Immunological monitoring of cancer vaccine therapy

2004 ◽  
Vol 4 (10) ◽  
pp. 1677-1684 ◽  
Author(s):  
Dirk Nagorsen ◽  
Carmen Scheibenbogen ◽  
Eckhard Thiel ◽  
Ulrich Keilholz
2006 ◽  
Vol 175 (4S) ◽  
pp. 201-201 ◽  
Author(s):  
Isao Hara ◽  
Junya Furukawa ◽  
Kazuki Yamanaka ◽  
Yuji Yamada ◽  
Masato Fujisawa

2003 ◽  
Vol 21 (2) ◽  
pp. 313-319 ◽  
Author(s):  
Mathew H. Chung ◽  
Rishab K. Gupta ◽  
Eddy Hsueh ◽  
Richard Essner ◽  
Wei Ye ◽  
...  

Purpose: A therapeutic polyvalent cancer vaccine (Canvaxin vaccine; CancerVax Corp, Carlsbad, CA) induces antibodies to a glycoprotein tumor-associated antigen (TA90). However, endogenous immune responses to TA90 have also been reported. This study examined anti-TA90 antibody responses with respect to the survival of patients who received adjuvant vaccine immunotherapy after resection of thick (≥ 4 mm) primary cutaneous melanoma. Patients and Methods: Serum specimens were obtained from 54 patients immediately before and then 1, 2, 4, and 6 months after wide local excision of thick primary cutaneous melanoma and sentinel lymphadenectomy. All patients were offered adjuvant therapies with the vaccine, high-dose interferon, or other agents. An enzyme-linked immunosorbent assay was used to determine serial serum titers of immunoglobulin G (IgG) and IgM antibodies against TA90. These titers were correlated with clinical course. Results: Forty-three patients chose vaccine therapy, and 11 patients chose postoperative observation. Preoperative anti-TA90 IgG and IgM titers were similar for vaccine and observation groups (P = .184). At a median follow-up of 26 months, univariate analysis of Cox regression showed that disease-free survival and overall survival of vaccine patients were significantly correlated with maximal IgM response (P = .0006 and .006, respectively) but not with maximal IgG response (P = .73 and .95, respectively). Neither response predicted survival in the observation group. Conclusion: Postoperative vaccine therapy may enhance IgG and IgM immune responses to TA90 after surgical resection, but only the IgM response is correlated with improved survival. These findings may become useful to guide selection of patients for postoperative adjuvant therapy of high-risk melanoma.


2014 ◽  
Vol 63 (5) ◽  
pp. 479-489 ◽  
Author(s):  
Takeshi Terashima ◽  
Eishiro Mizukoshi ◽  
Kuniaki Arai ◽  
Tatsuya Yamashita ◽  
Mariko Yoshida ◽  
...  

Blood Reviews ◽  
2018 ◽  
Vol 32 (4) ◽  
pp. 312-325 ◽  
Author(s):  
Myrna R. Nahas ◽  
Jacalyn Rosenblatt ◽  
Hillard M. Lazarus ◽  
David Avigan

2017 ◽  
Vol 40 (10) ◽  
pp. 1661-1668 ◽  
Author(s):  
Tetsuya Nomura ◽  
Keiichi Hirata ◽  
Takuto Shimaoka ◽  
Makie Yamakawa ◽  
Naoya Koizumi ◽  
...  

2012 ◽  
Vol 103 (1) ◽  
pp. 150-153 ◽  
Author(s):  
Norihiko Takahashi ◽  
Takayuki Ohkuri ◽  
Shigenori Homma ◽  
Junya Ohtake ◽  
Daiko Wakita ◽  
...  

Haigan ◽  
2009 ◽  
Vol 49 (6) ◽  
pp. 823-830
Author(s):  
Miki Sugiura ◽  
Yukihiro Yoshida ◽  
Jun Nakajima ◽  
Kazuhiro Kakimi ◽  
Hiromi Wada

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