Cellular Toxicity of Different Classes of Adjuvants

2008 ◽  
pp. 3-3-8
Author(s):  
H de Ruiter ◽  
E Nijhuis ◽  
H-W Wollenweber ◽  
H-G Mainx
Keyword(s):  
Cellular Toxicity

Cellular Toxicity and Apoptosis Studies in Osteocarcinoma Cells, a Comparison of 177Lu-EDTMP and Lu-EDTMP

2013 ◽  
Vol 6 (3) ◽  
pp. 146-151 ◽  
Author(s):  
Chandan Kumar ◽  
Aruna Korde ◽  
Kusum Kumari ◽  
Tapas Das ◽  
Grace Samuel
Keyword(s):  
Cellular Toxicity

In Vitro Methods for the Assessment of L-Cysteine Conjugate Toxicity

1994 ◽  
Vol 22 (2) ◽  
pp. 72-80
Author(s):  
Lorraine D. Buckberry ◽  
Harriet J. Adcock ◽  
Jeremy Adler ◽  
Ian S. Blagbrough ◽  
Peter J. Gaskin ◽  
...  
Keyword(s):  
Mechanism Of Action ◽  
Mammalian Species ◽  
Mercapturic Acid ◽  
Assay Method ◽  
Cellular Toxicity ◽  
In Vitro Methods ◽  
Metabolic Route ◽  
Assay Methods ◽  
Chang Liver

L-Cysteine conjugates are normally metabolised via N-acetylation to produce a mercapturic acid. However, a recently identified metabolic route (C-S lysis) may lead to the generation of an unstable thiol which has been demonstrated to be responsible for toxicity in various mammalian species. Human Chang liver cells were challenged with a number of established L-cysteine conjugates. The cellular toxicity of these compounds was determined using a range of assay procedures, which provided differing information, depending on the assay method used. These observations were then investigated in order to establish which system would provide the most reliable indication of C-S lyase toxicity and whether any information on the mechanism of action could be obtained by these assay methods.

Relationships between Cellular Toxicity, the Maximum Tolerated Dose, Lipophilicity and Electrophilicity

1992 ◽  
Vol 20 (4) ◽  
pp. 549-562
Author(s):  
Herbert S. Rosenkranz ◽  
Edwin J. Matthews ◽  
Gilles Klopman
Keyword(s):  
Cultured Cells ◽  
Chemical Properties ◽  
Maximum Tolerated Dose ◽  
Log P ◽  
Lumo Energy ◽  
Cellular Toxicity ◽  
Water Partition Coefficient ◽  
The Us ◽  
Lowest Unoccupied Molecular Orbital ◽  
Rats And Mice

Results on cellular toxicity and maximum tolerated dose (MTD) for rats and mice were available for approximately 175 chemicals tested by the US National Toxicology Program. Additionally, the computed log P (log octanol-water partition coefficient) and the lowest unoccupied molecular orbital (LUMO) energy values, a measure of electrophilicity were also available for most of these chemicals. Analysis of the chemicals on the basis of their physical and quantum chemical properties and their toxic effects on cultured cells and rodents showed that: 1) as a group, the more toxic chemicals showed a trend towards higher LUMO energies (i.e. less electrophilic); 2) cytotoxic chemicals exhibited increased lipophilicity; and 3) cytotoxic chemicals were associated with increased systemic toxicity (as measured by the MTD). None of these relationships was expressed in a significant linear fashion as a function of the concentration at which the chemicals exhibited cytotoxicity.

scholarly journals Formulation, characterization, and cellular toxicity assessment of tamoxifen-loaded silk fibroin nanoparticles in breast cancer

Drug Delivery ◽  
2021 ◽  
Vol 28 (1) ◽  
pp. 1626-1636
Author(s):  
Afrasim Moin ◽  
Shahid Ud Din Wani ◽  
Riyaz Ali Osmani ◽  
Amr S. Abu Lila ◽  
El-Sayed Khafagy ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Silk Fibroin ◽  
Toxicity Assessment ◽  
Cellular Toxicity ◽  
Silk Fibroin Nanoparticles

Placental ABC transporters, cellular toxicity and stress in pregnancy

2013 ◽  
Vol 203 (2) ◽  
pp. 456-466 ◽  
Author(s):  
Irving L.M.H. Aye ◽  
Jeffrey A. Keelan
Keyword(s):  
Abc Transporters ◽  
Cellular Toxicity ◽  
In Pregnancy

Cellular Toxicity of Various Inhalable Metal Nanoparticles on Human Alveolar Epithelial Cells

2007 ◽  
Vol 19 (sup1) ◽  
pp. 59-65 ◽  
Author(s):  
Seoyoung Park ◽  
Yong Kwon Lee ◽  
Moonju Jung ◽  
Ki Heon Kim ◽  
Namhyun Chung ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Metal Nanoparticles ◽  
Alveolar Epithelial Cells ◽  
Cellular Toxicity ◽  
Alveolar Epithelial ◽  
Human Alveolar Epithelial Cells

Extension of cellular toxicity cost functions to tissues

Cryobiology ◽  
2018 ◽  
Vol 80 ◽  
pp. 160
Author(s):  
Adam Z. Higgins ◽  
Ali Eroglu ◽  
James D. Benson
Keyword(s):  
Cost Functions ◽  
Cellular Toxicity

Dietary Uptake of Cu Sorbed to Hydrous Iron Oxide is Linked to Cellular Toxicity and Feeding Inhibition in a Benthic Grazer

2016 ◽  
Vol 50 (3) ◽  
pp. 1552-1560 ◽  
Author(s):  
Daniel J. Cain ◽  
Marie-Noële Croteau ◽  
Christopher C. Fuller ◽  
Amy H. Ringwood
Keyword(s):  
Iron Oxide ◽  
Cellular Toxicity ◽  
Feeding Inhibition ◽  
Dietary Uptake ◽  
Hydrous Iron Oxide
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