scholarly journals Analysis of Energy Consumption of Crushing Processes – Comparison of One-Stage and Two-Stage Processes

2017 ◽  
Vol 39 (2) ◽  
pp. 17-24
Author(s):  
Paweł Ciężkowski ◽  
Jan Maciejewski ◽  
Sebastian Bąk
Keyword(s):  
Energy Consumption ◽  
Experimental Comparison ◽  
Special Design ◽  
Two Stage ◽  
Jaw Crusher ◽  
Average Dimension ◽  
One Stage

Abstract This paper presents experimental comparison of two machine crushing technologies: one-stage and two-stage. The study was carried on a model double-toggle jaw crusher which allows crushing forces, energy and toggle displacement to be measured. The main aim of the work was to determine the energy consumption of crushing process assuming a given level of fragmentation. Studies were performed on three rocks: granite “Strzegom”, limestone “Morawica” and sandstone “Mucharz”. The material tested had a cubic shape and average dimension of 90 mm. One-stage crushing was carried out for outlet slot er = 11 mm, and two-stage crushing for er = 24 mm and 11 mm. In the tests special design of variable profile moving jaw was used and fixed jaw was flat. The analysis of the results shows that taking into account energy consumption, it is better to use two-stage crushing process. For given materials energy consumption in the two-stage crushing process was reduced by 30%.

scholarly journals Energy efficiency of staged reverse osmosis (RO) and closed-circuit reverse osmosis (CCRO) desalination: a model-based comparison

2020 ◽  
Vol 20 (8) ◽  
pp. 3096-3106
Author(s):  
Simeng Li ◽  
Karla Duran ◽  
Saied Delagah ◽  
Joe Mouawad ◽  
Xudong Jia ◽  
...  
Keyword(s):  
Energy Efficiency ◽  
Energy Consumption ◽  
Reverse Osmosis ◽  
Specific Energy ◽  
Numerical Models ◽  
Specific Energy Consumption ◽  
Closed Circuit ◽  
Two Stage ◽  
One Stage ◽  
Multi Stage

Abstract Reverse osmosis (RO) technologies have been widely implemented around the world to address the rising severity of freshwater scarcity. As desalination capacity increases, reducing the energy consumption of the RO process per permeate volume (i.e., specific energy consumption) is of particular importance. In this study, numerical models are used to characterize and compare the energy efficiency of one-stage continuous RO, multi-stage continuous RO, and closed-circuit RO (CCRO) processes. The simulated results across a broad range of feed salinity (5,000–50,000 ppm, i.e., 5–50 g kg−1) and recovery (40%–95%) demonstrate that, compared with the most common one-stage continuous RO, two-stage and three-stage continuous RO can reduce the specific energy consumption by up to 40.9% and 53.6%, respectively, while one-stage and two-stage CCRO can lead to 45.0% and 67.5% reduction, respectively. The differences in energy efficiencies of various RO configurations are more salient when desalinating high-salinity feed at a high recovery ratio. From the standpoints of energy saving and capital cost, the simulated results indicate that multi-stage CCRO is an optimal desalination process with great potential for practical implementation.

Analysis of one-stage and two-stage crushing of shale in jaw crusher ShchD 10M for manufacture of terrazzo tiles

2020 ◽  
pp. 78-84
Author(s):  
V. S. Bochkov ◽  
S. D. Dyagilev
Keyword(s):  
Size Distribution ◽  
Theory And Practice ◽  
Low Rank ◽  
Open Pit ◽  
Two Stage ◽  
Advantages And Disadvantages ◽  
Jaw Crusher ◽  
One Stage ◽  
Dark Color ◽  
The One

The article presents the experimental research data on oneand two-stage crushing of shale from the Rezh open pit mine in the Ural Region in jaw crusher ShchD 10M with a complex-moving jaw. Shale is a metamorphic rock of low rank, composed mainly of dark-color minerals and quartz or dark-color minerals and feldspar (except for amphiboles). Crushed shale is widely used in construction for coating of building sides, in production of roofing and in manufacture of tiles. For this reason, it is important for the theory and practice to determine rational parameters of shale crushing. The implemented studies into shale crushing show that as against the one-stage process, the two-stage crushing yields much more fines and reduces the yield of coarse (uncrushed) particles. The one-stage crushing offers acceptable coarseness of particles, as well as simplifies the process and allows less number of crushers to be involved. The productivity and time of crushing, as well as weight of shale samples are determined. Using testing screen A 20, size distribution of crushed shale was carried out, and the bar charts of the size distribution were constructed. Advantages and disadvantages of one-and two-stage crushing in a jaw crusher are described.

