scholarly journals Comparison of the Serum Levels of Interferon-α in the Patients With Crimean-Congo Hemorrhagic Fever Based on Disease Severity

2016 ◽  
Vol 1 (2) ◽  
pp. 58-62
Author(s):  
Maliheh Metanat ◽  
Masoud Salehi ◽  
Anita Ale Nabi ◽  
Masoume Noori Jangi ◽  
Alireza Noori Jangi ◽  
...  
Keyword(s):  
Disease Severity ◽  
Hemorrhagic Fever ◽  
Serum Levels ◽  
Interferon Α ◽  
Crimean Congo Hemorrhagic Fever

Evaluation of Platelet Activity Markers in Prognostic Value of Children with Crimean-Congo Hemorrhagic Fever

2020 ◽  
Vol 15 (03) ◽  
pp. 123-128
Author(s):  
Ahmet Sami Güven ◽  
Fatma Duksal ◽  
Özge Metin Akcan ◽  
Utku Aygüneş ◽  
Mehmet Burhan Oflaz
Keyword(s):  
Disease Severity ◽  
Prognostic Value ◽  
Severe Disease ◽  
Multivariate Logistic Regression Analysis ◽  
Prognostic Index ◽  
Hemorrhagic Fever ◽  
Healthy Children ◽  
Distribution Width ◽  
Crimean Congo Hemorrhagic Fever ◽  
Significant Difference

Abstract Objective The aim of this study is to investigate the prognostic value of platelet (PLT) activity markers in children with Crimean-Congo hemorrhagic fever (CCHF) and compare results with healthy controls. Materials and Methods A total of 135 patients with CCHF and 100 healthy children were included in this retrospective study. Mean age was 12.4 ± 3.3 years in CCHF group, and 92 patients were male. We measured PLT count, mean platelet volume (MPV), platelet distribution width (PDW), and mean platelet mass (MPM) as PLT activity markers. Results A statistically significant decrease in MPM and PLT, and significantly higher levels of PDW and activated partial thromboplastin time (aPTT) and no significant difference in MPV were observed in patients with CCHF compared with controls. Although there were no significant differences between the severe and nonsevere CCHF groups in term of MPV and PDW, the MPM value was significantly decreased in severe patients (p < 0.001). Furthermore, MPM values were inversely correlated with aPTT (r = −0.617, p = 0.015), and positively correlated with PLT (r = 0.703, p < 0.001) which are considered likely to be indicators of disease severity. Multivariate logistic regression analysis revealed MPM as an independent risk factor for severe disease. Conclusion Our study demonstrated that MPM values were decreased in severe cases compared with nonsevere in children with CCHF. The MPM as an indicator of PLT activation at the time of diagnosis in children with CCHF can be used as a prognostic index for disease severity.

Evaluation of the serum levels of soluble IL-2 receptor and endothelin-1 in children with Crimean-Congo hemorrhagic fever

Apmis ◽  
2013 ◽  
Vol 122 (7) ◽  
pp. 643-647 ◽  
Author(s):  
Koksal Deveci ◽  
Mehmet Burhan Oflaz ◽  
Enver Sancakdar ◽  
Elif Bilge Uysal ◽  
Ahmet Sami Guven ◽  
...  
Keyword(s):  
Hemorrhagic Fever ◽  
Serum Levels ◽  
Crimean Congo Hemorrhagic Fever ◽  
Endothelin 1

Evaluation of the relationship between serum levels of VEGF and sVEGFR1 with mortality and prognosis in patients with Crimean-Congo hemorrhagic fever

2013 ◽  
Vol 85 (10) ◽  
pp. 1794-1801 ◽  
Author(s):  
Mehmet Bakir ◽  
Sevtap Bakir ◽  
Ismail Sari ◽  
Veysel Kenan Celik ◽  
Mustafa Gokhan Gozel ◽  
...  
Keyword(s):  
Hemorrhagic Fever ◽  
Serum Levels ◽  
Crimean Congo Hemorrhagic Fever ◽  
The Relationship

scholarly journals Investigating dizziness symptom in adult cases with Crimean-Congo hemorrhagic fever using various scales

2021 ◽  
Vol 37 (1) ◽  
Author(s):  
Adem Bora ◽  
Seyit Ali Büyüktuna ◽  
Kasım Durmuş ◽  
Berat Baturay Demirkıran ◽  
Yasin Aslan ◽  
...  
Keyword(s):  
Activities Of Daily Living ◽  
Disease Severity ◽  
Daily Living ◽  
Clinical Symptoms ◽  
Hemorrhagic Fever ◽  
The Self ◽  
Multicenter Studies ◽  
Pathophysiological Mechanisms ◽  
Crimean Congo Hemorrhagic Fever ◽  
Vestibular Symptoms

