypertensive patients with DM2 (DM2+HBP) and 25 normal subjects. The plasma hs-CRP levels were significantly lower in the controls than in the HBP+DM2 group (p < 0.05). DM2 associated with HBP was also correlated with increased plasma hs-CRP levels (n = 89, r = 0.25, p = 0.0162). Only hypertensive patients with DM2 had higher levels of hs-CRP, a circulating inflammatory marker, than normal subjects. This finding suggests that patients with two associated diseases have a more active inflammatory state.

scholarly journals High-Sensitivity C-Reactive Protein Levels and Type 2 Diabetes in Urban North Indians

2009 ◽  
Vol 94 (6) ◽  
pp. 2123-2127 ◽  
Author(s):  
Anubha Mahajan ◽  
Rubina Tabassum ◽  
Sreenivas Chavali ◽  
Om Prakash Dwivedi ◽  
Mausumi Bharadwaj ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
High Risk ◽  
High Sensitivity ◽  
High Risk Group ◽  
Low Grade ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Reactive Protein ◽  
North Indians

Abstract Context: Elevated high-sensitivity C-reactive protein (hsCRP) levels have frequently been shown to be associated with type 2 diabetes (T2D); however, very little is known about this in Asian Indians, a high-risk group. Objective: The aim of the study was to assess the association of hsCRP with T2D and to determine its correlates in North Indians of Indo-European origin. Design and Patients: A cross-sectional population-based study of 2520 urban subjects, comprising 1410 T2D patients and 1110 nondiabetic subjects, was carried out and 18 metabolic traits were assessed. Results: Median hsCRP levels were significantly higher in both diabetic men and women as compared to their nondiabetic counterparts (P &lt; 0.0001). Elevated hsCRP was positively associated with T2D (odds ratio, 1.66; 95% confidence interval, 1.21–2.28; P = 0.002) even after adjusting for markers of obesity. After adjustments for age, sex, and BMI, HbA1c was the major correlate of hsCRP in nondiabetic subjects (β = 0.28; P = 0.03). We observed that T2D patients were at higher risk for cardiovascular disease compared to nondiabetic subjects when classified into low-, intermediate-, and high-risk groups based on hsCRP levels (ptrend = 3.8 ×10−15). Conclusions: We demonstrate the association of low-grade systemic inflammation, as indicated by elevated hsCRP levels, with T2D in North Indian population. This association was independent of obesity. Obesity and glycemic control were the major correlates of hsCRP levels. Future studies are required to evaluate the influence of modulators including genetic variations on the elevation of hsCRP levels in this population.

Obesity and Serum High Sensitivity C-Reactive Protein Levels Among Elderly Turkish Immigrants in the Netherlands with Type 2 Diabetes

2012 ◽  
Vol 39 (1) ◽  
pp. 68-80 ◽  
Author(s):  
Shiryn D. Sukhram ◽  
Gustavo G. Zarini ◽  
Lamya H. Shaban ◽  
Joan A. Vaccaro ◽  
Fatma G. Huffman
Keyword(s):  
Type 2 Diabetes ◽  
The Netherlands ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Turkish Immigrants ◽  
Protein Levels ◽  
Reactive Protein

scholarly journals High-Sensitivity C-Reactive Protein in Japanese Patients with Type 2 Diabetes

2005 ◽  
Vol 13 (10) ◽  
pp. 1810-1816 ◽  
Author(s):  
Yuji Tajiri ◽  
Kazuo Mimura ◽  
Fumio Umeda
Keyword(s):  
Type 2 Diabetes ◽  
High Sensitivity ◽  
Japanese Patients ◽  
C Reactive Protein ◽  
Reactive Protein

scholarly journals Evaluation of Serum High Sensitivity C-reactive Protein (hs-CRP) In Type-2 Diabetic Patient

1970 ◽  
Vol 11 (1) ◽  
pp. 20-23
Author(s):  
AKM Fazlul Haque ◽  
ARM Saifuddin Ekram ◽  
Quazi Tarikul Islam ◽  
Md Sarwar Jahan ◽  
Md Zahirul Haque
Keyword(s):  
Type 2 Diabetes ◽  
Diabetic Patient ◽  
Healthy Subjects ◽  
High Sensitivity ◽  
Diabetic Patients ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hs Crp ◽  
Type 2 Diabetic

Type-2 diabetes may remain in subclinical form for years before diagnosis. This quiescence of type-2 diabetes is a great concern for health care providers. The earliest change of the type-2 diabetes is the insulin resistance, which is associated with the increased macrovascular risk due to induction of chronic inflammation in the vessels of the body which leads to atherosclerotic change in the vessels. High sensitivity CRP (hs-CRP) is the measure of C-reactive protein with greater accuracy and the lower limit of its assay is .01 mg/L which is more than 100 times as sensitive as the usual CRP measurement (lower limit 5 mg/L). The median level of hs-CRP from blood samples of apparent healthy subjects is 0.8 mg/L. For this, physician uses the hs-CRP parameter as a marker of chronic inflammation in apparently normal healthy individuals, specially for the assessment of atherosclerosis, which is a chronic inflammatory procedure from the very beginning, in type-2 diabetic, obese and hypertensive patients. This vascular atherosclerosis assessment help them to calculate the cardiovascular as well as cerebrovascular risk of those patients. To help the type-2 diabetic patients from the very begining in respect of the prognostic view of the macrovascular risk, estimations of serum hs-CRP in the early stage of these patient may be a enthusiastic one. This descriptive study was carried out by choosing 70 diabetic patient who had no other comorbidity or any complications of diabetes and 35 healthy subjects who were neither diabetic nor had any diseases. Both the groups were non-smoker and non-alcoholic and non-hypertensive, hs-CRP level was measured in both the groups along with the HbA1c%. The mean hs-CRP in diabetic group was 1.13 mg/L and in normal healthy subjects was 0.39 mg/L. This higher level of mean hs-CRP (1.13 mg/L) in diabetic patients is statisticaly significant (P<0.01) compared with that of the normal healthy subjects mean hs-CRP (0.39 mg/L). This mean level of hs-CRP in normal healthy subjects was below the lower level of cardiovascular risk (1 mg/L). Keywords: High sensitivity CRP, C-reactive protein, diabetes DOI:10.3329/jom.v11i1.4263 J Medicine 2010: 11: 20-23

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