Further Meroterpenes Produced by Penicillium sp., an Endophyte Obtained from Melia azedarach

2003 ◽  
Vol 58 (9-10) ◽  
pp. 663-669 ◽  
Author(s):  
Regina M. Geris dos Santos ◽  
Edson Rodrigues-Fo.
Keyword(s):  
Spectroscopic Studies ◽  
Melia Azedarach ◽  
Root Bark ◽  
Surface Sterilization ◽  
Penicillium Sp

AbstractFrom the methanolextract of Penicillium sp. cultivated on sterilized rice for three weeks we isolated three new meroterpenes preaustinoid A1, A2 and B1. The fungus was isolated from the root bark of Melia azedarach after surface sterilization. The structures of these compounds were identified by intensive spectroscopic studies.

Four Additional Meroterpenes Produced by Penicillium sp Found in Association with Melia azedarach. Possible Biosynthetic Intermediates to Austin

2007 ◽  
Vol 62 (8) ◽  
pp. 1035-1044 ◽  
Author(s):  
Taicia Pacheco Fill ◽  
Grace Kelli Pereira ◽  
Regina M. Geris dos Santos ◽  
Edson Rodrigues-Fo
Keyword(s):  
Nmr Spectroscopy ◽  
Spectroscopic Studies ◽  
Melia Azedarach ◽  
Root Bark ◽  
Penicillium Sp ◽  
New Compounds

Four additional meroterpenes were isolated and identified from rice cultures of Penicillium sp, a fungus obtained from the root bark of Melia azedarach. These new compounds were named preaustinoid B2 (1), preaustinoid A3 (2), austinolide (3), and isoaustinone (4) in analogy with the formerly described compounds. The structures were identified by extensive spectroscopic studies, including 1 D and 2 D NMR spectroscopy and HRMS. Compounds 1 - 4 are probably biosynthetic intermediates to Austin.

scholarly journals Co-Production of Bisphenylpropanoid Amides and Meroterpenes by an Endophytic Penicillium brasilianum Found in the Root Bark of Melia azedarach

2009 ◽  
Vol 64 (5-6) ◽  
pp. 355-360 ◽  
Author(s):  
Taicia P. Fill ◽  
Regina M. Geris dos Santos ◽  
Anderson Barisson ◽  
Edson Rodrigues-Filho ◽  
Antonia Q. L. Souza
Keyword(s):  
Antimicrobial Activity ◽  
Pathogenic Bacteria ◽  
Its Region ◽  
2D Nmr ◽  
Melia Azedarach ◽  
Root Bark ◽  
Inhibitory Effects ◽  
Rice Culture ◽  
Physical Methods ◽  
Penicillium Brasilianum

A fungus, isolated from the root bark of Melia azedarach (Meliaceae), from which a series of meroterpenes have been reported, was identified as Penicillium brasilianum based on analysis of the ITS region of ribosomal DNA. From a rice culture of this fungus, the known phenylpropanoid amides brasiliamide A and B were obtained together with and a new, slightly modified congener, along with the meroterpenoids preaustinoid A1, preaustinoid B2 and austinolide. The compounds were isolated by the use of combined chromatographic procedures and identified by physical methods, mainly 1D and 2D NMR experiments, with distinction for 1H{15N} HMBC applied to brasiliamide A. The amides were tested for their antimicrobial activity and showed only weak inhibitory effects, against a set of pathogenic bacteria

Four Additional Meroterpenes Produced by Penicillium sp. Found in Association with Melia azedarach. Possible Biosynthetic Intermediates to Austin

ChemInform ◽  
2007 ◽  
Vol 38 (47) ◽  
Author(s):  
Taicia Pacheco Fill ◽  
Grace Kelli Pereira ◽  
Regina M. Geris dos Santos ◽  
Edson Rodrigues-Fo
Keyword(s):  
Melia Azedarach ◽  
Penicillium Sp

Meroterpenes from Penicillium sp found in association with Melia azedarach

2002 ◽  
Vol 61 (8) ◽  
pp. 907-912 ◽  
Author(s):  
Regina M. Geris dos Santos ◽  
Edson Rodrigues-Fo
Keyword(s):  
Melia Azedarach ◽  
Penicillium Sp

scholarly journals Cytotoxicity and Antifungal Activities of Root Bark of Calotropis gigantea

2010 ◽  
Vol 2 (2) ◽  
pp. 38-41 ◽  
Author(s):  
M Rowshanul Habib ◽  
M Ashraful Alam ◽  
MA Haque ◽  
Farjana Nikkon ◽  
M Rezaul Karim
Keyword(s):  
Antifungal Activity ◽  
Aspergillus Niger ◽  
Ethyl Acetate ◽  
Petroleum Ether ◽  
Trichoderma Harzianum ◽  
Brine Shrimp ◽  
Methanol Extract ◽  
Root Bark ◽  
Calotropis Gigantea ◽  
Penicillium Sp

In this study, methanol extract from the root bark of Calotropis gigantea L. and its petroleum ether (40°C-60°C), chloroform and ethyl acetate soluble fractions were tested for their cytotoxic activity against brine shrimp nauplii (Artemia salina, Leach) and for antifungal activity against Aspergillus flavus, Aspergillus niger, Penicillium sp and Trichoderma harzianum. Thin layer chromatography (TLC) screening showed that methanol extract and its different fractions contained different type compounds such as steroid, terpene, glycoside, heterocyclic and flavonoid. In brine shrimp lethality bioassay, it was found that chloroform fraction was highly cytotoxic (LD50 14.72 μg/ml) among the tested samples. Though methanol extract and ethyl acetate fraction have no activity against all the tested fungi but petroleum ether and chloroform fractions showed potent activity against Aspergillus niger, Penicillium sp, Trichoderma harzianum and Aspergillus niger, Trichoderma harzianum, respectively, in antifungal activity test.  Key words: Calotropis gigantea; Methanol extract; Antifungal activity; Cytotoxicty.DOI: 10.3329/sjps.v2i2.2187Stamford Journal of Pharmaceutical Sciences Vol.2(2) 2009: 38-41

Meroterpenes from Penicillium sp Found in Association with Melia azedarach.

ChemInform ◽  
2003 ◽  
Vol 34 (17) ◽  
Author(s):  
Regina M. Geris dos Santos ◽  
Edson Rodrigues-Fo
Keyword(s):  
Melia Azedarach ◽  
Penicillium Sp

Spectroscopic studies of Pd (II) complexes with cysteine and its di- and tripeptides

1987 ◽  
Vol 84 ◽  
pp. 443-448 ◽  
Author(s):  
Teresa Kowalik ◽  
Brigitte Decock-Le Reverend ◽  
Claude Loucheux ◽  
Damien Ficheux ◽  
Henryk Kozlowski
Keyword(s):  
Spectroscopic Studies
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