Molecular genetic background of haemophilia A patients with discrepancy between one-stage and two-stage factor VIII assays

2010 ◽  
Vol 30 (S 01) ◽  
pp. S153-S155
Author(s):  
D. Delev ◽  
S. Pahl ◽  
J. Driesen ◽  
H. Brondke ◽  
J. Oldenburg ◽  
...  
Keyword(s):  
Factor Viii ◽  
Genetic Background ◽  
Molecular Genetic ◽  
Haemophilia A ◽  
Two Stage ◽  
One Stage

Plasma Factor V Activation Is Prevented by Activated Protein C in the Presence of Phospholipid Vesicles, Not Platelets

1993 ◽  
Vol 69 (02) ◽  
pp. 124-129 ◽  
Author(s):  
Susan Solymoss ◽  
Kim Thi Phu Nguyen
Keyword(s):  
Western Blotting ◽  
Protein C ◽  
Thrombin Generation ◽  
Blood Platelets ◽  
Activated Protein C ◽  
Phospholipid Vesicles ◽  
Factor V ◽  
Two Stage ◽  
One Stage ◽  
Plasma Factor

SummaryActivated protein C (APC) is a vitamin K dependent anticoagulant which catalyzes the inactivation of factor Va and VIIIa, in a reaction modulated by phospholipid membrane surface, or blood platelets. APC prevents thrombin generation at a much lower concentration when added to recalcified plasma and phospholipid vesicles, than recalcified plasma and platelets. This observation was attributed to a platelet associated APC inhibitor. We have performed serial thrombin, factor V one stage and two stage assays and Western blotting of dilute recalcified plasma containing either phospholipid vesicles or platelets and APC. More thrombin was formed at a given APC concentration with platelets than phospholipid. One stage factor V values increased to higher levels with platelets and APC than phospholipid and APC. Two stage factor V values decreased substantially with platelets and 5 nM APC but remained unchanged with phospholipid and 5 nM APC. Western blotting of plasma factor V confirmed factor V activation in the presence of platelets and APC, but lack of factor V activation with phospholipid and APC. Inclusion of platelets or platelet membrane with phospholipid enhanced rather than inhibited APC catalyzed plasma factor V inactivation. Platelet activation further enhanced factor V activation and inactivation at any given APC concentration.Plasma thrombin generation in the presence of platelets and APC is related to ongoing factor V activation. No inhibition of APC inactivation of FVa occurs in the presence of platelets.

Two-Stage Procedure for the Quantitative Determination of Autoprothrombin III Concentration and Some Applications

1967 ◽  
Vol 18 (01/02) ◽  
pp. 198-210 ◽  
Author(s):  
Ronald S Reno ◽  
Walter H Seegers
Keyword(s):  
Prothrombin Time ◽  
Factor Vii ◽  
Two Stage ◽  
Pronounced Increase ◽  
One Stage ◽  
Assay Procedure ◽  
Bovine Plasma ◽  
The One ◽  
Autoprothrombin C

SummaryA two-stage assay procedure was developed for the determination of the autoprothrombin C titre which can be developed from prothrombin or autoprothrombin III containing solutions. The proenzyme is activated by Russell’s viper venom and the autoprothrombin C activity that appears is measured by its ability to shorten the partial thromboplastin time of bovine plasma.Using the assay, the autoprothrombin C titre was determined in the plasma of several species, as well as the percentage of it remaining in the serum from blood clotted in glass test tubes. Much autoprothrombin III remains in human serum. With sufficient thromboplastin it was completely utilized. Plasma from selected patients with coagulation disorders was assayed and only Stuart plasma was abnormal. In so-called factor VII, IX, and P.T.A. deficiency the autoprothrombin C titre and thrombin titre that could be developed was normal. In one case (prethrombin irregularity) practically no thrombin titre developed but the amount of autoprothrombin C which generated was in the normal range.Dogs were treated with Dicumarol and the autoprothrombin C titre that could be developed from their plasmas decreased until only traces could be detected. This coincided with a lowering of the thrombin titre that could be developed and a prolongation of the one-stage prothrombin time. While the Dicumarol was acting, the dogs were given an infusion of purified bovine prothrombin and the levels of autoprothrombin C, thrombin and one-stage prothrombin time were followed for several hours. The tests became normal immediately after the infusion and then went back to preinfusion levels over a period of 24 hrs.In other dogs the effect of Dicumarol was reversed by giving vitamin K1 intravenously. The effect of the vitamin was noticed as early as 20 min after administration.In response to vitamin K the most pronounced increase was with that portion of the prothrombin molecule which yields thrombin. The proportion of that protein with respect to the precursor of autoprothrombin C increased during the first hour and then started to go down and after 3 hrs was equal to the proportion normally found in plasma.

