scholarly journals A pediatric case of EDTA-related pseudothrombocytopenia and implementation of the histograms by the automated cell counters

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
F. Sinem Hocaoglu-Emre ◽  
Berna Yavuz Aksu
Keyword(s):  
Platelet Count ◽  
Case Report ◽  
Platelet Aggregation ◽  
Ethylenediaminetetraacetic Acid ◽  
Pediatric Case ◽  
Case Presentation ◽  
Low Platelet Count ◽  
Cell Counter ◽  
Persistent Thrombocytopenia

Abstract Objectives Platelet aggregation in the presence of ethylenediaminetetraacetic acid (EDTA), is called EDTA-related pseudothrombocytopenia (EDTA-PTP), resulting in low platelet count by automatic cell counters. Case presentation Herein, we present a case of a 5-year-old female, who was referred to our laboratory due to persistent thrombocytopenia. Conclusion Our case report discusses the efficiency of the histograms and flag warnings of the cell counter, indicating the importance of these variables.

EDTA‑dependent pseudothrombocytopenia in child (clinical case report)

2021 ◽  
pp. 51-54
Author(s):  
N. A. Sokolova ◽  
M. I. Savina ◽  
O. S. Shokhina
Keyword(s):  
Platelet Count ◽  
Clinical Case ◽  
Sodium Citrate ◽  
Ethylenediaminetetraacetic Acid ◽  
Hemorrhagic Diathesis ◽  
Platelet Dysfunction ◽  
Rare Presentation ◽  
Blood Samples ◽  
Low Platelet Count ◽  
Aggregation Of Platelets

Ethylenediaminetetraacetic acid (EDTA)-dependent pseudothrombocytopenia is the phenomenon of a spurious low platelet count due to antiplatelet antibodies that cause platelet clumping in blood anticoagulated with EDTA. The aggregation of platelets in EDTA-dependent pseudothrombocytopenia is usually prevented by other anticoagulants, such as sodium citrate. EDTA-dependent pseudothrombocytopenia has never been associated with hemorrhagic diathesis or platelet dysfunction. In this article, a 2,5-year-old boy with EDTA-dependent pseudothrombocytopenia is presented because of rare presentation. We report that EDTA can induce platelet clumping, and thus spuriously low platelet counts. However, aggregation of platelets was not detected in blood samples with sodium citrate, and platelet count was normal.

scholarly journals Ethylenediaminetetraacetic Acid‑Dependent Pseudothrombocytopenia in Patient Previously Treated as Dengue Fever

2021 ◽  
Vol 17 (1) ◽  
pp. 65
Author(s):  
Hendra Wana Nur’amin ◽  
Muhammad Darwin Prenggono ◽  
Wivina Riza Devi
Keyword(s):  
Bone Marrow ◽  
Platelet Count ◽  
Dengue Fever ◽  
Complete Blood Count ◽  
Ethylenediaminetetraacetic Acid ◽  
Bone Marrow Aspiration ◽  
Normal Platelet ◽  
Low Platelet Count ◽  
Bleeding Manifestation ◽  
Secondary Hospital

Abstract: One of the most widely used anticoagulants for a complete blood count is ethylenediaminetetraacetic acid (EDTA).  Pseudothrombocytopenia (PTCP) may be caused by EDTA, this condition may lead to inappropriate diagnosis and treatment. We report a 25-year-old female with unspecific headache and joint pain with very low platelet count since 1 month before hospital admission. She was diagnosed with Dengue fever infection and got some platelet transfusion from the previous secondary hospital. She was carried out for a blood test with another anticoagulant (sodium citrate) and bone marrow aspiration. The results showed that she had normal platelet count and bone marrow cellularity. When a patient was identified with thrombocytopenia without any bleeding manifestation, hematology disease, and family history, PTCP should be taken into consideration to prevent unnecessary intervention. Keywords: platelet, pseudothrombocytopenia, ethylenediaminetetraacetic acid, Dengue fever

Fructose-1,6-Bisphosphatase Deficiency: A Pediatric Case Report

2021 ◽  
Author(s):  
jiaying cao ◽  
lu xu ◽  
jiahua pan
Keyword(s):  
Case Report ◽  
Glucose Metabolism ◽  
Compound Heterozygote ◽  
Metabolic Decompensation ◽  
Pediatric Case ◽  
Case Presentation ◽  
Fructose 1,6 Bisphosphatase ◽  
Chromosome 9Q22 ◽  
Bisphosphatase Deficiency

Abstract Background: Fructose-1,6-bisphosphatase (FBPase) deficiency is a rare disorder of glucose metabolism, mainly revealed by hypoglycemia and lactic acidosis. The disease is caused by a mutation of FBP1 gene, which is clustered in a 31-kb region on chromosome 9q22. Case presentation: We described a two-and-half-year-old boy diagnosed as FBPase deficiency. The result of gene analysis showed that the patient had a compound heterozygote for the G164S and P308R, respectively inherited from his father and mother. To some degree, mutations are associated with activity of enzyme, which is corresponding to the level of glucose and extent of brain damage. Patients are advised to reduce intake of fructose and sucrose and avoid long-term fasting in order to reduce the risk of metabolic decompensation. Conclusions: This report would like to provide profound insights of FBPase deficiency.

Bilateral Non-Arteritic Anterior Ischemic Optic Neuropathy in a Patient with Autoimmune Thrombocytopenia

2000 ◽  
Vol 10 (2) ◽  
pp. 180-182 ◽  
Author(s):  
H.E. Killer ◽  
A. Huber ◽  
C. Portman ◽  
A. Forrer ◽  
J. Flammer
Keyword(s):  
Visual Acuity ◽  
Platelet Count ◽  
Case Report ◽  
Optic Neuropathy ◽  
Anterior Ischemic Optic Neuropathy ◽  
Ischemic Optic Neuropathy ◽  
Good Recovery ◽  
Autoimmune Thrombocytopenia ◽  
Low Platelet Count

Purpose To describe a patient with bilateral non-arteritic anterior ischemic optic neuropathy (NAION) and idiopathic autoimmune thrombocytopenia (ITP) with an extremely low platelet count. Method Case report. Results Remarkably good recovery of visual acuity. Conclusions Bilateral non-arteritic anterior ischemic optic neuropathy can develop in the presence of a very low platelet count.

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