scholarly journals Sex-Specific Role for Dopamine Receptor D2 in Dorsal Raphe Serotonergic Neuron Modulation of Defensive Acoustic Startle and Dominance Behavior

eNeuro ◽  
2020 ◽  
Vol 7 (6) ◽  
pp. ENEURO.0202-20.2020
Author(s):  
Krissy A. Lyon ◽  
Benjamin D. Rood ◽  
Lorna Wu ◽  
Rebecca A. Senft ◽  
Lisa V. Goodrich ◽  
...  
Keyword(s):  
Dopamine Receptor ◽  
Acoustic Startle ◽  
Dorsal Raphe ◽  
Specific Role ◽  
Dominance Behavior ◽  
Serotonergic Neuron ◽  
Dopamine Receptor D2 ◽  
Dorsal Raphé

scholarly journals Inactivation of the GATA Cofactor ZFPM1 Results in Abnormal Development of Dorsal Raphe Serotonergic Neuron Subtypes and Increased Anxiety-Like Behavior

2020 ◽  
Vol 40 (45) ◽  
pp. 8669-8682
Author(s):  
Laura Tikker ◽  
Plinio Casarotto ◽  
Parul Singh ◽  
Caroline Biojone ◽  
T. Petteri Piepponen ◽  
...  
Keyword(s):  
Dorsal Raphe ◽  
Abnormal Development ◽  
Serotonergic Neuron ◽  
Dorsal Raphé

scholarly journals Molecular and anatomical organization of the dorsal raphe nucleus

eLife ◽  
2019 ◽  
Vol 8 ◽  
Author(s):  
Kee Wui Huang ◽  
Nicole E Ochandarena ◽  
Adrienne C Philson ◽  
Minsuk Hyun ◽  
Jaclyn E Birnbaum ◽  
...  
Keyword(s):  
Single Cell ◽  
Dorsal Raphe Nucleus ◽  
Cell Types ◽  
Dorsal Raphe ◽  
Raphe Nucleus ◽  
Molecular Organization ◽  
Serotonergic Neuron ◽  
Multiple Cell ◽  
Dorsal Raphé

The dorsal raphe nucleus (DRN) is an important source of neuromodulators and has been implicated in a wide variety of behavioral and neurological disorders. The DRN is subdivided into distinct anatomical subregions comprised of multiple cell types, and its complex cellular organization has impeded efforts to investigate the distinct circuit and behavioral functions of its subdomains. Here we used single-cell RNA sequencing, in situ hybridization, anatomical tracing, and spatial correlation analysis to map the transcriptional and spatial profiles of cells from the mouse DRN. Our analysis of 39,411 single-cell transcriptomes revealed at least 18 distinct neuron subtypes and 5 serotonergic neuron subtypes with distinct molecular and anatomical properties, including a serotonergic neuron subtype that preferentially innervates the basal ganglia. Our study lays out the molecular organization of distinct serotonergic and non-serotonergic subsystems, and will facilitate the design of strategies for further dissection of the DRN and its diverse functions.

Buspirone-induced changes in the serotonergic and non-serotonergic cells in the dorsal raphe nucleus of rats

2010 ◽  
Vol 473 (2) ◽  
pp. 136-140 ◽  
Author(s):  
Ali Jahanshahi ◽  
Lee Wei Lim ◽  
Harry W.M. Steinbusch ◽  
Veerle Visser-Vandewalle ◽  
Yasin Temel
Keyword(s):  
Dorsal Raphe Nucleus ◽  
Dorsal Raphe ◽  
Raphe Nucleus ◽  
Induced Changes ◽  
Dorsal Raphé
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