Standardization of Factor VIII – IV. Establishment of the 3rd International Standard for Factor VIII: C Concentrate

1983 ◽  
Vol 50 (03) ◽  
pp. 697-702 ◽  
Author(s):  
T W Barrowcliffe ◽  
A D Curtis ◽  
D P Thomas
Keyword(s):  
Factor Viii ◽  
High Purity ◽  
Collaborative Study ◽  
World Health ◽  
Current Standard ◽  
Two Stage ◽  
International Standard ◽  
One Stage ◽  
The One ◽  
Health Organization

SummaryAn international collaborative study was carried out to establish a replacement for the current (2nd) international standard for Factor VIII: C, concentrate. Twenty-six laboratories took part, of which 17 performed one-stage assays, three performed two-stage assays and six used both methods. The proposed new standard, an intermediate purity concentrate, was assayed against the current standard, against a high-purity concentrate and against an International Reference Plasma, coded 80/511, previously calibrated against fresh normal plasma.Assays of the proposed new standard against the current standard gave a mean potency of 3.89 iu/ampoule, with good agreement between laboratories and between one-stage and two- stage assays. There was also no difference between assay methods in the comparison of high-purity and intermediate purity concentrates. In the comparison of the proposed standard with the plasma reference preparation, the overall mean potency was 4.03 iu/ampoule, but there were substantial differences between laboratories, and the two-stage method gave significantly higher results than the one stage method. Of the technical variables in the one-stage method, only the activation time with one reagent appeared to have any influence on the results of this comparison of concentrate against plasma.Accelerated degradation studies showed that the proposed standard is very stable. With the agreement of the participants, the material, in ampoules coded 80/556, has been established by the World Health Organization as the 3rd International Standard for Factor VIII :C, Concentrate, with an assigned potency of 3.9 iu/ampoule.

scholarly journals Comparing the use of aggregate data and various methods of integrating individual patient data to network meta-analysis and its application to first-line ART

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Steve Kanters ◽  
Mohammad Ehsanul Karim ◽  
Kristian Thorlund ◽  
Aslam H. Anis ◽  
Michael Zoratti ◽  
...  
Keyword(s):  
Meta Analysis ◽  
Evidence Base ◽  
Aggregate Data ◽  
World Health ◽  
Coefficient Estimates ◽  
Two Stage ◽  
Individual Patient Level ◽  
One Stage ◽  
Meta Regression ◽  
Empirical Priors

Abstract Background The 2018 World Health Organization HIV guidelines were based on the results of a network meta-analysis (NMA) of published trials. This study employed individual patient-level data (IPD) and aggregate data (AgD) and meta-regression methods to assess the evidence supporting the WHO recommendations and whether they needed any refinements. Methods Access to IPD from three trials was granted through ClinicalStudyDataRequest.com (CSDR). Seven modelling approaches were applied and compared: 1) Unadjusted AgD network meta-analysis (NMA) – the original analysis; 2) AgD-NMA with meta-regression; 3) Two-stage IPD-AgD NMA; 4) Unadjusted one-stage IPD-AgD NMA; 5) One-stage IPD-AgD NMA with meta-regression (one-stage approach); 6) Two-stage IPD-AgD NMA with empirical-priors (empirical-priors approach); 7) Hierarchical meta-regression IPD-AgD NMA (HMR approach). The first two were the models used previously. Models were compared with respect to effect estimates, changes in the effect estimates, coefficient estimates, DIC and model fit, rankings and between-study heterogeneity. Results IPD were available for 2160 patients, representing 6.5% of the evidence base and 3 of 24 edges. The aspect of the model affected by the choice of modeling appeared to differ across outcomes. HMR consistently generated larger intervals, often with credible intervals (CrI) containing the null value. Discontinuations due to adverse events and viral suppression at 96 weeks were the only two outcomes for which the unadjusted AgD NMA would not be selected. For the first, the selected model shifted the principal comparison of interest from an odds ratio of 0.28 (95% CrI: 10.17, 0.44) to 0.37 (95% CrI: 0.23, 0.58). Throughout all outcomes, the regression estimates differed substantially between AgD and IPD methods, with the latter being more often larger in magnitude and statistically significant. Conclusions Overall, the use of IPD often impacted the coefficient estimates, but not sufficiently as to necessitate altering the final recommendations of the 2018 WHO Guidelines. Future work should examine the features of a network where adjustments will have an impact, such as how much IPD is required in a given size of network.

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