Abstract Background This study was to investigate the frequency of self-reported dizziness symptom in cases with Crimean-Congo hemorrhagic fever (CCHF) and the severity of dizziness, if any, by using various scales. The frequency and severity of the self-reported dizziness symptom of CCHF patients, level of disability caused by dizziness, and to what extent vestibular symptoms affected activities of daily living were assessed by various scales. The frequency and severity of the self-reported dizziness symptom of CCHF patients, level of disability caused by dizziness, and to what extent vestibular symptoms affected activities of daily living were assessed by various scales. Results The frequency of dizziness in CCHF cases included in the study was 11.11% and all the cases were involved in the mild category in terms of disease severity. When the results of the scales applied to all of the cases were evaluated in general, it was seen that there was no vertigo or dizziness. Conclusion According to the results of the present study, we consider that multicenter studies with large series investigating pathophysiological mechanisms underlying these clinical symptoms are needed in order to evaluate dizziness symptom and to make definitive interpretations in CCHF disease.

scholarly journals Can Serum Ferritin Level Predict Disease Severity in Patients with Crimean-Congo Hemorrhagic Fever?

2013 ◽  
Vol 45 (2) ◽  
pp. 108-114 ◽  
Author(s):  
Maliheh Metanat ◽  
Batool Sharifi Mood ◽  
Mehdi Tabatabaei ◽  
Mohammed Sarraf Shirazi
Keyword(s):  
Disease Severity ◽  
Serum Ferritin ◽  
Serum Ferritin Level ◽  
Ferritin Level ◽  
Hemorrhagic Fever ◽  
Crimean Congo Hemorrhagic Fever

scholarly journals Evaluation of Serum TNF-alpha, IL-6, IL-10, and IFN-gamma Levels in Patients with Crimean–Congo Hemorrhagic Fever

2017 ◽  
Vol 4 (suppl_1) ◽  
pp. S312-S313
Author(s):  
Yilmaz Hülya ◽  
Gürdal Yilmaz ◽  
Ugur Kostakoglu ◽  
Mustafa Arslan ◽  
Süleyman Caner Karahan ◽  
...  
Keyword(s):  
Hospital Stay ◽  
Hemorrhagic Fever ◽  
Serum Levels ◽  
Cell Types ◽  
Tnf Alpha ◽  
Ifn Gamma ◽  
Crimean Congo Hemorrhagic Fever ◽  
Severe Group ◽  
High Concentrations ◽  
Immunologic Diseases

Abstract Background Crimean–Congo hemorrhagic fever (CCHF) is a potentially fatal disease caused by a tick-borne virus from the Bunyaviridae family. Cytokines plays an important role in the pathogenesis of viral, bacterial, and immunologic diseases. This study aimed to investigate the role of TNF-alpha, IL-6, IL-10, and IFN-gamma levels in the severity of infection and clinical outcome of patients with CCHF. Methods Patients with confirmed CCHF were divided into two groups (severe cases: Patients who exhibited hemorrhage during their hospital stay, and mild/moderate cases: Patients who displayed no hemorrhage during their hospital stay). Demographic characteristics, laboratory tests on admission of all patients with CCHF were investigated, and serum TNF-alpha, IL-6, IL-10, and IFN-gamma levels were measured. Results A total of 154 patients with confirmed CCHF were investigated. Forty-six (29.9%) of these patients were in the severe group. In patients with severe CCHF, significantly higher serum levels of TNF-alpha (68.2 ± 23.5; P = 0.008) and IL-6 (73.1 ± 41.6; P = 0.003) were detected, compared with cytokine levels in patients who mild/moderate CCHF (Table 1). No differences in serum IL-10 and IFN-gamma levels between patients who severe CCHF and those who mild/moderate CCHF were detected (P &gt; 0.05). Conclusion Cytokines, chemokines, and other inflammatory mediators function in a manner, acting on many different cell types to regulate the host’s immune response. When cytokines present in high concentrations, they might toxic or even lethal effects. In accordance with this view, we have detected increased serum TNF-alpha, IL-6 levels in the patients with severe CCHF. Disclosures All authors: No reported disclosures.

scholarly journals High serum levels of neopterin in patients with Crimean–Congo hemorrhagic fever and its relation with mortality

2008 ◽  
Vol 56 (5) ◽  
pp. 366-370 ◽  
Author(s):  
Pınar Onguru ◽  
Emin Ozgur Akgul ◽  
Esragul Akıncı ◽  
Halil Yaman ◽  
Yasemin Gulcan Kurt ◽  
...  
Keyword(s):  
Hemorrhagic Fever ◽  
Serum Levels ◽  
High Serum ◽  
Crimean Congo Hemorrhagic Fever
Sign in / Sign up

Export Citation Format

Share Document